Published in J Cell Biol on April 01, 1969
Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease. Proc Natl Acad Sci U S A (1982) 1.70
Beta granule formation in isolated islets of langerhans: a study by electron microscopic radioautography. J Cell Biol (1969) 1.51
Isolation and properties of secretory granules from rat islets of Langerhans. II. Ultrastructure of the beta granule. J Cell Biol (1969) 1.45
The role of adenosine 3':5'-cyclic monophosphate in the regulation of insulin release. Properties of islet-cell adenosine 3':5'-cyclic monophosphate phosphodiesterase. Biochem J (1972) 1.21
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Preparation and properties of islet-cell protein phosphokinase. Biochem J (1972) 1.13
Isolation and properties of secretory granules from rat islets of Langerhans. 3. Studies of the stability of the isolated beta granules. J Cell Biol (1969) 1.07
Stimulation by prostaglandin E2 of a high-affinity GTPase in the secretory granules of normal rat and human pancreatic islets. Biochem J (1994) 0.98
Regulation of actin polymerizaton in rat islets of Langerhans. Biochem J (1980) 0.90
Studies on proinsulin and proglucagon biosynthesis and conversion at the subcellular level. I. Fractionation procedure and characterization of the subcellular fractions. J Cell Biol (1977) 0.89
Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells. Proc Natl Acad Sci U S A (2015) 0.86
Transport of ascorbic acid and dehydroascorbic acid by pancreatic islet cells from neonatal rats. Biochem J (1991) 0.83
Mode of action of adenosine 3':5'-cyclic monophosphate in insulin secretion. Biochem J (1972) 0.80
The isolated pancreatic islet as a micro-organ and its transplantation to cure diabetes: celebrating the legacy of Paul Lacy. Islets (2010) 0.79
Insulin release and the microtubular system of the islets of Langerhans. Identification and characterization of tubulin-like protein. Biochem J (1975) 0.78
The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol (1963) 185.56
Staining of tissue sections for electron microscopy with heavy metals. J Biophys Biochem Cytol (1958) 74.43
A microspectrophotometric method for the determination of cytochrome oxidase. J Biol Chem (1951) 13.45
Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes (1967) 11.63
Principles of tissue fractionation. J Theor Biol (1964) 2.56
Electron microscopy of the beta cell of the pancreas. Am J Med (1961) 2.32
ISOLATION AND CULTURE OF THE ISLETS OF LANGERHANS OF THE GUINEA PIG. Gen Comp Endocrinol (1965) 1.95
Effects of glucose concentration on incorporation of [3H]leucine into insulin using isolated mammalian islets of Langerhans. Biochim Biophys Acta (1966) 1.75
Insulin secretion by isolated islets in presence of glucose, insulin and anti-insulin serum. Proc Soc Exp Biol Med (1967) 1.21
Interaction between insulin and zinc in the islets of Langerhans. Diabetes (1957) 1.20
ISOLATION OF AN INSULIN SECRETION GRANULE FRACTION. J Cell Biol (1963) 1.07
Glucagon antibodies. Lancet (1965) 0.95
[Preparation of highly purified chromaffin granules from ox adrenal medullae]. Biochem Pharmacol (1968) 0.87
Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes (1967) 11.63
Automated method for isolation of human pancreatic islets. Diabetes (1988) 8.23
New hypothesis of insulin secretion. Nature (1968) 4.33
Potassium ions and the secretion of insulin by islets of Langerhans incubated in vitro. Biochem J (1968) 3.26
Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc Natl Acad Sci U S A (1984) 3.14
Insulin independence after islet transplantation into type I diabetic patient. Diabetes (1990) 2.57
Automated islet isolation from human pancreas. Diabetes (1989) 2.13
The use of ficoll in the preparation of viable islets of langerhans from the rat pancreas. Transplantation (1973) 2.09
Transplantation of intact pancreatic islets in rats. Surgery (1972) 2.05
Perifusion of isolated rat islets in vitro. Participation of the microtubular system in the biphasic release of insulin. Diabetes (1972) 2.01
Results of our first nine intraportal islet allografts in type 1, insulin-dependent diabetic patients. Transplantation (1991) 1.98
Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats. Diabetologia (1973) 1.98
Prolongation of islet allograft survival following in vitro culture (24 degrees C) and a single injection of ALS. Science (1979) 1.82
Effects of glucose concentration on incorporation of [3H]leucine into insulin using isolated mammalian islets of Langerhans. Biochim Biophys Acta (1966) 1.75
Preliminary characterization of calcium binding in islet-cell plasma membranes. Diabetologia (1980) 1.75
64,000 Mr autoantibodies as predictors of insulin-dependent diabetes. Lancet (1990) 1.70
The stimulus-secretion coupling of glucose-induced insulin release. V. The participation of a microtubular-microfilamentous system. Diabetes (1971) 1.66
The pancreatic beta cell. Structure and function. N Engl J Med (1967) 1.59
Trophic factors from pancreatic islets in combined hepatocyte-islet allografts enhance hepatocellular survival. Surgery (1989) 1.59
Beta granule formation in isolated islets of langerhans: a study by electron microscopic radioautography. J Cell Biol (1969) 1.51
A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans. Methods Enzymol (1983) 1.48
Isolation and properties of secretory granules from rat islets of Langerhans. II. Ultrastructure of the beta granule. J Cell Biol (1969) 1.45
Transplantation of isolated pancreatic islets into the portal vein of diabetic rats. Nature (1973) 1.42
A morphologic study of intrahepatic portal-vein islet isografts. Diabetes (1977) 1.36
Cytochemical localization of adenyl cyclase activity in rat islets of Langerhans. J Histochem Cytochem (1972) 1.32
Effects of flavonoids on insulin secretion and 45Ca2+ handling in rat islets of Langerhans. J Endocrinol (1985) 1.31
Effects of diazoxide on insulin secretion in vitro. Lancet (1966) 1.29
Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA. Proc Natl Acad Sci U S A (1989) 1.27
Effects of Ca2+ and a phorbol ester on insulin secretion from islets of Langerhans permeabilised by high-voltage discharge. FEBS Lett (1985) 1.25
Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens. J Exp Med (1980) 1.23
Interleukin 1 is potent modulator of insulin secretion from isolated rat islets of Langerhans. Diabetes (1987) 1.23
Induction of rejection of successful allografts of rat islets by donor peritoneal exudate cells. Transplantation (1979) 1.22
The acute pancreatic effect of alloxan in the rabbit. J Endocrinol (1967) 1.21
Insulin secretion by isolated islets in presence of glucose, insulin and anti-insulin serum. Proc Soc Exp Biol Med (1967) 1.21
Ultrastructure of the A-cells of cat islets of Langerhans following sympathetic stimulation of glucagon secretion. J Cell Biol (1970) 1.19
Prolongation of islet xenograft survival without continuous immunosuppression. Science (1980) 1.18
Pentitols and the mechanism of insulin release. Nature (1967) 1.17
Synthesis and secretion of growth hormone in the rat anterior pituitary. I. The intracellular pathway, its time course and energy requirements. J Cell Sci (1973) 1.17
Regulation of insulin secretion from islets of Langerhans rendered permeable by electric discharge. Biochem J (1982) 1.16
A possible role of adenylate cyclase in the long-tern dietary regulation of insulin secretion from rat islets of Langerhans. Biochem J (1973) 1.15
Protein phosphorylation in electrically permeabilized islets of Langerhans. Effects of Ca2+, cyclic AMP, a phorbol ester and noradrenaline. Biochem J (1988) 1.14
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Preparation and properties of islet-cell protein phosphokinase. Biochem J (1972) 1.13
Alloxan uptake by isolated rat islets of Langerhans. Endocrinology (1978) 1.13
Adenylate cyclase activity in isolated rat islets of Langerhans. Effects of agents which alter rates of insulin secretion. Biochim Biophys Acta (1973) 1.13
Regulation of insulin secretion by cAMP in rat islets of Langerhans permeabilised by high-voltage discharge. FEBS Lett (1986) 1.12
Standardization fo a digestion-filtration method for isolation of pancreatic islets. Diabetes (1976) 1.11
Low-temperature culture of human islets or in vivo treatment with L3T4 antibody produces a marked prolongation of islet human-to-mouse xenograft survival. Proc Natl Acad Sci U S A (1987) 1.10
A re-assessment of the role of protein kinase C in glucose-stimulated insulin secretion. Biochem J (1987) 1.10
Biosynthesis of glucagon in isolated pancreatic islets of guinea pigs. Biochem J (1974) 1.08
Secretion of various endocrine substances by ACTH-secreting tumors--gastrin, melanotropin, norepinephrine, serotonin, parathormone, vasopressin, glucagon. Cancer (1968) 1.08
Insulin and glucagon secretion from rat islets maintained in a tissue culture-perifusion system. Diabetes (1979) 1.07
Isolation and properties of secretory granules from rat islets of Langerhans. 3. Studies of the stability of the isolated beta granules. J Cell Biol (1969) 1.07
Fatty acids as regulators of glucagon secretion. Nature (1969) 1.07
Effect of alloxan on insulin secretion in isolated rat islets perifused in vitro. Diabetes (1974) 1.06
Appendix: Electron miscroscopy of islets Of langerhans in rabbit pancreas slices incubated in vitro. Biochem J (1967) 1.06
Interaction between insulin-storage granules and F-actin in vitro. Biochem J (1979) 1.06
Endocrine secretory mechanisms. A review. Am J Pathol (1975) 1.03
Renal subcapsular transplantation of clusters of hepatocytes in conjunction with pancreatic islets. Transplantation (1988) 1.03
Comparison of the properties of active Ca2+ transport by the islet-cell endoplasmic reticulum and plasma membrane. Biochim Biophys Acta (1983) 1.03
Alveolar soft-part sarcoma--A malignant angioreninoma: Histochemical, immunocytochemical, and electron-microscopic study of four cases. Am J Surg Pathol (1982) 1.02
Translocation of protein kinase C in rat islets of Langerhans. Effects of a phorbol ester, carbachol and glucose. FEBS Lett (1989) 1.02
Transplantation of islets of Langerhans in diabetic rhesus monkeys. Surgery (1975) 1.02
Secretion of newly synthesized insulin in vitro. Nature (1965) 1.01
Active suppression in the maintenance of pancreatic islet allografts. Transplantation (1981) 1.01
Use of reflected green light for specific identification of islets in vitro after collagenase isolation. Diabetes (1979) 1.01
Effects of glucose and amino acids on the biosynthesis of DNA and insulin in fetal rat islets maintained in tissue culture. Diabetes (1980) 1.00
Transplantation of insulin-producing tissue. Am J Med (1981) 1.00
Glucose-stimulated insulin secretion is not dependent on activation of protein kinase A. Biochem Biophys Res Commun (1990) 1.00
Long-term perfusion of isolated rats islets in vitro. Diabetes (1976) 0.99
Calmodulin-activated protein kinase activity in rat pancreatic islet cell membranes. Arch Biochem Biophys (1982) 0.99
Protection of encapsulated human islets implanted without immunosuppression in patients with type I or type II diabetes and in nondiabetic control subjects. Diabetes (1994) 0.99
Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans. Diabetologia (1992) 0.98
Beta cell secretion--from the standpoint of a pathobiologist. Diabetes (1970) 0.98
Low-temperature culture of human islets isolated by the distention method and purified with Ficoll or Percoll gradients. Surgery (1987) 0.97
Cinemicrographic studies on beta granule movement in monolayer culture of islet cells. Lab Invest (1975) 0.97
Alloxan inhibition of a Ca2+- and calmodulin-dependent protein kinase activity in pancreatic islets. J Biol Chem (1983) 0.96
Regional pancreatic concentration and in-vitro secretion of canine pancreatic polypeptide, insulin, and glucagon. Diabetes (1978) 0.96
Calcium distribution in islets of Langerhans: a study of calcium concentrations and of calcium accumulation in B cell organelles. J Cell Sci (1975) 0.96
Active calcium uptake by islet-cell endoplasmic reticulum. J Biol Chem (1982) 0.95
Reversal of diabetes in nude mice after transplantation of fresh and 7-day-cultured (24 degrees C) human pancreatic islets. Transplantation (1988) 0.95
A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant. Proc Natl Acad Sci U S A (1992) 0.95
The ultrastructural basis for the identification of cell types in the pancreatic islets. II. Rabbit, dog and opossum. Z Zellforsch Mikrosk Anat (1965) 0.95
Transplantation of pancreatic islets. Annu Rev Immunol (1984) 0.94
Cyclic AMP and the physiology of the islets of Langerhans. Adv Cyclic Nucleotide Res (1975) 0.94
Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozocin-induced insulitis. Diabetes (1989) 0.93
Allergic interstitial pancreatitis in rats injected with guinea pig anti-insulin serum. Diabetes (1965) 0.93
Ca2(+)-induced insulin secretion from electrically permeabilized islets. Loss of the Ca2(+)-induced secretory response is accompanied by loss of Ca2(+)-induced protein phosphorylation. Biochem J (1992) 0.93
Studies on insulin secretion in vitro from isolated islets of the rat pancreas. Endocrinology (1968) 0.93
The mechanism of insulin secretion. Diabetologia (1984) 0.93
The effects of polymyxin B, a protein kinase C inhibitor, on insulin secretion from intact and permeabilized islets of Langerhans. Biochem Biophys Res Commun (1986) 0.93
Prolongation of islet allograft survival. Transplantation (1979) 0.93