Published in J Cell Physiol on October 01, 1971
Altered enzymes in drug-resistant variants of mammalian tissue culture cells. Proc Natl Acad Sci U S A (1973) 2.24
Mammalian cells with altered forms of RNA polymerase II. Proc Natl Acad Sci U S A (1972) 1.88
Mutations affecting the structure of hypoxanthine: guanine phosphoribosyltransferase in cultured Chinese hamster cells. Proc Natl Acad Sci U S A (1973) 1.78
Variants of mouse myeloma cells that produce short immunoglobulin heavy chains. Proc Natl Acad Sci U S A (1974) 1.66
A mammalian cell mutant with a temperature-sensitive leucyl-transfer RNA synthetase. Proc Natl Acad Sci U S A (1973) 1.65
The use of protoplasts for genetic research. Proc Natl Acad Sci U S A (1973) 1.54
Isolation of a clone of Chinese hamster ovary cells deficient in plant lectin-binding sites. Proc Natl Acad Sci U S A (1974) 1.50
Isolation and characterization of HL-A variants in cultured human lymphoid cells. Proc Natl Acad Sci U S A (1973) 1.39
Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy. Proc Natl Acad Sci U S A (2000) 1.36
A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proc Natl Acad Sci U S A (1975) 1.36
Receptors from glucocorticoid-sensitive lymphoma cells and two clases of insensitive clones: physical and DNA-binding properties. Proc Natl Acad Sci U S A (1974) 1.30
Comparison of the frequencies of spontaneous and chemically-induced 5-bromodeoxyuridine-resistance mutations in wild-type and revertant BHK-21-13 cells. Genetics (1974) 1.16
Tryptic peptide analysis of normal and mutant forms of hypoxanthine phosphoribosyltransferase from HeLa cells. Proc Natl Acad Sci U S A (1977) 1.16
Reversion of a Chinese hamster cell auxotrophic mutant. Proc Natl Acad Sci U S A (1974) 1.11
Origin of multidrug resistance in cells with and without multidrug resistance genes: chromosome reassortments catalyzed by aneuploidy. Proc Natl Acad Sci U S A (2001) 1.11
Phenotypic evolution of cells resistant to bromodeoxyuridine. Proc Natl Acad Sci U S A (1980) 1.10
Discontinuous variability, in the form of a geometric progression, of albumin production in hepatoma and hybrid cells. Proc Natl Acad Sci U S A (1974) 0.92
Chromosome segregation is frequently associated with the expression of recessive mutations in mouse cells. Proc Natl Acad Sci U S A (1981) 0.91
Gene dosage and the expression of electrophoretic patterns in heteroploid mouse cell lines. Genetics (1973) 0.90
Genetic control of melanization: isolation and analysis of amelanotic variants from cultured melanotic melanoma cells. Proc Natl Acad Sci U S A (1974) 0.81
Clonal variation in albumin messenger RNA activity in hepatoma cells. Proc Natl Acad Sci U S A (1976) 0.81
Chromosomal variation and the origin of drug-resistant mutants in mammalian cell lines. Proc Natl Acad Sci U S A (1974) 0.80
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The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
A gene map of the human genome. Science (1996) 14.32
The association of cytosol oestrogen and progesterone receptors with histological features of breast cancer and early recurrence of disease. Br J Cancer (1983) 4.33
An STS-based radiation hybrid map of the human genome. Genome Res (1997) 3.57
Neonatal leptin treatment reverses developmental programming. Endocrinology (2005) 3.51
Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families. Cancer Res (1994) 3.20
Third molar surgery: an audit of the indications for surgery, post-operative complaints and patient satisfaction. Br J Oral Maxillofac Surg (1995) 2.89
A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer (1984) 2.89
Randomised trial of cardiotocography alone or with ST waveform analysis for intrapartum monitoring. Lancet (1992) 2.88
Model of complications of NIDDM. II. Analysis of the health benefits and cost-effectiveness of treating NIDDM with the goal of normoglycemia. Diabetes Care (1997) 2.63
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc Natl Acad Sci U S A (1994) 2.39
Relative frequency and morphology of cancers in carriers of germline TP53 mutations. Oncogene (2001) 2.36
Mesotheliomas with deciduoid morphology: a morphologic spectrum and a variant not confined to young females. Am J Surg Pathol (2000) 2.33
Model of complications of NIDDM. I. Model construction and assumptions. Diabetes Care (1997) 2.32
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Conservative treatment of cutis aplasia. Plast Reconstr Surg (1990) 2.27
Audit of bone marrow trephines. J Clin Pathol (1992) 2.24
Evidence for multi-site closure of the neural tube in humans. Am J Med Genet (1993) 2.16
Multiple drug rescue therapy for HIV-infected individuals with prior virologic failure to multiple regimens. AIDS (2001) 2.15
Oral submucous fibrosis: its pathogenesis and management. Br Dent J (1986) 2.09
Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: a study of 26 cases. Histopathology (1999) 2.07
A survey of dental hygienists in the United Kingdom in 2011. Part 1--demographics and working patterns as dental hygienists. Br Dent J (2012) 2.04
Morphological and immunophenotypic variations in malignant melanoma. Histopathology (2000) 2.02
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease): continuing diagnostic difficulties. Histopathology (1998) 2.01
Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL/CAELYX) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: a study by the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer (2001) 1.99
Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498. Blood (1992) 1.97
Acute subdural hematoma: morbidity, mortality, and operative timing. J Neurosurg (1991) 1.93
Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Lancet (1994) 1.90
Induction of thymidine kinase in enzyme-deficient Chinese hamster cells. Cell (1982) 1.85
Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J Neurochem (1995) 1.84
Family accommodation in obsessive-compulsive disorder. Am J Psychiatry (1995) 1.84
Suppression of plasma viral load below 20 copies/ml is required to achieve a long-term response to therapy. AIDS (1998) 1.81
The incidence of schizophrenia in Nottingham. Br J Psychiatry (1987) 1.79
Plymouth randomized trial of cardiotocogram only versus ST waveform plus cardiotocogram for intrapartum monitoring in 2400 cases. Am J Obstet Gynecol (1993) 1.74
Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity. J Virol (1998) 1.72
Excess risk of breast cancer in the mothers of children with soft tissue sarcomas. Br J Cancer (1984) 1.70
Pseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases. Histopathology (1992) 1.63
A randomized clinical trial of supported employment for inner-city patients with severe mental disorders. Arch Gen Psychiatry (1999) 1.63
The steady-state pharmacokinetics of efavirenz and nevirapine when used in combination in human immunodeficiency virus type 1-infected persons. J Infect Dis (2001) 1.62
Role of viral load in heterosexual transmission of human immunodeficiency virus type 1 by blood transfusion recipients. Transfusion Safety Study Group. Am J Epidemiol (1997) 1.62
The prognostic significance of two epithelial membrane antigens expressed by human mammary carcinomas. Int J Cancer (1984) 1.61
Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome. Oncogene (1998) 1.59
p53 germline mutations in Li-Fraumeni syndrome. Lancet (1991) 1.58
Identification of the Nef-associated kinase as p21-activated kinase 2. Curr Biol (1999) 1.58
Lifetime suicide rates in treated schizophrenia: 1875-1924 and 1994-1998 cohorts compared. Br J Psychiatry (2006) 1.58
Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors. Am J Hum Genet (1999) 1.57
The ligamento-muscular stabilizing system of the spine. Spine (Phila Pa 1976) (1998) 1.56
Psychogenic facial pain: presentation and treatment. Br Med J (Clin Res Ed) (1984) 1.53
Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A. J Biol Chem (2000) 1.52
Epidemiology and predictors of post-concussive syndrome after minor head injury in an emergency population. Brain Inj (1999) 1.50
Modified nasopharyngeal tube for upper airway obstruction. Arch Dis Child (1999) 1.50
Audit of tumour histopathology reviewed by a regional oncology centre. J Clin Pathol (1995) 1.50
Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects. J Biol Chem (1996) 1.49
Tumour angiogenesis as a prognostic marker in infiltrating lobular carcinoma of the breast. J Pathol (1996) 1.49
Cancer in the families of children with soft tissue sarcoma. Cancer (1990) 1.47
GM-1 ganglioside administration combined with physical therapy restores ambulation in humans with chronic spinal cord injury. Neurosci Lett (1993) 1.46
Factors influencing human immunodeficiency virus type 1 transmission by blood transfusion. Transfusion Safety Study Group. J Infect Dis (1996) 1.46
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. Pharmacol Toxicol (1991) 1.45
Lipodystrophy-associated morphological, cholesterol and triglyceride abnormalities in a population-based HIV/AIDS treatment database. AIDS (2001) 1.45
Identification of factors associated with high breast cancer risk in the mothers of children with soft tissue sarcoma. J Clin Oncol (1990) 1.45
The use and perceived value of diabetes clinical management guidelines in general practice. Aust Fam Physician (2000) 1.44
Divergent differentiation in small round-cell tumours of the soft tissues with neural features--an analysis of 10 cases. Histopathology (1993) 1.44
Aminophylline does not protect against radiocontrast nephropathy in patients undergoing percutaneous angiographic procedures. J Invasive Cardiol (2001) 1.42
Neurotropic desmoplastic melanoma: a rare vulvar malignancy. Gynecol Oncol (1995) 1.41
Sustained reduction of exercise perfusion defect extent and severity with isosorbide mononitrate (Imdur) as demonstrated by means of technetium 99m sestamibi. J Nucl Cardiol (2000) 1.40
Call for diazepam replacement. Mil Med (2000) 1.40
Is GIFT (gamete intrafallopian transfer) the best treatment for unexplained infertility? Br J Obstet Gynaecol (1991) 1.40
Type X Toxoplasma gondii in a wild mussel and terrestrial carnivores from coastal California: new linkages between terrestrial mammals, runoff and toxoplasmosis of sea otters. Int J Parasitol (2008) 1.40
Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. J Biol Chem (2000) 1.39
The Christie Hospital breast conservation trial: an update at 8 years from inception. Clin Oncol (R Coll Radiol) (1993) 1.39
The concentration of sparfloxacin in lung tissues after single and multiple oral doses. Int J Antimicrob Agents (1994) 1.38
Integrated treatment for dually diagnosed homeless adults. J Nerv Ment Dis (1997) 1.38
Monovision. J Am Optom Assoc (1990) 1.38
Reasons for encounter and diagnosed health problems: convergence between doctors and patients. Fam Pract (1992) 1.37
Mechanisms of internalization of Staphylococcus aureus by cultured human osteoblasts. Infect Immun (1999) 1.37
Extended triple intrathecal chemotherapy trial for prevention of CNS relapse in good-risk and poor-risk patients with B-progenitor acute lymphoblastic leukemia: a Pediatric Oncology Group study. J Clin Oncol (1993) 1.36
Biomechanics of increased exposure to lumbar injury caused by cyclic loading: Part 1. Loss of reflexive muscular stabilization. Spine (Phila Pa 1976) (1999) 1.33
Evidence for a general-purpose genotype in Candida albicans, highly prevalent in multiple geographical regions, patient types and types of infection. Microbiology (1999) 1.29
Non-secretory multiple myeloma: a report of 13 cases with a review of the literature. Hematol Oncol (1987) 1.29
Cancer experience in the relatives of an unselected series of breast cancer patients. Br J Cancer (1994) 1.28
The effect of oestrogen and progesterone receptors on recurrence and survival in patients with carcinoma of the breast. Br J Cancer (1985) 1.26
Targeted disruption of the methionine synthase gene in mice. Mol Cell Biol (2001) 1.26
Dissecting aneurysm of the aorta due to giant cell arteritis. Br Heart J (1968) 1.24
Reduction of postoperative pain and swelling by ultrasound treatment: a placebo effect. Pain (1988) 1.23
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med (2012) 1.23
Anti-inflammatory effects of ultrasound therapy: evidence for a major placebo effect. Br J Rheumatol (1986) 1.23
Effects of different forms of central nervous system prophylaxis on neuropsychologic function in childhood leukemia. J Clin Oncol (1984) 1.22
A prospective study of computer-aided design and manufacture of titanium plate for cranioplasty and its clinical outcome. Br J Neurosurg (1999) 1.21
Cerebral responses to pain in patients with atypical facial pain measured by positron emission tomography. J Neurol Neurosurg Psychiatry (1994) 1.21
Neurofibromatosis in children with soft tissue sarcoma. Pediatr Hematol Oncol (1988) 1.21
Sclerosing epithelioid fibrosarcoma: a study of five cases emphasizing diagnostic criteria. Histopathology (1998) 1.20
Antiapoptotic effects of leptin in human neuroblastoma cells. Endocrinology (2004) 1.20
The effect of age and menstrual cycle upon proliferative activity of the normal human breast. Br J Cancer (1988) 1.19
The anti-inflammatory effects of dexamethasone and therapeutic ultrasound in oral surgery. Br J Oral Maxillofac Surg (1985) 1.18
Psychiatric bed utilization: 1896 and 1996 compared. Psychol Med (2001) 1.18
In vitro effects of therapeutic ultrasound on cell proliferation, protein synthesis, and cytokine production by human fibroblasts, osteoblasts, and monocytes. J Oral Maxillofac Surg (1999) 1.17
Carcinomatous meningitis in patients with breast cancer. An aggressive disease variant. Cancer (1994) 1.16