PubRank

W B Huttner

Author PubWeight™ 180.23‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J Cell Biol 1983 7.55
2 Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature 1999 4.15
3 Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci U S A 1997 4.04
4 Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles. Nat Cell Biol 2000 3.55
5 Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes. J Cell Biol 1983 3.49
6 The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions. J Biol Chem 2000 3.33
7 Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane. Nat Cell Biol 2000 3.27
8 Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium. Proc Natl Acad Sci U S A 1979 2.96
9 Chlorate--a potent inhibitor of protein sulfation in intact cells. Biochem Biophys Res Commun 1986 2.57
10 Secretogranins I and II: two tyrosine-sulfated secretory proteins common to a variety of cells secreting peptides by the regulated pathway. J Cell Biol 1985 2.53
11 Sulphation of tyrosine residues-a widespread modification of proteins. Nature 1982 2.39
12 The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region. EMBO J 1987 2.33
13 Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases. J Biol Chem 1981 2.26
14 Tyrosine-O-sulfated proteins of PC12 pheochromocytoma cells and their sulfation by a tyrosylprotein sulfotransferase. J Biol Chem 1983 2.26
15 Cell-free protein sorting to the regulated and constitutive secretory pathways. Cell 1990 2.12
16 Tyrosine sulfation is a trans-Golgi-specific protein modification. J Cell Biol 1987 2.10
17 Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network. J Cell Biol 1991 2.07
18 Prominin: a story of cholesterol, plasma membrane protrusions and human pathology. Traffic 2001 2.03
19 A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. Hum Mol Genet 2000 1.87
20 Characterization of the immature secretory granule, an intermediate in granule biogenesis. J Cell Biol 1991 1.87
21 XL alpha s is a new type of G protein. Nature 1995 1.82
22 Secretory granule biogenesis: rafting to the SNARE. Trends Cell Biol 2001 1.73
23 Synaptophysin and chromogranins/secretogranins--widespread constituents of distinct types of neuroendocrine vesicles and new tools in tumor diagnosis. Virchows Arch B Cell Pathol Incl Mol Pathol 1989 1.73
24 Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division. Proc Natl Acad Sci U S A 1999 1.73
25 Protein secretion: puzzling receptors. Curr Biol 1997 1.71
26 Loss of occludin and functional tight junctions, but not ZO-1, during neural tube closure--remodeling of the neuroepithelium prior to neurogenesis. Dev Biol 1996 1.69
27 Determination and occurrence of tyrosine O-sulfate in proteins. Methods Enzymol 1984 1.68
28 Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane. EMBO J 1991 1.63
29 The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation. J Biol Chem 1989 1.60
30 The primary structure of bovine chromogranin A: a representative of a class of acidic secretory proteins common to a variety of peptidergic cells. EMBO J 1986 1.52
31 Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. Proc Natl Acad Sci U S A 1998 1.51
32 A role for phosphatidylinositol transfer protein in secretory vesicle formation. Nature 1995 1.50
33 Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usage. EMBO J 2001 1.48
34 Requirement for GTP hydrolysis in the formation of secretory vesicles. Nature 1990 1.47
35 Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation. EMBO J 1992 1.46
36 Synaptic vesicle biogenesis. Annu Rev Cell Dev Biol 1999 1.46
37 Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin. Proc Natl Acad Sci U S A 1984 1.46
38 Synaptic-like microvesicles of neuroendocrine cells originate from a novel compartment that is continuous with the plasma membrane and devoid of transferrin receptor. J Cell Biol 1997 1.44
39 Tyrosine sulfation: a post-translational modification of proteins destined for secretion? FEBS Lett 1984 1.41
40 Selective storage of acetylcholine, but not catecholamines, in neuroendocrine synaptic-like microvesicles of early endosomal origin. Neuron 1993 1.40
41 An antibody against secretogranin I (chromogranin B) is packaged into secretory granules. J Cell Biol 1989 1.40
42 (Glu62, Ala30, Tyr8)n serves as high-affinity substrate for tyrosylprotein sulfotransferase: a Golgi enzyme. Proc Natl Acad Sci U S A 1985 1.39
43 Cholesterol is required for the formation of regulated and constitutive secretory vesicles from the trans-Golgi network. Traffic 2000 1.39
44 Purification and characterization of tyrosylprotein sulfotransferase. EMBO J 1990 1.35
45 Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles. Curr Opin Cell Biol 1993 1.32
46 The major tyrosine-sulfated protein of the bovine anterior pituitary is a secretory protein present in gonadotrophs, thyrotrophs, mammotrophs, and corticotrophs. J Cell Biol 1985 1.32
47 Sulfation of Tyr1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von Willebrand factor. J Biol Chem 1991 1.32
48 Tyrosine sulfation of yolk proteins 1, 2, and 3 in Drosophila melanogaster. J Biol Chem 1985 1.29
49 Monensin and brefeldin A differentially affect the phosphorylation and sulfation of secretory proteins. J Biol Chem 1992 1.27
50 Characterization of the extra-large G protein alpha-subunit XLalphas. I. Tissue distribution and subcellular localization. J Biol Chem 2000 1.22
51 The primary structure of human chromogranin A and pancreastatin. J Biol Chem 1987 1.22
52 Trimeric G-proteins of the trans-Golgi network are involved in the formation of constitutive secretory vesicles and immature secretory granules. FEBS Lett 1991 1.22
53 Inhibition of N-glycosylation induces tyrosine sulphation of hybridoma immunoglobulin G. EMBO J 1984 1.21
54 Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans-Golgi network causes its missorting to the constitutive secretory pathways. EMBO J 1993 1.20
55 Characterization of the extra-large G protein alpha-subunit XLalphas. II. Signal transduction properties. J Biol Chem 2000 1.18
56 Nomenclature of prominin-1 (CD133) splice variants - an update. Tissue Antigens 2007 1.17
57 Morphological and biochemical evidence showing neuronal properties in AtT-20 cells and their growth cones. Eur J Cell Biol 1989 1.12
58 Chromogranin B (secretogranin I), a secretory protein of the regulated pathway, is also present in a tightly membrane-associated form in PC12 cells. J Biol Chem 1992 1.12
59 Trimeric G proteins and vesicle formation. Trends Cell Biol 1992 1.12
60 Nature of sulphated macromolecules in mouse Reichert's membrane. Evidence for tyrosine O-sulphate in basement-membrane proteins. Biochem J 1985 1.11
61 Selective localization of the polytopic membrane protein prominin in microvilli of epithelial cells - a combination of apical sorting and retention in plasma membrane protrusions. J Cell Sci 1999 1.10
62 Differential extraction of proteins from paraformaldehyde-fixed cells: lessons from synaptophysin and other membrane proteins. Methods 1998 1.08
63 The disulfide-bonded loop of chromogranin B mediates membrane binding and directs sorting from the trans-Golgi network to secretory granules. EMBO J 1999 1.07
64 Chromogranin B (secretogranin I) promotes sorting to the regulated secretory pathway of processing intermediates derived from a peptide hormone precursor. Proc Natl Acad Sci U S A 1996 1.07
65 Cell-free sulfation of the contact site A glycoprotein of Dictyostelium discoideum and of a partially glycosylated precursor. J Biol Chem 1985 1.07
66 Involvement of the membrane lipid bilayer in sorting prohormone convertase 2 into the regulated secretory pathway. Biochem J 2000 1.06
67 Biogenesis of synaptic-like microvesicles in perforated PC12 cells. Methods 1998 1.05
68 Brefeldin A inhibits the formation of constitutive secretory vesicles and immature secretory granules from the trans-Golgi network. Eur J Cell Biol 1992 1.04
69 Essential role of the disulfide-bonded loop of chromogranin B for sorting to secretory granules is revealed by expression of a deletion mutant in the absence of endogenous granin synthesis. J Cell Biol 1998 1.04
70 Ephrin B1 is expressed on neuroepithelial cells in correlation with neocortical neurogenesis. J Neurosci 2001 1.04
71 Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein. Biochem Biophys Res Commun 2001 1.03
72 Cell-free formation of immature secretory granules and constitutive secretory vesicles from trans-Golgi network. Methods Enzymol 1992 1.02
73 An elevation of cytosolic protein phosphorylation modulates trimeric G-protein regulation of secretory vesicle formation from the trans-Golgi network. J Biol Chem 1994 1.00
74 The mesh hypothesis of Golgi dynamics. Nat Cell Biol 1999 0.99
75 Cell biology. Snappy exocytoxins. Nature 1993 0.99
76 Analysis of the substrate specificity of tyrosylprotein sulfotransferase using synthetic peptides. J Biol Chem 1990 0.99
77 In vivo sulfation of the contact site A glycoprotein of Dictyostelium discoideum. EMBO J 1983 0.98
78 Distribution of chromogranin A and secretogranin I (chromogranin B) in neuroendocrine cells and tumors. Am J Pathol 1988 0.98
79 Chromogranin A and pancreastatin. Nature 1987 0.97
80 Protein tyrosine sulfation, 1993--an update. Chem Biol Interact 1994 0.96
81 The disulfide-bonded loop of chromogranins, which is essential for sorting to secretory granules, mediates homodimerization. J Biol Chem 1998 0.95
82 Overall lack of regulated secretion in a PC12 variant cell clone. J Biol Chem 1996 0.94
83 A nomenclature proposal for the chromogranin/secretogranin proteins. Neuroscience 1987 0.93
84 A role for ADP-ribosylation factor 1, but not COP I, in secretory vesicle biogenesis from the trans-Golgi network. FEBS Lett 1996 0.92
85 Neurosecretory vesicles can be hybrids of synaptic vesicles and secretory granules. Proc Natl Acad Sci U S A 1995 0.92
86 Protein and lipid sorting from the trans-Golgi network to secretory granules-recent developments. Semin Cell Dev Biol 1998 0.91
87 Identification of gastroenteropancreatic neuroendocrine cells in normal and neoplastic human tissue with antibodies against synaptophysin, chromogranin A, secretogranin I (chromogranin B), and secretogranin II. Gastroenterology 1988 0.91
88 The organisation of the mouse chromogranin B (secretogranin I) gene. FEBS Lett 1990 0.90
89 Neuroepithelial cells downregulate their plasma membrane polarity prior to neural tube closure and neurogenesis. Mech Dev 1997 0.90
90 Inhibition of tyrosine sulfation in the trans-Golgi retards the transport of a constitutively secreted protein to the cell surface. J Cell Biol 1988 0.90
91 AC133 hematopoietic stem cell antigen: human homologue of mouse kidney prominin or distinct member of a novel protein family? Blood 1998 0.89
92 Long-term perfusion of the isolated rat liver: maintenance of its functional state by use of a fluorocarbon emulsion. Biochim Biophys Acta 1974 0.89
93 The disulfide bond in chromogranin B, which is essential for its sorting to secretory granules, is not required for its aggregation in the trans-Golgi network. FEBS Lett 1994 0.88
94 Chromogranin B (secretogranin I), a neuroendocrine-regulated secretory protein, is sorted to exocrine secretory granules in transgenic mice. EMBO J 1998 0.88
95 Cooperativity of phosphatidylinositol transfer protein and phospholipase D in secretory vesicle formation from the TGN--phosphoinositides as a common denominator? FEBS Lett 1997 0.87
96 Argyrophilic carcinoma of the male breast. A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I). Am J Surg Pathol 1991 0.87
97 Direct photoaffinity labeling of proteins with adenosine 3'-[32P]phosphate 5'-phosphosulfate. Atractyloside inhibits labeling of a Mr = 34,000 protein in an adrenal medullary Golgi fraction. J Biol Chem 1984 0.87
98 Co-localization of secretogranins/chromogranins with thyrotropin and luteinizing hormone in secretory granules of cow anterior pituitary. J Histochem Cytochem 1990 0.87
99 Expression of the extra-large G protein alpha-subunit XLalphas in neuroepithelial cells and young neurons during development of the rat nervous system. Neurosci Lett 2001 0.87
100 Two membrane-bound forms of tyrosylprotein sulfotransferase as revealed by phase partitioning in Triton X-114. Eur J Cell Biol 1992 0.86
101 Occurrence of tyrosine sulfate in proteins--a balance sheet. 1. Secretory and lysosomal proteins. Eur J Biochem 1990 0.86
102 Peptides derived from the granins (chromogranins/secretogranins). Biochimie 1994 0.86
103 Widespread occurrence of chromogranins/secretogranins in the matrix of secretory granules of endocrinologically silent pituitary adenomas. J Histochem Cytochem 1992 0.85
104 Biogenesis of small synaptic vesicles and synaptic-like microvesicles. Neurochem Res 1993 0.85
105 What the granins tell us about the formation of secretory granules in neuroendocrine cells. Cell Biophys 1993 0.85
106 Sulfation of two tyrosine-residues in human complement S-protein (vitronectin). Eur J Biochem 1989 0.85
107 Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferases. J Biol Chem 1990 0.84
108 Interaction of hydrocortisone and dibutyryl cyclic AMP in the induction of tyrosine amino-transferase and phosphoenolpyruvate carboxy-kinase in rat liver. FEBS Lett 1974 0.84
109 The organisation of the mouse secretogranin II gene. FEBS Lett 1992 0.84
110 In vivo expression and stoichiometric sulfation of the artificial protein sulfophilin, a polymer of tyrosine sulfation sites. J Biol Chem 1992 0.83
111 Regulation of chromogranin B/secretogranin I and secretogranin II storage in GH4C1 cells. J Histochem Cytochem 1990 0.82
112 Expression, tyrosine sulfation, and secretion of yolk protein 2 of Drosophila melanogaster in mouse fibroblasts. J Biol Chem 1988 0.82
113 Purification of yolk protein 2 of Drosophila melanogaster and identification of its site of tyrosine sulfation. J Biol Chem 1988 0.82
114 Biogenesis of secretory granules and synaptic vesicles. Facts and hypotheses. Ann N Y Acad Sci 1994 0.81
115 A Mr 70,000 phosphoprotein of sympathetic neurons regulated by nerve growth factor and by depolarization. J Biol Chem 1984 0.81
116 Neuroendocrine cell type-specific and inducible expression of the chromogranin B gene: crucial role of the proximal promoter. Endocrinology 2000 0.81
117 Occurrence of tyrosine sulfate in proteins--a balance sheet. 2. Membrane proteins. Eur J Biochem 1990 0.81
118 Expression of chromogranin A mRNA in small cell carcinoma of the lung. J Pathol 1991 0.80
119 Differential regulation of chromogranin B/secretogranin I and secretogranin II by forskolin in PC12 cells. Brain Res Mol Brain Res 1992 0.80
120 Subcellular localization of secretogranin II and synaptophysin by immunoelectron microscopy in differentiated hypothalamic neurons in culture. J Histochem Cytochem 1991 0.79
121 Immunohistochemical localization of secretogranin II in the rat cerebellum. Neuroscience 1989 0.79
122 Dispersion of chromogranin/secretogranin secretory protein family loci in mammalian genomes. Genomics 1996 0.79
123 Neuroendocrine cell type-specific and inducible expression of the secretogranin II gene: crucial role of cyclic adenosine monophosphate and serum response elements. Endocrinology 1999 0.79
124 Neurochemical and morphological studies of bulk-isolated rat brain cells. I. A new approach to the preparation of cerebral neurones. Hoppe Seylers Z Physiol Chem 1977 0.79
125 Sulfated oligosaccharides in human lysosomal enzymes. Biochem Biophys Res Commun 1987 0.79
126 Induction of rat liver phosphoenolpyruvate carbonxykinase (GTP) by cyclic AMP during starvation. The permissive action of glucocorticoids. Biochim Biophys Acta 1976 0.78
127 Synaptotagmin I- and II-deficient PC12 cells exhibit calcium-independent, depolarization-induced neurotransmitter release from synaptic-like microvesicles. FEBS Lett 1995 0.78
128 Subcellular distribution of secretogranins I and II in GH3 rat tumoral prolactin (PRL) cells as revealed by electron microscopic immunocytochemistry. J Histochem Cytochem 1989 0.78
129 Methyltransferase inhibitors block NGF-regulated survival and protein phosphorylation in sympathetic neurons. EMBO J 1986 0.78
130 Quantal neurotransmitter release from early endosomes? Trends Cell Biol 1994 0.77
131 Stimulation by 6-N,2'-O-dibutyryladenosine 3' :5'-cyclic monophosphate and glucocorticoids of phosphoenolpyruvate carboxykinase in the isolated perfused rat liver. Biochem J 1974 0.77
132 Induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase in the isolated perfused rat liver: interaction of dexamethasone and dibutyryl cyclic AMP. FEBS Lett 1975 0.77
133 The primary structure of rat secretogranin II deduced from a cDNA sequence. Nucleic Acids Res 1988 0.77
134 Neurochemical and morphological studies of bulk isolated rat brain cells. II. Preparation of viable cerebral neurons which retain synaptic complexes. Brain Res 1979 0.76
135 Phosphorylation of an 85-kd membrane protein by a novel mechanism. EMBO J 1988 0.75
136 Expression of tyrosine-sulfated secretory proteins in Xenopus laevis oocytes. Differential export of constitutive and regulated proteins. Eur J Biochem 1996 0.75
137 Effect of cold exposure on phosphoenolpyruvate carboxykinase (GTP) activity and cyclic amp concentration in livers of starved rats. Role of glucorticoids. Biochim Biophys Acta 1976 0.75
138 Maintenance and regeneration in vitro of bulk-isolated cortical neurones from adult rats. Hoppe Seylers Z Physiol Chem 1978 0.75
139 Secretogranin I (chromogranin B) mRNA accumulation is hormonally regulated in GH3B6 rat pituitary tumor cells. Mol Cell Endocrinol 1991 0.75