Interleukin 2 activity of human intestinal mucosa mononuclear cells. Decreased levels in inflammatory bowel disease.

PubWeight™: 1.49‹?› | Rank: Top 4%

🔗 View Article (PMID 6607860)

Published in Gastroenterology on April 01, 1984

Authors

C Fiocchi, M L Hilfiker, K R Youngman, N C Doerder, J H Finke

Articles citing this

Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens. Gut (1987) 2.44

Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease. Gut (1992) 1.68

Cytokine production in patients with inflammatory bowel disease. Gut (1992) 1.50

Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease. Clin Exp Immunol (1990) 1.16

Examination of the low proliferative capacity of human jejunal intraepithelial lymphocytes. Clin Exp Immunol (1986) 1.15

IL1beta- and LPS-induced serotonin secretion is increased in EC cells derived from Crohn's disease. Neurogastroenterol Motil (2008) 1.13

Plasma interleukin-2 and a soluble/shed interleukin-2 receptor in serum of patients with Crohn's disease. Effect of cyclosporin. Gut (1990) 1.06

Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn's disease and ulcerative colitis. Gut (2004) 1.04

Functional characteristics of intraepithelial lymphocytes from mouse small intestine. II. In vivo and in vitro responses of intraepithelial lymphocytes to mitogenic and allogeneic stimuli. Immunology (1986) 1.03

Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol (1993) 0.99

Functional characterization of Con A-responsive Lyt2-positive mouse small intestinal intraepithelial lymphocytes. Immunology (1986) 0.98

The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome. Clin Exp Immunol (2001) 0.93

The nature of the natural killer (NK) cell of human intestinal mucosa and mesenteric lymph node. Clin Exp Immunol (1985) 0.90

T cell receptor repertoire and mitotic responses of lamina propria T lymphocytes in inflammatory bowel disease. Clin Exp Immunol (1994) 0.87

Deficient interleukin 2 dependent proliferation pathway in T lymphocytes from active and inactive ulcerative colitis patients. Gut (1994) 0.86

IL-2 production by intestinal lamina propria cells in normal inflamed and cancer-bearing colons. Clin Exp Immunol (1992) 0.85

Cytotoxic activity of intestinal lamina propria lymphocytes on human immunodeficiency virus (HIV)-infected cells. Immunology (1992) 0.83

Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease. Gastroenterology (2012) 0.81

Effect of IL-2 on immunoregulatory function of intestinal lamina propria T cells in normal non-human primates. Clin Exp Immunol (1987) 0.79

Cytotoxic activity of human lymphocytes against differentiated intestinal tumour cell lines. Immunology (1993) 0.77

Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease. Gut (1989) 0.77

Interferon-alpha (IFN-alpha) production by human intestinal mononuclear cells. Response to virus in control subjects and in Crohn's disease. Gut (1992) 0.76

The role of cytokines in inflammatory bowel disease. Mediators Inflamm (1994) 0.75

Lymphocyte and macrophage interleukin receptors in inflammatory bowel disease: a more selective target for therapy? Gut (1994) 0.75

Articles by these authors

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol (1996) 6.21

Thymoma production of T cell growth factor (Interleukin 2). J Immunol (1980) 5.58

The biochemistry, biology, and role of interleukin 2 in the induction of cytotoxic T cell and antibody-forming B cell responses. Immunol Rev (1982) 4.43

Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. J Immunol (1995) 2.71

Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet (2001) 2.64

6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7. J Cell Biol (1998) 2.62

Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance. J Immunol (1999) 2.11

Review article: breath analysis in inflammatory bowel diseases. Aliment Pharmacol Ther (2014) 2.02

Macrophage-independent activation of helper T cells. I. Production of Interleukin 2. J Immunol (1980) 1.96

Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease. Gut (2001) 1.92

Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells. Gastroenterology (1993) 1.75

The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor. J Immunol (1998) 1.72

Biologic properties of chromatographically separated murine thymoma-derived Interleukin 2 and colony-stimulating factor. J Immunol (1981) 1.65

Gut mucosal lymphocytes in inflammatory bowel disease: isolation and preliminary functional characterization. Dig Dis Sci (1979) 1.60

Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients. Gut (2003) 1.56

Phorbol myristic acetate enhances the production of interleukin 2. Cell Immunol (1981) 1.54

Hierarchical cleavage of focal adhesion kinase by caspases alters signal transduction during apoptosis of intestinal epithelial cells. Gastroenterology (2001) 1.52

Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology (1997) 1.51

Endotoxin-induced T lymphocyte proliferation. J Immunol (1983) 1.51

Phenotypic analysis of lamina propria lymphocytes. Predominance of helper-inducer and cytolytic T-cell phenotypes and deficiency of suppressor-inducer phenotypes in Crohn's disease and control patients. Gastroenterology (1986) 1.50

Immunoregulatory function of human intestinal mucosa lymphoid cells: evidence for enhanced suppressor cell activity in inflammatory bowel disease. Gut (1983) 1.42

Selective resistance of mucosal T-cell activation to immunosuppression in Crohn's disease. Dig Liver Dis (2001) 1.39

Intestinal immunity and inflammation: recent progress. Gastroenterology (1986) 1.32

Splenic T-killer cells can be generated by allogeneic thymic cells in conjunction with assisting factor. Nature (1977) 1.32

Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity. Gastroenterology (1996) 1.31

Immunoregulatory function of lamina propria T cells in Crohn's disease. Gastroenterology (1985) 1.27

Interleukin 2 deficiency in murine Leishmaniasis donovani and its relationship to depressed spleen cell responses to phytohemagglutinin. J Immunol (1983) 1.25

Specific receptors for phorbol esters in lymphoid cell populations: role in enhanced production of T-cell growth factor. Proc Natl Acad Sci U S A (1981) 1.24

Interferon gamma production by human intestinal mucosal mononuclear cells. Decreased levels in inflammatory bowel disease. Dig Dis Sci (1988) 1.24

Adult murine lymph node cells respond blastogenically to a new differentiation antigen on isologous and autologous B lymphocytes. J Immunol (1975) 1.22

Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut (2007) 1.18

The CD40/CD40L costimulatory pathway in inflammatory bowel disease. Gut (2004) 1.18

Expression of HLA-DR antigens in inflammatory bowel disease mucosa: role of intestinal lamina propria mononuclear cell-derived interferon gamma. Dig Dis Sci (1988) 1.13

Generation of alloreactive cytotoxic T lymphocytes: evidence for a differentiation factor distinct from IL 2. J Immunol (1983) 1.12

CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria. J Immunol (1988) 1.11

New isolation technique to study apoptosis in human intestinal epithelial cells. Am J Pathol (1998) 1.10

Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells. Gastroenterology (1998) 1.10

Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells. Am J Physiol (1998) 1.10

Mechanisms of apoptosis in T cells from patients with renal cell carcinoma. Clin Cancer Res (1999) 1.09

Interferon gamma and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages. J Biol Chem (1990) 1.09

Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity. Gastroenterology (1985) 1.08

Antigen-nonspecific helper factors in the antibody response. Fed Proc (1982) 1.07

Loss of interleukin-2-producing intestinal CD4+ T cells in inflammatory bowel disease. Gastroenterology (1991) 1.07

Intestinal epithelial cells contribute to the enhanced generation of platelet activating factor in ulcerative colitis. Gut (1993) 1.07

Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease. Lancet (1998) 1.06

Intestinal immune reactivity to interleukin 2 differs among Crohn's disease, ulcerative colitis, and controls. Gastroenterology (1989) 1.05

Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn's disease and ulcerative colitis. Gut (2004) 1.04

Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide. J Neuroimmunol (1994) 1.03

Studies on isolated gut mucosal lymphocytes in inflammatory bowel disease. Detection of activated T cells and enhanced proliferation to Staphylococcus aureus and lipopolysaccharides. Dig Dis Sci (1981) 1.03

Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells. J Clin Invest (1999) 1.02

Critical role of the CD40 CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease. Gut (2007) 1.01

Amino acid position 11 of HLA-DRβ1 is a major determinant of chromosome 6p association with ulcerative colitis. Genes Immun (2011) 1.01

Responses of human intestinal microvascular endothelial cells to Shiga toxins 1 and 2 and pathogenesis of hemorrhagic colitis. Infect Immun (1999) 0.98

Placental mononuclear phagocytes as a source of interleukin-1. Science (1982) 0.97

Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species. J Immunol (1995) 0.97

Pathogenesis of inflammatory bowel disease. Curr Opin Gastroenterol (1999) 0.95

Transforming growth factor-beta1 preserves epithelial barrier function: identification of receptors, biochemical intermediates, and cytokine antagonists. J Cell Physiol (1999) 0.95

Alterations in NFkappaB activation in T lymphocytes of patients with renal cell carcinoma. J Natl Cancer Inst (1999) 0.94

Colonic vasoactive intestinal peptide nerves in inflammatory bowel disease. Gastroenterology (1992) 0.94

Successful treatment of congenital chylous ascites with a somatostatin analogue. Pediatr Surg Int (2013) 0.93

Dead or dying: necrosis versus apoptosis in caspase-deficient human renal cell carcinoma. Cancer Res (1999) 0.93

Caspase-dependent and -independent death pathways in cancer therapy. Apoptosis (2000) 0.92

Sensitization to epithelial antigens in chronic mucosal inflammatory disease. Characterization of human intestinal mucosa-derived mononuclear cells reactive with purified epithelial cell-associated components in vitro. J Clin Invest (1985) 0.92

Transcriptional regulation of the human polymeric immunoglobulin receptor gene by interferon-gamma. Mol Immunol (1997) 0.92

Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease. A molecular genetic evaluation of the immunoglobulin and T-cell antigen receptors. Gastroenterology (1988) 0.92

Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls. Neurogastroenterol Motil (2012) 0.91

Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes. Apoptosis (2001) 0.90

Regulation of life and death in lamina propria T cells. Semin Immunol (2001) 0.89

Regulation of ICAM-1-mediated fibroblast-T cell reciprocal interaction: implications for modulation of gut inflammation. Gastroenterology (1999) 0.89

Immune activation genes in inflammatory bowel disease. Gastroenterology (1993) 0.89

Defective granzyme B gene expression and lytic response in T lymphocytes infiltrating human renal cell carcinoma. J Immunother (1997) 0.88

Hypoproliferative human lamina propria T cells retain the capacity to secrete lymphokines when stimulated via CD2/CD28 pathways. Proc Assoc Am Physicians (1996) 0.88

Signal transduction abnormalities in T lymphocytes from patients with advanced renal carcinoma: clinical relevance and effects of cytokine therapy. Clin Cancer Res (1998) 0.88

Soluble interleukin 2 and CD8 and CD4 receptors in inflammatory bowel disease. Gastroenterology (1992) 0.86

IFN-gamma and IL-2 cooperatively activate NF kappa B in murine peritoneal macrophages. J Immunol (1992) 0.86

Generation of alloreactive cytotoxic T lymphocytes: production of T cell and macrophage helper factors in addition to IL 1 and IL 2 by peritoneal cells from mice immunized to Listeria monocytogenes. J Immunol (1981) 0.86

Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis. Oncogene (2012) 0.86

Reversal of phorbol ester-mediated reduction of cloned T lymphocyte cytolysis by interleukin 2. J Immunol (1985) 0.85

Clinical pharmacokinetics of nelfinavir combined with efavirenz and stavudine during rescue treatment of heavily pretreated HIV-infected patients. J Antimicrob Chemother (2000) 0.85

Soluble helper factor(s) participates in the generation of cell mediated cytotoxicity directed against syngeneic tumor cells. J Immunol (1979) 0.85

In vitro and ex vivo toxicological testing of sildenafil-loaded solid lipid nanoparticles. Inhal Toxicol (2013) 0.84

In vivo development of cytolytic T lymphocytes (CTL) to hapten-altered self: MIs-disparate cells facilitate the response by neutralizing IL 2 inhibitor. J Immunol (1983) 0.84

Tumor-induced dysfunction in interleukin-2 production and interleukin-2 receptor signaling: a mechanism of immune escape. Cancer J Sci Am (2000) 0.84

T-cell adoptive therapy of tumors: mechanisms of improved therapeutic performance. Crit Rev Immunol (2001) 0.84

Intrinsic hyperreactivity of mucosal T cells to interleukin-2 in pediatric Crohn's disease. J Pediatr (1998) 0.83

Chemokine gene expression in the murine renal cell carcinoma, RENCA, following treatment in vivo with interferon-alpha and interleukin-2. Am J Pathol (1994) 0.82

Interleukin 7 enhances the proliferation and effector function of tumor-infiltrating lymphocytes from renal-cell carcinoma. Int J Cancer (1993) 0.82

Isolation of human intestinal mucosal mononuclear cells. Curr Protoc Immunol (2001) 0.82

Identification of phorbol ester receptors in T-cell growth factor-producing and -nonproducing EL4 mouse thymoma cells. Cancer Res (1982) 0.82

Regulation by prostaglandin E2 of interleukin release by T lymphocytes in mucosa. J Cell Physiol (1996) 0.81

From immune activation to gut tissue injury: the pieces of the puzzle are coming together. Gastroenterology (1999) 0.81