Published in Proc West Pharmacol Soc on January 01, 1981
Molecular mechanisms and regulation of opioid receptor signaling. Annu Rev Pharmacol Toxicol (2000) 2.95
Simultaneous quantitative assessment of morphine tolerance and physical dependence. J Pharmacol Exp Ther (1969) 2.78
Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord. J Neurosci (1995) 2.62
Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified 987 or K99 pili: protection correlates with pilus homology of vaccine and challenge. Infect Immun (1978) 2.52
beta-endorphin is a potent analgesic agent. Proc Natl Acad Sci U S A (1976) 2.30
Blood dyscrasias and topical ophthalmic chloramphenicol. Am J Ophthalmol (1993) 2.04
Synthesis and analgesic activity of human beta-endorphin. J Med Chem (1977) 1.98
U73122 inhibits phospholipase C-dependent calcium mobilization in neuronal cells. Brain Res (1994) 1.48
Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization. J Biol Chem (2001) 1.46
Beta-Endorphin as a potent analgesic by intravenous injection. Nature (1976) 1.40
Lectins: endogenous carbohydrate-binding proteins from vertebrate tissues: functional role in recognition processes? Life Sci (1978) 1.37
Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene. Proc Natl Acad Sci U S A (1994) 1.34
Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice. J Pharmacol Exp Ther (2001) 1.27
The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids. Proc Natl Acad Sci U S A (1995) 1.25
Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified K99 or 987P pili: antibody production in response to vaccination. Infect Immun (1980) 1.25
Cyclic adenosine monophosphate antagonism of morphine analgesia. J Pharmacol Exp Ther (1973) 1.23
Insights into the receptor transcription and signaling: implications in opioid tolerance and dependence. Neuropharmacology (2004) 1.22
Regulation of opioid receptor activities. J Pharmacol Exp Ther (1999) 1.22
Receptor density and recycling affect the rate of agonist-induced desensitization of mu-opioid receptor. Mol Pharmacol (2000) 1.22
beta-Endorphin: structure-activity relationships in the guinea pig ileum and opiate receptor binding assays. Biochem Biophys Res Commun (1977) 1.20
delta-Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. J Neurosci (1995) 1.19
Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors. Brain Res Mol Brain Res (1994) 1.16
Effects of opioids on the immune system. Neurochem Res (1996) 1.16
Results of treating primary tumours of the trachea by irradiation. Thorax (1978) 1.15
Preservation of ovarian function in patients requiring radiotherapy for para-aortic and pelvic Hodgkin's disease. Lancet (1972) 1.13
Developmentally regulated lectin in neonatal rat brain. Nature (1977) 1.13
Deltorphin II-induced rapid desensitization of delta-opioid receptor requires both phosphorylation and internalization of the receptor. J Biol Chem (2000) 1.10
Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines. Brain Res Mol Brain Res (1995) 1.10
Molecular characterization of a new immunoglobulin superfamily protein with potential roles in opioid binding and cell contact. EMBO J (1989) 1.09
Delta opioid receptor enhancement of mu opioid receptor-induced antinociception in spinal cord. J Pharmacol Exp Ther (1998) 1.08
Pharmacological manipulation of gamma-aminobutyric acid (GABA) in morphine analgesia, tolerance and physical dependence. Life Sci (1976) 1.08
3H-Leu5-enkephalin specific binding to synaptic membrane-comparison with 3H-dihydromorphine and 3H-naloxone. Res Commun Chem Pathol Pharmacol (1978) 1.08
Molecular cloning of a novel protein regulated by opioid treatment of NG108-15 cells. Brain Res Mol Brain Res (1995) 1.06
Transcriptional regulation of mouse mu-opioid receptor gene. J Biol Chem (1998) 1.06
MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions. Brain Res Mol Brain Res (1998) 1.06
Effects of acute and chronic morphine treatments on calcium localization and binding in brain. J Pharmacol Exp Ther (1978) 1.06
Dual promoters of mouse mu-opioid receptor gene. Biochem Biophys Res Commun (1997) 1.05
mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit. Brain Res Mol Brain Res (1998) 1.04
Combination chemotherapy for small cell carcinoma of the lung. Cancer (1977) 1.04
Single-stranded DNA-binding complex involved in transcriptional regulation of mouse mu-opioid receptor gene. J Biol Chem (2001) 1.04
Unique behavioral effects of beta endorphin and their relationship to thermoregulation and hypothalamic function. Life Sci (1978) 1.03
Effects of withdrawal from chronic amphetamine intoxication on exploratory and stereotyped behaviors in the rat. Psychopharmacology (Berl) (1977) 1.03
Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells. Mol Pharmacol (1992) 1.03
Hierarchical phosphorylation of delta-opioid receptor regulates agonist-induced receptor desensitization and internalization. J Biol Chem (2000) 1.03
Expression of the mu-opioid receptor in CHO cells: ability of mu-opioid ligands to promote alpha-azidoanilido[32P]GTP labeling of multiple G protein alpha subunits. J Neurochem (1995) 1.02
Interaction of delta-opioid receptors with multiple G proteins: a non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins. Mol Pharmacol (1994) 1.01
Ethanol-induced fluidization of brain lipid bilayers: required presence of cholesterol in membranes for the expression of tolerance. Mol Pharmacol (1979) 1.00
Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes. Mol Pharmacol (1983) 1.00
Loss of opiate receptor activity in neuroblastoma X glioma NG108-15 hybrid cells after chronic opiate treatment. A multiple-step process. Mol Pharmacol (1982) 1.00
Quantitative aspects of precipitated abstinence in morphine-dependent rats. J Pharmacol Exp Ther (1973) 1.00
Morphine tolerance, physical dependence, and synthesis of brain 5-hydroxytryptamine. Science (1968) 1.00
Opiate and peptide interaction: effect of enkephalins on morphine analgesia. Eur J Pharmacol (1980) 0.98
Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists. Proc Natl Acad Sci U S A (1996) 0.98
A protein-lipid model of the opiate receptor. Life Sci (1980) 0.98
Endorphins may function in heat adaptation. Proc Natl Acad Sci U S A (1978) 0.98
Radiation cancer of the pharynx. Case reports. Acta Radiol Ther Phys Biol (1965) 0.98
Down-regulation of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Chloroquine promotes accumulation of tritiated enkephalin in the lysosomes. J Biol Chem (1984) 0.97
Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment. J Pharmacol Exp Ther (1987) 0.97
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells. J Neurosci (1994) 0.97
Brain serotonin turnover in morphine tolerant and dependent mice. J Pharmacol Exp Ther (1970) 0.97
Brain sites of precipitated abstinence in morphine-dependent rats. J Pharmacol Exp Ther (1973) 0.97
dsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm. Proc Natl Acad Sci U S A (2007) 0.96
The effect of nicotinamide and homologs on the activity of inducible enzymes and NAD content of the rat liver. Mol Pharmacol (1967) 0.96
Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density. J Biol Chem (1994) 0.95
The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation. J Biol Chem (1999) 0.94
The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation. Mol Pharmacol (1997) 0.94
beta-Endorphin in vitro inhibition of striatal dopamine release. Nature (1976) 0.94
Demonstration and characterization of opiate inhibition of the striatal adenylate cyclase. J Neurochem (1981) 0.94
Properties and localization of beta-endorphin receptor in rat brain. Proc Natl Acad Sci U S A (1979) 0.93
Circling behavior after narcotic drugs and during naloxone-precipitated abstinence in rats with unilateral nigral lesions. J Pharmacol Exp Ther (1976) 0.93
Dynorphin interaction at the kappa-opiate site. Eur J Pharmacol (1981) 0.93
Comparison of the effects of morphine on locomotor activity, analgesia and primary and protracted physical dependence in six mouse strains. J Pharmacol Exp Ther (1977) 0.93
Effects of divalent cations, cation chelators and an ionophore on morphine analgesia and tolerance. J Pharmacol Exp Ther (1975) 0.92
Mutational analysis of the structure and function of opioid receptors. Biopolymers (1999) 0.92
Cloning, sequencing and localization to chromosome 11 of a cDNA encoding a human opioid-binding cell adhesion molecule (OBCAM). Gene (1995) 0.92
Complementary DNA cloning of a mu-opioid receptor from rat peritoneal macrophages. Biochem Biophys Res Commun (1995) 0.92
Purification to apparent homogeneity of a mu-type opioid receptor from rat brain. Proc Natl Acad Sci U S A (1986) 0.91
Discrete changes in brain calcium with morphine analgesia, tolerance-dependence, and abstinence. Life Sci (1977) 0.91
Visualization of time-dependent redistribution of delta-opioid receptors in neuronal cells during prolonged agonist exposure. Brain Res Mol Brain Res (1999) 0.91
Effects of clonidine on morphine withdrawal signs in the rat. Eur J Pharmacol (1975) 0.90
Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma x glioma hybrid NG108-15 cells. Mol Pharmacol (1992) 0.90
Transcriptional modulation of mouse mu-opioid receptor distal promoter activity by Sox18. Mol Pharmacol (2001) 0.90
Regulation of mouse kappa opioid receptor gene expression by retinoids. J Neurosci (2001) 0.90
Opiate binding to cerebroside sulfate: a model system for opiate-receptor interaction. Life Sci (1975) 0.90
Human beta-endorphin: development of tolerance and behavioral activity in rats. Biochem Biophys Res Commun (1977) 0.89
Barbital-induced cross-tolerance to barbiturates by the intracisternal route of administration. Res Commun Chem Pathol Pharmacol (1975) 0.89
Identification of serine 356 and serine 363 as the amino acids involved in etorphine-induced down-regulation of the mu-opioid receptor. J Biol Chem (1998) 0.89
Distribution and metabolism of tritiated yohimbine in mice. Arch Int Pharmacodyn Ther (1971) 0.89
Kappa opioid properties of dynorphin and its peptide fragments on the guinea-pig Ileum. J Pharmacol Exp Ther (1982) 0.89
Mobilization of Ca2+ from intracellular stores in transfected neuro2a cells by activation of multiple opioid receptor subtypes. Biochem Pharmacol (1997) 0.89
Isolation of opiate binding components by affinity chromatography and reconstitution of binding activities. Proc Natl Acad Sci U S A (1983) 0.89
Pregnancy augments nitric oxide-dependent dilator response to acetylcholine in the human uterine artery. Hum Reprod (1998) 0.89
Effects of stimulants, anorectics, and related drugs on schedule-controlled behavior. Psychopharmacology (Berl) (1978) 0.89
Genomic structure of the mouse delta opioid receptor gene. Biochem Biophys Res Commun (1995) 0.89