Published in Annu Rev Biochem on January 01, 1984
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A (1987) 8.53
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A (1989) 7.41
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease. Proc Natl Acad Sci U S A (1989) 3.49
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol (1990) 3.03
Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc Natl Acad Sci U S A (1990) 2.48
Chromosomal localization of the human proenkephalin and prodynorphin genes. Am J Hum Genet (1988) 2.39
Proteinase inhibitors in Nicotiana alata stigmas are derived from a precursor protein which is processed into five homologous inhibitors. Plant Cell (1993) 2.03
Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent. Proc Natl Acad Sci U S A (1986) 1.92
Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA. Nucleic Acids Res (1985) 1.84
Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation. J Cell Biol (1994) 1.80
Sorting and processing of secretory proteins. Biochem J (1994) 1.65
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The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA. Proc Natl Acad Sci U S A (1986) 1.43
Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A. Proc Natl Acad Sci U S A (1987) 1.40
Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF. EMBO J (1991) 1.35
A C-terminal domain conserved in precursor processing proteases is required for intramolecular N-terminal maturation of pro-Kex2 protease. EMBO J (1994) 1.33
Single stranded DNA binding proteins derive from hnRNP proteins by proteolysis in mammalian cells. Nucleic Acids Res (1985) 1.32
Oryza sativa PSK gene encodes a precursor of phytosulfokine-alpha, a sulfated peptide growth factor found in plants. Proc Natl Acad Sci U S A (1999) 1.32
The propeptide of preprosomatostatin mediates intracellular transport and secretion of alpha-globin from mammalian cells. J Cell Biol (1989) 1.28
Characterization of the yeast KEX1 gene product: a carboxypeptidase involved in processing secreted precursor proteins. Mol Cell Biol (1989) 1.25
Mammalian single-stranded DNA binding proteins and heterogeneous nuclear RNA proteins have common antigenic determinants. Nucleic Acids Res (1985) 1.23
Multiple genes coding for precursors of rhodotorucine A, a farnesyl peptide mating pheromone of the basidiomycetous yeast Rhodosporidium toruloides. Mol Cell Biol (1989) 1.21
Molecular evolution of peptidergic signaling systems in bilaterians. Proc Natl Acad Sci U S A (2013) 1.19
From one gene to two proteins: the biogenesis of cytochromes b and c1 in Bradyrhizobium japonicum. Proc Natl Acad Sci U S A (1991) 1.17
Self-degradation of heat shock proteins. Proc Natl Acad Sci U S A (1985) 1.15
The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2. Proc Natl Acad Sci U S A (1994) 1.15
Three gonadotropin-releasing hormone genes in one organism suggest novel roles for an ancient peptide. Proc Natl Acad Sci U S A (1995) 1.14
Peptides from the calcitonin genes: molecular genetics, structure and function. Biochem J (1988) 1.14
Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease. Proc Natl Acad Sci U S A (1991) 1.12
Precursor polyprotein for multiple neuropeptides secreted from the suboesophageal ganglion of the silkworm Bombyx mori: characterization of the cDNA encoding the diapause hormone precursor and identification of additional peptides. Proc Natl Acad Sci U S A (1993) 1.09
An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number. Proc Natl Acad Sci U S A (1990) 1.08
Birnavirus precursor polyprotein is processed in Escherichia coli by its own virus-encoded polypeptide. J Virol (1988) 1.08
The mutant vasopressin gene from diabetes insipidus (Brattleboro) rats is transcribed but the message is not efficiently translated. EMBO J (1984) 1.07
Effects of site-directed mutations on processing and activities of penicillin G acylase from Escherichia coli ATCC 11105. J Bacteriol (1992) 1.07
Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes. Proc Natl Acad Sci U S A (1991) 1.06
Site-specific mutagenesis identifies amino acid residues critical in prohormone processing. EMBO J (1989) 1.04
UbiA, the major polyubiquitin locus in Caenorhabditis elegans, has unusual structural features and is constitutively expressed. Mol Cell Biol (1989) 1.03
Degradation of a-factor by a Saccharomyces cerevisiae alpha-mating-type-specific endopeptidase: evidence for a role in recovery of cells from G1 arrest. Mol Cell Biol (1991) 1.02
Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1. Proc Natl Acad Sci U S A (1991) 1.01
Isolation and expression of the eclosion hormone gene from the tobacco hornworm, Manduca sexta. Proc Natl Acad Sci U S A (1989) 1.00
Translational control of germ cell-expressed mRNA imposed by alternative splicing: opioid peptide gene expression in rat testis. Mol Cell Biol (1989) 1.00
Retrovirus-mediated expression of preprosomatostatin: posttranslational processing, intracellular storage, and secretion in GH3 pituitary cells. J Cell Biol (1988) 0.99
Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor. Proc Natl Acad Sci U S A (1987) 0.98
Four distinct and unusual linker proteins in a mitotically dividing nucleus are derived from a 71-kilodalton polyprotein, lack p34cdc2 sites, and contain protein kinase A sites. Mol Cell Biol (1994) 0.96
Evolutionary sequence modeling for discovery of peptide hormones. PLoS Comput Biol (2009) 0.96
Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the Dfur1 gene. EMBO J (1993) 0.95
Small, antibacterial and large, inactive peptides of neutrophil granules share immunoreactivity to a monoclonal antibody. Infect Immun (1988) 0.95
Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. Proc Natl Acad Sci U S A (1986) 0.93
Proenkephalin A is expressed in mesodermal lineages during organogenesis. EMBO J (1989) 0.91
Expression of the human proenkephalin gene in mouse pituitary cells: accurate and efficient mRNA production and proteolytic processing. EMBO J (1985) 0.89
Adventures with insulin in the islets of Langerhans. J Biol Chem (2011) 0.88
Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II. Biochem J (1991) 0.88
Brain-specific polypeptide 1B236 exists in multiple molecular forms. Proc Natl Acad Sci U S A (1985) 0.87
A novel transcriptional activator (PO-B) binds between the TATA box and cap site of the pro-opiomelanocortin gene. Nucleic Acids Res (1990) 0.87
Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus. Nucleic Acids Res (1990) 0.87
A second gene for gonadotropin-releasing hormone: cDNA and expression pattern in the brain. Proc Natl Acad Sci U S A (1994) 0.85
A serine protease activity in C3H/10T1/2 cells that is inhibited by anticarcinogenic protease inhibitors. Proc Natl Acad Sci U S A (1987) 0.85
The NH2 terminus of preproinsulin directs the translocation and glycosylation of a bacterial cytoplasmic protein by mammalian microsomal membranes. J Cell Biol (1986) 0.85
Mutations in the yeast KEX2 gene cause a Vma(-)-like phenotype: a possible role for the Kex2 endoprotease in vacuolar acidification. Mol Cell Biol (1998) 0.84
Structure and expression of the gene encoding the vasoactive intestinal peptide precursor. Proc Natl Acad Sci U S A (1987) 0.84
Expression of mutant ELH prohormones in AtT-20 cells: the relationship between prohormone processing and sorting. J Cell Biol (1993) 0.84
Characterization of the precursor for Manduca sexta diuretic hormone Mas-DH. Proc Natl Acad Sci U S A (1992) 0.84
Cleavage of a hydrophilic C-terminal domain increases growth-inhibitory activity of oncostatin M. Mol Cell Biol (1990) 0.82
Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus. Antimicrob Agents Chemother (2011) 0.82
Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases. J Biol Chem (1993) 0.82
Regulated expression of proenkephalin A during ontogenic development of mesenchymal derivative tissues. Mol Cell Biol (1990) 0.82
Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLoS One (2014) 0.80
Proteinase inhibitor-inducing activity of the prohormone prosystemin resides exclusively in the C-terminal systemin domain. Proc Natl Acad Sci U S A (1999) 0.80
Proenkephalin system in human polymorphonuclear cells. Production and release of a novel 1.0-kD peptide derived from synenkephalin. J Clin Invest (1990) 0.80
NN-dimethyl-1,4-phenylenediamine as an alternative reductant for peptidylglycine alpha-amidating mono-oxygenase catalysis. Biochem J (1994) 0.80
Molecular cloning of cDNA of mammalian and chicken II gonadotropin-releasing hormones (mGnRHs and cGnRH-II) in the beluga (Huso huso) and the disruptive effect of methylmercury on gene expression. Fish Physiol Biochem (2009) 0.80
Alternative splicing generates two distinct Eip28/29 gene transcripts in Drosophila Kc cells. Proc Natl Acad Sci U S A (1986) 0.80
Immunological and biochemical characterization of processing products from the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line. Biochem J (1993) 0.78
Cloning, overexpression, crystallization and preliminary X-ray crystallographic analysis of a slow-processing mutant of penicillin G acylase from Kluyvera citrophila. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.77
Proenkephalin A in bone-derived cells. Proc Natl Acad Sci U S A (1991) 0.77
Prosomatostatin-derived antrin is present in gastric D cells and in portal blood. J Clin Invest (1989) 0.76
Use of vaccinia virus vectors to study protein processing in human disease. Normal nerve growth factor processing and secretion in cultured fibroblasts from patients with familial dysautonomia. J Clin Invest (1988) 0.76
Gonadotropin-releasing peptide from human follicular fluid: isolation, characterization, and chemical synthesis. Proc Natl Acad Sci U S A (1987) 0.75
How the prohormone theory solved two important controversies in hormonal and neural Peptide biosynthesis. Front Endocrinol (Lausanne) (2013) 0.75
Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science (1995) 5.74
p1B15: a cDNA clone of the rat mRNA encoding cyclophilin. DNA (1988) 4.89
A cyclic AMP- and phorbol ester-inducible DNA element. Nature (1986) 4.60
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature (1991) 4.36
Multiple dopamine D4 receptor variants in the human population. Nature (1992) 4.08
Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. Proc Natl Acad Sci U S A (1992) 3.91
Cloning and expression of a rat D2 dopamine receptor cDNA. Nature (1989) 3.59
Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA. Nature (1982) 2.96
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Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J Comp Neurol (2001) 2.45
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Chromosomal localization of the human proenkephalin and prodynorphin genes. Am J Hum Genet (1988) 2.39
The human dopamine D2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP. Am J Hum Genet (1989) 2.25
Steps involved in the processing of common precursor forms of adrenocorticotropin and endorphin in cultures of mouse pituitary cells. Biochemistry (1978) 2.08
Molecular characterization of the melanin-concentrating-hormone receptor. Nature (1999) 2.00
Expression of a cloned rat brain potassium channel in Xenopus oocytes. Science (1989) 1.99
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Characterization of a common precursor to corticotropin and beta-lipotropin: cell-free synthesis of the precursor and identification of corticotropin peptides in the molecule. Proc Natl Acad Sci U S A (1977) 1.93
Two mammalian genes transcribed from opposite strands of the same DNA locus. Science (1987) 1.89
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Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease. Proc Natl Acad Sci U S A (1999) 1.82
Characterization of a common precursor to corticotropin and beta-lipotropin: identification of beta-lipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system. Proc Natl Acad Sci U S A (1977) 1.81
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Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat. J Comp Neurol (1999) 1.77
Cloning and expression of human and rat D1 dopamine receptors. Nature (1990) 1.65
Bovine chromogranin A sequence and distribution of its messenger RNA in endocrine tissues. Nature (1986) 1.63
Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene. J Biol Chem (1990) 1.63
Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress. Proc Natl Acad Sci U S A (1997) 1.62
A ribosomal gene mutation in streptomycin-resistant Mycobacterium tuberculosis isolates. J Infect Dis (1993) 1.60
Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron (1995) 1.56
Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J Neurosci (1990) 1.56
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Heteropolymeric potassium channels expressed in Xenopus oocytes from cloned subunits. Neuron (1990) 1.55
A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP. Am J Hum Genet (1990) 1.54
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Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis. J Neurosci (1989) 1.50
Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor. Proc Natl Acad Sci U S A (1979) 1.49
Orphanin FQ is a functional anti-opioid peptide. Neuroscience (1996) 1.48
Declining serum cholesterol levels prior to diagnosis of colon cancer. A time-trend, case-control study. JAMA (1990) 1.48
Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat Cell Biol (1999) 1.46
Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci (2000) 1.43
Complete amino acid sequence of mouse pro-opiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA. J Biol Chem (1983) 1.42
Sequence and expression of the rat prodynorphin gene. Proc Natl Acad Sci U S A (1985) 1.40
Detection and quantitation of pro-opiomelanocortin mRNA in pituitary and brain tissues from different species. J Biol Chem (1982) 1.39
Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics (1991) 1.38
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