Published in Methods Enzymol on January 01, 1983
Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A (1990) 3.36
Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit. J Clin Invest (1994) 2.25
Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). J Clin Invest (2001) 2.20
Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J (1992) 2.11
Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proc Natl Acad Sci U S A (1991) 1.91
G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc Natl Acad Sci U S A (1991) 1.90
Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3). EMBO J (1992) 1.86
Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement. EMBO J (1992) 1.35
Characterization of rabbit ileal receptors for Clostridium difficile toxin A. Evidence for a receptor-coupled G protein. J Clin Invest (1991) 1.34
Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A. J Clin Invest (1996) 1.26
The amino-terminal helix of GM-CSF and IL-5 governs high affinity binding to their receptors. EMBO J (1991) 1.22
Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation. Proc Natl Acad Sci U S A (2001) 1.21
Tumor necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells. Proc Natl Acad Sci U S A (1993) 1.20
Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding. Proc Natl Acad Sci U S A (1990) 1.17
Strain specificity and binding affinity requirements of neutralizing monoclonal antibodies to the C4 domain of gp120 from human immunodeficiency virus type 1. J Virol (1993) 1.16
Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes. Mol Cell Biol (1991) 1.10
Intercellular space is affected by the polysialic acid content of NCAM. J Cell Biol (1992) 1.08
IL-8 single-chain homodimers and heterodimers: interactions with chemokine receptors CXCR1, CXCR2, and DARC. Protein Sci (1997) 1.03
Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon. J Clin Invest (1988) 1.03
Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptors. J Clin Invest (1987) 1.01
IMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment. Proc Natl Acad Sci U S A (2000) 1.01
Inhibition of platelet function with synthetic peptides designed to be high-affinity antagonists of fibrinogen binding to platelets. Proc Natl Acad Sci U S A (1986) 1.01
Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor. Biochem J (1997) 0.99
Modulation of antibody affinity by a non-contact residue. Protein Sci (1993) 0.95
Identification of three adjacent amino acids of interleukin-2 receptor beta chain which control the affinity and the specificity of the interaction with interleukin-2. EMBO J (1992) 0.93
Insulin-like growth factor I is a growth-promoting factor for Leishmania promastigotes and amastigotes. Proc Natl Acad Sci U S A (1998) 0.92
High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domains. Proc Natl Acad Sci U S A (1994) 0.92
Enhancement in antigen binding by a combination of synergy and antibody capture. Immunology (1996) 0.86
An immune cell-selective interleukin 4 agonist. Proc Natl Acad Sci U S A (1998) 0.84
Anti-IgM-mediated B cell signaling. Molecular analysis of ligand binding requisites for human B cell clonal expansion and tolerance. J Exp Med (1988) 0.82
The significance of functional receptor heterogeneity in the biological responses of the rabbit neutrophil to stimulation by chemotactic formyl peptides. Biochem J (1991) 0.79
Characterization of AT2 receptor expression in NIH 3T3 fibroblasts. Cell Mol Neurobiol (1999) 0.78
Means for the assessment of radioligand quality and its importance in receptor-binding studies. Observations with radiolabelled formylmethionyl-leucyl-phenylalanine. Biochem J (1988) 0.78
Interaction between gallopamil and cardiac ryanodine receptors. Br J Pharmacol (1995) 0.77
Binding of tissue plasminogen activator to human aortic endothelial cells. Biochem J (1990) 0.75
Recent advances in receptor research. Postgrad Med J (1989) 0.75
Increased angiotensin II binding affinity in the nucleus tractus solitarius of spontaneously hypertensive rats. Proc Natl Acad Sci U S A (1985) 0.75
Enzyme-linked enzyme-binding assay for Pin1 WW domain ligands. Anal Biochem (2010) 0.75
Identification of a fibroblast growth factor-binding protein in Drosophila melanogaster. Mol Cell Biol (1991) 0.75
Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem (1980) 28.03
Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol (1978) 13.02
A novel randomized iterative strategy for aligning multiple protein sequences. Comput Appl Biosci (1991) 4.24
Transcriptome analysis and molecular signature of human retinal pigment epithelium. Hum Mol Genet (2010) 2.20
Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proc Natl Acad Sci U S A (2000) 2.19
A versatile method for simultaneous analysis of families of curves. FASEB J (1988) 1.97
Exocytotic fusion pores exhibit semi-stable states. J Membr Biol (1993) 1.62
UV light-induced cyclobutane pyrimidine dimers are mutagenic in mammalian cells. Mol Cell Biol (1986) 1.41
Number of receptor sites from Scatchard and Klotz graphs: a constructive critique. Science (1983) 1.27
Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome. Endocr Relat Cancer (2004) 1.21
Proteomic profiling of the cancer microenvironment by antibody arrays. Proteomics (2001) 1.19
Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand. Mol Pharmacol (1992) 1.18
Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann Neurol (1999) 1.17
Development of a prostate cDNA microarray and statistical gene expression analysis package. Mol Carcinog (2000) 1.16
A model-free approach to estimation of relative potency in dose-response curve analysis. Am J Physiol (1987) 1.08
Fold recognition using predicted secondary structure sequences and hidden Markov models of protein folds. Proteins (1997) 1.03
Multi-subsite receptors for multivalent ligands. Application to drugs, hormones, and neurotransmitters. Mol Pharmacol (1979) 1.02
Augmentation in expression of activation-induced genes differentiates memory from naive CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cells. J Immunol (2001) 1.02
The maternal hypothalamic-pituitary-adrenal axis in the third trimester of human pregnancy. Clin Endocrinol (Oxf) (1996) 1.01
The impact of early clinical training in medical education: a multi-institutional assessment. Acad Med (1999) 1.00
Molecular profiling of clinical tissue specimens: feasibility and applications. Am J Pathol (2000) 1.00
Radioiodinated nondegradable gonadotropin-releasing hormone analogs: new probes for the investigation of pituitary gonadotropin-releasing hormone receptors. Endocrinology (1979) 0.99
Molecular profiling of clinical tissues specimens: feasibility and applications. J Mol Diagn (2000) 0.98
Radioimmunoassay data processing with a small programmable calculator. J Immunoassay (1980) 0.97
DNA correlations. Nature (1992) 0.95
Multiple hormone deficiencies in children with hemochromatosis. J Clin Endocrinol Metab (1993) 0.95
Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways. Brain Behav Immun (2012) 0.94
Effects of serotonergic agonists and antagonists on corticotropin-releasing hormone secretion by explanted rat hypothalami. Peptides (1989) 0.91
Computer modeling of several ligands binding to multiple receptors. Endocrinology (1979) 0.90
The diagnosis of low-grade peripheral B-cell neoplasms in bone marrow trephines. Br J Haematol (2000) 0.90
Computerized estimation of size of nucleic acid fragments using the four-parameter logistic model. Anal Biochem (1990) 0.90
Aldosterone and corticosterone binding and effects on Na+ transport in cultured kidney cells. Am J Physiol (1982) 0.89
FORESST: fold recognition from secondary structure predictions of proteins. Bioinformatics (1999) 0.89
Protein topology recognition from secondary structure sequences: application of the hidden Markov models to the alpha class proteins. J Mol Biol (1997) 0.88
DESIGN: computerized optimization of experimental design for estimating Kd and Bmax in ligand binding experiments. I. Homologous and heterologous binding to one or two classes of sites. Anal Biochem (1988) 0.87
Endocrine, renal, and hemodynamic responses to graded dopamine infusions in normal men. J Clin Endocrinol Metab (1985) 0.85
EXPFIT: a program for simultaneous analysis of families of exponential decay curves. Comput Methods Programs Biomed (1988) 0.84
Vasopressin and oxytocin receptors in vagina, myometrium, and oviduct of rabbits. Endocrinology (1988) 0.84
Changes in glutamate receptors on synaptic membranes associated with hepatic encephalopathy or hyperammonemia in the rabbit. Hepatology (1984) 0.83
Improving protein secondary structure prediction with aligned homologous sequences. Protein Sci (1996) 0.83
Is there an osmotic threshold for vasopressin release? Am J Physiol (1978) 0.82
Experimental artifacts and the analysis of ligand binding data: results of a computer simulation. J Recept Res (1983) 0.81
Test of models for the sequence specificity of UV-induced mutations in mammalian cells. Mutat Res (1987) 0.81
Gamma-aminobutyric acid and benzodiazepine receptors in an animal model of fulminant hepatic failure. J Lab Clin Med (1983) 0.81
Linear growth in the rabbit is continuous, not saltatory. Endocrinology (1994) 0.81
Naloxonazine effects on the interaction of enkephalin analogs with mu-1, mu and delta opioid binding sites in rat brain membranes. J Pharmacol Exp Ther (1987) 0.81
New methods for characterization of complex receptor systems involving 3 or more binding sites: application to brain opiate receptors. J Recept Res (1984) 0.81
Dimeric pentapeptide enkephalin: a novel probe of delta opiate receptors. Life Sci (1982) 0.80
Characterization of ligand-binding systems by continuous affinity distributions of arbitrary shape. Anal Biochem (1980) 0.80
Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes. Allergy (2011) 0.79
Patterns of human growth. Science (1995) 0.79
Linkers of secondary structures in proteins. Protein Sci (1997) 0.79
A family practice education system based on patient care outcomes in family practice settings. J Fam Pract (1980) 0.79
Denominator definition by the utilization correction factor method. Fam Pract (1986) 0.79
Sequence databases and microarrays as tools for identifying prostate cancer biomarkers. Urology (2001) 0.78
Changes in the status of neurotransmitter receptors in a rabbit model of hepatic encephalopathy. Hepatology (1984) 0.78
Metabolic clearance rate and plasma half-life of radioiodinated corticotropin releasing factor in a primate. J Clin Endocrinol Metab (1982) 0.78
Incorporating global information into secondary structure prediction with hidden Markov models of protein folds. Proc Int Conf Intell Syst Mol Biol (1997) 0.78
Multiple types of binding sites for atrial natriuretic peptide in rat olfactory bulb membranes and synaptosomes. Brain Res (1995) 0.77
A very high affinity opioid binding site in rat brain: demonstration by computer modeling. Biochem Biophys Res Commun (1984) 0.77
[125I]iodopindolol: a new beta adrenergic receptor probe. J Cyclic Nucleotide Res (1981) 0.77
Comparing protein sequence-based and predicted secondary structure-based methods for identification of remote homologs. Protein Eng (1999) 0.77
KINFIT II: a nonlinear least-squares program for analysis of kinetic binding data. Mol Pharmacol (1996) 0.77
Recognizing the pleckstrin homology domain fold in mammalian phospholipase D using hidden Markov models. FEBS Lett (1999) 0.76
Mu1: a very high affinity subtype of enkephalin binding sites in rat brain. Life Sci (1985) 0.76
Use of a simian virus 40-based shuttle vector to analyze enhanced mutagenesis in mitomycin C-treated monkey cells. Mol Cell Biol (1988) 0.75
Specific binding of human alpha interferon to high-affinity cell-surface binding sites on peripheral blood mononuclear cells. J Lab Clin Med (1989) 0.75
Separation of different UDP glucuronosyltransferase activities according to charge heterogeneity by chromatofocusing using mouse liver microsomes. Three major types of aglycones. Biochem Pharmacol (1985) 0.75
Student-produced empathic responses: the second step in teaching communication skills to allied health supervisors. J Allied Health (1978) 0.75
Simplified representation of proteins. J Biomol Struct Dyn (1996) 0.75
Artifact from Deposits of Mid-Wisconsin Age in Illinois. Science (1965) 0.75
Forming a medical specialty. J Med Educ (1978) 0.75
Serotoninergic system in scrapie-infected hamsters. J Neurochem (1985) 0.75
Quantitative characterization of hormone receptors. Cancer (1980) 0.75
Evidence of strong earthquake shaking in the lower wabash valley from prehistoric liquefaction features. Science (1991) 0.75
A model for the effect of estrogen antagonists on cooperative estradiol binding. J Recept Res (1993) 0.75
Designing learning experiences for teachers...and students. J Biocommun (1983) 0.75
Computer analysis of radioligand data: advantages, problems, and pitfalls. NIDA Res Monogr (1986) 0.75
Differential effects of GTP and cations on binding of labeled dimeric and monomeric enkephalins to neuroblastoma-glioma cell delta opiate receptors. Biochem Biophys Res Commun (1982) 0.75
Computer modeling of subtypes of kappa opioid receptors in adrenal medulla. Eur J Pharmacol (1990) 0.75
Oncology education: a behavioral approach. J Med Educ (1973) 0.75
Quantitative characterization of multiple binding sites for phencyclidine and N-allylnormetazocine in membranes from rat and guinea pig brain. Neuropharmacology (1991) 0.75
Optimization of experimental design for ligand binding studies: improved estimation of affinity and binding capacity. Pharmacol Res (1990) 0.75
Increased affinity and selectivity of enkephalin tripeptide (Tyr-D-Ala-Gly) dimers. Eur J Pharmacol (1985) 0.75
Development of a friendly, self-teaching, interactive statistical package for analysis of clinical research data. The BRIGHT STAT-PACK. J Med Syst (1984) 0.75