Published in Experientia on September 15, 1968
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest (1996) 7.93
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest (1997) 6.18
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest (1997) 6.16
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci U S A (1999) 5.81
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J Clin Invest (1997) 4.75
Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem (1999) 4.48
Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. J Biol Chem (1998) 3.54
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev (2001) 3.52
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc Natl Acad Sci U S A (2001) 3.13
Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J Biol Chem (2001) 2.96
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Proc Natl Acad Sci U S A (1997) 2.57
Bochdalek hernia in the adult: demographics, presentation, and surgical management. Hernia (2010) 2.22
Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding. J Biol Chem (2000) 1.60
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). J Clin Invest (1998) 1.60
Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proc Natl Acad Sci U S A (2001) 1.30
Response to skin allografts in Xenopus laevis following thymectomy at early stages of lymphoid organ maturation. Transplantation (1972) 1.20
Histogenesis of lymphoid organs in larvae of the South African clawed toad, Xenopus laevis (Daudin). J Embryol Exp Morphol (1969) 1.04
Ontogeny of the immune response to skin allografts in relation to lymphoid organ development in the amphibian Xenopus laevis Daudin. J Exp Zool (1969) 0.97
Distance correction for precordial electrocardiographic voltage in estimating left ventricular mass: an echocardiographic study. Circulation (1977) 0.90
Use of different carriers to demonstrate thymic-dependent and thymic-independent anti-trinitrophenyl reactivity in the ambhibian Xenopus laevis. Dev Comp Immunol (1979) 0.88
Anabolic function of the type II isozyme of hexokinase in hepatic lipid synthesis. Biochem Biophys Res Commun (2000) 0.85
Critical role of the thymus in establishing humoral immunity in amphibians: studies on Xenopus thymectomized in larval and adult life. Dev Comp Immunol (1977) 0.85
Identification of a candidate CD5 homologue in the amphibian Xenopus laevis. J Immunol (1995) 0.83
Ontogeny and thymus-dependence of T cell surface antigens in Xenopus: flow cytometric studies on monoclonal antibody-stained thymus and spleen. Dev Comp Immunol (1996) 0.82
Impaired rejection of minor-histocompatibility-antigen-disparate skin grafts and acquisition of tolerance to thymus donor antigens in allothymus-implanted, thymectomized Xenopus. Transplantation (1986) 0.81
Xenopus NK cells identified by novel monoclonal antibodies. Eur J Immunol (2000) 0.81
Cytoarchitecture of the Xenopus thymus following gamma-irradiation. Development (1987) 0.81
Effect of early thymectomy on the cellular changes occuring in the spleen of the clawed toad following administration of soluble antigen. Immunology (1974) 0.81
Pericardial effusion associated with minoxidil therapy in dialyzed patients. Int J Artif Organs (1980) 0.80
The effect of thymectomy at different stages of larval development on the immune response of the clawed toad to sheep erythrocytes. J Exp Zool (1976) 0.79
Lymphocyte reactivity to "T" and "B" cell mitogens in Xenopus laevis: studies on thymus and spleen. Dev Comp Immunol (1980) 0.79
Ontogeny and characterization of mitogen-reactive lymphocytes in the thymus and spleen of the amphibian, Xenopus laevis. Immunology (1983) 0.79
Histogenesis of the lymphomyeloid complex in the larval leopard frog, Rana pipiens. J Morphol (1971) 0.78
NK-like activity against allogeneic tumour cells demonstrated in the spleen of control and thymectomized Xenopus. Immunol Cell Biol (1996) 0.78
Natural cytotoxicity towards allogeneic tumour targets in Xenopus mediated by diverse splenocyte populations. Dev Comp Immunol (1998) 0.78
Abnormal cholesterol uptake, storage, and synthesis in the livers of 2-acetylaminofluorene-fed rats. Cancer Res (1973) 0.78
Elevated CK-MB and CK-BB in serum and tumor homogenate of a patient with lung cancer. Clin Cardiol (1985) 0.77
In vitro correlates of in vivo skin graft rejection in Xenopus. Transplantation (1985) 0.77
Restoration of the antibody response to sheep erythrocytes in thymectomized Xenopus implanted with MHC-compatible or MHC-incompatible thymus. J Embryol Exp Morphol (1984) 0.76
Regulatory effects of n-3 polyunsaturated fatty acids on hepatic LDL uptake in the hamster and rat. J Lipid Res (1995) 0.76
NK cell evolution: studies on Xenopus. Biochem Soc Trans (1997) 0.76
In vivo studies on allotolerance perimetamorphically induced in control and thymectomized Xenopus. Immunology (1987) 0.76
Phylogenetic status of immune system in Xenopus. Transplant Proc (1970) 0.75
Criteria for mitral valve prolapse. Am J Cardiol (1978) 0.75
Repeated estimation of liver cholesterol synthesis in vivo, using the inhibitor AY-9944. Biochim Biophys Acta (1971) 0.75
Total electrical alternans in pericardial tamponade. Am Heart J (1981) 0.75
Natural history of asymptomatic pericardial effusions in patients on maintenance hemodialysis. Proc Clin Dial Transplant Forum (1977) 0.75
Lymphoid organ development in Xenopus thymectomized at eight days of age. J Morphol (1974) 0.75
Restoration of antibody responsiveness in early thymectomized Xenopus by implantation of major histocompatibility complex-mismatched larval thymus. Eur J Immunol (1982) 0.75
Amphibian metamorphosis: an immunologic opportunity! Bioessays (1989) 0.75
Splenocyte response to T cell-derived cytokines in thymectomized Xenopus. Dev Comp Immunol (1991) 0.75
Allograft rejection in larval and adult Xenopus following early thymectomy. Transplantation (1977) 0.75
In vitro cytotoxicity in adult Xenopus generated against larval targets and minor histocompatibility antigens. Transplantation (1989) 0.75
Metabolic controls in precancerous liver. II. Loss of feedback control of cholesterol synthesis, measured repeatedly in vivo, during treatment with the carcinogens N-2-fluorenylacetamide and aflatoxin. Eur J Cancer (1972) 0.75
Lack of expression of the T-cell marker XTLA-1 in Xenopus tropicalis: exploitation in thymus restoration studies. Dev Comp Immunol (1991) 0.75
Changes in antibody and complement production in Xenopus laevis during postmetamorphic development revealed in a primary in vivo or in vitro antibody response. J Embryol Exp Morphol (1984) 0.75
Splenic involvement in amphibian transplantation immunity. Transplantation (1977) 0.75
Metabolic controls in precancerous liver. V. Loss of control of cholesterol synthesis during feeding of the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene. Eur J Cancer (1973) 0.75