Published in Int J Cancer on January 15, 1970
Buoyant densities and hydration of nucleic acids, proteins and nucleoprotein complexes in metrizamide. Biochim Biophys Acta (1973) 2.60
Evidence for single copies of globin genes in the mouse genome. Nature (1972) 2.45
A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells/. Nature (1994) 2.35
Antitumour activity in a series of bisdiketopiperazines. Nature (1969) 1.89
Kinetic studies of gene frequency. I. Use of a DNA copy of reticulocyte 9 S RNA to estimate globin gene dosage in mouse tissues. J Mol Biol (1974) 1.87
Kinetic studies of gene frequency. II. Complexity of globin complementary DNA and its hybridization characteristics. J Mol Biol (1974) 1.78
A kinetic estimation of base sequence complexity of nuclear poly(A)-containing RNA in mouse Friend cells. Cell (1975) 1.63
A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow. Leuk Res (1985) 1.61
Metrizamide, a new density-gradient medium. FEBS Lett (1975) 1.55
The diversity of the messenger RNA population in growing Friend cells. Cell Differ (1974) 1.53
AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44. Mol Cell Biol (1997) 1.46
The site of the breakpoint within the bcr is a prognostic factor in Philadelphia-positive CML patients. Blood (1988) 1.42
Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression. J Pathol (1999) 1.41
Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality. J Pathol (1998) 1.41
Complexity and specificity of polysomal poly(A+) RNA in mouse tissues. Biochemistry (1976) 1.40
Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases. Genes Chromosomes Cancer (1999) 1.40
Cloning and characterisation of the abundant cytoplasmic 7S RNA from mouse cells. Nucleic Acids Res (1982) 1.36
Isopycnic centrifugation of sheared chromatin in metrizamide gradients. FEBS Lett (1973) 1.34
Myc oncogenes: the enigmatic family. Biochem J (1996) 1.32
Detection of intraoperative tumor cell dissemination in patients with breast cancer by use of reverse transcription and polymerase chain reaction. Surgery (1995) 1.31
The incorporation of 3H-thymidine and 3H-uridine into chick and mouse embryo cells cultured on stainless steel. Exp Cell Res (1967) 1.31
Reversible interaction of metrizamide with protein. Biochim Biophys Acta (1974) 1.12
Gene expression in Friend erythroleukemia cells following the induction of hemoglobin synthesis. Exp Cell Res (1978) 1.08
Genomic alterations involving the c-myc proto-oncogene locus during the evolution of a case of chronic granulocytic leukaemia. Lancet (1984) 1.05
Changes in nuclear and polysomal polyadenylated RNA sequences during rat-liver regeneration. Nucleic Acids Res (1979) 1.03
Fractionation of unfixed chromatin by buoyant-density centrifugation. Biochim Biophys Acta (1974) 1.00
Post-transcriptional regulation of rat liver gene expression by glucocorticoids. Nucleic Acids Res (1985) 0.99
Synthesis of DNAs complementary to human ribosomal RNAs polyadenylated in vitro. Biochim Biophys Acta (1976) 0.99
Comparison of the base-sequence complexities of polysomal and nuclear RNAs in growing Friend erythroleukemia cells. Biochemistry (1977) 0.99
Simultaneous determination of the rates of synthesis of 3H-RNA and 3H-DNA in mouse embryo cells grown as monolayers on stainless steel. Exp Cell Res (1968) 0.98
The diversity and specificity of nuclear and polysomal poly(A)+ RNA populations in normal and MSV-transformed cells. Cell Differ (1977) 0.98
Nick translation of mammalian DNA. Biochim Biophys Acta (1979) 0.98
Controlled fragmentation of DNA by DNase I. Anal Biochem (1972) 0.98
Putative markers for the detection of breast carcinoma cells in blood. Br J Cancer (1998) 0.98
Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines. Cancer Res (1998) 0.98
Expression of the components and regulatory proteins of the alternative complement pathway and the membrane attack complex in normal and diseased synovium. Rheumatol Int (1993) 0.97
Carbonyl reductase: a novel metastasis-modulating function. Cancer Res (2000) 0.97
A new estimate of human ribosomal gene number. Biochim Biophys Acta (1976) 0.96
Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase IIalpha. Mol Pharmacol (2000) 0.94
Isolation of polyoma virus and Semliki Forest virus from tissue culture fluid by continuous flow zonal ultracentrifugation. J Gen Virol (1967) 0.94
Interferon-mediated transcriptional and post-transcriptional modulation of complement gene expression in human monocytes. Eur J Biochem (1990) 0.94
Proceedings: Mechanism of action studies with IRCF 159: effects on the growth and morphology of BHK-21S cells. Br J Cancer (1974) 0.93
Post-transcriptional regulation of messenger abundance in rat liver and hepatoma. Nucleic Acids Res (1980) 0.93
Modulation by interferons of the expression of monocyte complement genes. Biochem J (1990) 0.92
The use of batch-type zonal ultracentrifuge rotors for the isolation and purification of viruses. J Gen Virol (1968) 0.92
An in vitro method for studying nucleic acid metabolism in murine peritoneal macrophages. Exp Cell Res (1969) 0.92
Transcription of in vitro polyadenylated ribonucleic acid with reverse transcriptase. Biochemistry (1974) 0.92
Isolation and preliminary characterisation of cDNA clones representing mRNAs associated with tumour progression and metastasis in colorectal cancer. Br J Cancer (1988) 0.91
Mutations at the stromal processing peptidase cleavage site of a thylakoid lumen protein precursor affect the rate of processing but not the fidelity. J Biol Chem (1994) 0.89
Temporal relationships between induced changes in c-myc mRNA abundance, proliferation, and differentiation in HL60 cells. Differentiation (1992) 0.89
A new approach to the classification of human leukaemias: measurement of the relative abundance of a specific RNA sequence by means of molecular hybridisation. Lancet (1983) 0.89
Transcription of repeated sequences of the mouse B1 family in Friend erythroleukaemic cells. Intermolecular RNA-RNA duplex formation between polyadenylated and non-polyadenylated nuclear RNAs. J Mol Biol (1982) 0.89
A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane). Biochem Pharmacol (1995) 0.88
Differences among the polyadenylated RNA sequences of human leucocyte populations: an approach to the objective classification of human leukaemias. EMBO J (1983) 0.87
Variation in myc gene amplification and expression in sublines of HL60 cells. Leuk Res (1985) 0.87
Isolation of nuclei from animal cells in culture. Methods Cell Biol (1978) 0.85
Isolation and purification of rat hepatoma nuclei active in the transport of messenger RNA in vitro. Eur J Biochem (1982) 0.85
Changes induced in rat liver polysomal polyadenylated RNAs by depletion of circulating glucocorticoids. Nucleic Acids Res (1982) 0.85
Characterization of a Chinese hamster ovary cell line with acquired resistance to the bisdioxopiperazine dexrazoxane (ICRF-187) catalytic inhibitor of topoisomerase II. Biochem Pharmacol (1997) 0.85
Mitindomide is a catalytic inhibitor of DNA topoisomerase II that acts at the bisdioxopiperazine binding site. Mol Pharmacol (1997) 0.85
A study of the interaction of histones with DNA using isopycnic centrifugation in metrizamide gradients. Nucleic Acids Res (1975) 0.85
A simple density-gradient engine for loading large-capacity zonal ultracentrifuge rotors. Anal Biochem (1968) 0.84
Complement biosynthesis in human synovial tissue. Clin Exp Immunol (1989) 0.83
Monocyte C1-inhibitor synthesis in patients with C1-inhibitor deficiency. Eur J Clin Invest (1989) 0.83
Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action. J Cell Sci (1997) 0.83
Properties of transcriptionally active chromatin. Cold Spring Harb Symp Quant Biol (1978) 0.83
Radioactive labeling of recombinant antibody fragments by phosphorylation using human casein kinase II and [gamma-32P]-ATP. Nat Biotechnol (1996) 0.83
The protective activity of ICRF-187 against doxorubicin-induced cardiotoxicity in the rat. Cancer Chemother Pharmacol (1992) 0.82
Fractionation of chromatin by buoyant density-gradient sedimentation in metrizamide. Methods Cell Biol (1978) 0.82
Expression of the myc gene locus in populations of leukocytes from leukaemia patients and normal individuals. Leuk Res (1986) 0.81
Frequency distribution of pre-messenger RNA sequences in polyadenylated and non-polyadenylated nuclear RNA from Friend cells. Nucleic Acids Res (1980) 0.81
Genomic rearrangements of the c-myc proto-oncogene in human malignant lymphomas. J Pathol (1986) 0.80
Isopycnic sedimentation of DNA in metrizamide: the effect of low concentrations of ions on buoyant density and hydration. Nucleic Acids Res (1974) 0.80
Recombinant anti-human melanoma antibodies are versatile molecules. J Invest Dermatol (1996) 0.80
Differential expression of topoisomerase I and RAD52 protein in yeast reveals new facets of the mechanism of action of bisdioxopiperazine compounds. Br J Cancer (1999) 0.79
Post-transcriptional control of messenger abundance. Mol Biol Rep (1981) 0.79
Concomitant transcriptional and post-transcriptional control of mRNA abundance during human myeloid cell differentiation. Nucleic Acids Res (1988) 0.78
Cell-cycle progression is not essential for c-Myc to block differentiation. Oncogene (1997) 0.77
Characterization of the RNA transcribed in vitro from native mammalian DNA by Escherichia coli RNA polymerase. Biochim Biophys Acta (1976) 0.77
Metal binding by pharmaceuticals. Part 5. Interaction of Cd(II), Ni(II) and Pb(II) with the intracellular hydrolysis products of the anti-tumour agent ICRF 159 and its inactive homologue ICRF 192. Agents Actions (1984) 0.77
Subdivision of the acute non-lymphoblastic leukaemias by measurement of the relative abundance of a specific RNA sequence. Leuk Res (1985) 0.77
The c-ets-1 proto-oncogene is rearranged in some cases of acute lymphoblastic leukaemia. Br J Cancer (1987) 0.77
The effect of bisdioxopiperazines on the synthesis of deoxyribonucleic acid, ribonucleic acid and protein in growing mouse-embryo fibroblasts. Biochem J (1969) 0.77
Metal binding by pharmaceuticals. Part 2. Interactions of Ca(II), Cu(II), Fe(II), Mg(II), Mn(II) and Zn(II) with the intracellular hydrolysis products of the antitumour agent ICRF 159 and its inactive homologue ICRF 192. Agents Actions (1982) 0.77
Isopycnic centrifugation in ionic media. Biochem Soc Trans (1980) 0.76
Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in Syrian golden hamsters. Res Commun Chem Pathol Pharmacol (1985) 0.76
Analysis of E-box DNA binding during myeloid differentiation reveals complexes that contain Mad but not Max. Biochem J (1997) 0.76
The serum response element and an AP-1/ATF sequence immediately downstream co-operate in the regulation of c-fos transcription. Cell Prolif (1992) 0.76
Control of gene function in differentiation. Br J Cancer (1980) 0.75
Conjugation of monoclonal antibodies to a synthetic peptide substrate for protein kinase: a method for labelling antibodies with 32P. Br J Cancer (1988) 0.75
The appearance of new polyadenylated nuclear RNA sequences during rat-liver regeneration. Nucleic Acids Res (1981) 0.75
Lineage-specific and differentiation-stage-specific gene expression in normal and leukaemic human myeloid cells. J R Soc Med (1984) 0.75
The synthesis of polydeoxyribonucleotide by cell-free extracts of embryonic mouse tissue. Biochem J (1967) 0.75
Tumour metastasis. Lancet (1992) 0.75
ICRF 159-induced cell-cycle perturbation in vitro: its relationship to inhibition of colony-forming ability. Br J Cancer (1981) 0.75
Fractionation of chromatin by differential solubility in dilute salt. Nucleic Acids Res (1978) 0.75
Prognostic significance of BCR breakpoint location in M-bcr. Leukemia (1991) 0.75
Incorporation of [3H] uridine ad [3H] thymidine by murine peritoneal macrophages in vitro. Biochem J (1969) 0.75