Published in Toxicol Appl Pharmacol on January 01, 1981
Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol (2007) 1.54
Enzymatic synthesis of D(-)-alpha-aminobenzylpenicillin by Kluyvera citrophila. J Antibiot (Tokyo) (1971) 1.33
Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Br J Pharmacol (1999) 1.28
A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-covalent van der Waals contacts dominant in the non-covalent CC-1065/B-DNA binding. Chem Biol Interact (1990) 1.24
Siderochrome production by Yersinia pestis and its relation to virulence. Infect Immun (1975) 1.13
Interaction of spleen and thymic cells in vitro. Int Arch Allergy Appl Immunol (1969) 1.10
Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit. Proc Natl Acad Sci U S A (1991) 1.05
Isolation and characterization of Streptomyces venezuelae mutants blocked in chloramphenicol biosynthesis. J Gen Microbiol (1985) 1.05
The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference. Jpn J Pharmacol (1992) 1.05
Mecamylamine-precipitated nicotine-withdrawal aversion in rats. Eur J Pharmacol (1996) 1.04
A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer. Cancer Gene Ther (2010) 1.03
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole. Food Chem Toxicol (2002) 1.00
Buprenorphine exerts its antinociceptive activity via mu 1-opioid receptors. Life Sci (1995) 1.00
Treatment of colonic post-polypectomy bleeding site by endoscopic band ligation. Gastrointest Endosc (1994) 1.00
The isolation of polyadenylate with unreacted cellulose. Biochem Biophys Res Commun (1972) 1.00
Global estimates of acute pesticide morbidity and mortality. Rev Environ Contam Toxicol (1992) 0.99
Comprehensive diagnostic ability of endocytoscopy compared with biopsy for colorectal neoplasms: a prospective randomized noninferiority trial. Endoscopy (2013) 0.99
Mecamylamine-precipitated nicotine-withdrawal aversion in Lewis and Fischer 344 inbred rat strains. Eur J Pharmacol (1999) 0.98
Different roles of mu-, delta- and kappa-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress. Eur J Pharmacol (1999) 0.96
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Flavor and Extract Manufacturers Association. Food Chem Toxicol (2002) 0.96
The role of time as a quantifiable variable of toxicity and the experimental conditions when Haber's c x t product can be observed: implications for therapeutics. J Pharmacol Exp Ther (2001) 0.96
Blockade of morphine reward through the activation of kappa-opioid receptors in mice. Neuropharmacology (1993) 0.95
Negative C-reactive protein in children with bacterial infection. Pediatr Int (1999) 0.95
Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice. Life Sci (2000) 0.94
Environmental effects on the polysome content of artificially cultured mouse cells. Exp Cell Res (1968) 0.94
Peroral endoscopic myotomy (POEM) in a 3-year-old girl with severe growth retardation, achalasia, and Down syndrome. Endoscopy (2012) 0.94
The FEMA GRAS assessment of alicyclic substances used as flavour ingredients. Food Chem Toxicol (1996) 0.93
Increased synthesis of ajmalicine and catharanthine by cell suspension cultures of Catharanthus roseus in response to fungal culture-filtrates. Appl Biochem Biotechnol (1987) 0.93
Estimating the number of viable animal cells in multi-well cultures based on their lactate dehydrogenase activities. Cytotechnology (2000) 0.93
Quantitation of immediate hypersensitivity in various mouse strains. Int Arch Allergy Appl Immunol (1971) 0.92
Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice. Inflamm Res (2009) 0.92
Designing a biological monitoring program to assess community exposure to chromium: conclusions of an expert panel. J Toxicol Environ Health (1993) 0.92
Involvement of the opioid system in the anxiolytic effect of diazepam in mice. Eur J Pharmacol (1996) 0.91
The FEMA GRAS assessment of trans-anethole used as a flavouring substance. Flavour and Extract Manufacturer's Association. Food Chem Toxicol (1999) 0.91
Increased accumulation of indole alkaloids by some cell lines of Catharanthus roseus in response to addition of vanadyl sulphate. Plant Cell Rep (1987) 0.91
Diazepam pretreatment suppresses morphine withdrawal signs in the mouse. Life Sci (1996) 0.90
Oxidative stress levels in myelodysplastic syndrome patients: their relationship to serum ferritin and haemoglobin values. J Int Med Res (2011) 0.90
Dose and time as variables of toxicity. Toxicology (2000) 0.90
Factors affecting the production of glutamine in cultured mouse cells. J Cell Physiol (1971) 0.90
Identification of serine esterases in tissue homogenates. Anal Biochem (1999) 0.89
Genetic differences in preferences for morphine and codeine in Lewis and Fischer 344 inbred rat strains. Jpn J Pharmacol (1988) 0.89
Effects of Y-27632 on acetylcholine-induced contraction of intact and permeabilized intrapulmonary bronchial smooth muscles in rats. Eur J Pharmacol (2001) 0.89
Antitussive effects of naltrindole, a selective delta-opioid receptor antagonist, in mice and rats. Eur J Pharmacol (1993) 0.89
Alteration in Ca2+ availability involved in antigen-induced airway hyperresponsiveness in rats. Eur J Pharmacol (1995) 0.89
Human exposure to dioxins from food, 1999-2002. Food Chem Toxicol (2005) 0.88
Pentazocine-induced biphasic analgesia in mice. Life Sci (1991) 0.88
Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones. J Med Chem (1987) 0.88
Involvement of mu-opioid receptor in the salsolinol-associated place preference in rats exposed to conditioned fear stress. Alcohol Clin Exp Res (2000) 0.88
Conditioned fear stress induces ethanol-associated place preference in rats. Eur J Pharmacol (1998) 0.87
Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine. Life Sci (1996) 0.87
Involvement of mu- and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress. Brain Res (1998) 0.87
Alkaloid Production in Root and Shoot Cultures of Catharanthus roseus. Planta Med (1987) 0.87
Acute toxicity of benzene inhalation to hemopoietic precursor cells. Toxicol Appl Pharmacol (1977) 0.87
A toxicologist's view of cancer risk assessment. Drug Metab Rev (1996) 0.87
Characteristics of muscarinic cholinoceptors in airways of antigen-induced airway hyperresponsive rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol (1995) 0.86
[Proposals for innovative pharmacology education from the perspective of several fields--in response to rapidly changing times]. Nihon Yakurigaku Zasshi (2000) 0.86
Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice. Life Sci (1997) 0.86
Differential sensitivity to physical dependence on morphine and codeine in three inbred strains of mice. Jpn J Pharmacol (1991) 0.86
Treatment of nitrite-induced methemoglobinemia with hyperbaric oxygen. Proc Soc Exp Biol Med (1971) 0.86
Effects of differential modulation of mu-, delta- and kappa-opioid systems on bicuculline-induced convulsions in the mouse. Brain Res (2000) 0.86
Hyperresponsiveness of bronchial but not tracheal smooth muscle in a murine model of allergic bronchial asthma. Inflamm Res (2004) 0.86
Enhanced Ca2+ sensitization of the bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Res Commun Mol Pathol Pharmacol (1999) 0.86
A study of mixed cell interactions between sensitized and allogeneic mouse spleen cells in vitro using the hemolytic plaque assay. J Immunol (1971) 0.86
A new pharyngitis model using capsaicin in rats. Gen Pharmacol (1998) 0.86
Potentiation of pentazocine conditioned place preference by tripelennamine in rats. Psychopharmacology (Berl) (1991) 0.86
Drug interactions in the reinforcing effects of over-the-counter cough syrups. Psychopharmacology (Berl) (1990) 0.86
Differential modification of the rewarding effects of methamphetamine and cocaine by opioids and antihistamines. Psychopharmacology (Berl) (1993) 0.85
Plant cell and tissue culture: alternatives for metabolite production. Biotechnol Adv (1995) 0.84
Role of central ATP-sensitive potassium channels in the analgesic effect and spinal noradrenaline turnover-enhancing effect of intracerebroventricularly injected morphine in mice. Brain Res (1992) 0.84
Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine. Eur J Pharmacol (1992) 0.84
Effects of the 5-HT(3) receptor antagonist ondansetron on the ketamine- and dizocilpine-induced place preferences in mice. Eur J Pharmacol (1999) 0.84
Cellular uptake and inhibition of DNA synthesis by dihydroxyanthraquinone and two analogues. Cancer Res (1983) 0.84
10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase. Bioorg Med Chem (1997) 0.84
Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats. Br J Pharmacol (2001) 0.84
Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit. Bioorg Med Chem (1993) 0.84
Occupational exposure limits for 30 organophosphate pesticides based on inhibition of red blood cell acetylcholinesterase. Toxicology (2000) 0.83
Colony formation in vitro by leukemic cells in acute lymphoblastic leukemia (ALL). Blood (1978) 0.83
Ethanol, but not the anxiolytic drugs buspirone and diazepam, produces a conditioned place preference in rats exposed to conditioned fear stress. Pharmacol Biochem Behav (2000) 0.83
Effect of the highly selective and nonpeptide delta opioid receptor agonist TAN-67 on the morphine-induced place preference in mice. J Pharmacol Exp Ther (1996) 0.83
Role of beta-adrenoceptors in the expression of morphine withdrawal signs. Life Sci (1994) 0.83
Effects of rimcazole, a specific antagonist of sigma sites, on the antitussive effects of non-narcotic antitussive drugs. Eur J Pharmacol (1993) 0.83
Attenuation of mecamylamine-precipitated nicotine-withdrawal aversion by the 5-HT3 receptor antagonist ondansetron. Life Sci (1997) 0.83
Genetic differences in the development of physical dependence upon diazepam in Lewis and Fischer 344 inbred rat strains. Pharmacol Biochem Behav (1992) 0.82
Antisense oligodeoxynucleotide to delta opioid receptors attenuates morphine dependence in mice. Life Sci (1997) 0.82
The role of delta-opioid receptors in the discriminative stimulus properties of a low dose of methamphetamine. Eur J Pharmacol (1997) 0.82
Possible involvement of mu 2-mediated mechanisms in mu-mediated antitussive activity in the mouse. Neurosci Lett (1993) 0.82
Antitussive effect of dihydroetorphine in mice. Eur J Pharmacol (1994) 0.81
Teratogenic effects of cholinergic insecticides in chick embryos. III. Development of cartilage and bone. J Toxicol Environ Health (1983) 0.81
Paracelsus, Haber and Arndt. Toxicology (2001) 0.81
Effects of kappa-agonist on the antinociception and locomotor enhancing action induced by morphine in mice. Jpn J Pharmacol (1993) 0.81
Elevated nitric oxide synthase activity concurrent with antigen-induced airway hyperresponsiveness in rats. Exp Lung Res (2001) 0.81
Inhibition of DNA synthesis in permeabilized L cells by novobiocin. Biochem Biophys Res Commun (1982) 0.81
Antibody transport in cultured tumor cell layers. J Control Release (1998) 0.81
Involvement of dopamine-dependent and -independent mechanisms in the rewarding effects mediated by delta opioid receptor subtypes in mice. Brain Res (1997) 0.81
Gq protein level increases concurrently with antigen-induced airway hyperresponsiveness in rats. Respir Physiol (2000) 0.81
Immunohistochemical demonstration of nonspecific cross-reacting antigen in normal and neoplastic human tissues using a monoclonal antibody. Comparison with carcinoembryonic antigen localization. Acta Pathol Jpn (1990) 0.81
Blockade of delta-opioid receptors prevents morphine-induced place preference in mice. Jpn J Pharmacol (1994) 0.81
In vitro differentiation of murine Sca-1+Lin- cells into myeloid, B cell and T cell lineages. Stem Cells (1996) 0.81
The role of the mu 2-opioid receptor in the antitussive effect of morphine in mu 1-opioid receptor-deficient CXBK mice. Eur J Pharmacol (1993) 0.81