Published in Biochem J on February 01, 1972
Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro. Proc Natl Acad Sci U S A (1977) 2.53
32P-labeling test for DNA damage. Proc Natl Acad Sci U S A (1981) 1.89
Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines. Biochem J (1975) 1.62
Purification and specificity of a human microsomal epoxide hydratase. Biochem J (1974) 1.14
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Structure of 7,12-dimethylbenz(a)anthracene-guanosine adducts. Proc Natl Acad Sci U S A (1976) 0.90
Carcinogenicity of ethylene oxide and 1,2-propylene oxide upon intragastric administration to rats. Br J Cancer (1982) 0.86
Selective alkylation of carcinogenic 9-anthryloxirane at the N-3 position of adenine in DNA. Proc Natl Acad Sci U S A (1985) 0.75
Alkylation by 1,2:5,6-dianhydrogalactitol of deoxyribonucleic acid and guanosine. Biochem J (1980) 0.75
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Methylation of DNA by N-methyl-N-nitrosourethane and N-methyl-N-nitroso-N'-nitroguanidine. Nature (1968) 1.33
The toxicity of inhaled ethylene oxide and propylene oxide vapors; acute and chronic toxicity of ethylene oxide and acute toxicity of propylene oxide. AMA Arch Ind Health (1956) 1.21
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Studies on the alkylation of purines and pyrimidines. Biochemistry (1962) 1.19
Soluble derivatives of feather keratin. 2. Molecular weight and conformation. Biochem J (1964) 1.06
Alkylation of rat liver RNA by cyclic N-nitrosamines in vivo. J Natl Cancer Inst (1966) 1.04
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The preparation and properties of N-hydroxyethyl derivatives of adenosine, adenosine triphosphate, and nicotinamide adenine dinucleotide. J Biol Chem (1961) 0.99
The alkylation of DNA in vitro by isopropyl methanesulfonate. Acta Chem Scand (1970) 0.87
Toxicity of propylene oxide determined on experimental animals. AMA Arch Ind Health (1956) 0.81
The reaction of mono- and di-functional alkylating agents with nucleic acids. Biochem J (1961) 5.85
The reaction of mustard gas with nucleic acids in vitro and in vivo. Biochem J (1960) 4.12
Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. J Med Chem (1995) 3.72
Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. Br J Cancer (2004) 3.32
Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J Steroid Biochem Mol Biol (1994) 3.19
Specific excision of methylation products from DNA of Escherichia coli treated with N-methyl-N'-nitro-N-nitrosoguanidine. Chem Biol Interact (1970) 2.56
Effects of some chemical mutagens and carcinogens on nucleic acids. Prog Nucleic Acid Res Mol Biol (1966) 2.31
The synthesis of oligoribonucleotides. IV. Preparation of dinucleoside phosphates from 2',5'-protected ribonucleoside derivatives. Tetrahedron (1968) 2.31
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Molecular mechanism of the cytotoxic action of difunctional alkylating agents and of resistance to this action. Nature (1965) 1.92
Some chemical aspects of dose-response relationships in alkylation mutagenesis. Mutat Res (1974) 1.84
Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines. Biochem J (1975) 1.62
Reaction of alkylating mutagens and carcinogens with nucleic acids: detection and estimation of a small extent of methylation at O-6 of guanine in DNA by methyl methanesulphonate in vitro. Chem Biol Interact (1972) 1.58
Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O4-methylthymidine. Biochem J (1973) 1.50
Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoral drug concentration. Lancet (1994) 1.49
Interstrand cross-linking of DNA by difunctional alkylating agents. J Mol Biol (1967) 1.44
The alkylation of 2'-deoxyguanosine and of thymidine with diazoalkanes. Some observations on o-alkylation. Biochem J (1973) 1.43
The synthesis of oligoribonucleotides. II. Methoxymethylidene derivatives of ribonucleosides and 5'-ribonucleotides. Tetrahedron (1967) 1.39
Prevention of isophosphamide-induced urothelial toxicity with 2-mercaptoethane sulphonate sodium (mesnum) in patients with advanced carcinoma. Lancet (1980) 1.38
Chemical trapping of a reactive metabolite. The metabolism of the AZO-mustard 2'-carboxy-4-di-(2-chloroethyl)amino-2-methylazobenzene. Biochem Pharmacol (1972) 1.38
Methylation of DNA by N-methyl-N-nitrosourethane and N-methyl-N-nitroso-N'-nitroguanidine. Nature (1968) 1.33
Inactivation of bacteriophage T7 by mono- and difunctional sulphur mustards in relation to cross-linking and depurination of bacteriophage DNA. J Mol Biol (1969) 1.32
Removal of minor methylation products 7-methyladenine and 3-methylguanine from DNA of Escherichia coli treated with dimethyl sulphate. Chem Biol Interact (1976) 1.30
Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide. Biochem Pharmacol (1974) 1.29
Biomethylation of deoxyribonucleic acid in cultured human tumour cells (HeLa). Methylated bases other than 5-methylcytosine not detected. Biochem J (1972) 1.17
Esters of 3-pyridylacetic acid that combine potent inhibition of 17 alpha-hydroxylase/C17,20-lyase (cytochrome P45017 alpha) with resistance to esterase hydrolysis. J Med Chem (1995) 1.15
High dose melphalan and non-cryopreserved autologous bone marrow treatment of malignant melanoma and neuroblastoma. Exp Hematol (1979) 1.13
Reaction of N-methyl-N-nitrosourea (MNUA) with 32P-labelled DNA: evidence for formation of phosphotriesters. Chem Biol Interact (1973) 1.13
Theory of tumour initiation by chemical carcinogens: dependence of activity on structure of ultimate carcinogen. Eur J Cancer (1968) 1.11
Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Cancer Chemother Pharmacol (1998) 1.10
3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer. J Med Chem (1996) 1.07
The molecular basis for biological inactivation of nucleic acids. The action of methylating agents on the ribonucleic acid-containing bacteriophage R17. Biochem J (1974) 1.04
Reaction of alkylating mutagens and carcinogens with nucleic acids: N-3 of guanine as a site of alkylation by N-methyl-N-nitrosourea and dimethyl sulphate. Chem Biol Interact (1972) 1.02
Methylated bases in liver acids from rats treated with dimethylnitrosamine. Biochim Biophys Acta (1968) 1.01
Analogues of aminoglutethimide: selective inhibition of cholesterol side-chain cleavage. J Med Chem (1983) 1.00
Mode of action of methylating carcinogens: comparative studies of murine and human cells. Carcinogenesis (1981) 0.99
Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen. Immunology (1983) 0.99
Differences in the patterns of methylation in rat liver ribosomal ribonucleic acid after reaction in vivo with methyl methanesulphonate and NN-dimethylnitrosamine. Biochem J (1972) 0.97
A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells. Biochem Pharmacol (1988) 0.97
Inhibition of protein prenylation by metabolites of limonene. Biochem Pharmacol (1999) 0.97
Pharmacokinetics of the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) in the mouse. Cancer Treat Rep (1986) 0.97
The action of mono- and di-functional sulphur mustards on the ribonucleic acid-containing bacteriophage mu2. Biochem J (1971) 0.96
Methylation of DNA by 3H-14C-methyl-labelled N-methyl-N-nitrosourea--evidence for transfer of the intact methyl group. Chem Biol Interact (1973) 0.96
Defective repair of 0(6)-methylguanine in autoimmune diseases. Lancet (1982) 0.96
Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N' -nitro-N-nitrosoguanidine: lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at 0-6 of guanine. Chem Biol Interact (1976) 0.95
Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2). Biochem Pharmacol (1992) 0.94
Inhibitory effect of simvastatin on the proliferation of human myeloid leukaemia cells in severe combined immunodeficient (SCID) mice. Br J Haematol (1998) 0.94
Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treated human fibroblasts. Nature (1981) 0.93
Effect of oestrogen receptor status and time on the intra-tumoural accumulation of tamoxifen and N-desmethyltamoxifen following short-term therapy in human primary breast cancer. Breast Cancer Res Treat (1993) 0.93
Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response. J Natl Cancer Inst (1980) 0.92
The importance of tamoxifen metabolism in tamoxifen-stimulated breast tumor growth. Cancer Chemother Pharmacol (1994) 0.92
Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines--studies of the kinetics of removal of O6-methylguanine and 3-methyladenine. Chem Biol Interact (1986) 0.91
Inhibition of 17 alpha-hydroxylase/C17-C20 lyase by bifluranol and its analogues. J Steroid Biochem (1989) 0.90
Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. J Med Chem (1990) 0.90
The quantitation of cyclophosphamide in human blood and urine by mass spectrometry-stable isotope dilution. Clin Chim Acta (1975) 0.90
Methylation of DNA in various organs of C57B1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stabiltty of some methylation products up to 18 hours. Chem Biol Interact (1975) 0.90
Identification of the methyl phosphotriester of thymidylyl (3',5')thymidine as a product from reaction of DNA with the carcinogen N-methyl-N-nitrosourea. Chem Biol Interact (1976) 0.89
Pharmaco-kinetics of melphalan following oral or intravenous administration in patients with malignant disease. Eur J Cancer (1978) 0.89
Metabolism of aminoglutethimide in humans: identification of hydroxylaminoglutethimide as an induced metabolite. Biomed Mass Spectrom (1983) 0.89
Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen. Carcinogenesis (1994) 0.88
Alkylation of DNA by the nitrogen mustard bis(2-chloroethyl)methylamine. Chem Res Toxicol (1995) 0.88
Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen, new analogues of the antiestrogen tamoxifen for the treatment of breast cancer. Cancer Res (1991) 0.87
Analogues of aminoglutethimide: selective inhibition of aromatase. J Med Chem (1985) 0.87
Comparative metabolism of 2-[bis(2-chloroethyl)amino]tetrahydro-2-H-1,3,2-oxazaphosphorine-2-oxide (cyclophosphamide) and its enantiomers in humans. Cancer Res (1979) 0.87
Polymorphically acetylated aminoglutethimide in humans. Br J Cancer (1982) 0.86
Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens. Biochem J (1973) 0.85
A monofunctional derivative of melphalan: preparation, DNA alkylation products, and determination of the specificity of monoclonal antibodies that recognize melphalan-DNA adducts. Chem Res Toxicol (1998) 0.85
Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients. Drug Metab Dispos (1994) 0.85
Alkylation of DNA by melphalan with special reference to adenine derivatives and adenine-guanine cross-linking. Chem Biol Interact (1993) 0.85
Derivatives of tamoxifen. Dependence of antiestrogenicity on the 4-substituent. J Med Chem (1989) 0.85
Specific excision of ethylated purines from DNA of Escherichia coli treated with N-ethyl-N-nitrosourea. Chem Biol Interact (1975) 0.85
Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues. Biochem Pharmacol (1995) 0.84
Virtual cofactors for an Escherichia coli nitroreductase enzyme: relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT). Biochem Pharmacol (1995) 0.84
The preparation and properties of some benzylated nucleosides. J Chem Soc Perkin 1 (1968) 0.84
Effects of a new antioestrogen, idoxifene, on cisplatin- and doxorubicin-sensitive and -resistant human ovarian carcinoma cell lines. Br J Cancer (1994) 0.84
Pharmacokinetics and pharmacodynamics of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione in patients with postmenopausal breast cancer. Cancer Chemother Pharmacol (1991) 0.84
Purification to homogeneity and partial amino acid sequence of a fragment which includes the methyl acceptor site of the human DNA repair protein for O6-methylguanine. Nucleic Acids Res (1990) 0.83
Effects of alkylating agents on the induced synthesis of beta-galactosidase by Escherichia coli Bs-1. Biochim Biophys Acta (1968) 0.83
Tamoxifen induces selective membrane association of protein kinase C epsilon in MCF-7 human breast cancer cells. Int J Cancer (1998) 0.83
Structure and reactivity of nitrosocimetidine. Cancer Lett (1980) 0.83
Idoxifene: report of a phase I study in patients with metastatic breast cancer. Cancer Res (1995) 0.82
Isotope effects in O- and N-demethylations mediated by rat liver microsomes: an application of direct insertion electron impact mass spectrometry. Chem Biol Interact (1974) 0.82
The metabolism of deuterated analogues of chlorambucil by the rat. Chem Biol Interact (1979) 0.82
Idoxifene antagonizes estradiol-dependent MCF-7 breast cancer xenograft growth through sustained induction of apoptosis. Cancer Res (1999) 0.82
Synthesis of 1-(2-hydroxyethyl)-1-nitrosourea and comparison of its carcinogenicity with that of 1-ethyl-1-nitrosourea. J Natl Cancer Inst (1979) 0.82
Direct assay for O6-methylguanine-DNA methyltransferase and comparison of detection methods for the methylated enzyme in polyacrylamide gels and electroblots. Biochem J (1991) 0.82
Metabolism of tamoxifen by rat liver microsomes: formation of the N-oxide, a new metabolite. Biochem Pharmacol (1980) 0.82
Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry. Drug Metab Dispos (1996) 0.82
Identification, synthesis and properties of 5-(aziridin-1-yl)-2-nitro-4-nitrosobenzamide, a novel DNA crosslinking agent derived from CB1954. Biochem Pharmacol (1993) 0.81
DNA as a target of alkylating carcinogens. Br Med Bull (1980) 0.81
Induction of thymomas by N-methyl-N-nitrosourea in AKR mice: interaction between the chemical carcinogen and endogenous murine leukaemia viruses. Carcinogenesis (1987) 0.80