Published in J Med Chem on March 01, 1984
Inhibition of Micrococcus luteus DNA gyrase by norfloxacin and 10 other quinolone carboxylic acids. Antimicrob Agents Chemother (1986) 2.08
Correlation of quinolone MIC and inhibition of DNA, RNA, and protein synthesis and induction of the SOS response in Escherichia coli. Antimicrob Agents Chemother (1990) 1.46
Computer automated structure evaluation of quinolone antibacterial agents. Antimicrob Agents Chemother (1987) 1.31
Anti-Mycobacterium avium activity of quinolones: in vitro activities. Antimicrob Agents Chemother (1993) 1.23
Anti-Mycobacterium avium activity of quinolones: structure-activity relationship studies. Antimicrob Agents Chemother (1993) 0.97
Antibacterial activity and pharmacokinetics of four new 7-azetidinyl fluoroquinolones. Antimicrob Agents Chemother (1996) 0.90
Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA. Proc Natl Acad Sci U S A (1985) 3.18
Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug--DNA binding model. Biochemistry (1989) 3.09
In vitro susceptibility of Coxiella burnetii to antibiotics, including several quinolones. Antimicrob Agents Chemother (1987) 1.82
Mass-length ratio of fibrin fibers from gel permeation and light scattering. Biopolymers (1977) 1.40
Granulosa cell tumors of the ovary: prognostic factors and outcome. Gynecol Oncol (1994) 1.38
The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors. Med Res Rev (2000) 1.38
Antimicrobial agents from higher plants. Antimicrobial agents from Peganum harmala seeds. J Nat Prod (1982) 1.38
Fortimicins A and B, new aminoglycoside antibiotics. III. Structural identification. J Antibiot (Tokyo) (1977) 1.37
Antimicrobial agents from higher plants. I. Introduction, rationale, and methodology. Lloydia (1972) 1.35
Incidence of exercise-induced bronchospasm in Olympic winter sport athletes. Med Sci Sports Exerc (2000) 1.35
Naloxone reverses inhibitory effect of electroacupuncture on sympathetic cardiovascular reflex responses. Am J Physiol (1999) 1.22
Carbon-11-FLB 457: a radioligand for extrastriatal D2 dopamine receptors. J Nucl Med (1995) 1.18
Valve prolapse in Behçet's disease. Br Heart J (1985) 1.16
Antimicrobial agents from higher plants. An investigation of Hunnemannia fumariaefolia pseudoalcoholates of sanguinarine and chelerythrine. Lloydia (1978) 1.15
Topoisomerase II poisoning by ICRF-193. J Biol Chem (2001) 1.10
Mechanism of differential activities of ofloxacin enantiomers. Antimicrob Agents Chemother (1996) 1.07
Effects of calcium ion and covalent crosslinking on formation and elasticity of fibrin cells. Thromb Res (1975) 1.07
Role of fibrinopeptide B release: comparison of fibrins produced by thrombin and Ancrod. Am J Physiol (1977) 1.06
Fibrin gel structure: influence of calcium and covalent cross-linking on the elasticity. Biochem Biophys Res Commun (1974) 1.02
The structural characterization of tetrangomycin and tetrangulol. J Org Chem (1966) 1.00
Rapid screening of natural products for antimycobacterial activity by using luciferase-expressing strains of Mycobacterium bovis BCG and Mycobacterium intracellulare. Antimicrob Agents Chemother (1997) 0.99
DNA cleavage activities of Staphylococcus aureus gyrase and topoisomerase IV stimulated by quinolones and 2-pyridones. Antimicrob Agents Chemother (1999) 0.99
Quinolone antimicrobial agents. 2. Methylenedioxy positional isomers of oxolinic acid. J Med Chem (1979) 0.99
Synthesis and structure-activity relationships of 2-pyridones: a novel series of potent DNA gyrase inhibitors as antibacterial agents. J Med Chem (1996) 0.97
Structures of LL-AC541 and LL-AB664: new streptothricin-type antibiotics. Tetrahedron (1970) 0.96
LL-A491, a monazomycin-like antibiotic. Appl Microbiol (1967) 0.95
Circular dichroism and solution conformation of the tetracycline antibiotics. Tetrahedron Lett (1968) 0.92
Characterization of DNA topoisomerase I from Candida albicans as a target for drug discovery. Antimicrob Agents Chemother (1992) 0.92
Butitaxel analogues: synthesis and structure-activity relationships. J Med Chem (1997) 0.91
Interaction of various tetracyclines with metallic cations in aqueous solutions as measured by by circular dichroism. Antimicrob Agents Chemother (Bethesda) (1969) 0.91
Some additional observations on the chemical nature of neutramycin. Experientia (1965) 0.91
Stereoselective binding of 11C-raclopride in living human brain--a search for extrastriatal central D2-dopamine receptors by PET. Psychopharmacology (Berl) (1988) 0.91
Kinetics of conformation change of sperm-whale myoglobin. I. Folding and unfolding of metmyoglobin following pH jump. Biochemistry (1972) 0.90
Differential activities of heparins in human plasma and in sheep plasma. Effects of heparin molecular sizes and sources. Thromb Res (1978) 0.89
Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones. J Med Chem (1987) 0.88
Circular dichroism and solution conformation of the tetracycline antibiotics. Antimicrob Agents Chemother (Bethesda) (1968) 0.87
A comparative PET-study of five carbon-11 or fluorine-18 labelled salicylamides. Preparation and in vitro dopamine D-2 receptor binding. Int J Rad Appl Instrum B (1991) 0.87
Potential antitumor phenoxazines. Med Res Rev (1991) 0.87
Antimicrobial agents from higher plants. Antimicrobial isoflavanoids and related substances from Glycyrrhiza glabra L. var. typica. J Nat Prod (1980) 0.86
The ability of certain antimutagenic agents to prevent development of antibiotic resistance. Mutat Res (2001) 0.86
Chemical-ionization mass spectrometry of beta-lactam antibiotics. J Antibiot (Tokyo) (1975) 0.86
Umbelliferone analogues and their potential to inhibit Benzo(a)pyrene- and hydrogen peroxide-induced mutations. J Nat Prod (1999) 0.84
5-hydroxy-7-chlortetracycline. II. Stability and biological properties. Antimicrob Agents Chemother (Bethesda) (1966) 0.84
A physical standard of fibrinogen: measurement of the elastic modulus of dilute fibrin gels with a new elastometer. Anal Biochem (1976) 0.84
Cloning and functional studies of splice variants of the alpha-subunit of the amiloride-sensitive Na+ channel. Am J Physiol (1998) 0.84
Mucinous borderline and malignant tumors of the ovary. A clinicopathologic and DNA ploidy study of 92 cases. Cancer (1994) 0.84
Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors. Biochemistry (1994) 0.83
Antimicrobial agents from higher plants. The quaternary alkaloids of Ptelea trifoliata. Lloydia (1975) 0.83
Early events in the plasmin digestion of fibrinogen and fibrin. Effects of plasmin on fibrin polymerization. J Biol Chem (1977) 0.83
Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors. Eur J Pharmacol (1993) 0.83
Potential hypolipidemic agents. 7. Synthesis and lipid-lowering properties of 2-(dibenzofuranyloxy)-2-methylpropionates and related compounds. J Med Chem (1974) 0.82
Use of the 295- to 300-nanometer circular dichroism through of ribonucleic acid to study helix winding: effect of acridine orange. Antimicrob Agents Chemother (1973) 0.82
Kinetics of dehydration of epitetracycline in solution. J Pharm Sci (1974) 0.82
Alectosarmentin, a new antimicrobial dibenzofuranoid lactol from the lichen, Alectoria sarmentosa. J Nat Prod (1994) 0.82
Isolation and identification of trachyloban-19-oic and (-)-kaur-16-en-19-oic acids as antimicrobial agents from the prairie sunflower, Helianthus annuus. J Nat Prod (1984) 0.81
Chiral DNA gyrase inhibitors. 1. Synthesis and antimicrobial activity of the enantiomers of 6-fluoro-7-(1-piperazinyl)-1-(2'-trans-phenyl-1'-cyclopropyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. J Med Chem (1986) 0.81
The prognostic information of DNA ploidy and S-phase fraction may vary with histologic grade in endometrial carcinoma. Acta Oncol (1995) 0.81
Postmenopausal extragenital choriocarcinoma. A case report and review of the literature. Eur J Gynaecol Oncol (1991) 0.81
Structure of chelocardin, a novel tetracycline antibiotic. J Am Chem Soc (1970) 0.81
Novel cytotoxic 3'-(tert-butyl) 3'-dephenyl analogs of paclitaxel and docetaxel. J Med Chem (1995) 0.81
The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of chemotherapy effects in some major tumour types--summary and conclusions. Acta Oncol (2001) 0.81
Urokinase plasminogen activator and its inhibitor, PAI-1, in association with progression-free survival in early stage endometrial cancer. Eur J Cancer (2001) 0.80
3'-de-o-methyl-2', 3'-anhydro-lankamycin, a new macrolide antibiotic from Streptomyces violaceoniger. Helv Chim Acta (1976) 0.80
Antimicrobial agents from higher plants. Dragon's blood resin. J Nat Prod (1983) 0.80
Tetrangomycin, a new quinone antibiotic. Antimicrob Agents Chemother (Bethesda) (1965) 0.80
Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison. Cancer Res (2000) 0.80
Synthesis and structure-activity relationships of 2-pyridones: II. 8-(Fluoro-substituted pyrrolidinyl)-2-pyridones as antibacterial agents. Bioorg Med Chem Lett (1998) 0.80
Isolation and structural determination of siderochelin C, a fermentation product of an unusual Actinomycetes sp. J Antibiot (Tokyo) (1984) 0.80
Antitumor activity and biochemical effects of topsentin. Biochem Pharmacol (1991) 0.80
Efficacy and tolerability of tropisetron in comparison with a combination of tropisetron and dexamethasone in the control of nausea and vomiting induced by cisplatin-containing chemotherapy. Eur J Cancer (1994) 0.79
Antimutagenic activity of extracts of leaves of four common edible vegetable plants in Nigeria (west Africa). Mutat Res (1993) 0.79
Conformational flexibility of erythronolide B, the 14-membered aglycon ring of the erythromycins. J Am Chem Soc (1975) 0.79
Microbiological transformation of 6,14-endo-ethenotetrahydrothebaine alkaloids. Experientia (1968) 0.79
A study evaluating the efficacy and tolerability of tropisetron in combination with dexamethasone in the prevention of delayed platinum-induced nausea and emesis. Cancer (1998) 0.79
The search for orally active medications through combinatorial chemistry. Med Res Rev (1998) 0.78
TP53 protein expression analysis by luminometric immunoassay in comparison with gene mutation status and prognostic factors in early stage endometrial cancer. Int J Gynecol Cancer (2002) 0.78
Stereoselective N-oxygenation of zimeldine and homozimeldine by the flavin-containing monooxygenase. Drug Metab Dispos (1988) 0.78
Prenatal diagnosis of chromosomal disorders in Delhi. Indian Pediatr (1990) 0.78
Induction of popliteal lymph node enlargement and antibody production in the mouse by pyridylallylamines related to zimeldine. Int J Immunopharmacol (1990) 0.78
Orexin A activates hypoglossal motoneurons and enhances genioglossus muscle activity in rats. Br J Pharmacol (2014) 0.78
Feeding stimulatory and inhibitory chemicals from an acceptable nonhost plant forManduca sexta: Improved detection by larvae deprived of selected chemosensory organs. J Chem Ecol (1992) 0.78
Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake. J Med Chem (1981) 0.78
Total chemical synthesis and antitumor evaluation of the 9-aza analogue of N-(trifluoroacetyl)-4-demethoxydaunomycin. J Med Chem (1986) 0.78
A new aminoglycoside antibiotic complex--the seldomycins. IV. The structure of seldomycin factor 5. J Antibiot (Tokyo) (1977) 0.78
Effects of solvation on the ionization and conformation of raclopride and other antidopaminergic 6-methoxysalicylamides: insight into the pharmacophore. J Med Chem (1993) 0.78
Circadian rhythms of spectral components of heart rate variability. Conf Proc IEEE Eng Med Biol Soc (2006) 0.77
Popliteal lymph node enlargement and antibody production in the mouse induced by zimeldine and related compounds with varying side chains. Int J Immunopharmacol (1990) 0.77
Malignant struma ovarii' with peritoneal dissemination. Histopathology (1997) 0.77
Nanocrystalline alpha-Ni(OH)2 prepared by ultrasonic precipitation. J Nanosci Nanotechnol (2002) 0.77