PubRank

R D Blakely

Author PubWeight™ 98.92‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 1991 3.46
2 Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 1997 3.36
3 Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci U S A 1993 2.80
4 Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med 2000 2.53
5 Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science 1999 1.85
6 Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J Neurosci 1996 1.76
7 Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. J Biol Chem 1987 1.64
8 Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. J Neurosci 1997 1.63
9 Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. Pharmacogenomics J 2002 1.60
10 Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism. Am J Med Genet B Neuropsychiatr Genet 2004 1.56
11 Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter. J Neurosci 1999 1.55
12 Transient developmental expression of monoamine transporters in the rodent forebrain. J Comp Neurol 1998 1.48
13 Norepinephrine transporters have channel modes of conduction. Proc Natl Acad Sci U S A 1996 1.43
14 Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. J Neurosci 2000 1.43
15 The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant- and cocaine-sensitive dopamine transporter. Mol Pharmacol 1998 1.41
16 Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants. J Exp Biol 1995 1.41
17 Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells. J Pharmacol Exp Ther 2000 1.34
18 Phosphorylation and regulation of antidepressant-sensitive serotonin transporters. J Biol Chem 1998 1.34
19 High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol. J Biol Chem 1998 1.34
20 Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. J Comp Neurol 2000 1.32
21 Molecular cloning of a human, hemicholinium-3-sensitive choline transporter. Biochem Biophys Res Commun 2000 1.30
22 Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain. Neuron 1992 1.29
23 Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J Neurosci 1995 1.26
24 Patch-clamp and amperometric recordings from norepinephrine transporters: channel activity and voltage-dependent uptake. Proc Natl Acad Sci U S A 1998 1.26
25 The effect of N-linked glycosylation on activity of the Na(+)- and Cl(-)-dependent serotonin transporter expressed using recombinant baculovirus in insect cells. J Biol Chem 1994 1.24
26 Novel fluorescence-based approaches for the study of biogenic amine transporter localization, activity, and regulation. J Neurosci Methods 2004 1.19
27 Psychiatric profile and attention deficits in postural tachycardia syndrome. J Neurol Neurosurg Psychiatry 2008 1.18
28 Acute regulation of norepinephrine transport: I. protein kinase C-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells. J Pharmacol Exp Ther 1998 1.17
29 Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Mol Pharmacol 2001 1.14
30 Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression. Genes Brain Behav 2007 1.12
31 Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells. J Pharmacol Exp Ther 2001 1.10
32 Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem J 1994 1.09
33 Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice. Genes Brain Behav 2006 1.09
34 Human norepinephrine transporter. Biosynthetic studies using a site-directed polyclonal antibody. J Biol Chem 1994 1.07
35 Pore models for transporters? Biophys J 1996 1.06
36 Sodium-dependent GABA-induced currents in GAT1-transfected HeLa cells. J Physiol 1996 1.05
37 Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. J Neurosci 1997 1.05
38 Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter. Mol Pharmacol 1996 1.03
39 Pharmacological profile of neuroleptics at human monoamine transporters. Eur J Pharmacol 1999 1.02
40 Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Mol Pharmacol 1994 1.02
41 Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins. J Pharmacol Exp Ther 1998 1.01
42 Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast. Biochemistry 1993 1.00
43 Cloning and expression of the mouse serotonin transporter. Brain Res Mol Brain Res 1996 0.99
44 Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster. Proc Natl Acad Sci U S A 1994 0.97
45 Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals. J Comp Neurol 2000 0.97
46 Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition. Mol Pharmacol 1996 0.96
47 Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. J Biol Chem 1993 0.96
48 The high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice. Handb Exp Pharmacol 2006 0.95
49 Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. Neuroscience 2008 0.94
50 ADHD and the dopamine transporter: are there reasons to pay attention? Handb Exp Pharmacol 2006 0.94
51 Molecular cloning and characterization of a murine hemicholinium-3-sensitive choline transporter. Biochem Soc Trans 2001 0.93
52 Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland. Mol Cell Neurosci 1997 0.91
53 Alternative splicing of the human serotonin transporter gene. J Neurochem 1997 0.91
54 Expression of serotonin transporter messenger RNA in the human brain. J Neurochem 1994 0.90
55 Familial orthostatic tachycardia due to norepinephrine transporter deficiency. Ann N Y Acad Sci 2001 0.90
56 Cell-specific sorting of biogenic amine transporters expressed in epithelial cells. J Biol Chem 1996 0.90
57 Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters. J Neurochem 1997 0.89
58 Cloning and chromosomal mapping of the murine norepinephrine transporter. J Neurochem 1998 0.88
59 Restriction site-independent formation of chimeras from homologous neurotransmitter-transporter cDNAs. Biotechniques 1994 0.87
60 Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension. Neuroscience 2006 0.87
61 Autocrine regulation of norepinephrine transporter expression. Mol Cell Neurosci 2001 0.85
62 Human norepinephrine transporter kinetics using rotating disk electrode voltammetry. Anal Chem 1996 0.85
63 Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. Am J Physiol 1994 0.85
64 Co-localization of N-acetyl-aspartyl-glutamate in central cholinergic, noradrenergic, and serotonergic neurons. Synapse 1987 0.84
65 Drug targets in the embryo. Studies on the cocaine- and antidepressant-sensitive serotonin transporter. Ann N Y Acad Sci 1996 0.84
66 Motor neuron-specific overexpression of the presynaptic choline transporter: impact on motor endurance and evoked muscle activity. Neuroscience 2010 0.83
67 A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter. Mol Pharmacol 1996 0.83
68 Natural and engineered coding variation in antidepressant-sensitive serotonin transporters. Neuroscience 2011 0.83
69 Expression of the rat brain creatine transporter in situ and in transfected HeLa cells. Dev Neurosci 1996 0.82
70 Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine. J Neurochem 1998 0.82
71 Serotonergic dorsal raphe nucleus projections to the cholinergic and noncholinergic neurons of the pedunculopontine tegmental region: a light and electron microscopic anterograde tracing and immunohistochemical study. J Comp Neurol 1997 0.82
72 Neurochemical and immunocytochemical studies on the distribution of N-acetyl-aspartylglutamate and N-acetyl-aspartate in rat spinal cord and some peripheral nervous tissues. J Neurochem 1987 0.82
73 Modified structure of the human serotonin transporter promoter. Mol Psychiatry 2000 0.80
74 Quisqualate selectively inhibits a brain peptidase which cleaves N-acetyl-L-aspartyl-L-glutamate in vitro. Eur J Pharmacol 1986 0.80
75 Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes Brain Behav 2014 0.80
76 Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain Behav 2013 0.80
77 Structural determinants of neurotransmitter transport using cross-species chimeras: studies on serotonin transporter. Methods Enzymol 1998 0.79
78 Biosynthesis, N-glycosylation, and surface trafficking of biogenic amine transporter proteins. Methods Enzymol 1998 0.79
79 Developmental expression of the high affinity choline transporter in cholinergic sympathetic neurons. Auton Neurosci 2005 0.79
80 SNARE-ing neurotransmitter transporters. Nat Neurosci 2000 0.78
81 Subcellular localization of chromogranins, calcium channels, amine carriers, and proteins of the exocytotic machinery in bovine splenic nerve. J Neurochem 1999 0.78
82 Molecular cloning and characterization of an L-epinephrine transporter from sympathetic ganglia of the bullfrog, Rana catesbiana. J Neurosci 1997 0.77
83 Voltammetric recording from neostriatum of behaving rhesus monkey. Brain Res 1981 0.77
84 Expression and development of a functional plasmalemmal 5-hydroxytryptamine transporter by thyroid follicular cells. Endocrinology 1996 0.77
85 [Decrease in the platelet level of 43 kDa immunoreactive fraction of serotonin transporting protein correlates with depressive symptoms in patients with somatoform disorders]. Vopr Med Khim 1999 0.77
86 Voltammetric approaches to kinetics and mechanism of the norepinephrine transporter. Adv Pharmacol 1998 0.76
87 Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate. Brain Res 1987 0.76
88 Synaptosomal transport of radiolabel from N-acetyl-aspartyl-[3H]glutamate suggests a mechanism of inactivation of an excitatory neuropeptide. J Neurochem 1986 0.76
89 Orthostatic intolerance: emerging genetic and environmental etiologies. J Gravit Physiol 1999 0.76
90 Neuroleptics increase striatal catecholamine metabolites but not ascorbic acid in dialyzed perfusate. Brain Res 1984 0.75
91 Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay. Brain Res 1988 0.75
92 Increases in testosterone levels and in copulatory behavior of male rhesus monkeys following treatment with human chorionic gonadotrophin. Horm Behav 1980 0.75
93 The state of the serotonin transporter protein in the platelets of patients with somatoform [correction of somatiform] disorders. Neurosci Behav Physiol 2001 0.75
94 Genetic linkage study of bipolar disorder and the serotonin transporter. Am J Med Genet 1996 0.75
95 A device to rapidly core out tissue culture plates for autoradiographic visualization of cells transfected with cDNA libraries. Biotechniques 1990 0.75
96 [The status of serotonin protein -- a serotonin transporter in thrombocytes in patients with somatoform disorders]. Zh Nevrol Psikhiatr Im S S Korsakova 1999 0.75
97 A microcomputer controlled system for monitoring multiple voltammetric electrodes in vivo. Brain Res Bull 1983 0.75