Published in J Med Chem on February 01, 1983
Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses. J Clin Invest (1987) 1.61
Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition. Antimicrob Agents Chemother (1993) 1.36
Orally active fusion inhibitor of respiratory syncytial virus. Antimicrob Agents Chemother (2004) 1.26
Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells. Antimicrob Agents Chemother (1994) 1.18
RhoA interacts with the fusion glycoprotein of respiratory syncytial virus and facilitates virus-induced syncytium formation. J Virol (1999) 1.14
Effect of synthetic protease inhibitors of the amidine type on cell injury by Rickettsia rickettsii. Antimicrob Agents Chemother (1984) 1.00
Enhancement of respiratory syncytial virus-induced cytopathology by trypsin, thrombin, and plasmin. Infect Immun (1983) 0.90
(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase. Proc Natl Acad Sci U S A (2000) 0.85
Mechanism of action of the antirhinovirus flavanoid 4',6-dicyanoflavan. Antimicrob Agents Chemother (1992) 0.83
Amelioration of immune complex-mediated glomerulonephritis by synthetic protease inhibitors. Am J Pathol (1987) 0.82
In vitro inhibition of human sarcoma cells' invasive ability by bis(5-amidino-2-benzimidazolyl)methane--a novel esteroprotease inhibitor. Am J Pathol (1986) 0.78
Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds. Bioorg Med Chem (2015) 0.77
Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. Br J Pharmacol (2007) 2.96
Spatial relationships of the proteins of vesicular stomatitis virus: induction of reversible oligomers by cleavable protein cross-linkers and oxidation. J Virol (1977) 2.77
Viral cytopathogenicity correlated with integration of ubiquitin-coding sequences. Virology (1991) 2.16
Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia. J Med Chem (1990) 2.04
Rearrangement of viral sequences in cytopathogenic pestiviruses. Virology (1992) 1.98
Segregation of bovine viral diarrhea virus into genotypes. Virology (1994) 1.97
Neutralizing monoclonal antibodies to bovine viral diarrhoea virus bind to the 56K to 58K glycoprotein. J Gen Virol (1988) 1.83
Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. J Med Chem (1978) 1.75
Monoclonal antibody analyses of cytopathic and noncytopathic viruses from fatal bovine viral diarrhea virus infections. J Virol (1988) 1.72
A new animal model for human respiratory tract disease due to adenovirus. J Infect Dis (1984) 1.71
Comparison of tilmicosin with long-acting oxytetracycline for treatment of respiratory tract disease in calves. J Am Vet Med Assoc (1996) 1.70
Role of temperature-sensitive mutants in persistent infections initiated with vesicular stomatitis virus. J Virol (1976) 1.68
Pathogenesis of mucosal disease: a cytopathogenic pestivirus generated by an internal deletion. J Virol (1994) 1.63
Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrob Agents Chemother (1990) 1.56
Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis. Antimicrob Agents Chemother (1990) 1.49
Analysis of proteins synthesized in respiratory syncytial virus-infected cells. J Virol (1982) 1.49
Structure and DNA binding activity of analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) J Med Chem (1992) 1.46
Thrombocytopenia associated with acute bovine virus diarrhea infection in cattle. J Vet Intern Med (1989) 1.45
Inhibition of topoisomerases from Pneumocystis carinii by aromatic dicationic molecules. J Protozool (1992) 1.45
Cytopathogenicity of a pestivirus correlates with a 27-nucleotide insertion. J Virol (1996) 1.44
Characterization of a panel of monoclonal antibodies and their use in the study of the antigenic diversity of bovine viral diarrhea virus. Am J Vet Res (1990) 1.43
Equine herpesvirus type 2: prevalence and seroepidemiology in foals. Equine Vet J (1996) 1.40
Dicationic diarylfurans as anti-Pneumocystis carinii agents. J Med Chem (1995) 1.38
Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition. Antimicrob Agents Chemother (1993) 1.36
Thrombocytopenia and hemorrhages in veal calves infected with bovine viral diarrhea virus. J Am Vet Med Assoc (1990) 1.34
Control of pyrimidine biosynthesis by phage T4: mutants unable to catalyze the reduction of cytidine diphosphate. Virology (1969) 1.33
Protease inhibitors suppress the in vitro and in vivo replication of rotavirus. J Clin Invest (1988) 1.33
Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden. J Infect Dis (1999) 1.32
Severe thrombocytopenia in young calves experimentally infected with noncytopathic bovine viral diarrhea virus. J Virol (1989) 1.30
Comparison of equine arteritis virus isolates using neutralizing monoclonal antibodies and identification of sequence changes in GL associated with neutralization resistance. J Gen Virol (1995) 1.30
Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents. Antimicrob Agents Chemother (1998) 1.29
8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models. Antimicrob Agents Chemother (1991) 1.27
Airborne stability of tailless bacterial viruses S-13 and MS-2. Appl Microbiol (1970) 1.25
Development of pentamidine analogues as new agents for the treatment of Pneumocystis carinii pneumonia. Ann N Y Acad Sci (1990) 1.25
Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity. Antimicrob Agents Chemother (1991) 1.24
Anti-Pneumocystis activities of aromatic diamidoxime prodrugs. Antimicrob Agents Chemother (1998) 1.23
Inhibition of in vitro splicing of a group I intron of Pneumocystis carinii. J Eukaryot Microbiol (1994) 1.23
Inhibition of respiratory syncytial virus-host cell interactions by mono- and diamidines. Antimicrob Agents Chemother (1981) 1.19
Simultaneous determination of lamivudine and zidovudine concentrations in human seminal plasma using high-performance liquid chromatography and tandem mass spectrometry. J Chromatogr B Biomed Sci Appl (2000) 1.19
Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells. Antimicrob Agents Chemother (1994) 1.18
Effect of prehumidification on sampling of selected airborne viruses. Appl Microbiol (1969) 1.18
Inhibition of respiratory syncytial virus by bis(5-amidino-2-benzimidazolyl)methane. Virology (1980) 1.18
Molecular specificity of the antibody responses of cattle naturally and experimentally infected with cytopathic and noncytopathic bovine viral diarrhea virus biotypes. Am J Vet Res (1987) 1.17
Epidemiologic and pathologic characteristics of respiratory tract disease in dairy heifers during the first three months of life. J Am Vet Med Assoc (1996) 1.16
The prevalence of bovine viral diarrhea virus infection in a population of feedlot calves in western Canada. Can J Vet Res (1995) 1.14
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. J Med Chem (1998) 1.14
Biological activity of the nucleic acids extracted from two aerosolized bacterial viruses. Appl Microbiol (1971) 1.13
Differences in virus-induced polypeptides in cells infected by cytopathic and noncytopathic biotypes of bovine virus diarrhea-mucosal disease virus. Virology (1987) 1.13
Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). J Med Chem (1993) 1.13
Bovine viral diarrhea virus: characterization of a cytopathogenic defective interfering particle with two internal deletions. J Virol (1996) 1.13
Viral membranes: model systems for studying biological membranes. CRC Crit Rev Biochem (1979) 1.10
Diamidino-alpha,omega-diphenoxyalkanes. Structure-activity relationships for the inhibition of thrombin, pancreatic kallikrein, and trypsin. J Med Chem (1973) 1.10
Experimental bovine respiratory syncytial virus infection in conventional calves: light microscopic lesions, microbiology, and studies on lavaged lung cells. Am J Vet Res (1985) 1.09
Bovine virus diarrhea--clinical syndromes in dairy herds. Cornell Vet (1987) 1.09
Baculovirus expression of pestivirus non-structural proteins. J Gen Virol (1992) 1.08
Monoclonal antibody-based immunohistochemical detection of bovine viral diarrhea virus in formalin-fixed, paraffin-embedded tissues. Vet Pathol (1992) 1.08
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. J Med Chem (1998) 1.07
Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines. Antimicrob Agents Chemother (1991) 1.06
In vitro antifungal activities of a series of dication-substituted carbazoles, furans, and benzimidazoles. Antimicrob Agents Chemother (1998) 1.06
Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases. J Pharmacol Exp Ther (1993) 1.03
The cotton rat as an experimental model of human parainfluenza virus type 3 disease. Exp Lung Res (1981) 1.02
An epizootic of blindness and encephalitis associated with a herpesvirus indistinguishable from equine herpesvirus I in a herd of alpacas and llamas. J Am Vet Med Assoc (1988) 1.02
Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2. J Med Chem (1996) 1.02
Examination of the activities of 43 chemotherapeutic agents against Neospora caninum tachyzoites in cultured cells. Am J Vet Res (1994) 1.02
In vitro metabolism of an orally active O-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis. Xenobiotica (2005) 1.02
Identification and phylogenetic comparison of Salem virus, a novel paramyxovirus of horses. Virology (2000) 1.01
Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in vervet monkeys after oral administration. Antimicrob Agents Chemother (2008) 1.01
Sequential events in the pathogenesis of streptococcal cell wall-induced arthritis and their modulation by bis(5-amidino-2-benzimidazolyl)methane (BABIM). Am J Pathol (1990) 1.01
Amidino-substituted aromatic heterocycles as probes of the specificity pocket of trypsin-like proteases. Arch Biochem Biophys (1979) 1.00
Effect of synthetic protease inhibitors of the amidine type on cell injury by Rickettsia rickettsii. Antimicrob Agents Chemother (1984) 1.00
Airborne stability of simian virus 40. Appl Microbiol (1973) 1.00
Detection of bovine herpesvirus-1 in bovine semen by a nested PCR assay. J Virol Methods (1993) 0.99
Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan. J Med Chem (1999) 0.99
Identification and characterization of an endo/exonuclease in Pneumocystis carinii that is inhibited by dicationic diarylfurans with efficacy against Pneumocystis pneumonia. J Eukaryot Microbiol (1998) 0.99
Inhibitory effect of aromatic diamidines on trypsin and enterokinase. Experientia (1969) 0.98
2,4-Diphenyl furan diamidines as novel anti-Pneumocystis carinii pneumonia agents. J Med Chem (1999) 0.98
Treatment of experimental Pneumocystis carinii pneumonia with analogs of pentamidine. J Protozool (1989) 0.97
Monoclonal antibody-based blocking enzyme-linked immunosorbent assay for specific detection and titration of peste-des-petits-ruminants virus antibody in caprine and ovine sera. J Clin Microbiol (1993) 0.97
Microtiter virus isolation and enzyme immunoassays for detection of bovine viral diarrhea virus in cattle serum. J Clin Microbiol (1997) 0.97
Primary and secondary metabolism of pentamidine by rats. Antimicrob Agents Chemother (1992) 0.96
Comparative efficacy evaluation of dicationic carbazole compounds, nitazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model. Antimicrob Agents Chemother (1998) 0.94
Characterization of bovine viral diarrhoea-mucosal disease virus-specific proteins in bovine cells. J Gen Virol (1987) 0.94
Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures. Antimicrob Agents Chemother (1991) 0.94
Interferon induction by Colorado tick fever virus: a double-stranded RNA virus. Proc Soc Exp Biol Med (1972) 0.93
Suppression of respiratory syncytial virus infection in cotton rats by bis(5-amidino-2-benzimidazolyl)methane. Antimicrob Agents Chemother (1984) 0.93
Recombinant polypeptide from the gp48 region of the bovine viral diarrhea virus (BVDV) detects serum antibodies in vaccinated and infected cattle. Vet Microbiol (1992) 0.93
Inhibition of pseudorabies virus replication by vesicular stomatitis virus. II Activity of defective interfering particles. J Virol (1976) 0.93
Hydroxylation of pentamidine by rat liver microsomes. J Pharmacol Exp Ther (1991) 0.92
Glycoproteins of bovine viral diarrhoea-mucosal disease virus in infected bovine cells. J Gen Virol (1987) 0.92