J P McKearn

Author PubWeight™ 49.35‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989 6.66
2 Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol 1990 5.26
3 Cellular and developmental properties of fetal hematopoietic stem cells. Cell 1990 2.83
4 Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population. Mol Cell Biol 1990 2.25
5 Interleukin-3 supports growth of mouse pre-B-cell clones in vitro. Nature 1984 1.76
6 Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors. Proc Natl Acad Sci U S A 1985 1.75
7 Phage display mutagenesis of the chimeric dual cytokine receptor agonist myelopoietin. Leukemia 2001 1.40
8 Mapping cell surface antigens on mouse pre-B cell lines. Eur J Immunol 1985 1.29
9 Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein. Proc Natl Acad Sci U S A 1989 1.29
10 B cell subsets and differential responses to mitogens. Immunol Rev 1982 1.26
11 Cell surface antigens expressed by subsets of pre-B cells and B cells. J Immunol 1984 1.26
12 Differentiation of murine B cell precursors in agar culture. Frequency, surface marker analysis and requirements for growth of clonable pre-B cells. Eur J Immunol 1984 1.18
13 Combination therapy for radiation-induced bone marrow aplasia in nonhuman primates using synthokine SC-55494 and recombinant human granulocyte colony-stimulating factor. Blood 1996 0.98
14 Biochemical and immunological properties of cytokines conjugated to dendritic polymers. Biomed Microdevices 2004 0.88
15 Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced bone marrow aplasia. Blood 1996 0.86
16 Ontogeny of murine B-cell responses to thymus-independent trinitrophenyl antigens. Cell Immunol 1979 0.86
17 Activation and growth of colony-stimulating factor-dependent cell lines is cell cycle stage dependent. J Exp Med 1987 0.86
18 The immune response in NZB mice of different ages to thymus-dependent and thymus-independent phosphorylcholine antigens. Immunology 1978 0.85
19 Monoclonal antibodies specific for novel murine cell surface markers define subpopulations of germinal center cells. Cell Immunol 1992 0.85
20 Polymorphism of Fc receptor on murine B cells is Igh-linked. J Exp Med 1985 0.84
21 B cell heterogeneity. I. A study of B cell subpopulations involved in the reconstitution of an X-linked immune defect of B cell differentiation. J Immunol 1979 0.84
22 Inhaled misoprostol blocks guinea pig antigen-induced bronchoconstriction and airway inflammation. Am J Respir Crit Care Med 1996 0.83
23 Myelopoietin, an engineered chimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression. Blood 2000 0.83
24 Transformation of B and non-B cell lines with the 2,4,6,-trinitrophenyl (TNP)-specific immunoglobulin genes. Eur J Immunol 1985 0.82
25 Leridistim, a chimeric dual G-CSF and IL-3 receptor agonist, enhances multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression: effect of schedule, dose, and route of administration. Stem Cells 2001 0.82
26 Delineation of tolerance-sensitive and tolerance-insensitive B cells in normal and immune defective mice. J Immunol 1980 0.81
27 Use of combinatorial mutagenesis to select for multiply substituted human interleukin-3 variants with improved pharmacologic properties. Exp Hematol 1999 0.80
28 Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. Proc Natl Acad Sci U S A 1995 0.80
29 Circular permutation of granulocyte colony-stimulating factor. Biochemistry 1999 0.79
30 The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling. J Biol Chem 1997 0.79
31 Progenipoietins: biological characterization of a family of dual agonists of fetal liver tyrosine kinase-3 and the granulocyte colony-stimulating factor receptor. Exp Hematol 2001 0.78
32 Idiotype-specific tolerance: preferential alteration of idiotype expression after neonatal exposure to tolerogen. J Immunol 1980 0.78
33 Cytokine production by T helper cell subpopulations during prolonged in vitro stimulation. Immunol Lett 1991 0.78
34 Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin. Biochemistry 1999 0.78
35 A single dose of pegylated leridistim significantly improves neutrophil recovery in sublethally irradiated rhesus macaques. Stem Cells 2001 0.77
36 Structure and expression of the T cell receptor gamma locus in pre-B and early hemopoietic cells. Eur J Immunol 1989 0.77
37 Secondary structure of human interleukin-3. Int J Biochem 1991 0.77
38 Phage presentation and affinity selection of a deletion mutant of human interleukin-3. Appl Biochem Biotechnol 1997 0.76
39 Progenipoietin-1: a multifunctional agonist of the granulocyte colony-stimulating factor receptor and fetal liver tyrosine kinase-3 is a potent mobilizer of hematopoietic stem cells. Exp Hematol 2001 0.76
40 Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally x-irradiated nonhuman primates. Exp Hematol 1999 0.75
41 Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells. Leukemia 2001 0.75
42 Receptor binding kinetics of human IL-3 variants with altered proliferative activity. Biochem Biophys Res Commun 2001 0.75
43 Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways. Exp Hematol 2001 0.75
44 Immune modifying effects of misoprostol and natural prostaglandins. Br J Rheumatol 1991 0.75
45 The dual regulatory role of interleukin 4 is mediated through a direct effect on the target cell. Exp Hematol 1990 0.75
46 Administration of daniplestim and granulocyte colony-stimulating factor for the mobilization of hematopoietic progenitor cells in nonhuman primates. Biol Blood Marrow Transplant 1999 0.75
47 Interleukin-3 and phorbol esters induce different patterns of immediate-early gene expression in an interleukin-3 dependent cell line. Oncogene Res 1991 0.75
48 The combined administration of daniplestim and Mpl ligand augments the hematopoietic reconstitution observed with single cytokine administration in a nonhuman primate model of myelosuppression. Stem Cells 1998 0.75
49 B-cell subsets: functional and structural characteristics. Crit Rev Immunol 1985 0.75
50 Promegapoietin-1a, an engineered chimeric IL-3 and Mpl-L receptor agonist, stimulates hematopoietic recovery in conventional and abbreviated schedules following radiation-induced myelosuppression in nonhuman primates. Stem Cells 2001 0.75
51 Modulation of the binding affinity of myelopoietins for the interleukin-3 receptor by the granulocyte colony-stimulating factor receptor agonist. Biochemistry 2001 0.75
52 The enhanced in vitro hematopoietic activity of leridistim, a chimeric dual G-CSF and IL-3 receptor agonist. Leukemia 2002 0.75