Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study.
|
BMJ
|
2005
|
2.22
|
2
|
Carcinogen hemoglobin adducts, urinary mutagenicity, and metabolic phenotype in active and passive cigarette smokers.
|
J Natl Cancer Inst
|
1990
|
1.78
|
3
|
Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium.
|
Nature
|
1975
|
1.66
|
4
|
Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?
|
Carcinogenesis
|
1996
|
1.65
|
5
|
Ingested mutagens from opium and tobacco pyrolysis products and cancer of the oesophagus.
|
Lancet
|
1978
|
1.59
|
6
|
DNA repair polymorphisms and cancer risk in non-smokers in a cohort study.
|
Carcinogenesis
|
2005
|
1.54
|
7
|
Human, rat and mouse liver-mediated mutagenicity of vinyl chloride in S. typhimurium strains.
|
Int J Cancer
|
1975
|
1.53
|
8
|
Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride.
|
Biochem Biophys Res Commun
|
1975
|
1.52
|
9
|
DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study.
|
Int J Cancer
|
2001
|
1.48
|
10
|
Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100.
|
Biochem Biophys Res Commun
|
1975
|
1.39
|
11
|
Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens.
|
Nature
|
1994
|
1.31
|
12
|
Mutagenicity of vinyl chloride, chloroethyleneoxide, chloroacetaldehyde and chloroethanol.
|
Biochem Biophys Res Commun
|
1975
|
1.23
|
13
|
Mutagens produced by the pyrolysis of opium and its alkaloids as possible risk factors in cancer of the bladder and oesophagus.
|
Carcinogenesis
|
1982
|
1.21
|
14
|
Detection of carcinogen-DNA adducts in exfoliated urothelial cells of cigarette smokers: association with smoking, hemoglobin adducts, and urinary mutagenicity.
|
Cancer Epidemiol Biomarkers Prev
|
1993
|
1.17
|
15
|
Genetic polymorphism of N-acetyltransferases, glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase in relation to malignant and benign pancreatic disease risk. The International Pancreatic Disease Study Group.
|
Eur J Cancer Prev
|
1998
|
1.15
|
16
|
Characterization and identification of 6 mutagens in opium pyrolysates implicated in oesophageal cancer in Iran.
|
Mutat Res
|
1985
|
1.11
|
17
|
Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.
|
Arch Toxicol
|
1979
|
1.10
|
18
|
Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.
|
Ann Oncol
|
2007
|
1.05
|
19
|
Combined effect of polymorphic GST genes on individual susceptibility to lung cancer.
|
Int J Cancer
|
1998
|
1.04
|
20
|
DNA adducts in urothelial cells: relationship with biomarkers of exposure to arylamines and polycyclic aromatic hydrocarbons from tobacco smoke.
|
Int J Cancer
|
1996
|
1.02
|
21
|
In vitro metabolism and microsome-mediated mutagenicity of dialkylnitrosamines in rat, hamster, and mouse tissues.
|
Cancer Res
|
1975
|
1.02
|
22
|
Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions.
|
Carcinogenesis
|
2006
|
1.01
|
23
|
Levels of direct-acting mutagens, total N-nitroso compounds in nitrosated fermented fish products, consumed in a high-risk area for gastric cancer in southern China.
|
Mutat Res
|
1992
|
1.01
|
24
|
High microsome-mediated mutagenicity of the 3,4-dihydrodiol of 7-methylbenz[a]anthracene in S. typhimurium TA 98.
|
Biochem Biophys Res Commun
|
1977
|
1.00
|
25
|
Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids.
|
Epigenetics
|
2009
|
1.00
|
26
|
Epstein-Barr virus activation in Raji cells by extracts of preserved food from high risk areas for nasopharyngeal carcinoma.
|
Carcinogenesis
|
1988
|
0.99
|
27
|
Black (air-cured) and blond (flue-cured) tobacco cancer risk. IV: Molecular dosimetry studies implicate aromatic amines as bladder carcinogens.
|
Eur J Cancer
|
1993
|
0.98
|
28
|
Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems.
|
Mutat Res
|
1980
|
0.98
|
29
|
White blood cell DNA adducts and fruit and vegetable consumption in bladder cancer.
|
Carcinogenesis
|
2000
|
0.98
|
30
|
Inducible nitric oxide synthase, anti-oxidant enzymes and Helicobacter pylori infection in gastritis and gastric precancerous lesions in humans.
|
Eur J Cancer Prev
|
1998
|
0.96
|
31
|
Carcinogenic nitrosamines: free radical aspects of their action.
|
Free Radic Biol Med
|
1989
|
0.96
|
32
|
Carcinogenicity of chloroethylene oxide, an ultimate reactive metabolite of vinyl chloride, and bis(chloromethyl)ether after subcutaneous administration and in initiation-promotion experiments in mice.
|
Cancer Res
|
1980
|
0.95
|
33
|
Comparative mutagenicity of N-nitrosamines in a semi-solid and in a liquid incubation system in the presence of rat or human tissue fractions.
|
Mutat Res
|
1976
|
0.94
|
34
|
Quantitative comparison of carcinogenicity, mutagenicity and electrophilicity of 10 direct-acting alkylating agents and of the initial O6:7-alkylguanine ratio in DNA with carcinogenic potency in rodents.
|
Mutat Res
|
1983
|
0.93
|
35
|
Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells.
|
Mutat Res
|
1977
|
0.91
|
36
|
Volatile nitrosamine levels and genotoxicity of food samples from high-risk areas for nasopharyngeal carcinoma before and after nitrosation.
|
Int J Cancer
|
1989
|
0.91
|
37
|
White blood cell DNA adducts, smoking, and NAT2 and GSTM1 genotypes in bladder cancer: a case-control study.
|
Cancer Epidemiol Biomarkers Prev
|
1998
|
0.88
|
38
|
Immunohistochemical detection of pulmonary cytochrome P450IA and metabolic activities associated with P450IA1 and P450IA2 isozymes in lung cancer patients.
|
Environ Health Perspect
|
1992
|
0.88
|
39
|
Analysis of 4-aminobiphenyl-DNA adducts in human urinary bladder and lung by alkaline hydrolysis and negative ion gas chromatography-mass spectrometry.
|
Environ Health Perspect
|
1994
|
0.87
|
40
|
Prevalence of genotoxic chemicals among animal and human carcinogens evaluated in the IARC Monograph Series.
|
Cell Biol Toxicol
|
1989
|
0.86
|
41
|
32P Postlabelling analysis of urinary mutagens from smokers of black tobacco implicates 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) as a major DNA-damaging agent.
|
Carcinogenesis
|
1991
|
0.86
|
42
|
Methodology of laboratory measurements in prospective studies on gene-environment interactions: the experience of GenAir.
|
Mutat Res
|
2005
|
0.85
|
43
|
32P-postlabelling analysis of DNA adducted with urinary mutagens from smokers of black tobacco.
|
Carcinogenesis
|
1990
|
0.85
|
44
|
Some factors determining the concentration of liver proteins for optimal mutagenicity of chemicals in the Salmonella/microsome assay.
|
Mutat Res
|
1979
|
0.84
|
45
|
Transplacental carcinogenic effect of 3-methylcholanthrene in mice and its quantitation in fetal tissues.
|
J Natl Cancer Inst
|
1971
|
0.84
|
46
|
Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?
|
Cancer Causes Control
|
2008
|
0.84
|
47
|
Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans.
|
Pharmacogenetics
|
1995
|
0.84
|
48
|
Substituted hydroxyphenanthrenes in opium pyrolysates implicated in oesophageal cancer in Iran: structures and in vitro metabolic activation of a novel class of mutagens.
|
Carcinogenesis
|
1987
|
0.83
|
49
|
Critical importance of microsome concentration in mutagenesis assay with V79 Chinese hamster cells.
|
Mutat Res
|
1979
|
0.81
|
50
|
In vivo nitrosoproline formation and other risk factors in Costa Rican children from high- and low-risk areas for gastric cancer.
|
Cancer Epidemiol Biomarkers Prev
|
1994
|
0.81
|
51
|
Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels.
|
Cancer Epidemiol Biomarkers Prev
|
1996
|
0.81
|
52
|
Hydroxylation and nitroreduction are required to activate dimethylnitramine into alkylating and mutagenic agents.
|
Carcinogenesis
|
1983
|
0.81
|
53
|
Mutagens, N-nitroso compounds and their precursors in gastric juice from patients with and without precancerous lesions of the stomach.
|
Eur J Cancer
|
1993
|
0.81
|
54
|
Microsome-mediated mutagenicities of the dihydrodiols of 7,12-dimethylbenz[a]anthracene: high mutagenic activity of the 3,4-dihydrodiol.
|
Biochem Biophys Res Commun
|
1978
|
0.80
|
55
|
Mutagenicity and metabolism of vinyl chloride and related compounds.
|
Environ Health Perspect
|
1976
|
0.80
|
56
|
DNA adduct formation and 7-ethoxyresorufin O-deethylase induction in primary culture of rainbow trout hepatocytes exposed to benzo[a]pyrene.
|
Toxicol In Vitro
|
1992
|
0.80
|
57
|
Impact of polymorphisms in xeno(endo)biotic metabolism on pattern and frequency of p53 mutations in bladder cancer.
|
Mutat Res
|
2000
|
0.79
|
58
|
Factors for efficiency of the Salmonella/microsome mutagenicity assay.
|
Chem Biol Interact
|
1977
|
0.79
|
59
|
Interstrain comparison of hepatic and renal microsomal carcinogen metabolism and liver S9-mediated mutagenicity in DA and Lewis rats phenotyped as poor and extensive metabolizers of debrisoquine.
|
Drug Metab Dispos
|
1986
|
0.79
|
60
|
Comparison of the hydroxylation of benzo(a)pyrene with the metabolism of vinyl chloride, N-nitrosomorpholine, and N-nitroso-N'-methylpiperazine to mutagens by human and rat liver microsomal fractions.
|
Cancer Res
|
1980
|
0.78
|
61
|
Interrelationships in mice of antipyrine half-life, hepatic monooxygenase activities and liver S9-mediated mutagenicity of aflatoxin B1, benzo[alpha]pyrene 7,8-dihydrodiol, 2-acetylaminofluorene and N-nitrosomorpholine.
|
Chem Biol Interact
|
1983
|
0.78
|
62
|
Epstein-Barr virus activators, mutagens and volatile nitrosamines in preserved food samples from high-risk areas for nasopharyngeal carcinoma.
|
IARC Sci Publ
|
1991
|
0.78
|
63
|
Intragastric mutagens and lowered anti-oxidant defence as risk factors for gastric cancer.
|
Eur J Cancer Prev
|
1993
|
0.78
|
64
|
DNA adduct detection: some applications in monitoring exposure to environmental genotoxic chemicals.
|
IARC Sci Publ
|
1993
|
0.77
|
65
|
4-Aminobiphenyl-DNA adducts and p53 mutations in bladder cancer.
|
Int J Cancer
|
1998
|
0.77
|
66
|
Urinary excretion of S-benzylmercapturic acid as an indicator of N-nitroso-N-methylbenzylamine exposure.
|
Cancer Lett
|
1991
|
0.77
|
67
|
The choice of controls in a case-control study on WBC-DNA adducts and metabolic polymorphisms.
|
Biomarkers
|
2000
|
0.77
|
68
|
Detection of aflatoxins and related metabolites by radioimmunoassay.
|
J Natl Cancer Inst
|
1982
|
0.77
|
69
|
Interaction between genetic polymorphism of cytochrome P450-1B1 and environmental pollutants in breast cancer risk.
|
Eur J Cancer Prev
|
2004
|
0.77
|
70
|
Bacterial and mammalian mutagenicity tests: validation and comparative studies on 180 chemicals.
|
IARC Sci Publ
|
1980
|
0.76
|
71
|
Exposure to N-nitrosamines and other risk factors for gastric cancer in Costa Rican children.
|
IARC Sci Publ
|
1991
|
0.76
|
72
|
The association of bacterial mutagenicity of hydrocarbon-derived 'bay-region' dihydrodiols with the Iball indices for carcinogenicity and with the extents of DNA-binding on mouse skin of the parent hydrocarbons.
|
Chem Biol Interact
|
1979
|
0.76
|
73
|
Formation of direct-acting genotoxic substances in nitrosated smoked fish and meat products: identification of simple phenolic precursors and phenyldiazonium ions as reactive products.
|
Food Chem Toxicol
|
1989
|
0.76
|
74
|
Inhibition by specific antibodies of the mutagenicity of aflatoxin B1 in bacteria.
|
Oncodev Biol Med
|
1982
|
0.76
|
75
|
Some aspects of metabolic activation of chemical carcinogens in relation to their organ specificity.
|
Arch Toxicol
|
1977
|
0.75
|
76
|
Subcellular metabolic activation systems: their utility and limitations in predicting organ and species specific carcinogenesis of chemicals.
|
Basic Life Sci
|
1983
|
0.75
|
77
|
Synthesis, structure-activity relationships and a reaction mechanism for mutagenic N-nitroso derivatives of glycosylamines and Amadori compounds--model substances for N-nitrosated early Maillard reaction products.
|
Food Chem Toxicol
|
1987
|
0.75
|
78
|
Synthesis, analysis and mutagenic activity of N-nitroso derivatives of glycosylamines and Amadori compounds: nitrosated model substances for the early Maillard reaction products.
|
IARC Sci Publ
|
1987
|
0.75
|
79
|
Carcinogen-metabolizing enzymes and susceptibility to chemical carcinogenesis.
|
IARC Sci Publ
|
1983
|
0.75
|
80
|
Monoclonal antibody-directed analysis of cytochrome P-450-dependent monooxygenases and mutagen activation in the livers of DBA/2 and C57BL/6 mice.
|
Cancer Res
|
1986
|
0.75
|
81
|
Contribution of DNA methylation and benzylation to N-nitroso-N-benzyl-methylamine-induced mutagenesis in bacteria: effects of rat liver cytochrome P450 isozymes and glutathione transferases.
|
Carcinogenesis
|
1990
|
0.75
|
82
|
Rat and mouse tissue-mediated mutagenicity of ring-substituted 3,3-dimethyl-1-phenyltriazenes in Salmonella typhimurium.
|
Mutat Res
|
1976
|
0.75
|
83
|
Effect of glutathione and uridine 5'-diphosphoglucuronic acid on benzo(a)pyrene mutagenesis in the Salmonella/microsome assay.
|
Dev Toxicol Environ Sci
|
1980
|
0.75
|
84
|
Absence of mutagenicity of praziquantel, a new, effective, anti-schistosomal drug, in bacteria, yeasts, insects and mammalian cells.
|
Mutat Res
|
1978
|
0.75
|
85
|
Quantification of the genotoxic effects of alkylating agents in bacterial assays.
|
Mutagenesis
|
1988
|
0.75
|
86
|
High mutagenicity of N-(alpha-acyloxy)alkyl-N-alkylnitrosamines in S. typhimurium: model compounds for metabolically activated N,N-dialkylnitrosamines.
|
Mutat Res
|
1978
|
0.75
|
87
|
Short-term assays to predict carcinogenicity. Short-term assays for the analysis of body fluids and excreta.
|
IARC Sci Publ
|
1986
|
0.75
|
88
|
Differential effect of phenobarbitone, pregnenolone-16-a-carbonitrile and adinoacetonitrile on dialkylnitrosamine metabolism and mutagenicity in vitro.
|
Chem Biol Interact
|
1975
|
0.75
|
89
|
Possible involvement of a vicinal, non-bay-region dihydrodiol-epoxide in the activation of dibenzo[a,e]fluoranthene into bacterial mutagens.
|
Carcinogenesis
|
1984
|
0.75
|
90
|
[Genotoxicity of carcinogenic substances in humans and animals].
|
J Toxicol Clin Exp
|
1989
|
0.75
|
91
|
Mutagenicity studies in Salmonella typhimurium on some carcinogenic N-nitramines in vitro and in the host-mediated assay in rats.
|
Cancer Res
|
1981
|
0.75
|
92
|
Mutagenicity and carcinogenicity of environmental chemicals.
|
Regul Toxicol Pharmacol
|
1982
|
0.75
|
93
|
Proceedings: Comparative mutagenicity studies with S. typhimurium of dimethylnitrosamine (DMN) and diethylnitrosamine (DEN), after metabolic activation with liver and lung microsomes.
|
Mutat Res
|
1975
|
0.75
|
94
|
Basic requirements for in vitro metabolic activation systems in mutagenesis testing.
|
IARC Monogr Eval Carcinog Risk Chem Hum Suppl
|
1980
|
0.75
|
95
|
Short-term assays to predict carcinogenicity. Short-term assays using bacteria.
|
IARC Sci Publ
|
1986
|
0.75
|
96
|
Comparative electrophilicity, mutagenicity, DNA repair induction activity, and carcinogenicity of some N- and O-acyl derivatives of N-hydroxy-2-aminoflourene.
|
Cancer Res
|
1977
|
0.75
|
97
|
[Distribution of (14C)MCA and its derivatives in mouse tissues (author's transl)].
|
Chem Biol Interact
|
1973
|
0.75
|
98
|
Short-term assays to predict carcinogenicity. DNA damage and repair.
|
IARC Sci Publ
|
1986
|
0.75
|
99
|
Studies on the efficiency of the Salmonella/rat hepatocyte assay for the detection of carcinogens as mutagens: activation of 1,2-dimethyl-hydrazine and procarbazine into bacterial mutagens.
|
Carcinogenesis
|
1983
|
0.75
|
100
|
Destruction of aromatic amines in laboratory wastes through oxidation with potassium permanganate/sulfuric acid into non-mutagenic derivatives.
|
Am Ind Hyg Assoc J
|
1985
|
0.75
|
101
|
N-nitroso compounds, genotoxins and their precursors in gastric juice from humans with and without precancerous lesions of the stomach.
|
IARC Sci Publ
|
1991
|
0.75
|
102
|
Identification, occurrence and mutagenicity in Salmonella typhimurium of two synthetic nitroarenes, musk ambrette and musk xylene, in Indian chewing tobacco and betel quid.
|
Food Chem Toxicol
|
1986
|
0.75
|
103
|
[Metabolic activation and the mutagenic properties of carcinogenic N-nitramines in a liquid incubation test].
|
Vopr Onkol
|
1981
|
0.75
|
104
|
Lack of mutagenicity of synthetic pyrethroids in Salmonella typhimurium strains and in V79 Chinese hamster cells.
|
Mutat Res
|
1984
|
0.75
|
105
|
Effect of glutathione and uridine 5'-diphosphoglucuronic acid on mutagenesis by benzo[a]pyrene and aflatoxin B1 in the Salmonella/microsome assay.
|
Mutat Res
|
1981
|
0.75
|
106
|
Metabolic and mutagenicity studies on DDT and 15 derivatives. Detection of 1,1-bis(p-chlorophenyl)-2,2-dichloroethane and 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethyl acetate (kelthane acetate) as mutagens in Salmonella typhimurium and of 1,1-bis(p-chlorophenyl) ethylene oxide, a likely metabolite, as an alkylating agent.
|
Chem Biol Interact
|
1979
|
0.75
|
107
|
Mutagenic and alkylating activities of 3-methyl-1-phenyltriazenes and their possible role as carcinogenic metabolites of the parent dimethyl compounds.
|
Cancer Res
|
1982
|
0.75
|
108
|
Carcinogen-metabolizing enzymes and susceptibility to chemical carcinogenesis.
|
IARC Sci Publ
|
1982
|
0.75
|
109
|
Mutagenicity of benzo[a]pyrene 7,8-dihydrodiol and 7,12-dimethylbenz[a]anthracene 3,4-dihydrodiol in S. typhimurium mediated by microsomes from rat liver and mouse skin.
|
Chem Biol Interact
|
1980
|
0.75
|
110
|
[The relation between carcinogenesis and mutagenesis: a re-evaluation].
|
Bull Acad Natl Med
|
1989
|
0.75
|
111
|
[In vivo and in vitro studies of mutagenic properties of carcinogenic N-nitramines].
|
Vopr Onkol
|
1981
|
0.75
|
112
|
Short-term assays to predict carcinogenicity. Metabolic activation.
|
IARC Sci Publ
|
1986
|
0.75
|
113
|
Metabolic activation of 3-methylcholanthrene: mutagenic and transforming activities of the 9,10-dihydrodiol.
|
Biochem Biophys Res Commun
|
1978
|
0.75
|
114
|
Quantitative comparisons between carcinogenicity, mutagenicity and electrophilicity of direct-acting N-nitroso compounds and other alkylating agents.
|
IARC Sci Publ
|
1982
|
0.75
|
115
|
Short-term tests and mycotoxins.
|
Ann Nutr Aliment
|
1977
|
0.75
|
116
|
Mutagenicity of beta-oxidized N,N,-di-n-propylnitrosamine derivatives in S. typhimurium mediated by rat and hamster tissues.
|
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol
|
1976
|
0.75
|
117
|
Destruction of carcinogenic and mutagenic N-nitrosamides in laboratory wastes.
|
IARC Sci Publ
|
1984
|
0.75
|
118
|
Preparation of aflatoxin B1-BSA conjugate with high hapten/carrier molar ratio.
|
J Immunol Methods
|
1983
|
0.75
|
119
|
Short-term assays to predict carcinogenicity. The host-mediated assay.
|
IARC Sci Publ
|
1986
|
0.75
|
120
|
Screening assays for carcinogenic agents and mixtures: an appraisal based on data in the IARC Monograph series.
|
IARC Sci Publ
|
1990
|
0.75
|