Published in Int J Cancer on January 15, 1981
Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J Virol (1987) 5.00
Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells. J Virol (1986) 3.03
Nitric oxide and arthritis. Arthritis Rheum (1993) 2.83
Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma. J Virol (1989) 2.64
The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene. Oncogene Res (1988) 2.42
Quantitative studies of in vitro transformation by chemical carcinogens. J Natl Cancer Inst (1969) 2.26
Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine (Phila Pa 1976) (1996) 2.13
Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 18 DNA. Cancer Res (1988) 2.10
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol (1991) 2.07
Relative difficulties in transforming human and animal cells in vitro. J Natl Cancer Inst (1983) 1.97
Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases. Spine (Phila Pa 1976) (1997) 1.94
Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci U S A (1993) 1.65
Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA. Gene Ther (1995) 1.63
Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes. Cytogenet Cell Genet (1987) 1.62
Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathways. Arthritis Rheum (2009) 1.60
Human cervical and foreskin epithelial cells immortalized by human papillomavirus DNAs exhibit dysplastic differentiation in vivo. Cancer Res (1990) 1.55
Incorporation of 5-substituted uracil derivatives into nucleic acids. II. Incorporation of 5-vinyluracil into the DNA of Escherichia coli. Biochim Biophys Acta (1973) 1.54
Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc Natl Acad Sci U S A (1998) 1.54
Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther (2002) 1.53
Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene. Spine (Phila Pa 1976) (1999) 1.51
The natural history of the anterior cruciate ligament-deficient knee. Changes in synovial fluid cytokine and keratan sulfate concentrations. Am J Sports Med (1998) 1.51
Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes. J Immunol (2000) 1.47
Adenoviral transduction of human osteoblastic cell cultures: a new perspective for gene therapy of bone diseases. Acta Orthop Scand (1999) 1.42
N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis Rheum (1994) 1.39
Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther (2000) 1.39
Human papillomavirus type 18 DNA is integrated at a single chromosome site in cervical carcinoma cell line SW756. J Virol (1987) 1.38
Gene transfer to synoviocytes: prospects for gene treatment of arthritis. DNA Cell Biol (1992) 1.37
Cyclic tensile stress exerts antiinflammatory actions on chondrocytes by inhibiting inducible nitric oxide synthase. J Immunol (1999) 1.36
Chromosomal localization of three human ras genes by in situ molecular hybridization. Somat Cell Mol Genet (1985) 1.35
Neoplastic transformation of guinea pig fetal cells in culture induced by chemical carcinogens. Cancer Res (1975) 1.35
Refined localization of the erbB-3 proto-oncogene by direct visualization of FISH signals on LUT-inverted and contrast-enhanced digital images of DAPI-banded chromosomes. Cancer Genet Cytogenet (1995) 1.34
Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J Immunol (1996) 1.33
Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective. J Immunol (1997) 1.32
Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis. J Immunol (1997) 1.31
Nitric oxide in osteoarthritis. Osteoarthritis Cartilage (1999) 1.29
Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis (1988) 1.29
Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J Immunol (2001) 1.27
Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws. J Immunol (1999) 1.24
Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment. Nature (1978) 1.24
Gene delivery to cartilage defects using coagulated bone marrow aspirate. Gene Ther (2004) 1.24
Astrocytoma mimicking the features of pheochromocytoma. N Engl J Med (1972) 1.23
Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. Proc Natl Acad Sci U S A (1985) 1.22
Sarcoma-producing cell lines derived from clones transformed in vitro by benzo[a]pyrene. Science (1969) 1.22
Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo. Arthritis Rheum (1996) 1.22
Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J Immunol (1999) 1.19
Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res (1997) 1.19
Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum (2000) 1.17
Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone. Bone (1999) 1.16
Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts. Cancer Res (1979) 1.16
Synovial fluid cytokine concentrations as possible prognostic indicators in the ACL-deficient knee. Knee Surg Sports Traumatol Arthrosc (1994) 1.15
Quantitation of chemically induced neoplastic transformation of BALB-3T3 cloned cell lines. Cancer Res (1972) 1.15
Integration of human papillomavirus 16 DNA and genomic rearrangements in immortalized human keratinocyte lines. Cancer Res (1990) 1.15
In vitro transformation of Syrian hamster embryo cells by diverse chemical carcinogens. Nature (1972) 1.14
Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target. Biochem J (1997) 1.13
Leukoregulin, a direct-acting anticancer immunological hormone that is distinct from lymphotoxin and interferon. Cancer Res (1985) 1.13
GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis. J Biomed Mater Res (2000) 1.12
Genetic modification of chondrocytes with insulin-like growth factor-1 enhances cartilage healing in an equine model. J Bone Joint Surg Br (2007) 1.12
Transforming growth factors beta 1 and 2 transcriptionally regulate human papillomavirus (HPV) type 16 early gene expression in HPV-immortalized human genital epithelial cells. J Virol (1990) 1.11
Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine (Phila Pa 1976) (1995) 1.10
In vitro transformation of hamster cells by polycyclic hydrocarbons: factors influencing the number of cells transformed. Nat New Biol (1971) 1.09
The biochemical and histological effects of artificial ligament wear particles: in vitro and in vivo studies. Am J Sports Med (1989) 1.09
Adenovirus-mediated gene transfer to nucleus pulposus cells. Implications for the treatment of intervertebral disc degeneration. Spine (Phila Pa 1976) (1998) 1.09
Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection. Oncogene (1992) 1.08
HIG-82: an established cell line from rabbit periarticular soft tissue, which retains the "activatable" phenotype. In Vitro Cell Dev Biol (1988) 1.08
Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis. Gene Ther (2004) 1.08
Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther (2005) 1.08
Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects. Gene Ther (2007) 1.07
Enhancement of viral transformation for evaluation of the carcinogenic or mutagenic potential of inorganic metal salts. Cancer Res (1979) 1.06
Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta1 gene into articular chondrocytes. J Orthop Res (2000) 1.05
Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4. Arthritis Res (2000) 1.05
Experimental arthritis induced by intraarticular injection of allogenic cartilaginous particles into rabbit knees. Arthritis Rheum (1984) 1.05
Host-mediated in vivo-in vitro assay for chemical carcinogenesis. Arch Pathol (1973) 1.04
Inhibition of HPV-16 E6/E7 immortalization of normal keratinocytes by hairpin ribozymes. Proc Natl Acad Sci U S A (1998) 1.04
Enhancement of adenovirus transformation by pretreatment of hamster cells with carcinogenic polycyclic hydrocarbons. Cancer Res (1973) 1.03
Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model. Gene Ther (2008) 1.03
Preferential sites for viral integration on mammalian genome. Cancer Genet Cytogenet (1989) 1.03
Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts. Am J Physiol (1995) 1.03
Effect of growth factors on the proliferation of fibroblasts from the medial collateral and anterior cruciate ligaments. J Orthop Res (1995) 1.02
Nonrandom chromosome alterations in human malignant mesothelioma. Cancer Res (1988) 1.02
The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ cultures. J Immunol (1996) 1.02
Nitric oxide synthesis and its regulation by rabbit synoviocytes. J Rheumatol (1994) 1.02
Differences in nitric oxide production by superficial and deep human articular chondrocytes: implications for proteoglycan turnover in inflammatory joint diseases. J Immunol (1998) 1.02
Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture. FEBS Lett (1994) 1.02
Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders. Spine (Phila Pa 1976) (2000) 1.01
Nitric oxide and energy production in articular chondrocytes. J Cell Physiol (1994) 1.01
Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy. Gene Ther (1997) 1.01
Human herpesvirus 6 infects cervical epithelial cells and transactivates human papillomavirus gene expression. J Virol (1994) 1.00
Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium. Gene Ther (1994) 1.00
Induction of chromosome banding by trypsin/EDTA for gene mapping by in situ hybridization. Cytogenet Cell Genet (1985) 1.00
Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model. Arthritis Rheum (1999) 1.00
Effect of growth factors on the proliferation of ligament fibroblasts from skeletally mature rabbits. Connect Tissue Res (1997) 1.00
Nitric oxide inhibits chondrocyte response to IGF-I: inhibition of IGF-IRbeta tyrosine phosphorylation. Am J Physiol Cell Physiol (2000) 0.99
Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther (2001) 0.99
Leukoregulin induction of prostaglandin-endoperoxide H synthase-2 in human orbital fibroblasts. An in vitro model for connective tissue inflammation. J Biol Chem (1996) 0.98
Changes in the uptake of 2-deoxy-D-glucose in BALB-3T3 cells chemically transformed in culture. J Cell Physiol (1974) 0.97
The antimitochondrial action of 2-choloro-4', 4"-bis(2-imidazolin-2-yl)terephthalanilide and methylglyoxal bis(guanylhydrazone). Cancer Res (1966) 0.97
Ultraviolet mutagenesis of normal and xeroderma pigmentosum variant human fibroblasts. Mutat Res (1979) 0.97
Effect of BMP-2 gene transfer on bone healing in sheep. Gene Ther (2006) 0.97