PubRank

G S Salvesen

Author PubWeight™ 188.79‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 1993 15.04
2 Regulation of cell death protease caspase-9 by phosphorylation. Science 1998 11.26
3 Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995 9.22
4 X-linked IAP is a direct inhibitor of cell-death proteases. Nature 1997 8.26
5 Human plasma proteinase inhibitors. Annu Rev Biochem 1983 6.61
6 Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell 1992 5.54
7 IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J 1998 5.28
8 Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci U S A 1993 4.86
9 The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem 2001 4.81
10 The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 1997 4.66
11 An induced proximity model for caspase-8 activation. J Biol Chem 1998 4.18
12 Structural basis for the inhibition of caspase-3 by XIAP. Cell 2001 3.91
13 Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J 1999 3.51
14 Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem 1997 3.41
15 A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med 2000 3.24
16 Caspase-9 can be activated without proteolytic processing. J Biol Chem 1999 3.20
17 Biochemical characteristics of caspases-3, -6, -7, and -8. J Biol Chem 1997 3.04
18 Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci U S A 2001 3.04
19 Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem 1998 2.93
20 The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 1998 2.81
21 Caspase substrates. Cell Death Differ 2006 2.79
22 Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol 1997 2.64
23 A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem 1998 2.64
24 Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem 2000 2.62
25 Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell 1999 2.58
26 Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. Biochem J 2000 2.58
27 The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 1997 2.57
28 Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death Differ 2007 2.48
29 Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem 1998 2.23
30 Structural basis for the activation of human procaspase-7. Proc Natl Acad Sci U S A 2001 2.14
31 Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem 1999 2.09
32 Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases. J Neurosci 1997 2.01
33 FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem 1997 2.01
34 ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol 2000 2.01
35 Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A 1999 1.93
36 Caspases: preparation and characterization. Methods 1999 1.92
37 Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc Natl Acad Sci U S A 1996 1.90
38 Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. J Biol Chem 1995 1.88
39 Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem 1997 1.88
40 Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem 1999 1.66
41 Properties of the caspases. Biochim Biophys Acta 1998 1.63
42 Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases. J Biol Chem 1996 1.57
43 Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry 1998 1.48
44 Caspases - controlling intracellular signals by protease zymogen activation. Biochim Biophys Acta 2000 1.42
45 Covalent binding of proteinases in their reaction with alpha 2-macroglobulin. Biochem J 1980 1.41
46 Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity. Biochem J 1997 1.35
47 Further characterization of the covalent linking reaction of alpha 2-macroglobulin. Biochem J 1981 1.35
48 Caspase assays. Methods Enzymol 2000 1.35
49 Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem 1998 1.34
50 Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proc Natl Acad Sci U S A 2000 1.26
51 Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death. Cell Death Differ 1998 1.26
52 Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood 1999 1.24
53 Primary structure of the reactive site of human C1-inhibitor. J Biol Chem 1985 1.23
54 Catalytic properties of the caspases. Cell Death Differ 1999 1.17
55 Endogenous inhibitors of caspases. J Clin Immunol 1999 1.15
56 Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis. J Biol Chem 2000 1.14
57 Granzyme release and caspase activation in activated human T-lymphocytes. J Biol Chem 1998 1.10
58 Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC. Cell Death Differ 2008 1.08
59 TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. J Biol Chem 2000 1.08
60 Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. J Biol Chem 1999 1.02
61 Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment. Biochem Biophys Res Commun 1996 1.00
62 Mechanism-based inactivation of caspases by the apoptotic suppressor p35. Biochemistry 2001 0.98
63 Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion. Cell Death Differ 2010 0.98
64 The mechanism of peptide-binding specificity of IAP BIR domains. Cell Death Differ 2008 0.96
65 Metacaspases are not caspases--always doubt. Cell Death Differ 2010 0.90
66 Interaction of subtilisins with serpins. Protein Sci 1996 0.90
67 Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3. Cell Death Differ 1998 0.87
68 Crystal structure of the apoptotic suppressor CrmA in its cleaved form. Structure 2000 0.87
69 Viral caspase inhibitors CrmA and p35. Methods Enzymol 2000 0.86
70 Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6. Cell Death Differ 2012 0.83
71 Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA. Adv Exp Med Biol 1996 0.82
72 Inhibition of distant caspase homologues by natural caspase inhibitors. Biochem J 2001 0.82
73 Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy. Protein Sci 1996 0.81
74 Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. Acta Physiol Scand 2005 0.77
75 Symmetry of the inhibitory unit of human alpha 2-macroglobulin. Biochemistry 1988 0.77
76 Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region. Hoppe Seylers Z Physiol Chem 1983 0.75
77 Comparison of the structure and aspects of the proteinase-binding properties of cystic fibrotic alpha-macroglobulin with normal alpha 2-macroglobulin. Pediatr Res 1982 0.75