Published in Comp Biochem Physiol B on November 15, 1972
The viral thymidine kinase gene as a tool for the study of mutagenesis in Trypanosoma brucei. Nucleic Acids Res (1996) 0.96
Trypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding. J Biol Chem (2012) 0.79
Trypanosoma brucei Methylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine: IMPLICATIONS FOR THE PHARMACOLOGY OF ADENOSINE ANTIMETABOLITES. J Biol Chem (2016) 0.76
Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major. PLoS Negl Trop Dis (2015) 0.76
Pyrimidine Metabolism in Schistosomes: A comparison with Other Parasites and the Search for Potential Chemotherapeutic Targets. Comp Biochem Physiol B Biochem Mol Biol (2017) 0.75
BIOCHEMICAL AND NUTRITIONAL STUDIES ON THE INDUCTION OF FATTY LIVERS BY DIETARY OROTIC ACID. Proc Natl Acad Sci U S A (1960) 1.25
The effects of phenobarbital, chloral betaine, and glutethimide administration on warfarin plasma levels and hypoprothrombinemic responese in man. Clin Pharmacol Ther (1969) 1.15
Dependence of 5-methyltetrahydrofolate utilization by L5178Y murine leukemia cells in vitro on the presence of hydroxycobalamin and transcobalamin II. Cancer Res (1973) 1.15
Dihydrofolate reductase from Trypanosoma equiperdum. I. Isolation, partial purification, and properties. Mol Pharmacol (1967) 1.09
Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo. Cancer Res (1981) 1.05
Comparative properties of schistosomal and filarial dihydrofolate reductases. Biochem Pharmacol (1972) 0.98
5-methyl-5,6,7,8-tetrahydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with methionine synthetase from bovine brain. Biochemistry (1975) 0.90
Sensitivity of Trypanosoma equiperdum to the action of tumor-inhibitory antibiotics in vitro. Biochem Pharmacol (1965) 0.89
Effect of methionine deprivation on L5178Y murine leukemia cells in culture interference with the antineoplastic effect of methotrexate. Biochem Pharmacol (1976) 0.89
Presence and properties of dihydrofolate reductases within the genus Crithidia. Biochim Biophys Acta (1969) 0.88
Antischistosomal action of tubercidin administered after absorption into red cells. Nature (1971) 0.87
Glutathione S-transferase in adult Dirofilaria immitis and Brugia pahangi. Mol Biochem Parasitol (1986) 0.86
Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism. J Med Chem (1982) 0.85
Antitumor activity of a folate-cleaving enzyme, carboxypeptidase G 1 . Cancer Res (1972) 0.85
Nucleoside analogs as antiparasitic agents. Ann N Y Acad Sci (1975) 0.84
The conversion of exogenous retinol and related compounds into retinyl phosphate mannose by adult Brugia pahangi in vitro. Biochem J (1983) 0.84
Comparative activity and properties of lactate dehydrogenase, xanthine dehydrogenase, and dihydrofolate reductase in normal and Brugia pagangi-infected Aedes aegypti. J Parasitol (1977) 0.83
Comparative effects of folate antagonists versus enzymatic folate depletion on folate and thymidine enzymes in cultured mammalian cells. Cancer Treat Rep (1977) 0.83
Dihydrofolate reductases within the genus Trypanosoma. Exp Parasitol (1969) 0.82
Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cells. Biochem Pharmacol (1980) 0.82
Improved purification of tetrahydrofolate dehydrogenase from L1210 leukemia by affinity chromatography. Biochim Biophys Acta (1972) 0.82
Dihydrofolate reductase from Trypanosoma equiperdum. II. Inhibition by 2,4-diaminopyrimidines and related heterocycles. J Med Chem (1969) 0.82
Stereospecificity at carbon 6 of fomyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro. Biochem Pharmacol (1979) 0.82
Initial rate kinetics and evidence for duality of mediated transport of adenosine, related purine nucleosides, and nucleoside analogues in L1210 cells. Cancer Res (1983) 0.82
The gel-filtration behaviour of dihydrofolate reductases from culture forms of trypanosomatids. Biochim Biophys Acta (1969) 0.81
Isolation, partial purification, and properties of thymidine kinase from Trypanosoma (trypanozoon) brucei rhodesiense. J Parasitol (1972) 0.80
Growth inhibitory, transport and biochemical properties of the gamma-glutamyl and gamma-aspartyl peptides of methotrexate in L1210 leukemia cells in vitro. Biochem Pharmacol (1978) 0.79
Specificity of systems mediating transport of adenosine, 9-beta-d-arabinofuranosyl-2-fluoroadenine, and other purine nucleoside analogues in L1210 cells. Cancer Res (1983) 0.79
Biochemical and pharmacologic properties of a new folate analog, 10-deaza-aminopterin, in mice. Cancer Treat Rep (1982) 0.79
Alterations in the kinetics of methotrexate transport during growth of L1210 murine leukemia cells in culture. Mol Pharmacol (1980) 0.79
Glycosyl transferase activity in homogenates of adult Dirofilaria immitis. Mol Biochem Parasitol (1982) 0.79
Isoprenoid biosynthesis in adult Brugia pahangi and Dirofilaria immitis. J Parasitol (1981) 0.78
Dihydrofolate reductase from filarial worms and schistosomes. Ann N Y Acad Sci (1971) 0.78
Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists. Cancer Res (1976) 0.78
Folate analog transport by plasma membrane vesicles isolated from L1210 leukemia cells. J Biol Chem (1979) 0.77
Trypanocidal properties of 5'-O-Sulfamoyladenosine, a close structural analog of nucleocidin. Exp Parasitol (1970) 0.77
Treatment of schistosomiasis mansoni and japonica in baboons with tubercidin given by direct intravenous injection. Am J Trop Med Hyg (1975) 0.77
Phosphatidylserine synthesis in adult Dirofilaria immitis females. Int J Parasitol (1986) 0.76
Folate metabolism in filariae: enzymes associated with 5,10-methylenetetrahydrofolate. J Parasitol (1980) 0.76
Two types of pyruvate kinase in schistosomes and filariae. Comp Biochem Physiol B (1973) 0.76
De novo synthesis of methionine in normal and Brugia-infected Aedes aegypti. J Parasitol (1979) 0.76
Phosphofructokinase activity in particulate-free extracts of Trypanosoma (Trypanozoon) rhodesiense. Comp Biochem Physiol B (1971) 0.76
Effects of tubercidin and its ribonucleotides on various metabolic pathways in Schistosoma mansoni. Biochem Pharmacol (1972) 0.76
Antischistosomal activity of tubercidin in monkeys. Am J Trop Med Hyg (1973) 0.76
Involvement of tetrahydrofolate cofactors in de novo purine ribonucleotide synthesis by adult Brugia pahangi and Dirofilaria immitis. Mol Biochem Parasitol (1981) 0.76
Retinol and filarial glycoprotein synthesis. Trans R Soc Trop Med Hyg (1983) 0.76
Sensitivity of Trypanosoma equiperdum to the action of tumor-inhibitory antibiotics in vivo. Nature (1967) 0.76
Thymidine kinase activity and thymidine salvage in adult Brugia pahangi and Dirofilaria immitis. Mol Biochem Parasitol (1982) 0.75
Inhibition of L5178Y cells in culture by methotrexate and antibiotics. Antimicrob Agents Chemother (1976) 0.75
Presence and properties of dihydrofolate reductases within the genus Trypanosoma. Br J Pharmacol (1968) 0.75
Metabolic patterns of Dirofilaria immitis microfilariae in vitro. J Parasitol (1970) 0.75
Further studies stereospecificity at carbon 6 for membrane transport of tetrahydrofolates. Diastereoisomers of 5-methyltetrahydrofolates as competitive inhibitors of transport of methotrexate in L1210 cells. Biochem Pharmacol (1982) 0.75
Leukotriene C4 synthesis catalyzed by Dirofilaria immitis glutathione S-transferase. Am J Trop Med Hyg (1989) 0.75
Different effects of vincristine on methotrexate uptake by L1210 cells and mouse intestinal epithelia in vitro and in vivo. Cancer Res (1979) 0.75
Phosphatidylinositol, phosphatidylglycerol and cardiolipin synthesis in adult Dirofilaria immitis females. Int J Parasitol (1987) 0.75
Sequential combination of methotrexate and vindesine in previously treated children with acute leukemia. A phase I-II study. Am J Clin Oncol (1984) 0.75
Some aspects of methionine metabolism by Trypanosoma equiperdum, in vitro. Biochem Pharmacol (1966) 0.75
Activity of tubercidin against immature Fasciola hepatica in mice. J Parasitol (1976) 0.75
Comparative efficacy of one and two treatments with tubercidin against Schistosomiasis japonica in monkeys. Am J Trop Med Hyg (1974) 0.75
Synthesis of ubiquinone 9 by adult Brugia pahangi and Dirofilaria immitis: evidence against its involvement in the oxidation of 5-methyltetrahydrofolate. Mol Biochem Parasitol (1981) 0.75
Synthesis and properties of the sulfonyl analogues of 4(5)-aminoimidazole-5(4)-carboxamide, 4(5)-(formylamino)imidazole-5(4)-carboxamide, guanine, and xanthine. J Med Chem (1980) 0.75
Folate metabolism in filariae. Enzymes associated with 5,10-methenyltetrahydrofolate and 10-formyltetrahydrofolate. J Parasitol (1980) 0.75
Isolation, partial purification and some properties of two acid proteases from adult Dirofilaria immitis. Mol Biochem Parasitol (1983) 0.75
Schedule-dependent synergism of methotrexate and vincristine against murine L1210 leukemia. Cancer Treat Rep (1980) 0.75
Comparative effects of methylglyoxal-bis (guanylhydrazone), phenformin, and insulin upon the metabolism of glucose and acetate by rat epididymal fat pads in vitro. Mol Pharmacol (1967) 0.75
Analog specific aberrancies in antifolate inhibition of L1210 cell dihydrofolate reductase. Biochem Pharmacol (1980) 0.75
10-Formyltetrahydrofolate synthetase activity in normal and brugia pahangi-infected Aedes aegypti. J Parasitol (1979) 0.75
Evidence that sulfisoxazole, an antibacterial sulfonamide, can adversely affect the development of Brugia pahangi in Aedes aegypti mosquitoes. J Parasitol (1978) 0.75
Methylenetetrahydrofolate dehydrogenase and reductase activity in normal and Brugia pahangi-infected Aedes aegypti. J Parasitol (1978) 0.75
Thymidylate synthetase activity in normal and brugia pahangi-infected aedes aegypti. Biochem Pharmacol (1979) 0.75
Phosphatidylcholine synthesis in adult Dirofilaria immitis females. Int J Parasitol (1985) 0.75
Intraerythrocytically administered tubercidin (7-deazaadenosine) and immune protection of mice. Proc Soc Exp Biol Med (1974) 0.75
Phosphatidylethanolamine synthesis in adult Dirofilaria immitis females. Int J Parasitol (1985) 0.75
Presence and properties of dihydrofolate reductases in Trypanosomatid flagellate. Trans R Soc Trop Med Hyg (1969) 0.75
Trypanocidal activity of a nitrovinylfuran derivative (SQ 18,506) in mice. Exp Parasitol (1973) 0.75
Increased schedule-dependent synergism of vindesine versus vincristine in combination with methotrexate against L1210 leukemia. Cancer Treat Rep (1982) 0.75
Long-term efficacy of tubercidin against schistosomiasis japonica and mansoni in primates. Am J Trop Med Hyg (1975) 0.75
Serine transhydroxymethylase activity in normal and Brugia pahangi-infected Aedes aegypti. J Parasitol (1978) 0.75
Therapeutic relevance of differences in the structural specificity of the transport systems for folate analogs in L1210 tumor cells and in isolated murine intestinal epithelial cells. Cancer Res (1977) 0.75
Cobalamin and folate metabolism in helminths. Blood Rev (1987) 0.75
In vitro antifilarial activity of organometallic complexes against infective larvae of Molinema dessetae and adult females of Brugia pahangi. Int J Parasitol (1998) 0.75
Determination of molecular weights of dihydrofolate reductases from trypanosomatid flagellates. Trans R Soc Trop Med Hyg (1970) 0.75
Comparative effects of diverse mammalian sera on the uptake and protein incorporation of 14C-labelled amino acids by blood stream forms of T. brucei and T. rhodesiense in vitro. Trans R Soc Trop Med Hyg (1969) 0.75
Sensitivity of trypanosomes to metabolic inhibitors. Trans N Y Acad Sci (1967) 0.75
Synthetic pathways of glycerophospholipids in adult Brugia pahangi and Brugia patei. Int J Parasitol (1987) 0.75
Synthesis of an N-aminopyrazinonium analogue of cytidine. J Med Chem (1983) 0.75