Published in J Clin Invest on October 01, 1967
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest (1985) 4.38
Amino acid metabolism during prolonged starvation. J Clin Invest (1969) 4.06
Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues. Biochem J (1971) 3.48
Liver and kidney metabolism during prolonged starvation. J Clin Invest (1969) 3.47
Ketone-body utilization by adult and suckling rat brain in vivo. Biochem J (1971) 3.32
Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J Clin Invest (1974) 2.40
D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. J Clin Invest (2003) 2.25
Neural dysfunction during hypoglycaemia. Arch Dis Child (1988) 2.19
Failure of thermoregulation in the cold during hypoglycaemia induced by exercise and ethanol. J Physiol (1973) 2.16
BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures. Neuron (2012) 2.05
Acetoacetate metabolism in infant and adult rat brain in vitro. Biochem J (1970) 1.93
Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition (2010) 1.89
Effect of ketone infusions on amino acid and nitrogen metabolism in man. J Clin Invest (1975) 1.87
Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. J Clin Invest (1994) 1.79
Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutr Metab (Lond) (2009) 1.79
Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats. Biochem J (1974) 1.78
Ketogenesis from butyrate and acetate by the caecum and the colon of rabbits. Biochem J (1972) 1.73
Brain lactate metabolism: the discoveries and the controversies. J Cereb Blood Flow Metab (2011) 1.71
Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab (2007) 1.70
Increased brain monocarboxylic acid transport and utilization in type 1 diabetes. Diabetes (2006) 1.65
Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. Br J Cancer (2003) 1.61
Human forearm metabolism during progressive starvation. J Clin Invest (1971) 1.52
Effect of insulin on the distribution and disposition of glucose in man. J Clin Invest (1985) 1.49
13C MRS studies of neuroenergetics and neurotransmitter cycling in humans. NMR Biomed (2011) 1.47
Glycerol metabolism in the neonatal rat. Biochem J (1970) 1.47
Protein sparing therapy during periods of starvation with sepsis of trauma. Ann Surg (1973) 1.45
How wasting is saving: weight loss at altitude might result from an evolutionary adaptation. Bioessays (2014) 1.45
Famine versus feast: understanding the metabolism of tumors in vivo. Trends Biochem Sci (2015) 1.42
Targeting energy metabolism in brain cancer: review and hypothesis. Nutr Metab (Lond) (2005) 1.40
Ketoacids? Good medicine? Trans Am Clin Climatol Assoc (2003) 1.40
Hepatic ketogenesis and gluconeogenesis in humans. J Clin Invest (1974) 1.37
Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutr Metab (Lond) (2011) 1.35
Effect of insulin and acute diabetes on plasma FFA and ketone bodies in the fasting rat. J Clin Invest (1970) 1.34
Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects. J Clin Invest (1985) 1.32
The ketogenic diet: metabolic influences on brain excitability and epilepsy. Trends Neurosci (2012) 1.31
Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol (2013) 1.29
The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect. Annu Rev Nutr (2007) 1.28
Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr (2013) 1.25
Activities of hexokinase, phosphofructokinase, 3-oxo acid coenzyme A-transferase and acetoacetyl-coenzyme A thiolase in nervous tissue from vertebrates and invertebrates. Biochem J (1973) 1.25
Effect of citrate on the activities of 6-phosphofructokinase from nervous and muscle tissues from different animals and its relationships to the regulation of glycolysis. Biochem J (1977) 1.24
Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies. Nutr Metab (Lond) (2004) 1.22
Cerebral glucose transport and oxygen consumption in sheep and rabbits. J Physiol (1973) 1.22
Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans. J Clin Invest (1988) 1.21
The transcriptomic signature of fasting murine liver. BMC Genomics (2008) 1.19
Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues. Br J Cancer (1983) 1.19
Glucose turnover and disposal in maturity-onset diabetes. J Clin Invest (1973) 1.19
Thermodynamics of weight loss diets. Nutr Metab (Lond) (2004) 1.17
Development of mitochondrial energy metabolism in rat brain. Biochem J (1977) 1.16
Hypoglycaemia of the newborn: a review. Bull World Health Organ (1997) 1.16
Rapid intravenous sodium acetoacetate infusion in man. Metabolic and kinetic responses. J Clin Invest (1973) 1.15
Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain. Biochem J (1973) 1.12
Reduction of weight loss and tumour size in a cachexia model by a high fat diet. Br J Cancer (1987) 1.12
Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans. Lipids Health Dis (2006) 1.12
Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects. Regul Toxicol Pharmacol (2012) 1.10
Ketone bodies in epilepsy. J Neurochem (2012) 1.10
Starvation and survival. Trans Am Clin Climatol Assoc (1968) 1.09
Fasting: the history, pathophysiology and complications. West J Med (1982) 1.09
The pathophysiology of traumatic brain injury at a glance. Dis Model Mech (2013) 1.09
Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass. Int J Mol Sci (2016) 1.08
Fatty acid metabolism in the perfused rat liver. Biochem J (1970) 1.08
Ketone bodies as a therapeutic for Alzheimer's disease. Neurotherapeutics (2008) 1.08
Hypercarnivory and the brain: protein requirements of cats reconsidered. J Comp Physiol B (2010) 1.08
Plasma pH does not influence the cerebral metabolic ratio during maximal whole body exercise. J Physiol (2010) 1.08
Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern. Biochem J (1985) 1.06
Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the rat. Alcohol Clin Exp Res (2009) 1.06
Ketone-body production and oxidation in fasting obese humans. J Clin Invest (1974) 1.06
Insulin resistance and elevated triglyceride in muscle: more important for survival than "thrifty" genes? J Physiol (2003) 1.05
The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat. J Neurotrauma (2009) 1.05
Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Curr Neuropharmacol (2009) 1.04
A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat. J Biol Chem (2010) 1.04
The effects of dietary conditions and glycerol concentration on glycerol uptake by rat liver and kidney-cortex slices. Biochem J (1969) 1.03
[2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain. J Cereb Blood Flow Metab (2002) 1.02
Fluid therapy for children: facts, fashions and questions. Arch Dis Child (2006) 1.01
Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease. Front Physiol (2014) 1.01
Metabolic response to human growth hormone during prolonged starvation. J Clin Invest (1971) 1.01
Gene expression of calpains and their specific endogenous inhibitor, calpastatin, in skeletal muscle of fed and fasted rabbits. Biochem J (1992) 1.00
Dynamics of starvation in humans. J Math Biol (2006) 0.98
Obligate role for ketone body oxidation in neonatal metabolic homeostasis. J Biol Chem (2011) 0.97
Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague-Dawley rats. Nutr Metab (Lond) (2016) 0.96
Ketone body transport in the human neonate and infant. J Clin Invest (1986) 0.96
Substrate interaction in intravenous feeding: comparative effects of carbohydrate and fat on amino acid utilization in fasting man. Ann Surg (1977) 0.96
The role of glucose transporters in brain disease: diabetes and Alzheimer’s Disease. Int J Mol Sci (2012) 0.96
Metabolic substrate utilization by tumour and host tissues in cancer cachexia. Biochem J (1991) 0.96
Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration. Front Neurosci (2015) 0.94
Hypoglycemia in critically ill children. J Diabetes Sci Technol (2012) 0.94
Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet. FASEB J (2012) 0.94
Astrocytic energetics during excitatory neurotransmission: What are contributions of glutamate oxidation and glycolysis? Neurochem Int (2013) 0.94
Interorgan coordination of the murine adaptive response to fasting. J Biol Chem (2011) 0.93
Effects of brief starvation on muscle amino acid metabolism in nonobese man. J Clin Invest (1976) 0.93
Incorporation of label from D- -hydroxy( 14 C)butyrate and (3- 14 C)acetoacetate into amino acids in rat brain in vivo. Biochem J (1971) 0.93
Bioenergetic medicine. Br J Pharmacol (2014) 0.93
¹H NMR-based metabolic profiling of human rectal cancer tissue. Mol Cancer (2013) 0.92
Proteomic analysis and functional characterization of mouse brain mitochondria during aging reveal alterations in energy metabolism. Proteomics (2015) 0.91
Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus. Neurobiol Dis (2010) 0.91
Regulation of hypothalamic neuronal sensing and food intake by ketone bodies and fatty acids. Diabetes (2013) 0.91
Glycerol: major contributor to the short term protein sparing effect of fat emulsions in normal man. Ann Surg (1975) 0.91
Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2. Cancer Cell Int (2009) 0.91
Ketone bodies, glycolysis, and KATP channels in the mechanism of the ketogenic diet. Epilepsia (2008) 0.91
Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases. Curr Pharm Des (2011) 0.90
A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. J Biol Chem (1954) 23.09
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood. Biochem J (1962) 12.21
THE BLOOD FLOW AND OXYGEN CONSUMPTION OF THE HUMAN BRAIN IN DIABETIC ACIDOSIS AND COMA. J Clin Invest (1948) 10.63
Titration of free fatty acids of plasma: a study of current methods and a new modification. J Lipid Res (1960) 7.08
Hormone-fuel interrelationships during fasting. J Clin Invest (1966) 6.44
EQUATIONS FOR MEASURING BLOOD FLOW BY EXTERNAL MONITORING OF RADIOISOTOPES. Circ Res (1965) 3.82
REGIONAL CEREBRAL BLOOD FLOW IN MAN DETERMINED BY KRYPTON. Neurology (1963) 1.97
A consideration of energy exchange in human trauma. Bull N Y Acad Med (1960) 1.95
Carbon dioxide fixation in the brain. J Biol Chem (1962) 1.94
Substrate and enzyme distribution in cells and cell fractions of the nervous system. Am J Physiol (1952) 1.86
A study in man of cerebral blood flow and cerebral glucose, lactate and pyruvate metabolism before and after eating. J Clin Invest (1959) 1.56
The oxidation of ketone bodies by mitochondria from liver and peripheral tissues. J Biol Chem (1957) 1.46
Cerebral metabolism of isotopic glucose in normal human subjects. J Appl Physiol (1957) 1.44
Effects of high spinal anesthesia on cerebral circulation and metabolism in man. J Clin Invest (1958) 1.22
Pyruvate carboxylase activity of mammalian brain cortex. Life Sci (1967) 1.18
Cerebral blood flow. N Engl J Med (1966) 1.15
[Glucose consumption of the human brain under the influence of intravenous infusions of glucose, glucagon and glucose-insulin]. Klin Wochenschr (1965) 1.13
HUMAN CEREBRAL LACTATE AND PYRUVATE EXTRACTION. I. CONTROL SUBJECTS. Arch Neurol (1965) 1.06
Hormone-fuel interrelationships during fasting. J Clin Invest (1966) 6.44
Aneurysmal coronary artery disease. Circulation (1983) 5.58
Plasma amino acid levels and insulin secretion in obesity. N Engl J Med (1969) 4.18
Editorial: "Control" and diabetes. N Engl J Med (1976) 4.11
Amino acid metabolism during prolonged starvation. J Clin Invest (1969) 4.06
Starvation in man. N Engl J Med (1970) 3.67
Liver and kidney metabolism during prolonged starvation. J Clin Invest (1969) 3.47
Alanine: key role in gluconeogenesis. Science (1970) 3.43
Vitamin A supplementation and child mortality. A meta-analysis. JAMA (1993) 3.09
Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels. J Clin Invest (1969) 2.94
Complications of coronary arteriography from the Collaborative Study of Coronary Artery Surgery (CASS). Circulation (1979) 2.87
Apoptosis. Acad Emerg Med (1998) 2.66
Renal gluconeogenesis in acidosis, alkalosis, and potassium deficiency: its possible role in regulation of renal ammonia production. J Clin Invest (1966) 2.64
Glucagon levels and metabolic effects in fasting man. J Clin Invest (1970) 2.58
Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver. J Lipid Res (1967) 2.58
Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci (2000) 2.56
Prospective correlative study of ventricular aneurysm. Mechanistic concept and clinical recognition. Am J Med (1967) 2.56
The anginal syndrome associated with normal coronary arteriograms. Report of a six year experience. Am J Med (1973) 2.50
Seven year survival of patients with normal or near normal coronary arteriograms: a CASS registry study. J Am Coll Cardiol (1986) 2.44
Pharmacologic control of thromboembolic complications of cardiac-valve replacement. N Engl J Med (1971) 2.40
Propranolol and angina pectoris. Am J Cardiol (1966) 2.32
Muscle and splanchnic glutmine and glutamate metabolism in postabsorptive andstarved man. J Clin Invest (1971) 2.10
Ketone bodies, potential therapeutic uses. IUBMB Life (2001) 1.98
Studies of streptozotocin-induced insulitis and diabetes. Proc Natl Acad Sci U S A (1977) 1.94
Insulin-dependent diabetes mellitus: the initial lesion. N Engl J Med (1981) 1.93
Regulation of the readily releasable vesicle pool by protein kinase C. Neuron (1998) 1.88
The anginal syndrome with normal coronary arteriography. Trans Assoc Am Physicians (1967) 1.81
Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. J Neurochem (2001) 1.81
Role of endothelial cell cytoskeleton in control of endothelial permeability. Circ Res (1982) 1.79
Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J Neurosci (1995) 1.77
Brainstem projections of sensory and motor components of the vagus nerve in the rat. J Comp Neurol (1982) 1.76
Fractal analysis of a voltage-dependent potassium channel from cultured mouse hippocampal neurons. Biophys J (1987) 1.74
The Banting Memorial Lecture 1971. Physiology of insulin in man. Diabetes (1971) 1.68
Short- and long-acting angiotensin-converting enzyme inhibitors: a randomized trial of lisinopril versus captopril in the treatment of congestive heart failure. The Multicenter Lisinopril-Captopril Congestive Heart Failure Study Group. J Am Coll Cardiol (1989) 1.66
Glucose regulation of hepatic gluconeogenesis. Am J Physiol (1968) 1.64
Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha. J Cereb Blood Flow Metab (1997) 1.60
Left ventricular function in patients with the anginal syndrome and normal coronary arteriograms. Am J Cardiol (1973) 1.59
Metabolic interactions of glucose, lactate, and beta-hydroxybutyrate in rat brain slices. Am J Physiol (1969) 1.56
Nutritional supplementation, maternal education, and cognitive development of infants at risk of malnutrition. Am J Clin Nutr (1981) 1.55
Acid-base alterations and renal gluconeogenesis: effect of pH, bicarbonate concentration, and PCO2. J Clin Invest (1967) 1.55
Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania. Am J Clin Nutr (1998) 1.53
Human forearm metabolism during progressive starvation. J Clin Invest (1971) 1.52
Reassessment of body mass indices. Am J Clin Nutr (1990) 1.51
Somatostatin suppresses secretin and pancreatic exocrine secretion. Science (1975) 1.45
Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons. J Neurosci (1999) 1.45
Estrogen replacement. Circulation (1996) 1.45
Bile acid concentrations in the refluxate of patients with reflux oesophagitis. Br J Surg (1988) 1.41
Reduced epinephrine secretion and hypoglycemia unawareness in diabetic autonomic neuropathy. Ann Intern Med (1982) 1.41
A group-IV ferromagnetic semiconductor: MnxGe1-x. Science (2002) 1.38
Pharmacologic control of thromboembolic complications of cardiac-valve replacement. A preliminary report. N Engl J Med (1968) 1.38
Hepatic ketogenesis and gluconeogenesis in humans. J Clin Invest (1974) 1.37
Progression of coronary artery disease. A clinical arteriographic study. Circulation (1973) 1.37
A reappraisal of caloric requirements in healthy women. Am J Clin Nutr (1986) 1.35
Three distinct structural environments of a transmembrane domain in the inwardly rectifying potassium channel ROMK1 defined by perturbation. Proc Natl Acad Sci U S A (1995) 1.35
An electron microscopic study of lipoprotein production and release by the isolated perfused rat liver. Proc Soc Exp Biol Med (1966) 1.33
Severe insulin-induced hypoglycemia associated with deficiencies in the release of counterregulatory hormones. N Engl J Med (1981) 1.30
beta-adrenergic blockade in essential hypertension: reduced renin release despite renal vasoconstriction. Circ Res (1976) 1.28
Sequential system failure after rupture of abdominal aortic aneurysms: an unsolved problem in postoperative care. Ann Surg (1973) 1.28
Amino acid metabolism in lactic acidosis. Am J Med (1972) 1.26
Renal function and effects of partial rehydration during diabetic ketoacidosis. Diabetes (1981) 1.25
Nutritional supplementation and the outcome of pregnancy. I. Birth weight. Am J Clin Nutr (1979) 1.25
Energy metabolism in feasting and fasting. Adv Exp Med Biol (1979) 1.24
Starvation in man. Clin Endocrinol Metab (1976) 1.24
Jejunoileostomy for extreme obesity: rationale, metabolic observations, and results in a single case. Ann Surg (1967) 1.24
Non-hormonal factors in the control of gluconeogenesis. Adv Enzyme Regul (1966) 1.24
Coronary atherosclerosis, coronary collaterals, and their relation to cardiac function. Ann Intern Med (1970) 1.23
Plasma acetone metabolism in the fasting human. J Clin Invest (1979) 1.21
Acute myocardial infarction in a nineteen-year-old student in the absence of coronary obstructive disease. N Engl J Med (1970) 1.21
Water and sanitation associated with improved child growth. Eur J Clin Nutr (2003) 1.20
Pancreatic beta cell toxicity by streptozotocin anomers. Diabetes (1977) 1.20
Nucleobase orientation and ordering in films of single-stranded DNA on gold. J Am Chem Soc (2006) 1.18
Thermic effect of food in lean and obese men. J Clin Invest (1988) 1.18
Carbohydrate oxidation and storage in obese non-insulin-dependent diabetic patients. Effects of improving glycemic control. Diabetes (1983) 1.18
Rapid intravenous sodium acetoacetate infusion in man. Metabolic and kinetic responses. J Clin Invest (1973) 1.15
Intragastric bile acids and scintigraphy in the assessment of duodenogastric reflux. Br J Surg (1986) 1.14
Effect of hyperinsulinemia on urea pool size and substrate oxidation rates. Diabetes (1988) 1.14
Atrial pacing in coronary heart disease. Effect on hemodynamics, metabolism and coronary circulation. Am J Cardiol (1971) 1.14
In vitro regulation of rat heart 5'-nucleotidase by adenine nucleotides and magnesium. J Biol Chem (1971) 1.14
Composition of gastro-oesophageal refluxate. Gut (1991) 1.13
Phospholipids, acute pancreatitis, and the lungs: effect of lecithinase infusion on pulmonary surface activity in dogs. Ann Surg (1968) 1.13
Effects of intraduodenal amino acids, fatty acids, and sugars on secretin concentrations. Gastroenterology (1975) 1.12
Bypass surgery with the internal mammary artery graft: 15 year follow-up. Circulation (1986) 1.12
Amino acid metabolism in the regulation of gluconeogenesis in man. Am J Clin Nutr (1970) 1.11
Models for the estimation of the probability of dying between birth and exact ages of early childhood. Popul Stud (Camb) (1972) 1.10
Diffusion of glucose, insulin, inulin, and Evans blue protein into thoracic duct lymph of man. J Clin Invest (1967) 1.10
Thermolysis of a fluorinated indolylfulgide features a novel 1,5-indolyl shift. J Org Chem (2001) 1.09
Starvation and survival. Trans Am Clin Climatol Assoc (1968) 1.09
The pulmonary toxicity of oxygen. Anesthesiology (1968) 1.09
Heterogeneity in type II diabetes. West J Med (1985) 1.08
Effects of nitroglycerin on regional myocardial blood flow in coronary artery disease. J Clin Invest (1971) 1.08
Ketosis of starvation: a revisit and new perspectives. Clin Endocrinol Metab (1983) 1.08
Percutaneous transluminal coronary angioplasty in New York State. Risk factors and outcomes. JAMA (1992) 1.07
Regional myocardial blood flow. J Clin Invest (1967) 1.07