Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
|
Proc Natl Acad Sci U S A
|
1992
|
5.24
|
2
|
Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.
|
Cancer Res
|
1985
|
5.09
|
3
|
Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein.
|
Br J Pharmacol
|
1986
|
4.75
|
4
|
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
|
Proc Natl Acad Sci U S A
|
1992
|
3.22
|
5
|
Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors.
|
Cancer Res
|
1983
|
2.90
|
6
|
Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues.
|
Cancer Res
|
1987
|
2.67
|
7
|
Reversal of adriamycin resistance by verapamil in human ovarian cancer.
|
Science
|
1984
|
2.24
|
8
|
Microscopic benign and invasive malignant neoplasms and a cancer-prone phenotype in prophylactic oophorectomies.
|
J Natl Cancer Inst
|
1996
|
2.17
|
9
|
Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion.
|
Biochem Pharmacol
|
1985
|
1.86
|
10
|
Spontaneous transformation of rat ovarian surface epithelial cells: association with cytogenetic changes and implications of repeated ovulation in the etiology of ovarian cancer.
|
J Natl Cancer Inst
|
1992
|
1.82
|
11
|
BRL 34915, a novel antihypertensive agent: comparison of effects on blood pressure and other haemodynamic parameters with those of nifedipine in animal models.
|
J Cardiovasc Pharmacol
|
1986
|
1.79
|
12
|
AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells.
|
Cancer Res
|
1998
|
1.61
|
13
|
Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results.
|
J Natl Cancer Inst
|
1992
|
1.61
|
14
|
Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells: role of ERCC1-XPF.
|
Biochem Pharmacol
|
2000
|
1.58
|
15
|
Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell lines.
|
Cancer Res
|
1988
|
1.55
|
16
|
Inhibition by glibenclamide of the vasorelaxant action of cromakalim in the rat.
|
Br J Pharmacol
|
1989
|
1.52
|
17
|
Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.
|
J Clin Oncol
|
1987
|
1.50
|
18
|
The biology of ovarian cancer.
|
Semin Oncol
|
1998
|
1.46
|
19
|
Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells.
|
Br J Cancer
|
2005
|
1.42
|
20
|
Genes amplified and overexpressed in human multidrug-resistant cell lines.
|
Cancer Res
|
1988
|
1.42
|
21
|
Experimental model systems of ovarian cancer: applications to the design and evaluation of new treatment approaches.
|
Semin Oncol
|
1984
|
1.41
|
22
|
Ovarian cancer biology.
|
Semin Oncol
|
1991
|
1.40
|
23
|
Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines.
|
Cancer Res
|
1997
|
1.39
|
24
|
The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts.
|
Cancer Res
|
1998
|
1.39
|
25
|
Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion.
|
Cancer Res
|
1984
|
1.35
|
26
|
Metallothionein gene expression and resistance to cisplatin in human ovarian cancer.
|
Int J Cancer
|
1990
|
1.35
|
27
|
The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel.
|
Cancer Res
|
2000
|
1.27
|
28
|
Characterization of a xenograft model of human ovarian carcinoma which produces ascites and intraabdominal carcinomatosis in mice.
|
Cancer Res
|
1984
|
1.25
|
29
|
Quantitative evidence for protein denaturation as the cause of thermal death.
|
Nature
|
1971
|
1.24
|
30
|
Identification of two candidate tumor suppressor genes on chromosome 17p13.3.
|
Cancer Res
|
1996
|
1.21
|
31
|
Characterization of chromosome 9 in human ovarian neoplasia identifies frequent genetic imbalance on 9q and rare alterations involving 9p, including CDKN2.
|
Cancer Res
|
1995
|
1.18
|
32
|
Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells.
|
Cancer Res
|
1994
|
1.14
|
33
|
Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines.
|
Cancer Res
|
1985
|
1.12
|
34
|
Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines.
|
J Natl Cancer Inst
|
1989
|
1.11
|
35
|
Cross-resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines.
|
Cancer Res
|
1993
|
1.11
|
36
|
Autonomy of the epithelial phenotype in human ovarian surface epithelium: changes with neoplastic progression and with a family history of ovarian cancer.
|
Int J Cancer
|
1996
|
1.11
|
37
|
Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines.
|
Cancer Res
|
1995
|
1.11
|
38
|
Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential.
|
Med Res Rev
|
1992
|
1.11
|
39
|
The biology of ovarian cancer development.
|
Cancer
|
1993
|
1.10
|
40
|
Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer.
|
J Clin Oncol
|
1996
|
1.07
|
41
|
Mechanisms of drug resistance in ovarian cancer.
|
Cancer
|
1993
|
1.06
|
42
|
Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells.
|
J Biol Chem
|
2001
|
1.05
|
43
|
Clinical studies of reversal of drug resistance based on glutathione.
|
Chem Biol Interact
|
1998
|
1.03
|
44
|
Phase I and pharmacokinetic study of ormaplatin (tetraplatin, NSC 363812) administered on a day 1 and day 8 schedule.
|
Cancer Res
|
1994
|
1.03
|
45
|
Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexity.
|
Cancer Res
|
1994
|
1.03
|
46
|
Expression of insulin-like growth factor I, its binding proteins, and its receptor in ovarian cancer.
|
Cancer Res
|
1991
|
1.03
|
47
|
Adriamycin accumulation and metabolism in adriamycin-sensitive and -resistant human ovarian cancer cell lines.
|
Biochem Pharmacol
|
1986
|
1.02
|
48
|
Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors.
|
Oncogene
|
1997
|
1.02
|
49
|
Enhanced DNA repair and resistance to cisplatin in human ovarian cancer.
|
Biochem Pharmacol
|
1988
|
1.02
|
50
|
Advanced epithelial ovarian cancer: 1998 consensus statements.
|
Ann Oncol
|
1999
|
1.02
|
51
|
Mechanisms of resistance to cisplatin and alkylating agents.
|
Cancer Treat Res
|
1989
|
1.01
|
52
|
Use of a surrogate marker (human secreted alkaline phosphatase) to monitor in vivo tumor growth and anticancer drug efficacy in ovarian cancer xenografts.
|
Gynecol Oncol
|
2000
|
1.01
|
53
|
Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione.
|
Biochem Pharmacol
|
1987
|
1.00
|
54
|
Mechanisms and modulation of resistance to chemotherapy in ovarian cancer.
|
Cancer
|
1993
|
1.00
|
55
|
Antitumor activity and biochemical effects of aphidicolin glycinate (NSC 303812) alone and in combination with cisplatin in vivo.
|
Cancer Res
|
1994
|
0.99
|
56
|
Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells.
|
Cancer Res
|
1997
|
0.99
|
57
|
A comparison of clonogenic, microtetrazolium and sulforhodamine B assays for determination of cisplatin cytotoxicity in human ovarian carcinoma cell lines.
|
Eur J Cancer
|
1993
|
0.98
|
58
|
Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and -resistant human hepatoma cell lines.
|
Exp Cell Res
|
1996
|
0.98
|
59
|
Androgen and oestrogen binding in cytosols of human ovarian tumours.
|
J Endocrinol
|
1981
|
0.96
|
60
|
Synthesis and antihypertensive activity of 4-(cyclic amido)-2H-1-benzopyrans.
|
J Med Chem
|
1986
|
0.96
|
61
|
Synthesis and antihypertensive activity of 4-(substituted-carbonylamino)-2H-1-benzopyrans.
|
J Med Chem
|
1990
|
0.96
|
62
|
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
|
Eur J Pharmacol
|
1988
|
0.95
|
63
|
Characterization of immunotoxins active against ovarian cancer cell lines.
|
J Clin Invest
|
1985
|
0.95
|
64
|
Synthesis and antihypertensive activity of substituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols.
|
J Med Chem
|
1983
|
0.95
|
65
|
Recent insights into platinum drug resistance in cancer.
|
Drug Resist Updat
|
1998
|
0.95
|
66
|
Development and characterization of a clinically useful animal model of epithelial ovarian cancer in the Fischer 344 rat.
|
Am J Obstet Gynecol
|
1996
|
0.95
|
67
|
Glutathione and drug resistance.
|
Cancer Invest
|
1996
|
0.95
|
68
|
Serial determinations of glutathione levels and glutathione-related enzyme activities in human tumor cells in vitro.
|
Biochem Pharmacol
|
1986
|
0.94
|
69
|
Resistance to alkylating agents and cisplatin: insights from ovarian carcinoma model systems.
|
Pharmacol Ther
|
1990
|
0.93
|
70
|
Estrogen and anti-estrogen effects on the growth of human epithelial ovarian cancer in vitro.
|
Obstet Gynecol
|
1989
|
0.93
|
71
|
Role of platinum-DNA adduct formation and removal in cisplatin resistance in human ovarian cancer cell lines.
|
Biochem Pharmacol
|
1994
|
0.93
|
72
|
Expression of two mucin antigens in cultured human ovarian surface epithelium: influence of a family history of ovarian cancer.
|
Am J Obstet Gynecol
|
1995
|
0.93
|
73
|
Modification of the vascular response to isoprenaline by cholinomimetic drugs.
|
Br J Pharmacol
|
1971
|
0.92
|
74
|
Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz.
|
J Clin Invest
|
1996
|
0.92
|
75
|
Disassociation of MAPK activation and c-Fos expression in F9 embryonic carcinoma cells following retinoic acid-induced endoderm differentiation.
|
J Biol Chem
|
2001
|
0.90
|
76
|
Talc in normal and malignant ovarian tissue.
|
Lancet
|
1979
|
0.90
|
77
|
Cromakalim, a potassium channel activator: a comparison of its cardiovascular haemodynamic profile and tissue specificity with those of pinacidil and nicorandil.
|
J Cardiovasc Pharmacol
|
1988
|
0.89
|
78
|
Transcriptional activation of c-myc proto-oncogene by estrogen in human ovarian cancer cells.
|
Mol Cell Endocrinol
|
1994
|
0.88
|
79
|
Multidrug resistance in ovarian cancer.
|
Cancer
|
1987
|
0.88
|
80
|
Synthesis and antihypertensive activity of 6,7-disubstituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols.
|
J Med Chem
|
1984
|
0.88
|
81
|
Retroviral-like sequences specifically expressed in the rat ovary detect genetic differences between normal and transformed rat ovarian surface epithelial cells.
|
Endocrinology
|
1995
|
0.87
|
82
|
Antihypertensive and haemodynamic properties of the potassium channel activating (-) enantiomer of cromakalim in animal models.
|
Arzneimittelforschung
|
1991
|
0.87
|
83
|
Modulation of induced resistance to adriamycin in two human breast cancer cell lines with tamoxifen or perhexiline maleate.
|
Cancer Chemother Pharmacol
|
1988
|
0.86
|
84
|
Effects of dopamine on the conductance of perfused vascular beds of the chloralosed cat.
|
Br J Pharmacol
|
1972
|
0.86
|
85
|
Quantitative analysis of ciliary and contractile responses during habituation training in Spirostomum ambiguum.
|
Behav Biol
|
1974
|
0.86
|
86
|
Studies on the cardiovascular effects of pindolol in DOCA/saline hypertensive rats.
|
Br J Pharmacol
|
1977
|
0.85
|
87
|
Mechanisms of cross-resistance between radiation and antineoplastic drugs.
|
NCI Monogr
|
1988
|
0.85
|
88
|
Variable baseline gamma-glutamylcysteine synthetase messenger RNA expression in peripheral mononuclear cells of cancer patients, and its induction by buthionine sulfoximine treatment.
|
Cancer Res
|
1993
|
0.85
|
89
|
Diminishing hypotensive effect of increasing doses of pindolol in DOCA/saline hypertensive rats.
|
Br J Pharmacol
|
1978
|
0.85
|
90
|
Oestrogen receptor-like binding in the surface germinal epithelium of the rat ovary.
|
J Endocrinol
|
1982
|
0.85
|
91
|
Telomeric instability and reduced proliferative potential in ovarian surface epithelial cells from women with a family history of ovarian cancer.
|
Gynecol Oncol
|
1999
|
0.85
|
92
|
In vitro interactions between platinum analogues in human ovarian-carcinoma cell lines.
|
Cancer Chemother Pharmacol
|
1992
|
0.84
|
93
|
A method for the continuous recording of peripheral vascular conductance.
|
J Pharm Pharmacol
|
1971
|
0.84
|
94
|
Adoptive cellular immunotherapy of human ovarian carcinoma xenografts in nude mice.
|
Cancer Res
|
1986
|
0.84
|
95
|
Effect of intracerebroventricular 5,6-dihydroxytryptamine on blood pressure of spontaneously hypertensive rats.
|
Eur J Pharmacol
|
1976
|
0.84
|
96
|
Motor dysfunction in a photothrombotic focal ischaemia model.
|
Behav Brain Res
|
1996
|
0.83
|
97
|
Effects of BRL 38227 on neurally-mediated responses in the guinea-pig isolated bronchus.
|
Br J Pharmacol
|
1992
|
0.83
|
98
|
beta-Adrenoceptor blocking drugs and hypertension.
|
Gen Pharmacol
|
1979
|
0.83
|
99
|
Effects of talc on the rat ovary.
|
Br J Exp Pathol
|
1984
|
0.82
|
100
|
Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer.
|
Cancer Res
|
1987
|
0.82
|
101
|
Vascular endothelial growth factor in ovarian cancer.
|
Curr Oncol Rep
|
1999
|
0.82
|
102
|
LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein.
|
Oncogene
|
1999
|
0.82
|
103
|
Summary of symposium: Biology and therapy of ovarian cancer.
|
Semin Oncol
|
1991
|
0.82
|
104
|
The role of glutathione in drug resistance.
|
Cancer Treat Rev
|
1990
|
0.82
|
105
|
Ovarian epithelial cell lineage-specific gene expression using the promoter of a retrovirus-like element.
|
Cancer Res
|
2001
|
0.82
|
106
|
Early ovarian cancer: a review of its genetic and biologic factors, detection, and treatment.
|
Curr Probl Cancer
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1996
|
0.81
|
107
|
Ribonucleic acid in plasma from normal adults and multiple myeloma patients.
|
Clin Chem
|
1979
|
0.81
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108
|
Evaluation of carboplatin pharmacokinetics in the absence and presence of paclitaxel.
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Clin Cancer Res
|
1996
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0.81
|
109
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Involvement of central alpha 2-adrenoceptors in the mediation of clonidine-induced hypotension in the cat.
|
J Pharm Pharmacol
|
1980
|
0.80
|
110
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The effects of some phosphodiesterase inhibitors on the conductance of the perfused vascular beds of the chloralosed cat.
|
Br J Pharmacol
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1972
|
0.80
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111
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Effects of synthetic peptides and protease inhibitors on the interaction of a human ovarian cancer cell line (NIH:OVCAR-3) with a reconstituted basement membrane (Matrigel).
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Invasion Metastasis
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1991
|
0.80
|
112
|
Collateral susceptibility of adriamycin-, melphalan- and cisplatin-resistant human ovarian tumor cells to bleomycin.
|
Jpn J Cancer Res
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1986
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0.80
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113
|
A comparison of the cardiovascular and sedative actions of the alpha-adrenoceptor agonists, FLA-136 and clonidine, in the rat.
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Br J Pharmacol
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1982
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0.79
|
114
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Bufuralol, a new beta-adrenoceptor blocking agent.
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Experientia
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1975
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0.79
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115
|
Potentiation of cisplatin cytotoxicity in human ovarian carcinoma cell lines by trifluoperazine, a calmodulin inhibitor.
|
Gynecol Oncol
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1992
|
0.79
|
116
|
Increased DT-diaphorase expression and cross-resistance to mitomycin C in a series of cisplatin-resistant human ovarian cancer cell lines.
|
Biochem Pharmacol
|
1996
|
0.79
|
117
|
The chemopreventive agent oltipraz stimulates repair of damaged DNA.
|
Cancer Res
|
1997
|
0.79
|
118
|
Comparative cytotoxicity of CI-973, cisplatin, carboplatin and tetraplatin in human ovarian carcinoma cell lines.
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Int J Cancer
|
1991
|
0.79
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119
|
Time-dependent pharmacodynamic models in cancer chemotherapy: population pharmacodynamic model for glutathione depletion following modulation by buthionine sulfoximine (BSO) in a Phase I trial of melphalan and BSO.
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Cancer Res
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1995
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0.79
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120
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Comparison of the cardiovascular effects of the novel 5-HT(1B/1D) receptor agonist, SB 209509 (VML251), and sumatriptan in dogs.
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J Cardiovasc Pharmacol
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1997
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0.78
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121
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Induction of progesterone receptor with 17 beta-estradiol in human ovarian cancer.
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J Clin Endocrinol Metab
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1984
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0.78
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122
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Presynaptic dopamine receptors mediate the inhibitory action of dopamine agonists on stimulation-evoked pressor responses in the rat.
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J Auton Pharmacol
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1982
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0.78
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123
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Stereoselective pharmacokinetics of L-buthionine SR-sulfoximine in patients with cancer.
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Drug Metab Dispos
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1995
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0.78
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124
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Plasma prolactin concentrations in hypertensive rats.
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J Pharm Pharmacol
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1979
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0.78
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125
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Bufuralol, a new beta-adrenoceptor blocking agent in a series of benzofuran-2-ethanolamines. Part 2: pharmacology.
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Arzneimittelforschung
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1977
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0.78
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126
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Comparison of the anti-hypertensive response to beta-adrenoceptor blocking drugs in intact and adrenal-demedullated spontaneously hypertensive rats.
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Br J Pharmacol
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1980
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0.78
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127
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Genome scanning detects amplification of the cathepsin B gene (CtsB) in transformed rat ovarian surface epithelial cells.
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J Soc Gynecol Investig
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1999
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0.77
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128
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Gracile nucleus absent in adult opossums after leg removal in infancy.
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Brain Res
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1972
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0.77
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129
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Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats.
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Exp Neurol
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1997
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0.77
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130
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Growth inhibition and cytotoxicity induced by Bowman-Birk inhibitor concentrate in cisplatin-resistant human ovarian cancer cells.
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Nutr Cancer
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1998
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0.77
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131
|
Neuroprotective effect of recombinant neutrophil inhibitory factor in transient focal cerebral ischaemia in the rat.
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Neurodegeneration
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1996
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0.77
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132
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Influence of anti-hypertensive drug treatment on vascular reactivity in spontaneously hypertensive rats.
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Br J Pharmacol
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1975
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0.77
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133
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Cellular glutathione levels and sensitivity to radiation and antineoplastic agents in human ovarian cancer.
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Prog Clin Biol Res
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1988
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0.77
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134
|
Transformation of rat ovarian epithelial and Rat-1 fibroblast cell lines by RAST24 does not influence cisplatin sensitivity.
|
Cancer Res
|
1993
|
0.77
|
135
|
Growth regulation of ovarian cancer.
|
Hematol Oncol Clin North Am
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1992
|
0.77
|
136
|
Alkylating agents and immunotoxins exert synergistic cytotoxic activity against ovarian cancer cells. Mechanism of action.
|
J Clin Invest
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1993
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0.77
|
137
|
The role of molecular biology in understanding ovarian cancer initiation and progression.
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Int J Gynecol Cancer
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2001
|
0.77
|
138
|
Identification of zinc finger mRNAs using domain-specific differential display.
|
Anal Biochem
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1996
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0.77
|
139
|
Differential expression of c-fos, Hsp70 and Hsp27 after photothrombotic injury in the rat brain.
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Brain Res Mol Brain Res
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1997
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0.77
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140
|
Hypotensive responses following oral adminstration of beta-adrenoceptor blocking drugs to the conscious cat.
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Eur J Pharmacol
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1976
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0.76
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141
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Decreased cisplatin damage-dependent DNA synthesis in cellular extracts of mismatch repair deficient cells.
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Biochem Pharmacol
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1999
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0.76
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142
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[Epithelial ovarian cancer (advanced stage): consensus conference (1998)].
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Gynecol Obstet Fertil
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2000
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0.76
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143
|
Somatotopic organization related to nuclear morphology in the cuneate-gracile complex of opossums Didelphis marsupialis virginiana.
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Brain Res
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1973
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0.76
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144
|
Evaluation of in vitro drug screening leads using experimental models of human ovarian cancer.
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Invest New Drugs
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1992
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0.76
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145
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Involvement of the adrenal glands in the hypotensive response to bromocriptine in spontaneously hypertensive rats.
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Br J Pharmacol
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1981
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0.75
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146
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Re: Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone.
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J Natl Cancer Inst
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1999
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0.75
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