Published in Br J Pharmacol on June 01, 1983
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A (1986) 3.97
Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc Natl Acad Sci U S A (1988) 3.31
Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci (2012) 3.11
Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartate receptors on cultured mouse central neurones. J Physiol (1988) 3.08
Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex. Br J Pharmacol (1985) 2.67
General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci (1999) 2.43
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology (Berl) (2003) 2.28
Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl) (2005) 2.25
Mechanisms of long-lasting hyperpolarizations underlying slow sleep oscillations in cat corticothalamic networks. J Physiol (1996) 1.87
Ketamine: review of its pharmacology and its use in pediatric anesthesia. Anesth Prog (1999) 1.81
3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine. Proc Natl Acad Sci U S A (1987) 1.79
Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction. Anesthesiology (2012) 1.74
Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones. J Physiol (1991) 1.65
Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease. Exp Neurol (2008) 1.63
From drugs to deprivation: a Bayesian framework for understanding models of psychosis. Psychopharmacology (Berl) (2009) 1.60
NMDA receptor and schizophrenia: a brief history. Schizophr Bull (2012) 1.59
Chronic ketamine use increases serum levels of brain-derived neurotrophic factor. Psychopharmacology (Berl) (2010) 1.57
A magnesium-sensitive post-synaptic potential in rat cerebral cortex resembles neuronal responses to N-methylaspartate. J Physiol (1986) 1.47
Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo. J Gen Physiol (1990) 1.46
Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses. Proc Natl Acad Sci U S A (1990) 1.39
Ketamine for treatment-resistant unipolar depression: current evidence. CNS Drugs (2012) 1.38
Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA. Proc Natl Acad Sci U S A (1988) 1.35
Ketamine increases human motor cortex excitability to transcranial magnetic stimulation. J Physiol (2003) 1.35
Glutamatergic model psychoses: prediction error, learning, and inference. Neuropsychopharmacology (2010) 1.34
Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders? Neuropsychopharmacology (2014) 1.33
New advances in NMDA receptor pharmacology. Trends Pharmacol Sci (2011) 1.32
Prolongation of inhibitory postsynaptic currents by pentobarbitone, halothane and ketamine in CA1 pyramidal cells in rat hippocampus. Br J Pharmacol (1985) 1.29
Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data. Psychopharmacology (Berl) (2005) 1.29
Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder. PLoS One (2011) 1.27
A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat. Br J Pharmacol (1987) 1.21
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc Natl Acad Sci U S A (1988) 1.21
Ketamine and its preservative, benzethonium chloride, both inhibit human recombinant alpha7 and alpha4beta2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes. Br J Pharmacol (2001) 1.20
¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism. Biol Psychiatry (2011) 1.14
Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications. Handb Exp Pharmacol (2012) 1.12
The role of N-methylaspartate receptors in mediating responses of rat and cat spinal neurones to defined sensory stimuli. J Physiol (1987) 1.08
The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones. J Physiol (1990) 1.05
The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture. Br J Pharmacol (1989) 1.03
The impact of NMDA receptor blockade on human working memory-related prefrontal function and connectivity. Neuropsychopharmacology (2013) 1.02
Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of zinc. Br J Pharmacol (1988) 1.02
Dopamine modulates the kinetics of ion channels gated by excitatory amino acids in retinal horizontal cells. Proc Natl Acad Sci U S A (1990) 1.02
Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors. Anesthesiology (2009) 0.99
Effects of indomethacin, piroxicam and selected prostanoids on gastric acid secretion by the rat isolated gastric mucosa. Br J Pharmacol (1985) 0.99
6-Cyano-7-nitroquinoxaline-2,3-dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus. Br J Pharmacol (1989) 0.99
Nicotine improves working memory span capacity in rats following sub-chronic ketamine exposure. Neuropsychopharmacology (2011) 0.98
Ketamine and phencyclidine: the good, the bad and the unexpected. Br J Pharmacol (2015) 0.97
Antagonism of responses to excitatory amino acids on rat cortical neurones by the spider toxin, argiotoxin636. Br J Pharmacol (1989) 0.97
Anaesthetic/amnesic agents disrupt beta frequency oscillations associated with potentiation of excitatory synaptic potentials in the rat hippocampal slice. Br J Pharmacol (1999) 0.97
Serotonergic/glutamatergic interactions: the effects of mGlu2/3 receptor ligands in rats trained with LSD and PCP as discriminative stimuli. Psychopharmacology (Berl) (2003) 0.97
Ketamine inhibits fetal ACTH responses to cerebral hypoperfusion. Am J Physiol Regul Integr Comp Physiol (2006) 0.96
Interaction of [3H]MK-801 with multiple states of the N-methyl-D-aspartate receptor complex of rat brain. Proc Natl Acad Sci U S A (1989) 0.95
Glutamate transporter type 3 knockout mice have a decreased isoflurane requirement to induce loss of righting reflex. Neuroscience (2010) 0.95
mRNA from NCB-20 cells encodes the N-methyl-D-aspartate/phencyclidine receptor: a Xenopus oocyte expression study. Proc Natl Acad Sci U S A (1989) 0.95
The effects of sigma ligands and of neuropeptide Y on N-methyl-D-aspartate-induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin. Br J Pharmacol (1994) 0.95
Direct, intraoperative observation of ~0.1 Hz hemodynamic oscillations in awake human cortex: implications for fMRI. Neuroimage (2013) 0.94
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis. Nat Rev Neurosci (2016) 0.94
Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia. Dialogues Clin Neurosci (2010) 0.94
Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of light. Front Behav Neurosci (2011) 0.94
Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker. Proc Natl Acad Sci U S A (1989) 0.93
Acute ketamine induces hippocampal synaptic depression and spatial memory impairment through dopamine D1/D5 receptors. Psychopharmacology (Berl) (2013) 0.93
The induction of N-methyl-D-aspartate receptor-dependent long-term potentiation. Philos Trans R Soc Lond B Biol Sci (2003) 0.93
Mapping the central effects of ketamine in the rat using pharmacological MRI. Psychopharmacology (Berl) (2006) 0.93
Electroencephalographic coherence and cortical acetylcholine during ketamine-induced unconsciousness. Br J Anaesth (2015) 0.92
Phencyclidine is a negative allosteric modulator of signal transduction at two subclasses of excitatory amino acid receptors. Proc Natl Acad Sci U S A (1987) 0.91
A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists. Br J Pharmacol (1988) 0.91
Glycine receptors contribute to hypnosis induced by ethanol. Alcohol Clin Exp Res (2009) 0.90
Quantitative autoradiography of [3H]-MK-801 binding sites in mammalian brain. Br J Pharmacol (1988) 0.89
Targeting kynurenine aminotransferase II in psychiatric diseases: promising effects of an orally active enzyme inhibitor. Schizophr Bull (2014) 0.88
Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rats: an in vivo study. Br J Pharmacol (1995) 0.87
Excitability changes of somatic and viscero-somatic nociceptive reflexes in the decerebrate-spinal rabbit: role of NMDA receptors. J Physiol (1995) 0.87
General anesthetic and the risk of dementia in elderly patients: current insights. Clin Interv Aging (2014) 0.87
Loss of surface N-methyl-D-aspartate receptor proteins in mouse cortical neurones during anaesthesia induced by chloral hydrate in vivo. Br J Anaesth (2009) 0.86
R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol (1991) 0.86
Essential role of NMDA receptor channel ε4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine. PLoS One (2010) 0.86
Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats. Evid Based Complement Alternat Med (2011) 0.85
Kappa-opioid receptors in the caudal nucleus tractus solitarius mediate 100 hz electroacupuncture-induced sleep activities in rats. Evid Based Complement Alternat Med (2012) 0.83
Excitation-inhibition discoordination in rodent models of mental disorders. Biol Psychiatry (2015) 0.83
The effects of substance P analogues on the scratching, biting and licking response induced by intrathecal injection of N-methyl-D-aspartate in mice. Br J Pharmacol (1990) 0.82
The epidemiology and patterns of acute and chronic toxicity associated with recreational ketamine use. Emerg Health Threats J (2011) 0.82
How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia. Antioxid Redox Signal (2012) 0.82
Hippocampal serotonin depletion unmasks differences in the hyperlocomotor effects of phencyclidine and MK-801: quantitative versus qualitative analyses. Front Pharmacol (2013) 0.82
Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801. Antimicrob Agents Chemother (1991) 0.82
Synthesis and characterization of a series of diarylguanidines that are noncompetitive N-methyl-D-aspartate receptor antagonists with neuroprotective properties. Proc Natl Acad Sci U S A (1989) 0.82
Phencyclidine in low doses selectively blocks a presynaptic voltage-regulated potassium channel in rat brain. Proc Natl Acad Sci U S A (1986) 0.82
Subanesthetic ketamine for pain management in hospitalized children, adolescents, and young adults: a single-center cohort study. J Pain Res (2017) 0.81
Evidence against an involvement of the haloperidol-sensitive sigma recognition site in the discriminative stimulus properties of (+)-N-allylnormetazocine ((+)-SKF 10,047). Br J Pharmacol (1990) 0.81
Ketamine self-administration in the rat: evidence for a critical role of setting. Psychopharmacology (Berl) (2010) 0.81
Development of PET and SPECT probes for glutamate receptors. ScientificWorldJournal (2015) 0.81
Identification of the binding subunit of the sigma-type opiate receptor by photoaffinity labeling with 1-(4-azido-2-methyl[6-3H]phenyl)-3-(2-methyl[4,6-3H]phenyl)guanidine. Proc Natl Acad Sci U S A (1988) 0.80
Rapid development of tolerance to sub-anaesthetic dose of ketamine: an oculomotor study in macaque monkeys. Psychopharmacology (Berl) (2010) 0.79
Effects of injectable anaesthetics on responses to L-glutamate and on spontaneous synaptic activity in lamprey reticulo-spinal neurones. Br J Pharmacol (1984) 0.79
Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N-methyl-D-aspartate receptor mediated synaptic responses in rat hippocampal slices. Br J Pharmacol (1987) 0.79
Effects of ionotropic glutamate receptor antagonists on rat dural artery diameter in an intravital microscopy model. Br J Pharmacol (2010) 0.79
Prevention by NMDA receptor antagonists of the centrally-evoked increases of cardiac inotropic responses in rabbits. Br J Pharmacol (1994) 0.79
A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia. PLoS One (2015) 0.79
Prolonged ketamine infusion as a therapy for complex regional pain syndrome: synergism with antagonism? Br J Clin Pharmacol (2014) 0.79
Antidepressant Actions of Ketamine Mediated by the Mechanistic Target of Rapamycin, Nitric Oxide, and Rheb. Neurotherapeutics (2017) 0.79
Ketamine: 50 Years of Modulating the Mind. Front Hum Neurosci (2016) 0.78
Interactions of benztropine, atropine and ketamine with veratridine-activated sodium channels: effects on membrane depolarization, K+-efflux and neurotransmitter amino acid release. Br J Pharmacol (1988) 0.78
Effects of ketamine on response properties of neurons in the superior paraolivary nucleus of the mouse. Neuroscience (2011) 0.78
Contributions of experimental psychiatry to research on the psychosis prodrome. Front Psychiatry (2013) 0.78
Excitatory amino acid transmitters. Annu Rev Pharmacol Toxicol (1981) 6.70
Amino acid transmitters in the mammalian central nervous system. Ergeb Physiol (1974) 5.99
Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord. J Physiol (1979) 1.76
Dissociative anesthesia: further pharmacologic studies and first clinical experience with the phencyclidine derivative CI-581. Anesth Analg (1966) 1.75
The synaptic excitation of Renshaw cells. Exp Brain Res (1966) 1.74
Specific [3H]phencyclidine binding in rat central nervous system. Proc Natl Acad Sci U S A (1979) 1.69
The antagonism of amino acid-induced excitation of spinal neurones in the cat. Brain Res (1979) 1.47
Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes. Proc Natl Acad Sci U S A (1979) 1.43
Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film. Proc Natl Acad Sci U S A (1981) 1.39
New class of glutamate agonist structurally related to ibotenic acid. Nature (1980) 1.38
GENERAL ANESTHETIC AND OTHER PHARMACOLOGICAL PROPERTIES OF 2-(O-CHLOROPHENYL)-2-METHYLAMINO CYCLOHEXANONE HCL (CI-58L). J New Drugs (1965) 1.33
NEUROBIOLOGY OF PHENCYCLIDINE (SERNYL), A DRUG WITH AN UNUSUAL SPECTRUM OF PHARMACOLOGICAL ACTIVITY. Int Rev Neurobiol (1964) 1.20
Mg2+-like selective antagonism of excitatory amino acid-induced responses by alpha, epsilon-diaminopimelic acid, D-alpha-aminoadipate and HA-966 in isolated spinal cord of frog and immature rat. Brain Res (1978) 1.16
Lamina-specific suppression of dorsal-horn unit activity by detamine hydrochloride. Anesthesiology (1973) 1.15
Selective antagonism by D-alpha-aminoadipate of amino acid and synaptic excitation of cat spinal neurons. Brain Res (1978) 1.12
The cataleptic state induced by ketamine: a review of the neuropharmacology of anesthesia. Neuropharmacology (1972) 1.10
Actions of L- and D-homocysteate in rat CNS: a correlation between low-affinity uptake and the time courses of excitation by microelectrophoretically applied L-glutamate analogues. J Neurochem (1977) 1.07
D-alpha-aminoadipate, alpha, epsilon-diominopimelic acid and HA-966 as antagonists of amino acid-induced and synpatic excitation of mammalian spinal neurones in vivo. Brain Res (1978) 1.07
Blockade by amino acid antagonists of neuronal excitation mediated by the pyramidal tract. J Physiol (1976) 1.00
The effect of anaesthetics on the uptake and release of gamma-aminobutyrate and D-aspartate in rat brain slices. Br J Pharmacol (1981) 0.98
Amino acids as neurotransmitters of corticofugal neurones in the rat: a comparison of glutamate and aspartate. Br J Pharmacol (1979) 0.97
Spinal-cord depressant effects of ketamine and etoxadrol in the cat and the rat. Anesthesiology (1973) 0.95
Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine. Neurosci Lett (1982) 0.95
Ketamine as the sole anaesthetic agent for minor surgical procedures. Anaesthesia (1971) 0.94
Acetylcholine receptors on Renshaw cells of the rat. Eur J Pharmacol (1975) 0.92
In vivo inactivation of quisqualate: studies in the cat spinal cord. Brain Res (1980) 0.92
The involvement of opiate and monoaminergic neuronal systems in the analgesic effects of ketamine. Pain (1982) 0.91
The effect of anaesthetic agents on cerebral cortical responses in the rat. Br J Pharmacol (1982) 0.91
Specific effects of alpha-D,L-aminoadipic acid on synaptic transmission in frog spinal cord. Can J Physiol Pharmacol (1980) 0.89
Use of ketamine hybrochloride as an anesthetic in laboratory rabbits, rats, mice, and guinea pigs. Lab Anim Sci (1972) 0.89
Sites of action of phencyclidine. III. Interactions with muscarinic receptors. Mol Pharmacol (1980) 0.89
Electrophysiological evidence for presynaptic actions of phencyclidine on noradrenergic transmission in rat cerebellum. J Pharmacol Exp Ther (1980) 0.88
Multiple opioid receptors: a little about their history and some implications related to evolution. Life Sci (1981) 0.88
Effects of ketamine (CI 581) on cell responses to cutaneous stimulations in laminae IV and V in the cat's dorsal horn. Eur J Pharmacol (1972) 0.87
1-Hydroxy-3-amino-pyrrolidone-2(HA-966): a new GABA-like compound, with potential use in extrapyramidal diseases. Br J Pharmacol (1971) 0.86
On the pharmacology of the ketamine enantiomorphs in the rat. J Pharmacol Exp Ther (1977) 0.85
The use of ketamine (CI-581) in feline anaesthetic practice. Vet Rec (1973) 0.84
Effects of ketamine on nociceptive cells in the medial medullary reticular formation of the cat. Anesthesiology (1979) 0.83
Neurophysiological approach as a tool to study effects of drugs on the central nervous system: dose-effect of ketamine. Exp Neurol (1978) 0.83
Properties of the optical isomers and metabolites of ketamine on the high affinity transport and catabolism of monoamines. Neuropharmacology (1981) 0.83
Dissociation of limbic and neocortical EEG patterns in cats under ketamine anesthesia. J Neurosurg (1972) 0.82
Action of phencyclidine on synaptic transmission in the hippocampus. Brain Res (1982) 0.82
Failure to produce analgesia with ketamine in two patients with cortical disease. Anesthesiology (1972) 0.82
Neuronal responses to ketamine administered microiontophoretically or intraperitoneally in the rat. Gen Pharmacol (1979) 0.82
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science (1988) 4.00
A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature (1997) 2.74
Kainate receptors are involved in synaptic plasticity. Nature (1999) 2.43
An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine? Nature (1985) 1.81
Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat. Brain Res (1987) 1.58
The antagonism of amino acid-induced excitation of spinal neurones in the cat. Brain Res (1979) 1.47
Proceedings: Rhythmical field potentials induced in the inferior olive complex by iontophoretically applied harmaline and other unrelated alkaloids. Br J Pharmacol (1973) 1.45
Neuropharmacology of AMPA and kainate receptors. Neuropharmacology (1999) 1.43
New class of glutamate agonist structurally related to ibotenic acid. Nature (1980) 1.38
Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate. Neurosci Lett (1987) 1.36
Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles. Neuropharmacology (1996) 1.32
Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology (1993) 1.31
A new class of GABA agonist. Nature (1977) 1.28
A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP. Neuron (2001) 1.27
Selective effects of (-)-baclofen on spinal synaptic transmission in the cat. Exp Brain Res (1981) 1.26
The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology (1998) 1.25
Effects of ketamine and three other anaesthetics on spinal reflexes and inhibitions in the cat. Br J Anaesth (1984) 1.21
The in vivo inactivation of GABA and other inhibitory amino acids in the cat nervous system. Exp Brain Res (1976) 1.20
Comparison of sigma- and kappa-opiate receptor ligands as excitatory amino acid antagonists. Br J Pharmacol (1984) 1.20
DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists. Neuropharmacology (1999) 1.20
The pharmacology of the inhibition of dorsal horn neurones by impulses in myelinated cutaneous afferents in the cat. Exp Brain Res (1975) 1.19
Central actions of benzodiazepines. Brain Res (1976) 1.16
Ketamine acts as a non-competitive N-methyl-D-aspartate antagonist on frog spinal cord in vitro. Neuropharmacology (1985) 1.14
NMDA receptors and ligands in the vertebrate CNS. Prog Neurobiol (1988) 1.12
Selective antagonism by D-alpha-aminoadipate of amino acid and synaptic excitation of cat spinal neurons. Brain Res (1978) 1.12
Drug-induced rhythmical activity in the inferior olivary complex of the rat. Brain Res (1976) 1.12
Studies on field potentials and on single cells in the inferior olivary complex of the rat. Brain Res (1976) 1.10
The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus. Neuropharmacology (1999) 1.08
The depolarization of feline ventral horn group Ia spinal afferent terminations by GABA. Exp Brain Res (1982) 1.08
Muscimol uptake, release and binding in rat brain slices. J Neurochem (1978) 1.06
GABA and spinal afferent terminal excitability in the cat. Brain Res (1977) 1.03
Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices. Neurosci Lett (1996) 1.02
Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum-Schild equations. Br J Pharmacol (1988) 1.02
Pentobarbitone enhancement of the inhibitory action of GABA. Nature (1977) 1.00
Effects of excitants on neurones and cerebellar-evoked field potentials in the inferior olivary complex of the rat. Brain Res (1973) 0.99
A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices. Br J Pharmacol (2000) 0.99
Inhibition of rat brain glutamate receptors by philanthotoxin. J Pharmacol Exp Ther (1989) 0.99
Quinoxalinediones selectively block quisqualate and kainate receptors and synaptic events in rat neocortex and hippocampus and frog spinal cord in vitro. Br J Pharmacol (1988) 0.99
Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices. Eur J Pharmacol (1988) 0.99
Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes. Neuropharmacology (1995) 0.98
NMDA receptor antagonism, but not AMPA receptor antagonism attenuates induced ischaemic tolerance in the gerbil hippocampus. Eur J Pharmacol (1999) 0.98
Morphology of the facial nucleus of the rat. Brain Res (1977) 0.97
Effects of phencyclidine on excitatory amino acid activation of spinal interneurones in the cat. Eur J Pharmacol (1982) 0.97
Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res (1977) 0.97
Does uptake limit the actions of GABA agonists in vivo? Experiments with muscimol, isoguvacine and THIP in cat spinal cord. J Neurochem (1978) 0.96
Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine. Neurosci Lett (1982) 0.95
A pharmacological study of Renshaw cell inhibition. J Physiol (1976) 0.94
Piperidine-4-sulphonic acid, a new specific GABA agonist. J Neurochem (1980) 0.94
Identification of pore-forming subunit of P-type calcium channels: an antisense study on rat cerebellar Purkinje cells in culture. Neuropharmacology (1997) 0.93
Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands. Eur J Pharmacol (1988) 0.93
Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia. Neuropharmacology (1999) 0.93
Validation of a neocortical slice preparation for the study of epileptiform activity. J Neurosci Methods (1988) 0.93
Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate. J Neurochem (1980) 0.92
LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia. Neurosci Lett (1999) 0.92
Acetylcholine receptors on Renshaw cells of the rat. Eur J Pharmacol (1975) 0.92
In vivo inactivation of quisqualate: studies in the cat spinal cord. Brain Res (1980) 0.92
The sensitivity of rat spinal interneurones and renshaw cells to L-glutamate and L-aspartate. Exp Brain Res (1976) 0.91
New developments in the molecular pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate receptors. Pharmacol Ther (1996) 0.90
Human autoantibodies specific for the alpha1A calcium channel subunit reduce both P-type and Q-type calcium currents in cerebellar neurons. Proc Natl Acad Sci U S A (1998) 0.90
Pharmacological characterization of non-NMDA subtypes of glutamate receptor in the neonatal rat hemisected spinal cord in vitro. Br J Pharmacol (1992) 0.90
Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. J Pharmacol Exp Ther (2000) 0.89
Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo. Br J Pharmacol (2002) 0.89
Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands. J Pharmacol Exp Ther (1989) 0.89
The synaptic activation of the GluR5 subtype of kainate receptor in area CA3 of the rat hippocampus. Neuropharmacology (1998) 0.87
Nuciferine and central glutamate receptors. J Pharm Pharmacol (1979) 0.87
Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J Neurochem (1979) 0.87
Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia. Neuroreport (1998) 0.87
Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines. Neuropharmacology (1998) 0.86
Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo. Neuropharmacology (1995) 0.86
LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia. Neuropharmacology (2000) 0.86
Depolarization of feline primary afferent fibres by acidic amino acids. J Physiol (1984) 0.85
Influence of agonists on desensitization of glutamate receptors on locust muscle. J Physiol (1981) 0.85
Acetylcholine-sensitive cells in the caudal medulla of the rat: distribution, pharmacology and effects of pentobarbitone. Br J Pharmacol (1975) 0.84
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro. Neurosci Lett (1992) 0.84
Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids. Eur J Pharmacol (1985) 0.84
ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res (2000) 0.84
Choline derivatives and sodium fluoride protect acetylcholinesterase against irreversible inhibition and aging by DFP and paraoxon. J Biochem Toxicol (1994) 0.84
Actions of pancuronium on Renshaw cells of the rat spinal cord. Comp Gen Pharmacol (1973) 0.83
(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist. J Med Chem (1993) 0.83
The dual effects of GABA and related amino acids on the electrical threshold of ventral horn group Ia afferent terminations in the cat. Exp Brain Res (1982) 0.83
Philanthotoxin blocks quisqualate-, AMPA- and kainate-, but not NMDA-, induced excitation of rat brainstem neurones in vivo. Br J Pharmacol (1990) 0.83
Antagonism between bicuculline, strychnine, and picrotoxin and depressant amino-acids in the rat nervous system. Comp Gen Pharmacol (1972) 0.82
Phencyclidine receptors and N-methyl-D-aspartate antagonism: electrophysiologic data correlates with known behaviours. Pharmacol Biochem Behav (1988) 0.82
Distribution of alpha 1A, alpha 1B and alpha 1E voltage-dependent calcium channel subunits in the human hippocampus and parahippocampal gyrus. Neuroscience (1996) 0.82
In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid. Neuropharmacology (1995) 0.82
The location of neurones with pontamine sky blue. Neuropharmacology (1974) 0.82
Some actions of bicuculline and strychnine on neurones of the spinal cord and cerebral cortex of the rat. J Physiol (1972) 0.82
Non-competitive antagonism of N-methyl-d-aspartate by displacement of an endogenous glycine-like substance. Eur J Neurosci (1989) 0.82
Bidirectional transport of NMDA receptor and ionophore in the vagus nerve. Eur J Pharmacol (1989) 0.82
The excitation and depression of spinal neurones by ibotenic acid. J Physiol (1979) 0.82
The effects of morphine, etorphine and sinomenine on the chemical sensitivity and synaptic responses of Renshaw cells and other spinal neurones in the rat. Eur J Pharmacol (1974) 0.81
Structure-activity studies on ibotenic acid and related muscimol analogues. Adv Biochem Psychopharmacol (1981) 0.81
Benzodiazepines and central glycine receptors. Br J Pharmacol (1976) 0.81