A comparison of the concentration of glycine, a transmitter suspect, in different areas of the brain and spinal cord in seven different vertebrates.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMID 5786830)

Published in Comp Biochem Physiol on March 01, 1969

Authors

M H Aprison, R P Shank, R A Davidoff

Associated clinical trials:

A Study of the Effects of Sarcosine on Symptoms and Brain Glycine Levels in People With Schizophrenia (Sarc) | NCT00538070

Articles citing this

D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci U S A (1995) 3.51

Strychnine binding associated with glycine receptors of the central nervous system. Proc Natl Acad Sci U S A (1973) 2.37

Interaction of benzodiazepines with central nervous glycine receptors: possible mechanism of action. Proc Natl Acad Sci U S A (1974) 1.41

Requirement for Acetate and Glycine (or Serine) for Sporulation Without Growth of Bacillus subtilis. J Bacteriol (1970) 1.30

Taurine activates excitatory non-synaptic glycine receptors on dopamine neurones in ventral tegmental area of young rats. J Physiol (2005) 1.03

Quantification of high-resolution (1)H NMR spectra from rat brain extracts. Anal Chem (2010) 1.02

The N-methyl D-aspartate receptor glycine site and D-serine metabolism: an evolutionary perspective. Philos Trans R Soc Lond B Biol Sci (2004) 0.99

Oral glycine administration increases brain glycine/creatine ratios in men: a proton magnetic resonance spectroscopy study. Psychiatry Res (2009) 0.84

Fifth Gaddum Memorial Lecture, University of Bristol, September 1974, The glycine synaptic receptor in the mammalian central nervous system. Br J Pharmacol (1975) 0.82

4-bromopropofol decreases action potential generation in spinal neurons by inducing a glycine receptor-mediated tonic conductance. Br J Pharmacol (2014) 0.78

Development of L-glutamate- and glycine-activated currents in spinal cord neurones during early chick embryogenesis. J Physiol (1990) 0.76

Articles by these authors

Time Course of Fixation of N2 by Excised Soybean Nodules. Science (1952) 5.76

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther (1992) 3.58

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J Biol Chem (2000) 2.96

Inhibitory of glycine on spinal neurons in the cat. J Neurophysiol (1968) 2.17

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. J Pharmacol Exp Ther (1993) 1.71

Inhibition of motoneurones by iontophoresis of glycine. Nature (1967) 1.65

Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res (1985) 1.62

Antispasticity drugs: mechanisms of action. Ann Neurol (1985) 1.48

Distribution of some synaptic transmitter suspects in cat spinal cord: glutamic acid, aspartic acid, gamma-aminobutyric acid, glycine and glutamine. J Neurochem (1967) 1.47

Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors. J Neurochem (2000) 1.47

The distribution of glycine in cat spinal cord and roots. Life Sci (1965) 1.45

Gamma-aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord. Science (1972) 1.42

Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther (1995) 1.38

Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia (2000) 1.34

The effects of strychnine on the inhibition of interneurons by glycine and gamma-aminobutyric acid. Int J Neuropharmacol (1969) 1.30

2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor. Bioorg Med Chem (2000) 1.27

Association of glycine with spinal interneurones. Nature (1967) 1.27

The effects of Lioresal on synaptic activity in the isolated spinal cord. Neurology (1974) 1.25

Determination of the equilibrium dissociation constants and number of glycine binding sites in several areas of the rat central nervous system, using a sodium-independent system. J Neurochem (1981) 1.18

Dacrystic epilepsy. J Neurol Neurosurg Psychiatry (1976) 1.16

The effects of bicuculline on the isolated spinal cord of the frog. Exp Neurol (1972) 1.15

Determination of calcium, copper, iron, magnesium, manganese, potassium, sodium, zinc, and chloride concentrations in several brain areas. Anal Biochem (1967) 1.08

Changes in amino acid concentrations associated with loss of spinal interneurons. J Neurochem (1967) 1.07

Mammalian brain acetylcholinesterase. Purification and properties. J Neurochem (1966) 1.06

Brain acetylcholine studies: a new extraction procedure. J Neurochem (1966) 1.05

Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. J Med Chem (1998) 1.05

Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate and related compounds. J Med Chem (1987) 1.05

Pharmacology of spasticity. Neurology (1978) 1.04

The metabolism in vivo of glycine and serine in eight areas of the rat central nervous system. J Neurochem (1970) 1.03

High affinity amino acid transport by frog spinal cord slices. J Neurochem (1975) 1.02

Fluorometric determination of aspartate, glutamate, and gamma-aminobutyrate in nerve tissue using enzymic methods. Anal Biochem (1966) 1.01

Picrotoxin antagonism of the inhibition of interneurons by glycine. Life Sci (1969) 0.99

Present status and significance of the glutamine cycle in neural tissues. Life Sci (1981) 0.95

The distribution of glutamic acid, a transmitter candidate, and other amino acids in the dorsal sensory neuron of the cat. Brain Res (1970) 0.95

Cooperative interaction of glutamate and aspartate with receptors in the neuromuscular excitatory membrane in walking limbs of the lobster. J Neurobiol (1975) 0.95

Alpha-ketoglutarate and malate uptake and metabolism by synaptosomes: further evidence for an astrocyte-to-neuron metabolic shuttle. J Neurochem (1984) 0.94

Phenytoin-induced ophthalmoplegia. Neurology (1976) 0.94

Bicuculline and picrotoxin as antagonists of gamma-aminobutyrate and neuromuscular inhibition in the lobster. Brain Res (1974) 0.94

Distribution of several amino acids in regions of the cerebellum of the rat. J Neurochem (1977) 0.93

Galanin inhibits acetylcholine release from rat cerebral cortex via a pertussis toxin-sensitive G(i)protein. Neuropeptides (1999) 0.93

Penicillin and presynaptic inhibition in the amphibian spinal cord. Brain Res (1972) 0.92

Post mortem changes in the content and specific radioactivity of several amino acids in four areas of the rat brain. J Neurobiol (1971) 0.91

Glutamate and aspartate as mediators of neuromuscular excitation in the lobster. Comp Biochem Physiol C (1975) 0.91

Putative transmitters in denervated olfactory complex. J Neurochem (1975) 0.90

Determination of nanomole levels of 5-hydroxytryptophan, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in the same sample. Anal Biochem (1972) 0.89

Glutamine and alpha-ketoglutarate uptake and metabolism by nerve terminal enriched material from mouse cerebellum. Neurochem Res (1982) 0.89

GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons. J Neurophysiol (1999) 0.89

Pharmacologically novel GABA receptor in human dorsal root ganglion neurons. J Neurophysiol (1996) 0.89

Catecholamines and serotonin in the caudal medulla of the rat: combined neurochemical-histofluorescence study. Brain Res Bull (1983) 0.89

Regional distribution and properties of the glycine cleavage system within the central nervous system of the rat: evidence for an endogenous inhibitor during in vitro assay. J Neurochem (1976) 0.87

Distribution of serine hydroxymethyltransferase and glycine transaminase in several areas of the central nervous system of the rat. J Neurochem (1974) 0.87

Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. J Med Chem (1998) 0.86

A combined neurochemical and neurophysiological approach to identification of central nervous system transmitters. Neurosci Res (N Y) (1968) 0.86

Microdetermination of glutamate in single cat spinal roots. Life Sci (1965) 0.84

Distribution of some enzymes associated with the metabolism of glutamate, aspartate, gamma-aminobutyrate and glutamine in cat spinal cord. J Neurochem (1969) 0.84

Serotonergic and cholinergic mechanisms during disruption of approach and avoidance behavior. Fed Proc (1975) 0.84

Distribution and uptake of glycine, glutamate and gamma-aminobutyric acid in the vagal nuclei and eight other regions of the rat medulla oblongata. Neurochem Res (1982) 0.83

Changes in membrane potential of frog motoneurons induced by activation of serotonin receptor subtypes. Neuroscience (1990) 0.83

Antinociceptive action of McN-5195 in rodents: a structurally novel (indolizine) analgesic with a nonopioid mechanism of action. J Pharmacol Exp Ther (1990) 0.83

An enzymatic method for measuring picomole quantities of acetylcholine and choline in CNS tissue. Anal Biochem (1973) 0.83

Penicillin and inhibition in the cat spinal cord. Brain Res (1972) 0.83

Amino acid uptake, content, and metabolism by neuronal and glial enriched cellular fractions from mouse cerebellum. J Neurosci (1984) 0.83

Alcohol and presynaptic inhibition in an isolated spinal cord preparation. Arch Neurol (1973) 0.83

Hyperpolarization of frog primary afferent fibres caused by activation of a sodium pump. J Physiol (1980) 0.83

Mammalian brain acetylcholinesterase. Effects of surface active agents. J Neurochem (1966) 0.83

Evidence for the net accumulation of glycine into a synaptosomal fraction isolated from the telencephalon and spinal cord of the rat. Life Sci I (1973) 0.83

Avid Na+-dependent, high-affinity uptake of alpha-ketoglutarate by nerve terminal enriched material from mouse cerebellum. Life Sci (1981) 0.82

Behavioral depression in pigeons following l-tryptophan administration. Life Sci (1975) 0.82

Neurochemical correlates of behavior. V. Differential effects of drugs on approach and avoidance behavior in rats with related changes in brain serotonin and norepinephrine. Recent Adv Biol Psychiatry (1965) 0.82

Ion dependence of neurotransmitter uptake: inhibitory effects of ion substitutes. J Neurochem (1987) 0.82

Serotonin1A facilitation of frog motoneuron responses to afferent stimuli and to N-methyl-D-aspartate. Neuroscience (1992) 0.82

The inhibitory action of cystathionine. Life Sci (1966) 0.82

Metabolism of glucose, amino acids, and some related metabolites in the brain of toads (Bufo boreas) adapted to fresh water or hyperosmotic environments. J Neurochem (1973) 0.82

Levels of free amino acids in excitatory, inhibitory and sensory axons of the walking limbs of the lobster. Life Sci (1974) 0.82

Potential anxiolytic agents. Pyrido[1,2-a]benzimidazoles: a new structural class of ligands for the benzodiazepine binding site on GABA-A receptors. J Med Chem (1995) 0.82

A method for concurrent measurement of picomole quantities of acetylcholine, choline, dopamine, norepinephrine, serotonin, 5-hydroxytryptophan, 5-hydroxyindoleacetic acid, tryptophan, tyrosine, glycine, aspartate, glutamate, alanine, and gamma-aminobutyric acid in single tissue samples from different areas of rat central nervous system. Anal Biochem (1975) 0.81

GABA and glycine transport in frog CNS: high affinity uptake and potassium-evoked release in vitro. Brain Res (1976) 0.81

Optokinetic nystagmus and cerebral disease; clinical and pathological study. Arch Neurol (1966) 0.81

Identifying agonistic and antagonistic mechanisms operative at the GABA receptor. J Neurosci Res (1995) 0.81

Subcellular distribution of potassium, sodium, magnesium, calcium and chloride in cerebral cortex. J Neurochem (1972) 0.81

Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNS. Brain Res (1995) 0.80

Spinal seizures and excitatory amino acid-mediated synaptic transmission. Neurosci Lett (1984) 0.80

Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord. Br J Pharmacol (1999) 0.80

The flux of radioactive label through components of the serotonergic system following the injection of [3H]tryptophan: product--precursor anomalies providing evidence that serotonin exists in multiple pools. J Neurochem (1978) 0.80

In vivo determination of endogenous biogenic amines in rat brain using HPLC and push-pull cannula. Pharmacol Biochem Behav (1980) 0.80