PubRank

K P Hofmann

Author PubWeight™ 87.28‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem Sci 2001 3.04
2 Light-dependent delay in the falling phase of the retinal rod photoresponse. Vis Neurosci 1992 2.78
3 Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit. Science 1988 2.66
4 Rhodopsin mutants that bind but fail to activate transducin. Science 1990 2.16
5 Micropatterned immobilization of a G protein-coupled receptor and direct detection of G protein activation. Nat Biotechnol 1999 2.04
6 Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. Biochemistry 1994 1.99
7 Maximal rate and nucleotide dependence of rhodopsin-catalyzed transducin activation: initial rate analysis based on a double displacement mechanism. J Biol Chem 2000 1.93
8 Three cytoplasmic loops of rhodopsin interact with transducin. Proc Natl Acad Sci U S A 1989 1.83
9 Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin. Biochemistry 1996 1.76
10 Complex formation between metarhodopsin II and GTP-binding protein in bovine photoreceptor membranes leads to a shift of the photoproduct equilibrium. FEBS Lett 1982 1.73
11 Two different forms of metarhodopsin II: Schiff base deprotonation precedes proton uptake and signaling state. Proc Natl Acad Sci U S A 1993 1.72
12 Kinetics, binding constant, and activation energy of the 48-kDa protein-rhodopsin complex by extra-metarhodopsin II. Biochemistry 1989 1.66
13 A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. J Biol Chem 1994 1.63
14 Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin alpha and gamma subunits. J Biol Chem 2000 1.60
15 Measurements on fast light-induced light-scattering and -absorption changes in outer segments of vertebrate light sensitive rod cells. Biophys Struct Mech 1976 1.54
16 Photic modulation of a highly sensitive, near-infrared light-scattering signal recorded from intact retinal photoreceptors. Proc Natl Acad Sci U S A 1988 1.46
17 Phosphorylated rhodopsin and heparin induce similar conformational changes in arrestin. J Biol Chem 1991 1.36
18 Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors. Nature 1999 1.32
19 Interaction of rhodopsin with the G-protein, transducin. Bioessays 1993 1.21
20 Diffusible ligand all-trans-retinal activates opsin via a palmitoylation-dependent mechanism. J Biol Chem 2000 1.19
21 Interaction between photoactivated rhodopsin and its kinase: stability and kinetics of complex formation. Biochemistry 1993 1.18
22 Functional differences in the interaction of arrestin and its splice variant, p44, with rhodopsin. Biochemistry 1997 1.17
23 Interactions of metarhodopsin II. Arrestin peptides compete with arrestin and transducin. J Biol Chem 2000 1.17
24 Structure and function of proteins in G-protein-coupled signal transfer. Biochim Biophys Acta 1996 1.16
25 Signaling states of rhodopsin. Retinal provides a scaffold for activating proton transfer switches. J Biol Chem 2000 1.13
26 Shift in the relation between flash-induced metarhodopsin I and metarhodpsin II within the first 10% rhodopsin bleaching in bovine disc membranes. FEBS Lett 1981 1.11
27 G-protein-effector coupling: a real-time light-scattering assay for transducin-phosphodiesterase interaction. Biochemistry 1993 1.08
28 Recovery kinetics of human rod phototransduction inferred from the two-branched alpha-wave saturation function. J Opt Soc Am A Opt Image Sci Vis 1996 1.08
29 Interactions of the beta-ionone ring with the protein in the visual pigment rhodopsin control the activation mechanism. An FTIR and fluorescence study on artificial vertebrate rhodopsins. Biochemistry 1994 1.07
30 Signal transfer from rhodopsin to the G-protein: evidence for a two-site sequential fit mechanism. Proc Natl Acad Sci U S A 1999 1.06
31 Reaction rate and collisional efficiency of the rhodopsin-transducin system in intact retinal rods. Biophys J 1991 1.06
32 Binding of inositol phosphates to arrestin. FEBS Lett 1991 1.05
33 Light-induced reorganization of phospholipids in rod disc membranes. J Biol Chem 2000 1.05
34 Palmitoylation of rhodopsin with S-protein acyltransferase: enzyme catalyzed reaction versus autocatalytic acylation. Biochim Biophys Acta 1998 1.00
35 Interplay between hydroxylamine, metarhodopsin II and GTP-binding protein in bovine photoreceptor membranes. Biochim Biophys Acta 1983 1.00
36 Photoactivation of rhodopsin and interaction with transducin in detergent micelles. Effect of 'doping' with steroid molecules. FEBS Lett 1989 0.99
37 Proton transfer reactions linked to rhodopsin activation. Biochemistry 1998 0.99
38 Measurement of fast light-induced disc shrinkage within bovine rod outer segments by means of a light-scattering transient. Biochim Biophys Acta 1977 0.98
39 Two distinct rhodopsin molecules within the disc membrane of vertebrate rod outer segments. Biochim Biophys Acta 1978 0.96
40 Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays. J Biol Chem 1995 0.96
41 Signaling states of rhodopsin: absorption of light in active metarhodopsin II generates an all-trans-retinal bound inactive state. J Biol Chem 2001 0.96
42 Effect of bleached rhodopsin on signal amplification in rod visual receptors. Nature 1990 0.95
43 Photoregeneration of bovine rhodopsin from its signaling state. Biochemistry 1995 0.95
44 Molecular motions and hydration of purple membranes and disk membranes studied by neutron scattering. Eur Biophys J 1998 0.94
45 Stochastic simulation of the transducin GTPase cycle. Biophys J 1996 0.94
46 Kinetic study on the equilibrium between membrane-bound and free photoreceptor G-protein. J Membr Biol 1987 0.94
47 Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotide-binding protein, transducin. J Biol Chem 1987 0.93
48 Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein. J Biol Chem 2001 0.93
49 The transbilayer distribution of phospholipids in disc membranes is a dynamic equilibrium evidence for rapid flip and flop movement. Eur J Biochem 2000 0.93
50 Intrinsic biophysical monitors of transducin activation: fluorescence, UV-visible spectroscopy, light scattering, and evanescent field techniques. Methods Enzymol 2000 0.93
51 Temperature dependence of G-protein activation in photoreceptor membranes. Transient extra metarhodopsin II on bovine disk membranes. Biophys J 1987 0.91
52 Molecular determinants of the reversible membrane anchorage of the G-protein transducin. Biochemistry 1999 0.91
53 Incorporation of rhodopsin in laterally structured supported membranes: observation of transducin activation with spatially and time-resolved surface plasmon resonance. Biochemistry 1998 0.91
54 Displacement of rhodopsin by GDP from three-loop interaction with transducin depends critically on the diphosphate beta-position. J Biol Chem 1990 0.90
55 FTIR spectroscopy of complexes formed between metarhodopsin II and C-terminal peptides from the G-protein alpha- and gamma-subunits. FEBS Lett 2000 0.89
56 Light scattering methods to monitor interactions between rhodopsin-containing membranes and soluble proteins. Methods Enzymol 2000 0.89
57 Light-induced axial and radial shrinkage effects and changes of the refractive index in isolated bovine rod outer segments and disc vesicles: physical analysis of near-infrared scattering changes. Biophys Struct Mech 1981 0.88
58 Effect of GTP on the rhodopsin-G-protein complex by transient formation of extra metarhodopsin II. Biochim Biophys Acta 1985 0.88
59 Proton uptake by light induced interaction between rhodopsin and G-protein. Z Naturforsch C 1985 0.86
60 Assays for activation of opsin by all-trans-retinal. Methods Enzymol 2000 0.86
61 Deoxylysolecithin and a new biphenyl detergent as solubilizing agents for bovine rhodopsin. Functional test by formation of metarhodopsin II and binding of G-protein. Biochemistry 1987 0.84
62 Elemental diet alters macrophage function in mice. J Surg Res 1991 0.84
63 ATP can promote activation and deactivation of the rod cGMP-phosphodiesterase. Kinetic light scattering on intact rod outer segments. FEBS Lett 1986 0.84
64 Chemical probing of the light-induced interaction between rhodopsin and G-protein. Near-infrared light-scattering and sulfhydryl modifications. J Biol Chem 1985 0.83
65 Rhodopsin--advances and perspectives. Vision Res 2006 0.83
66 A model for the recovery kinetics of rod phototransduction, based on the enzymatic deactivation of rhodopsin. Biophys J 1998 0.83
67 Light-induced activation of the rod phosphodiesterase leads to a rapid transient increase of near-infrared light scattering. FEBS Lett 1985 0.83
68 [Efficacy of ultrasonography in pancreatic disorders compared to endoscopic retrograde pancreaticography (author's transl)]. Klin Wochenschr 1975 0.82
69 Monitoring proton uptake from aqueous phase during rhodopsin activation. Methods Enzymol 2000 0.80
70 Interaction of pulmonary surfactant protein A with phospholipid liposomes: a kinetic study on head group and fatty acid specificity. Biochim Biophys Acta 1999 0.80
71 Surface tension and viscosity of surfactant from the resonance of an oscillating drop. Eur Biophys J 2000 0.79
72 Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells. Eur J Biochem 1999 0.78
73 Reversible calcium-dependent interaction of liposomes with pulmonary surfactant protein A. Analysis by resonant mirror technique and near-infrared light scattering. J Biol Chem 1997 0.78
74 Carcinoma of the head of the pancreas. Surg Gynecol Obstet 1991 0.78
75 On the light-stimulated coupling between rhodopsin and its disk membrane environment. Biochemistry 1978 0.77
76 Large hydration structure changes on hydrolysing ATP. Experientia 1974 0.75
77 [Signal changes in biomembranes]. Verh Dtsch Ges Inn Med 1975 0.75
78 Time-resolved angular dependent measurement of triggered light scattering changes in biological suspensions. J Biochem Biophys Methods 1983 0.75
79 Intermolecular interaction in systems with energy-rich phosphates. I. Stepwise protonation of PO4 3 minus, ADP and ATP salts, IR investigations. Z Naturforsch C 1974 0.75
80 Kinetics and saturation of light-induced near-infrared scattering changes in isolated bovine rod outer segments. Biophys Struct Mech 1981 0.75
81 Intermolecular interaction in systems with energy-rich phosphates. II. Effect of the protons arising in aqueous hydrolysing ATP solutions, IR investigations. Z Naturforsch C 1974 0.75
82 Sulfhydryl group modification of photoreceptor G-protein prevents its light-induced binding to rhodopsin. FEBS Lett 1984 0.75
83 [Collagenous sprue (author's transl)]. Dtsch Med Wochenschr 1978 0.75