Published in J Med Chem on May 01, 1973
Nitric oxide metabolites induced in Anopheles stephensi control malaria parasite infection. Free Radic Biol Med (2006) 1.39
Fifty years of diazeniumdiolate research. From laboratory curiosity to broad-spectrum biomedical advances. ACS Chem Biol (2011) 1.12
Development of Chiral Bis-hydrazone Ligands for the Enantioselective Cross-Coupling Reactions of Aryldimethylsilanolates. J Org Chem (2014) 0.77
Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry. Biochemistry (1998) 1.83
Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography. J Lab Clin Med (1974) 1.24
Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide. Biochem Pharmacol (1998) 1.21
Relationship of urinary metabolites of theophylline to serum theophylline levels. Clin Pharmacol Ther (1976) 1.12
Reaction of nitric oxide with the free sulfhydryl group of human serum albumin yields a sulfenic acid and nitrous oxide. Biochemistry (1995) 1.03
Chemical approaches toward generation of nitroxyl. Methods Enzymol (1999) 0.98
Mechanism for the inhibition of aldehyde dehydrogenase by nitric oxide. Alcohol (1997) 0.98
Inhibition of aminonucleoside nephrosis in rats. IV. Prevention by N6-methyladenosine. J Lab Clin Med (1968) 0.97
N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties. Biochem Biophys Res Commun (1992) 0.95
Reaction of nitroxyl, an aldehyde dehydrogenase inhibitor, with N-acetyl-L-cysteine. Alcohol (2000) 0.95
Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase. J Med Chem (1992) 0.94
2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity. J Med Chem (1984) 0.93
Isoprene, an endogenous constituent of human alveolar air with a diurnal pattern of excretion. Life Sci (1978) 0.89
Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids. J Med Chem (1987) 0.89
Alcoholic cardiomyopathy in mice. Electron microscopic observations. J Mol Cell Cardiol (1977) 0.86
Metabolism of puromycin aminonucleoside in the normal, "pre-nephrotic," and nephrotic rat. Proc Soc Exp Biol Med (1967) 0.86
Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice. Mech Ageing Dev (2000) 0.85
Alcoholic cardiomyopathy in mice. Myocardial glycogen, lipids and certain enzymes. J Mol Cell Cardiol (1977) 0.84
Structural requirements for the sequestration of metabolically generated acetaldehyde. J Med Chem (1980) 0.84
Catalase mediated conversion of cyanamide to an inhibitor of aldehyde dehydrogenase. Alcohol (1985) 0.83
Latentiated forms of the transport-inhibitory alpha-amino acid adamantanine. J Pharm Sci (1980) 0.83
N-hydroxybenzenecarboximidic acid derivatives: a new class of nitroxyl-generating prodrugs. Nitric Oxide (2001) 0.83
Lowering of ethanol-derived circulating blood acetaldehyde in rats by D-penicillamine. Life Sci (1977) 0.83
Teratogenic effect of puromycin aminonucleoside on rat kidney. Nephron (1966) 0.82
The reaction of nitroxyl (HNO) with nitrosobenzene gives cupferron (N-nitrosophenylhydroxylamine). Nitric Oxide (1998) 0.82
Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase. Biochem Pharmacol (1986) 0.82
Decomposition of methylazoxymethanol, the aglycone of cycasin, in D 2 O. Nature (1972) 0.81
The mechanism of alkylation of DNA by 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (MIC), a metabolite of DIC (NSC-45388). Non-involvement of diazomethane. Chem Biol Interact (1974) 0.81
The metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase is catalyzed by catalase. Biochem Biophys Res Commun (1984) 0.81
Ethanol metabolism by the rat heart and alcohol dehydrogenase activity. Can J Biochem (1976) 0.81
Drug latentiation by gamma-glutamyl transpeptidase. J Med Chem (1982) 0.81
Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by chlorpropamide analogues. Biochem Pharmacol (1998) 0.81
2,5,5-Trimethylthiazolidine-4-carboxylic acid, a D(-)-penicillamine-directed pseudometabolite of ethanol. Detoxication mechanism for acetaldehyde. J Med Chem (1978) 0.81
Nitrosyl cyanide, a putative metabolic oxidation product of the alcohol-deterrent agent cyanamide. Biochem Pharmacol (1996) 0.80
Metabolism of aminonucleoside-8-14C in the rat and guinea pig. Biochem Pharmacol (1967) 0.79
Novel prodrugs of cyanamide that inhibit aldehyde dehydrogenase in vivo. J Med Chem (1997) 0.79
Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on extrahepatic sulfhydryl levels in mice treated with acetaminophen. Biochem Pharmacol (2001) 0.79
Prevention of naphthalene-induced cataract and hepatic glutathione loss by the L-cysteine prodrugs, MTCA and PTCA. Exp Eye Res (1996) 0.79
Prodrugs of L-cysteine as liver-protective agents. 2(RS)-Methylthiazolidine-4(R)-carboxylic acid, a latent cysteine. J Med Chem (1982) 0.79
Cyanide is a product of the catalase-mediated oxidation of the alcohol deterrent agent, cyanamide. Toxicol Lett (1987) 0.78
Differential inhibition of rat tissue catalase by cyanamide. Biochem Pharmacol (1986) 0.78
N-Terminal dipeptides of D(-)-penicillamine as sequestration agents for acetaldehyde. J Med Chem (2000) 0.78
Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues. Chem Biol Interact (2001) 0.78
Propiolaldehyde, a pargyline metabolite that irreversibly inhibits aldehyde dehydrogenase. Isolation from a hepatic microsomal system. J Med Chem (1979) 0.78
Yeast aldehyde dehydrogenase sensitivity to inhibition by chlorpropamide analogues as an indicator of human aldehyde dehydrogenase sensitivity to these agents. Adv Exp Med Biol (1997) 0.77
Generation of nitric oxide and possibly nitroxyl by nitrosation of sulfohydroxamic acids and hydroxamic acids. Nitric Oxide (1999) 0.77
An HPLC radiotracer method for assessing the ability of L-cysteine prodrugs to maintain glutathione levels in the cultured rat lens. Curr Eye Res (1996) 0.77
Identification and synthesis of the major nucleoside metabolite in rabbit urine after administration of puromycin aminonucleoside. J Med Chem (1972) 0.77
Redistribution and enhanced urinary excretion of 2,2',4,4',5,5'-hexachlorobiphenyl (HCB) in rats using HCB-specific IgG and Fab fragments. Biochem Pharmacol (1994) 0.77
Involvement of nitroxyl (HNO) in the cyanamide-induced vasorelaxation of rabbit aorta. Biochem Pharmacol (1994) 0.77
Metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase in vitro. Pharmacol Biochem Behav (1983) 0.77
Prevention of naphthalene-induced pulmonary toxicity by glutathione prodrugs: roles for glutathione depletion in adduct formation and cell injury. J Biochem Mol Toxicol (2005) 0.76
Metabolic activation of cyanamide by liver mitochondria, a requirement for the inhibition of aldehyde dehydrogenase enzymes. Biochem Biophys Res Commun (1982) 0.76
Inhibition of aldehyde dehydrogenase by propiolaldehyde, a possible metabolite of pargyline. Res Commun Chem Pathol Pharmacol (1978) 0.76
Disulfiram-induced acetonemia in the rat and man. Res Commun Chem Pathol Pharmacol (1977) 0.76
Microsomal N-depropargylation of pargyline to propiolaldehyde, an irreversible inhibitor of mitochondrial aldehyde dehydrogenase. Adv Exp Med Biol (1980) 0.76
Potential inhibitors of collagen biosynthesis. 5,5-Difluoro-DL-lysine and 5,5-dimethyl-DL-lysine and their activation by lysyl-tRNA ligase. J Med Chem (1977) 0.76
The antiviral drug amantadine has a direct inhibitory effect on T-lymphocytes. Immunopharmacology (1990) 0.76
Inhibition of lymphocyte proliferation by amantadine and its isomer, 2-aminoadamantane; impact on Lyt-2+ T cells while sparing L3T4+ T cells. Immunopharmacology (1991) 0.75
Prevention of acetaminophen- and naphthalene-induced cataract and glutathione loss by CySSME. Invest Ophthalmol Vis Sci (1996) 0.75
Prodrugs of nitroxyl and nitrosobenzene as cascade latentiated inhibitors of aldehyde dehydrogenase. J Med Chem (1998) 0.75
N1-hydroxylated derivatives of chlorpropamide and its analogs as inhibitors of aldehyde dehydrogenase in vivo. J Med Chem (1992) 0.75
Diethylcarbamoylating/nitroxylating agents as dual action inhibitors of aldehyde dehydrogenase: a disulfiram-cyanamide merger. J Med Chem (1999) 0.75
Potential inhibitors of collagen biosynthesis, 4,4-Difluoro-L-proline and 4,4-dimethyl-DL-proline and their activation by prolyl-tRNA ligase. J Med Chem (1977) 0.75
Metabolic basis for the lack of nephrotoxicity of acetylated puromycin aminonucleoside in rats. Toxicol Appl Pharmacol (1970) 0.75
Lowering of blood acetaldehyde levels-a possible approach to prevention of alcoholic cardiomyopathy. Recent Adv Stud Cardiac Struct Metab (1978) 0.75
Synthesis of 1-hydroxy-L-proline and related cyclic N-hydroxyamino acids. Metabolic disposition of 14 C-labeled 1-hydroxy-L-proline in rodents. J Med Chem (1972) 0.75
An intestinal arylamidase that selectively hydrolyzes certain aromatic amides. Biochem Pharmacol (1976) 0.75
Maintenance of hepatic glutathione homeostasis and prevention of acetaminophen-induced cataract in mice by L-cysteine prodrugs. Biochem Pharmacol (1996) 0.75
Medium ring homologs of proline as potential amino acid antimetabolites. J Med Chem (1971) 0.75
Metabolism of cyanamide to cyanide and an inhibitor of aldehyde dehydrogenase (ALDH) by rat liver microsomes. Alcohol Alcohol Suppl (1987) 0.75
Metabolism of paraldehyde to acetaldehyde by rat liver microsomes. Res Commun Chem Pathol Pharmacol (1981) 0.75
Effect of pargyline on hepatic glutathione levels in rats treated acutely and chronically with ethanol. Res Commun Chem Pathol Pharmacol (1980) 0.75
Studies on the cyanamide-ethanol interaction. Dimethylcyanamide as an inhibitor of aldehyde dehydrogenase in vivo. Biochem Pharmacol (1982) 0.75
Metabolic depropargylation and its relationship to aldehyde dehydrogenase inhibition in vivo. J Med Chem (1980) 0.75
Analysis of hepatic reduced glutathione, cysteine and homocysteine by cation-exchange high-performance liquid chromatography with electrochemical detection. J Chromatogr (1984) 0.75
An interaction between aminopurines, aminopyrimidines, and fluorescent thin-layer plates. J Chromatogr (1966) 0.75
Structure vs. activity in the sulfonylurea-mediated disulfiram-ethanol reaction. Alcohol (1985) 0.75
Chromatographic properties of some cyclic alpha-imino acids homologous to proline, and their DNP-, DNS- and PTH-derivatives. J Chromatogr (1969) 0.75
Potential latentiation forms of biologically active compounds based on action of leucine aminopeptidase. Dipeptide derivatives of the tricycloaliphatic alpha-amino acid, adamantanine. J Med Chem (1975) 0.75
Glutaramyl-beta-alanyl spacer group for haptenic coupling to proteins. Preparation of immunogens for antibody production against polychlorinated biphenyls. Bioconjug Chem (1995) 0.75
An active puromycin analog derived from a non-nephrotoxic aminonucleoside. Life Sci (1976) 0.75
Hypopituitarism in male. N Y State J Med (1967) 0.75
Protection against acetaminophen hepatotoxicity by ribose-cysteine (RibCys). Pharmacol Toxicol (1992) 0.75
A simple, rapid and semi-automated method for the quantitative determination of expired 14CO2 in metabolism studies with laboratory animals. Res Commun Chem Pathol Pharmacol (1977) 0.75
Metabolic activation of n-butyraldoxime by rat liver microsomal cytochrome P450. A requirement for the inhibition of aldehyde dehydrogenase. Biochem Pharmacol (1993) 0.75
Methanethiol and derivatives in hepatic failure. J Lab Clin Med (1988) 0.75
Omicron-methoxy derivatives of the carcinogen, N-2-fluorenylacetamide. Potential latent biological arylating agents. J Med Chem (1966) 0.75
Synergism between cobalt and ethanol on rat growth rate. J Nutr (1970) 0.75
Nitramino acids. Synthesis and biological evaluation of 1-nitroproline, 1-nitropipecolic acid, and N-nitrosarcosine. J Med Chem (1977) 0.75
Letter: Cardiotoxicity of alcohol. Am Heart J (1974) 0.75
N-Acetyl-DL-penicillamine and acetaminophen toxicity in mice. J Pharm Sci (1980) 0.75
Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues. Chem Biol Interact (2001) 0.75
N-acetylcyanamide, the major urinary metabolite of cyanamide in rat, rabbit, dog, and man. Drug Metab Dispos (1984) 0.75
Failure of glutathione and cysteine prodrugs to block the chlorpropamide-induced inhibition of aldehyde dehydrogenase in vivo. Biochem Pharmacol (1992) 0.75
Acetaldehyde metabolism by the rat heart. Proc Soc Exp Biol Med (1973) 0.75
Latent inhibitors of aldehyde dehydrogenase as alcohol deterrent agents. J Med Chem (1984) 0.75
Pargyline-induced hepatotoxicity: possible mediation by the reactive metabolite, propiolaldehyde. Toxicol Appl Pharmacol (1982) 0.75