Published in Can Med Assoc J on July 06, 1968
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The molecular basis of Turcot's syndrome. N Engl J Med (1995) 6.65
Familial breast-ovarian cancer locus on chromosome 17q12-q23. Lancet (1991) 6.61
Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med (1993) 6.13
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med (1996) 4.87
Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med (1987) 4.55
Molecular diagnosis of familial adenomatous polyposis. N Engl J Med (1993) 4.07
Extracolonic cancer in hereditary nonpolyposis colorectal cancer. Cancer (1993) 3.86
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The risk of upper gastrointestinal cancer in familial adenomatous polyposis. Gastroenterology (1992) 3.59
Conversion of diploidy to haploidy. Nature (2000) 3.28
Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers. J Natl Cancer Inst (1999) 3.26
Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res (1994) 3.25
Colorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members. Cancer (1998) 2.91
Hereditary factors in cancer. Study of two large midwestern kindreds. Arch Intern Med (1966) 2.86
Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers. J Natl Cancer Inst (1992) 2.82
Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma. Cancer (2001) 2.82
hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res (1994) 2.39
Prophylactic surgery decisions and surveillance practices one year following BRCA1/2 testing. Prev Med (2000) 2.39
Familial gastric cancer: overview and guidelines for management. J Med Genet (1999) 2.38
Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2. Lancet (1999) 2.36
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Effect of smoking on breast cancer in carriers of mutant BRCA1 or BRCA2 genes. J Natl Cancer Inst (1998) 2.33
Genetic epidemiology of breast cancer and associated cancers in high-risk families. I. Segregation analysis. J Natl Cancer Inst (1983) 2.21
Genetic instability of microsatellites in endometrial carcinoma. Cancer Res (1993) 2.20
Microscopic benign and invasive malignant neoplasms and a cancer-prone phenotype in prophylactic oophorectomies. J Natl Cancer Inst (1996) 2.17
Mutations in BRCA1 and BRCA2 in breast cancer families: are there more breast cancer-susceptibility genes? Am J Hum Genet (1997) 2.15
Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat. Am J Hum Genet (1999) 2.14
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet (2004) 2.10
Desmoid tumours in familial adenomatous polyposis. Gut (1994) 2.08
MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Nat Genet (2000) 2.00
A polymorphic stop codon in BRCA2. Nat Genet (1996) 1.95
Familial atypical multiple mole-melanoma syndrome. J Med Genet (1978) 1.88
Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. Gut (1993) 1.85
The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. Gynecol Oncol (2001) 1.84
Modification of BRCA1- and BRCA2-associated breast cancer risk by AIB1 genotype and reproductive history. Cancer Res (2001) 1.81
Colorectal neoplasia in juvenile polyposis or juvenile polyps. Arch Dis Child (1991) 1.81
Cancer family "G" revisited: 1895-1970. Cancer (1971) 1.81
Rectal cancer in FAP patient after sulindac. Lancet (1994) 1.80
Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus. Nat Genet (1996) 1.79
A BRCA1 nonsense mutation causes exon skipping. Am J Hum Genet (1998) 1.77
Ehlers-Danlos syndrome and "congenital" arteriovenous fistulae. A clinicopathologic study of a family. JAMA (1965) 1.77
Prevalence and importance of pigmented ocular fundus lesions in Gardner's syndrome. N Engl J Med (1987) 1.76
A breast-ovarian cancer susceptibility gene maps to chromosome 17q21. Am J Hum Genet (1993) 1.66
Genetic testing in families with hereditary nonpolyposis colon cancer. JAMA (1999) 1.61
A follow-up study of colonic epithelial proliferation as a biomarker ina Native-American family with hereditary nonpolyposis colon cancer. J Natl Cancer Inst (1991) 1.57
Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. Am J Pathol (1998) 1.55
What you don't know can hurt you: adverse psychologic effects in members of BRCA1-linked and BRCA2-linked families who decline genetic testing. J Clin Oncol (1998) 1.55
Epidemiology of pancreatic cancer: an overview. Cancer Detect Prev (2003) 1.54
Natural history of hereditary cancer of the breast and colon. Cancer (1982) 1.53
An Alu-mediated 6-kb duplication in the BRCA1 gene: a new founder mutation? Am J Hum Genet (1999) 1.52
Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies. Cancer (1985) 1.51
Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. Br J Cancer (2011) 1.51
Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer. J Gastrointest Surg (1999) 1.51
Genetic and pathologic findings in a kindred with hereditary sarcoma, breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma. Cancer (1978) 1.49
Pathology of hereditary non-polyposis colorectal cancer. Anticancer Res (1994) 1.49
A 1-kb Alu-mediated germ-line deletion removing BRCA1 exon 17. Cancer Res (1997) 1.49
Characteristics of small bowel carcinoma in hereditary nonpolyposis colorectal carcinoma. International Collaborative Group on HNPCC. Cancer (1998) 1.48
Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). I. Clinical description of resource. Cancer (1985) 1.48
Phenotypic variability of familial adenomatous polyposis in 11 unrelated families with identical APC gene mutation. Gastroenterology (1994) 1.48
Molecular genetic evidence of the occurrence of breast cancer as an integral tumor in patients with the hereditary nonpolyposis colorectal carcinoma syndrome. Cancer (1996) 1.48
The influence of psychological distress on use of genetic testing for cancer risk. J Consult Clin Psychol (1997) 1.46
Rapid progression of prostate cancer in men with a BRCA2 mutation. Br J Cancer (2008) 1.45
Hereditary proximal colonic cancer. Dis Colon Rectum (1978) 1.45
A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families. Am J Hum Genet (1996) 1.45
The cancer family syndrome. Rare cutaneous phenotypic linkage of Torre's syndrome. Arch Intern Med (1981) 1.45
Risk and surveillance of individuals with heritable factors for colorectal cancer. WHO Collaborating Centre for the Prevention of Colorectal Cancer. Bull World Health Organ (1990) 1.44
Surveillance and management of patients at high genetic risk for ovarian carcinoma. Obstet Gynecol (1982) 1.43
Parental communication of BRCA1/2 genetic test results to children. Patient Educ Couns (2001) 1.43
Tritiated thymidine (phi p, phi h) labeling distribution as a marker for hereditary predisposition to colon cancer. Cancer Res (1983) 1.42
Patent ductus arteriosus. Study of two families. JAMA (1965) 1.41
Familial association of breast/ovarian carcinoma. Cancer (1978) 1.40
Genetic risk in ovarian cancer. Gynecol Oncol (1992) 1.38
Screening for germ-line rearrangements and regulatory mutations in BRCA1 led to the identification of four new deletions. Cancer Res (1999) 1.36
Male breast cancer in the hereditary nonpolyposis colorectal cancer syndrome. Breast Cancer Res Treat (1999) 1.35
The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Proc Natl Acad Sci U S A (1995) 1.34
Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst (2004) 1.34
Pancreatic carcinoma and hereditary nonpolyposis colorectal cancer: a family study. Br J Cancer (1985) 1.34
Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis. Ann Surg Oncol (2002) 1.34
The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers. Br J Cancer (2012) 1.34
Family studies of malignant melanoma and associated cancer. Surg Gynecol Obstet (1975) 1.34
Family history in an oncology clinic. Implications for cancer genetics. JAMA (1979) 1.30
Family history of colorectal cancer as a marker of potential malignancy within a screening program. Cancer (1987) 1.30
Phenotypic expression of disease in families that have mutations in the 5' region of the adenomatous polyposis coli gene. Ann Intern Med (1997) 1.29
Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis. Dis Colon Rectum (1999) 1.29
Colorectal adenomas in the Lynch syndromes. Results of a colonoscopy screening program. Gastroenterology (1990) 1.26
Tumour spectrum in the FAMMM syndrome. Br J Cancer (1981) 1.24
Identifying hereditary nonpolyposis colorectal cancer. N Engl J Med (1998) 1.23
Heredity and intraocular malignant melanoma. Study of two families and review of forty-five cases. Cancer (1968) 1.21
Pigmented ocular fundus lesions in the inherited gastrointestinal polyposis syndromes and in hereditary nonpolyposis colorectal cancer. Ophthalmology (1988) 1.21
The cancer family syndrome: a status report. Dis Colon Rectum (1981) 1.21
Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus. Science (1980) 1.21
An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome. Am J Hum Genet (2003) 1.21
Risk of hepatoblastoma in familial adenomatous polyposis. J Pediatr (1991) 1.20