A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura.

PubWeight™: 24.69‹?› | Rank: Top 0.01% | All-Time Top 10000

🔗 View Article (PMC 1211185)

Published in Genetics on August 01, 1966

Authors

J L Hubby, R C Lewontin

Articles citing this

A molecular approach to the study of genic heterozygosity in natural populations. II. Amount of variation and degree of heterozygosity in natural populations of Drosophila pseudoobscura. Genetics (1966) 30.66

A molecular approach to the study of genic heterozygosity in natural populations. IV. Patterns of genic variation in central, marginal and isolated populations of Drosophila pseudoobscura. Genetics (1969) 16.51

A molecular approach to the study of genic heterozygosity in natural populations. 3. Direct evidence of coadaptation in gene arrangements of Drosophila. Proc Natl Acad Sci U S A (1968) 8.98

A computer model allowing maintenance of large amounts of genetic variability in mendelian populations. I. Assumptions and results for large populations. Genetics (1970) 5.54

Heterosis as a major cause of heterozygosity in nature. Genetics (1967) 4.73

The effect of a selected locus on linked neutral loci. Genetics (1977) 4.53

Still more genetic variability in natural populations. Proc Natl Acad Sci U S A (1973) 4.31

Continuously distributed factors affecting fitness. Genetics (1967) 3.76

Mechanistic approaches to the study of evolution: the functional synthesis. Nat Rev Genet (2007) 3.43

The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. VII Synergistic Interaction of Spontaneous Mutant Polygenes Controlling Viability. Genetics (1969) 3.14

SPECIATION IN MAMMALS AND THE GENETIC SPECIES CONCEPT. J Mammal (2006) 2.75

An estimate of average heterozygosity in man. Am J Hum Genet (1967) 2.62

Population genetic inference from genomic sequence variation. Genome Res (2010) 2.29

Evidence for Linkage Disequilibrium Maintained by Selection in Two Natural Populations of DROSOPHILA SUBOBSCURA. Genetics (1973) 2.23

A study of linkage disequilibrium in populations of Drosophila melanogaster. Genetics (1973) 2.20

Polymorphism for dimerizing ability at the esterase-5 locus in Drosophila pseudoobscura. Genetics (1976) 2.10

Modulation of protein levels in chromosomal dosage series of maize: the biochemical basis of aneuploid syndromes. Genetics (1981) 1.99

Heterozygosity, heteromorphy, and phylogenetic trees in asexual eukaryotes. Genetics (1996) 1.97

Protein differences in Drosophila. 3. Allelic differences and species differences in in vitro hybrid enzyme formation. Genetics (1967) 1.88

Extent of genetic variation at a highly polymorphic esterase locus in Drosophila pseudoobscura. Proc Natl Acad Sci U S A (1978) 1.78

Further studies on the Xavante Indians. X. Some hypotheses-generalizations resulting from these studies. Am J Hum Genet (1967) 1.55

Genic variability and strategies of adaptation in animals. Proc Natl Acad Sci U S A (1973) 1.54

Genetic variation in natural populations of Drosophila obscura. Genetics (1971) 1.51

Additivity and trans-acting effects on gene expression in male Drosophila simulans. Genetics (2004) 1.51

Molecular evolution, intracellular organization, and the quinary structure of proteins. Proc Natl Acad Sci U S A (1982) 1.45

Measurement of fitness at the esterase-5 locus in Drosophila pseudoobscura. Genetics (1971) 1.44

Reevaluation of level of genic heterozygosity in natural population of Drosophila melanogaster by two-dimensional electrophoresis. Proc Natl Acad Sci U S A (1979) 1.40

How genetic background masks single-gene heterosis in Drosophila (polymorphism-selection-isoenzymes-inbreeding-fly). Proc Natl Acad Sci U S A (1972) 1.39

Polymorphism and protein evolution. The neutral mutation-random drift hypothesis. J Med Genet (1971) 1.39

A temporal survey of allelic variation in natural and laboratory populations of Drosophila melanogaster. Genetics (1971) 1.36

Application of multilocus enzyme gel electrophoresis to Haemophilus influenzae. Infect Immun (1986) 1.30

Darwin's finches: population variation and natural selection. Proc Natl Acad Sci U S A (1976) 1.27

Allelic heterogeneity within allozymes separated by electrophoresis in Drosophila pseudoobscura. Proc Natl Acad Sci U S A (1976) 1.26

A molecular approach to the study of genic heterozygosity in natural populations. V. Further direct evidence of coadaptation in inversions of Drosophila. Genetics (1971) 1.25

Analysis of plant diversity with retrotransposon-based molecular markers. Heredity (Edinb) (2010) 1.24

Advances in plant gene-targeted and functional markers: a review. Plant Methods (2013) 1.23

An Experimental Investigation of the Unit Charge Model of Protein Polymorphism and Its Relation to the Esterase-5 Locus of DROSOPHILA PSEUDOOBSCURA, DROSOPHILA PERSIMILIS, and DROSOPHILA MIRANDA. Genetics (1977) 1.23

The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. IX:a Prediction of Genetic Equilibrium. Genetics (1971) 1.17

Dosage compensation of genes on the left and right arms of the X chromosome of Drosophila pseudoobscura and Drosophila willistoni. Genetics (1974) 1.14

Recombination-induced chromosomal heterosis. Genetics (1968) 1.14

Neighborhood Size in LITHOSPERMUM CAROLINIENSE. Genetics (1968) 1.11

Response to allegations against James V. Neel in Darkness in El Dorado, by Patrick Tierney. Am J Hum Genet (2001) 1.08

Gene differences between the sex ratio and standard gene arrangements of the X chromosome and linkage disequilibrium between loci in the standard gene Drosophila pseudoobscura. Genetics (1974) 1.07

Maternal inheritance of enzymes in the mealybug Pseudococcus obscurus (Homoptera). Genetics (1977) 1.07

Further evidence for selective differences between isoalleles in Drosophila. Genetics (1975) 1.01

Esterases of Drosophila. II. Biochemical studies of esterase-5 in D. pseudoobscura. Genetics (1974) 1.00

Molecular analysis of evolutionary changes in the expression of Drosophila esterases. Proc Natl Acad Sci U S A (1990) 0.99

The genetic basis of evolutionary change in gene expression levels. Philos Trans R Soc Lond B Biol Sci (2010) 0.97

Genetic divergence between rodent species assessed by using two-dimensional electrophoresis. Proc Natl Acad Sci U S A (1981) 0.96

Structural flexibility of isozyme variants: genetic variants in Drosophila disguised by cofactor and subunit binding. Proc Natl Acad Sci U S A (1978) 0.93

Three kinds of genetic variability in yeast populations. Proc Natl Acad Sci U S A (1968) 0.93

DNA hybridization in the genus Drosophila. Genetics (1970) 0.93

Determinants of genetic diversity. Nat Rev Genet (2016) 0.92

A novel approach to study of the structural basis of enzyme polymorphism. Analysis of carboxylesterase B of Escherichia coli as model. Biochem J (1987) 0.92

The generation and maintenance of genetic variation by frequency-dependent selection: constructing polymorphisms under the pairwise interaction model. Genetics (2008) 0.92

A comparative study of the esterase-5 locus in Drosophila pseudoobscura, D. persimilis and D. miranda. Genetics (1977) 0.91

Fitness of karyotypes in Drosophila pseudoobscura. Genetics (1975) 0.89

Inbred strains of zebrafish exhibit variation in growth performance and myostatin expression following fasting. Comp Biochem Physiol A Mol Integr Physiol (2012) 0.87

Effect of breeding structure on population genetic parameters in Drosophila. Genetics (2004) 0.83

The genetic variability of third chromosomes in a local population of Drosophila melanogaster. Genetics (1976) 0.82

Population genetics from 1966 to 2016. Heredity (Edinb) (2016) 0.82

Nucleotide sequence homology within the genome of Drosophila melanogaster. Genetics (1968) 0.81

Gene Flow in Natural Populations of DROSOPHILA MELANOGASTER with Special Reference to Lethal Allelism Rates and Protein Variation. Genetics (1986) 0.81

Models of frequency-dependent selection with mutation from parental alleles. Genetics (2013) 0.81

Physiological genetics of melanotic tumors in Drosophila melanogaster. V. Amino acid metabolism and tumor formation in the tu bw; st su-tu strain. Genetics (1968) 0.81

An electrophoretically silent polymorphism for the beta chains of rabbit hemoglobin and associated polyribosome patterns. Genetics (1974) 0.80

Structural and functional properties of polymorphic hemoglobins from orangutans. Genetics (1968) 0.79

Geographic distributions of Idh-1 alleles in a cricket are linked to differential enzyme kinetic performance across thermal environments. BMC Evol Biol (2009) 0.79

The ribosomes of Drosophila. III. RNA and protein homology between D. melanogaster and D. virilis. Genetics (1976) 0.77

Amino acid polymorphism and rare electrophoretic variants of G6PD from natural populations of Drosophila melanogaster. Genetics (1996) 0.77

Hubby and Lewontin on Protein Variation in Natural Populations: When Molecular Genetics Came to the Rescue of Population Genetics. Genetics (2016) 0.76

Fin whale MDH-1 and MPI allozyme variation is not reflected in the corresponding DNA sequences. Ecol Evol (2014) 0.76

Analysis of enzyme variation in natural populations of the butterfly Colias eurytheme. Proc Natl Acad Sci U S A (1971) 0.75

Genetic characterization of human populations: from ABO to a genetic map of the British people. Genetics (2015) 0.75

Evolution of xanthine dehydrogenase in Drosophila. Genetics (1968) 0.75

Genetic variability at the esterase-6 locus in natural populations of Drosophila simulans in relation to environmental heterogeneity. Genetics (1981) 0.75

A Bibliometric History of the Journal GENETICS. Genetics (2016) 0.75

Nature, nurture and eugenics. Postgrad Med J (1972) 0.75

Cellular and secretory proteins of the salivary glands of Sciara coprophila during the larval-pupal transformation. J Cell Biol (1972) 0.75

Molecular and reproductive biology in animal genetics. Genetics (1974) 0.75

Further studies on gene polymorphism in the mainbody and geographically isolated populations of Drosophila pseudoobscura. Genetics (1977) 0.75

Molecular Evolution in Historical Perspective. J Mol Evol (2016) 0.75

The long and winding road of molecular data in phylogenetic analysis. J Hist Biol (2014) 0.75

Articles by these authors

A molecular approach to the study of genic heterozygosity in natural populations. II. Amount of variation and degree of heterozygosity in natural populations of Drosophila pseudoobscura. Genetics (1966) 30.66

A molecular approach to the study of genic heterozygosity in natural populations. IV. Patterns of genic variation in central, marginal and isolated populations of Drosophila pseudoobscura. Genetics (1969) 16.51

The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme. Proc R Soc Lond B Biol Sci (1979) 14.03

Is the gene the unit of selection? Genetics (1970) 12.32

Distribution of gene frequency as a test of the theory of the selective neutrality of polymorphisms. Genetics (1973) 10.95

A molecular approach to the study of genic heterozygosity in natural populations. 3. Direct evidence of coadaptation in gene arrangements of Drosophila. Proc Natl Acad Sci U S A (1968) 8.98

Genetic heterogeneity within electrophoretic "alleles" of xanthine dehydrogenase in Drosophila pseudoobscura. Genetics (1976) 4.92

On population growth in a randomly varying environment. Proc Natl Acad Sci U S A (1969) 4.62

Still more genetic variability in natural populations. Proc Natl Acad Sci U S A (1973) 4.31

Pitfalls of genetic testing. N Engl J Med (1996) 3.01

The study of genic variation by electrophoretic and heat denaturation techniques at the octanol dehydrogenase locus in members of the Drosophila virilis group. Genetics (1975) 2.82

An estimate of average heterozygosity in man. Am J Hum Genet (1967) 2.62

Annotation: the analysis of variance and the analysis of causes. Am J Hum Genet (1974) 2.54

Molecular heterosis for heat-sensitive enzyme alleles. Proc Natl Acad Sci U S A (1974) 2.46

The effect of genetic linkage on the mean fitness of a population. Proc Natl Acad Sci U S A (1971) 2.41

Sequence of the structural gene for xanthine dehydrogenase (rosy locus) in Drosophila melanogaster. Genetics (1987) 2.23

The sensitivity of gel electrophoresis as a detector of genetic variation. Genetics (1979) 2.18

The heritability hang-up. Science (1975) 2.09

DNA fingerprinting report. Science (1993) 2.07

Distinguishing the forces controlling genetic variation at the Xdh locus in Drosophila pseudoobscura. Genetics (1989) 2.03

Protein differences in Drosophila. 3. Allelic differences and species differences in in vitro hybrid enzyme formation. Genetics (1967) 1.88

Extent of genetic variation at a highly polymorphic esterase locus in Drosophila pseudoobscura. Proc Natl Acad Sci U S A (1978) 1.78

Population genetics. Annu Rev Genet (1973) 1.73

Letters to the editors: Testing the heterogeneity of F values. Genetics (1975) 1.62

Nucleotide variation and conservation at the dpp locus, a gene controlling early development in Drosophila. Genetics (1997) 1.60

Nearly identical allelic distributions of xanthine dehydrogenase in two populations of Drosophila pseudoobscura. Mol Biol Evol (1985) 1.57

Purification of esterase-5 from Drosophila pseudoobscura. Biochim Biophys Acta (1966) 1.53

Detecting heterogeneity of substitution along DNA and protein sequences. Genetics (1996) 1.52

Population genetics. Annu Rev Genet (1985) 1.42

Forensic DNA typing dispute. Nature (1994) 1.38

The meaning of stability. Brookhaven Symp Biol (1969) 1.31

Gene flow and the geographical distribution of a molecular polymorphism in Drosophila pseudoobscura. Genetics (1981) 1.30

A molecular approach to the study of genic heterozygosity in natural populations. V. Further direct evidence of coadaptation in inversions of Drosophila. Genetics (1971) 1.25

The genetics of electrophoretic variation. Genetics (1979) 1.17

Locating regions of differential variability in DNA and protein sequences. Genetics (1999) 1.12

Adaptation. Sci Am (1978) 1.10

Stable equilibria under optimizing selection. Proc Natl Acad Sci U S A (1966) 0.98

The principle of historicity in evolution. Wistar Inst Symp Monogr (1967) 0.91

Selection in complex genetic systems III. An effect of allele multiplicity with two loci. Genetics (1975) 0.88

Response. Science (1992) 0.83

Sociobiology as an adaptationist program. Behav Sci (1979) 0.81

The problem of genetic diversity. Harvey Lect (1977) 0.79

Genetic aspects of intelligence. Annu Rev Genet (1975) 0.77

What does electrophoretic variation tell us about protein variation? Mol Biol Evol (1996) 0.77

Which population? Am J Hum Genet (1993) 0.75

DNA fingerprinting. Science (1994) 0.75

Letter: Publication policies of Genetics. Genetics (1976) 0.75

Developmental Selection of Mutations. Science (1960) 0.75

Allelic form of enzymes. Science (1970) 0.75

Sociobiology: another biological determinism. Int J Health Serv (1980) 0.75

Macroevolution conference. Science (1981) 0.75

Differences in bristle-making abilities in scute and wild-type Drosophila melanogaster. Genet Res (1966) 0.75

Heritability of IQ. Science (1976) 0.75

Toward a Modern Synthesis of Evolutionary Thought: Can the result of biochemical investigation provide significant insight into evolutionary processes? Science (1963) 0.75

Comment on an erroneous conception of the meaning of heritability. Behav Genet (1976) 0.75

Ken-Ichi Kojima September 17, 1930-November 14, 1971. Genetics (1972) 0.75

People are not commodities. N Y Times Web (1999) 0.75

Correlation between relatives for colorectal cancer mortality in familial adenomatous polyposis. Ann Hum Genet (1993) 0.75

The uses of knowledge. Science (1972) 0.75

Molecular and Classical Biology. Science (1964) 0.75