Published in Circ Res on October 01, 1984
Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence. Biophys J (1990) 1.07
Tonic and phasic block of neuronal sodium currents by 5-hydroxyhexano-2',6'-xylide, a neutral lidocaine homologue. J Gen Physiol (1989) 0.94
Properties of the block of single Na+ channels in guinea-pig ventricular myocytes by the local anaesthetic penticainide. J Physiol (1989) 0.88
The thermodynamics of general and local anesthesia. Biophys J (2014) 0.77
Clinical judgment and statistics. Lessons from a simulated randomized trial in coronary artery disease. Circulation (1980) 7.96
Analysis of categorical data by linear models. Biometrics (1969) 7.85
Quality of life and clinical outcomes in elderly patients treated with ventricular pacing as compared with dual-chamber pacing. Pacemaker Selection in the Elderly Investigators. N Engl J Med (1998) 4.22
Catheter technique for closed-chest ablation of the atrioventricular conduction system. N Engl J Med (1982) 2.62
A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes. J Physiol (1997) 2.60
Evidence of a selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias. N Engl J Med (1991) 2.44
Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics. Biophys J (1984) 2.33
Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols. J Gen Physiol (1996) 2.24
Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol (1995) 2.15
Electrophysiologial and beta-receptor blocking effects of MJ 1999 on dog and rabbit cardiac tissue. Circ Res (1970) 1.96
Distinct transient outward potassium current (Ito) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J Gen Physiol (1999) 1.86
Premature atrial stimulation as a key to the understanding of sinoatrial conduction in man. Presentation of data and critical review of the literature. Circulation (1973) 1.85
Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. Circ Res (2000) 1.82
A sensitivity analysis of enzymatic estimation of infarct size. Circulation (1975) 1.77
C-type inactivation controls recovery in a fast inactivating cardiac K+ channel (Kv1.4) expressed in Xenopus oocytes. J Physiol (1995) 1.67
Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. Circulation (1990) 1.60
The nature of treatment selection in coronary artery disease. Experience with medical and surgical treatment of a chronic disease. Circulation (1974) 1.59
Altering the topology of gap junctions a major therapeutic target for atrial fibrillation. Cardiovasc Res (1995) 1.58
The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. I. Basic characterization and kinetic analysis. J Gen Physiol (1993) 1.56
A new information system for medical practice. Arch Intern Med (1975) 1.55
Antiarrhythmic drug action. Blockade of the inward sodium current. Circ Res (1984) 1.55
Radioimmunoassay of iodinated gentamicin. Clin Chim Acta (1976) 1.54
Modulation of HERG affinity for E-4031 by [K+]o and C-type inactivation. FEBS Lett (1997) 1.51
Immunologic biomarkers associated with an acute exposure to exothermic byproducts of a ureaformaldehyde spill. Environ Health Perspect (1991) 1.49
Electric shock hazards in clinical cardiology. Mod Concepts Cardiovasc Dis (1967) 1.46
A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. J Biol Chem (1995) 1.45
Time, voltage and ionic concentration dependence of rectification of h-erg expressed in Xenopus oocytes. FEBS Lett (1996) 1.45
Cloning and characterization of an Ito-like potassium channel from ferret ventricle. Am J Physiol (1994) 1.42
Use of ionic currents to identify and estimate parameters in models of channel blockade. Am J Physiol (1990) 1.40
Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cells. Am J Physiol (1998) 1.40
Electric shock hazards in radiology departments. Am J Roentgenol Radium Ther Nucl Med (1965) 1.39
Radioimmunoassay of iodinated tobramycin. Antimicrob Agents Chemother (1976) 1.38
Role of alpha-adrenoceptors in constrictor responses of rat, guinea-pig and rabbit small arteries to neural activation. J Physiol (1988) 1.36
Intracellular calcium, currents, and stimulus-response coupling in endothelial cells. Hypertension (1993) 1.35
Inactivation of voltage-gated cardiac K+ channels. Circ Res (1998) 1.33
Phasic ion channel blockade. A kinetic model and parameter estimation procedure. Mol Pharmacol (1985) 1.33
The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. II. Closed state reverse use-dependent block by 4-aminopyridine. J Gen Physiol (1993) 1.33
Role of Mahaim fibers in cardiac arrhythmias in man. Circulation (1981) 1.31
Pressure-flow studies in man. An evaluation of the duration of the phases of systole. J Clin Invest (1969) 1.30
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. J Clin Invest (1997) 1.27
Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysis. Circ Res (1987) 1.27
Indomethacin-induced intestinal inflammation. Am J Dig Dis (1977) 1.25
The electrophysiologic basis and management of symptomatic recurrent tachycardia in patients with Ebstein's anomaly of the tricuspid valve. Am J Cardiol (1982) 1.25
Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments. Circulation (1991) 1.23
Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor. Circ Res (1995) 1.21
Regulation of extracellular calcium entry in endothelial cells: role of intracellular calcium pool. Am J Physiol (1992) 1.21
Spurious hypertension in the obese patient. Effect of sphygmomanometer cuff size on prevalence of hypertension. Arch Intern Med (1984) 1.20
Blockade of cardiac sodium channels by lidocaine. Single-channel analysis. Circ Res (1989) 1.18
Optical measurements of transmembrane potential changes during electric field stimulation of ventricular cells. Circ Res (1993) 1.17
Activation and inactivation kinetics of an E-4031-sensitive current from single ferret atrial myocytes. Biophys J (1996) 1.16
Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs. Pacing Clin Electrophysiol (1995) 1.15
Ionic current mechanisms generating vertebrate primary cardiac pacemaker activity at the single cell level: an integrative view. Annu Rev Physiol (1992) 1.14
Cholinergic modulation of the coronary vasoconstriction induced by cocaine in conscious dogs. Circulation (1993) 1.13
Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation and atrial flutter: a dose-response study. J Am Coll Cardiol (1996) 1.12
In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ Res (1996) 1.12
A quantitative description of QX222 blockade of sodium channels in squid axons. Biophys J (1986) 1.12
Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells. Biophys J (2000) 1.11
Blockade of rabbit atrial sodium channels by lidocaine. Characterization of continuous and frequency-dependent blocking. Circ Res (1989) 1.08
Potassium channel of cardiac sarcoplasmic reticulum is a multi-ion channel. Biophys J (1989) 1.08
Digoxin Immune Fab therapy in the management of digitalis intoxication: safety and efficacy results of an observational surveillance study. J Am Coll Cardiol (1991) 1.08
Lidocaine blockade of continuously and transiently accessible sites in cardiac sodium channels. J Mol Cell Cardiol (1991) 1.07
Regional localization of ERG, the channel protein responsible for the rapid component of the delayed rectifier, K+ current in the ferret heart. Circ Res (1997) 1.06
Time- and voltage-dependent modulation of a Kv1.4 channel by a beta-subunit (Kv beta 3) cloned from ferret ventricle. Am J Physiol (1995) 1.05
Unitary sodium channels in isolated cardiac myocytes of rabbit. Circ Res (1983) 1.05
The course of acute myocardial infarction. Feasibility of early discharge of the uncomplicated patient. Circulation (1975) 1.04
Editorial: Data bank use in management of chronic disease. Comput Biomed Res (1974) 1.04
Theoretical study of the voltage and concentration dependence of the anomalous mole fraction effect in single calcium channels. New insights into the characterization of multi-ion channels. Biophys J (1988) 1.03
The report of the American Heart Association task force on strategies to increase federal research funding. Circulation (1990) 1.03
Electrophysiological properties of the rabbit sinoatrial perinodal fibers. Circ Res (1972) 1.03
Asymmetrical electrically induced injury of rabbit ventricular myocytes. J Mol Cell Cardiol (1995) 1.03
Analysis of secondary pauses following termination of rapid atrial pacing in man. Circulation (1976) 1.02
Late Na channels in cardiac cells: the physiological role of background Na channels. Biophys J (1994) 1.02
Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma. Circ Res (1995) 1.01
The relationship between enzymatic and histologic estimates of the extent of myocardial infarction in conscious dogs with permanent coronary occlusion. Circulation (1977) 1.00
Electrophysiologic evaluation of sinus node function in patients with sinus node dysfunction. Circulation (1976) 0.99
Theoretical characterization of ion channel blockade: ligand binding to periodically accessible receptors. J Theor Biol (1986) 0.99
Blockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugs. J Clin Invest (1992) 0.98
Modulation of L-type Ca2+ current by extracellular ATP in ferret isolated right ventricular myocytes. J Physiol (1993) 0.97
Na channel kinetics remain stable during perforated-patch recordings. Am J Physiol (1992) 0.97
Radioimmunoassay of sisomicin. Antimicrob Agents Chemother (1976) 0.97
Bleomycin pharmacokinetics in man. I. Intravenous administration. Cancer Chemother Pharmacol (1978) 0.96
The influence of pH on th electrophysiological effects of lidocaine in guinea pig ventricular myocardium. Circ Res (1980) 0.96
Measurement of sinoatrial conduction time by premature atrial stimulation in the rabbit. Circ Res (1974) 0.95
Safety of pacemaker implantation in patients with transvenous (nonthoracotomy) implantable cardioverter defibrillators. Pacing Clin Electrophysiol (1994) 0.95
Bi-stable block by 4-aminopyridine of a transient K+ channel (Kv1.4) cloned from ferret ventricle and expressed in Xenopus oocytes. J Physiol (1995) 0.95
Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias. Circulation (1995) 0.95