Published in Can J Biochem on June 01, 1978
Obesity may be due to a malfunctioning of brown fat. Can Med Assoc J (1979) 1.72
GDP binding to brown-adipose-tissue mitochondria of diabetic--obese (db/db) mice. Decreased binding in both the obese and pre-obese states. Biochem J (1981) 1.20
The mitochondrial uncoupling protein from guinea-pig brown adipose tissue. Synchronous increase in structural and functional parameters during cold-adaptation. Biochem J (1984) 1.01
Evidence for unmasking of rat brown-adipose-tissue mitochondrial GDP-binding sites in response to acute cold exposure. Effects of washing with albumin on GDP binding. Biochem J (1986) 0.95
The effects of corticosterone, cold exposure and overfeeding with sucrose on brown adipose tissue of obese Zucker rats (fa/fa). Biochem J (1983) 0.91
Regulation of GDP binding and uncoupling-protein concentration in brown-adipose-tissue mitochondria. The effects of cold-acclimation, warm-reacclimation and noradrenaline. Biochem J (1988) 0.91
Evidence for decreased GDP binding to brown-adipose-tissue mitochondria of obese Zucker (fa/fa) rats in the very first days of life. Biochem J (1984) 0.90
Cold exposure induces different uncoupling-protein thermogenin masking/unmasking processes in brown adipose tissue depending on mitochondrial subtypes. Biochem J (1994) 0.88
Increase of uncoupling protein and its mRNA in brown adipose tissue of rats fed on 'cafeteria diet'. Biochem J (1985) 0.84
Evidence for masking of brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation. Effects of reversion to standard diet. Biochem J (1991) 0.83
Long photophase is not a sufficient stimulus to reduce thermogenic capacity in winter-acclimatized short-tailed field voles (Microtus agrestis) during long-term cold acclimation. J Comp Physiol B (1994) 0.80
Brown adipose tissue thermogenic responses of rats induced by central stimulation: effect of age and cold acclimation. J Physiol (1990) 0.80
Exercise during intermittent cold exposure prevents acclimation to cold rats. J Physiol (1987) 0.79
The influence of GDP on Ca2+ uptake by mitochondria of brown adipose tissue from lean and genetically obese (ob/ob) mice. Biochem J (1983) 0.77
Effects of hypothyroidism and hyperthyroidism on GDP binding to brown-adipocyte mitochondria from rats. Biochem J (1989) 0.76
Thermogenic and lipogenic activities in brown adipose tissue of I-strain mice. Biochem J (1985) 0.75
ATPase-inhibitor proteins of brown-adipose-tissue mitochondria from warm- and cold-acclimated rats. Biochem J (1992) 0.75
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature (1994) 7.86
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84
Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle? J Biol Chem (1982) 2.41
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Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem (1995) 2.27
Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria. J Biol Chem (1982) 1.92
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Sympathetic regulation of metabolism. Pharmacol Rev (1967) 1.73
Obesity may be due to a malfunctioning of brown fat. Can Med Assoc J (1979) 1.72
Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist. Biochem Pharmacol (1997) 1.64
Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J Biol Chem (1997) 1.53
Cellular thermogenesis. Annu Rev Physiol (1976) 1.46
A mitochondrial defect in brown adipose tissue of the obese (ob/ob) mouse: reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding. Biochem Biophys Res Commun (1978) 1.45
The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res (2001) 1.45
Liver mitochondria contain an ATP-dependent, vanadate-sensitive pathway for the degradation of proteins. Proc Natl Acad Sci U S A (1982) 1.36
On raising energy expenditure in ob/ob mice. Science (1997) 1.26
Thermogenesis in brown adipose tissue as an energy buffer. Implications for obesity. N Engl J Med (1984) 1.21
Food restriction increases torpor and improves brown adipose tissue thermogenesis in ob/ob mice. Am J Physiol (1985) 1.16
Brown adipose tissue metabolism and thermogenesis. Annu Rev Nutr (1985) 1.13
Roles of noradrenaline and protein synthesis in the cold-induced increase in purine nucleotide binding by rat brown adipose tissue mitochondria. Can J Biochem (1979) 1.11
Abnormal brown adipose tissue in obese (ob/ob) mice: response to acclimation to cold. Am J Physiol (1980) 1.10
Adrenergic receptors for metabolic responses in adipose tissue. Fed Proc (1970) 1.06
Lipid metabolism during cold-exposure and during cold-acclimation. Lipids (1972) 1.03
Brown adipose tissue in genetically obese (fa/fa) rats: response to cold and diet. Am J Physiol (1983) 1.01
Brown adipose tissue thermogenesis, torpor, and obesity of glutamate-treated mice. Am J Physiol (1986) 1.00
Role of thyroid hormone in cold-induced changes in rat brown adipose tissue mitochondria. Can J Biochem (1982) 0.98
Brown adipose tissue thermogenesis, energy balance, and obesity. Can J Biochem Cell Biol (1984) 0.97
Long-term decrease in body fat and in brown adipose tissue in capsaicin-desensitized rats. Am J Physiol (1992) 0.96
Unilaterality of the sympathetic innervation of each pad of rat interscapular brown adipose tissue. Can J Physiol Pharmacol (1982) 0.95
Mitochondrial thermogenin content is unchanged during atrophy of BAT of fasting mice. Am J Physiol (1985) 0.95
Raising at thermoneutrality prevents obesity and hyperphagia in BAT-ablated transgenic mice. Am J Physiol (1997) 0.94
Mitochondrial efficiency: lessons learned from transgenic mice. Biochim Biophys Acta (2001) 0.94
Temperature-dependent feeding: lack of role for leptin and defect in brown adipose tissue-ablated obese mice. Am J Physiol (1998) 0.92
Capsaicin desensitization induces atrophy of brown adipose tissue in rats. Am J Physiol (1990) 0.92
The ATP dependent pathway for protein breakdown in bacteria and mitochondria. Prog Clin Biol Res (1985) 0.90
Defective cold-induced stimulation of thyroxine 5'-deiodinase in brown adipose tissue of the genetically obese (ob/ob) mouse. Biochem Biophys Res Commun (1985) 0.89
Resistance to aging-associated obesity in capsaicin-desensitized rats one year after treatment. Obes Res (1995) 0.88
Overexpression of UCP-3 in skeletal muscle of mice results in increased expression of mitochondrial thioesterase mRNA. Biochem Biophys Res Commun (2001) 0.88
Differentiation-dependent expression of cathepsin D and importance of lysosomal proteolysis in the degradation of UCP1 in brown adipocytes. Can J Physiol Pharmacol (2002) 0.88
Selective loss of uncoupling protein from mitochondria of surgically denervated brown adipose tissue of cold-acclimated mice. Biochem Cell Biol (1986) 0.87
Parallel regression of cold-induced changes in ultrastructure, composition, and properties of brown adipose tissue mitochondria during recovery of rats from acclimation to cold. Can J Biochem (1980) 0.87
Structure of Cdc4p, a contractile ring protein essential for cytokinesis in Schizosaccharomyces pombe. J Biol Chem (2000) 0.87
Brown adipose tissue thermogenesis in obese animals. Nutr Rev (1983) 0.86
Regulation of metabolic processes in brown adipose tissue in relation to nonshivering thermogenesis. Adv Enzyme Regul (1970) 0.85
Increased sensitivity of the genetically obese mouse to corticosterone. Am J Physiol (1987) 0.85
Brown adipose tissue of rats with obesity-inducing ventromedial hypothalamic lesions. Am J Physiol (1982) 0.84
Brown adipose tissue of mice with gold thioglucose-induced obesity: effect of cold and diet. Am J Physiol (1983) 0.84
Neural influences on trophic changes in brown adipose tissue during cold acclimation. Am J Physiol (1988) 0.84
Attenuated cold-induced increase in mRNA for uncoupling protein in brown adipose tissue of obese (ob/ob) mice. Biochem Cell Biol (1988) 0.83
Defective brown adipose tissue thermogenesis in obese mice. Int J Obes (1985) 0.83
Glycerol metabolism in rabbits. Can J Biochem (1968) 0.83
The role of brown adipose tissue in the calorigenic effect of adrenaline and noradrenaline in cold-acclimated rats. J Physiol (1969) 0.82
Nonshivering thermogenesis. Brain Res Bull (1984) 0.82
Brown adipose tissue of cafeteria-fed rats. Am J Physiol (1981) 0.82
Cold-stimulated sympathetic activity in brown adipose tissue of obese (ob/ob) mice. Am J Physiol (1983) 0.82
Thyroxine 5'-deiodinase in hamster and rat brown adipose tissue: effect of cold and diet. Am J Physiol (1986) 0.82
Impaired thermogenesis and brown fat in obesity. Can J Surg (1984) 0.82
Control of proteolysis by norepinephrine and insulin in brown adipocytes: role of ATP, phosphatidylinositol 3-kinase, and p70 S6K. Can J Physiol Pharmacol (2002) 0.81
Thermogenic mechanisms and their control. Experientia Suppl (1978) 0.81
Lack of diet-induced thermogenesis in brown adipose tissue of obese medial hypothalamic-lesioned rats. Physiol Behav (1985) 0.81
Effect of antacids in didanosine tablet on bioavailability of isoniazid. Antimicrob Agents Chemother (1994) 0.81
Rapid but transient atrophy of brown adipose tissue in capsaicin-desensitized rats. Am J Physiol (1992) 0.81
Decreased half-life of some mitochondrial proteins in skeletal muscle and brown adipose tissue of cold-acclimated rats. Can J Physiol Pharmacol (1971) 0.80
Gluconeogenesis in rats during cold acclimation. Can J Biochem (1968) 0.80
Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements. Diabetes (1998) 0.80
Selective loss of uncoupling protein mRNA in brown adipose tissue on deacclimation of cold-acclimated mice. Biochem Cell Biol (1987) 0.80
The ATP-dependent breakdown of proteins in mammalian mitochondria. Biochem Soc Trans (1985) 0.79
Polypeptide turnover in brown adipose tissue mitochondria during acclimation of rats to cold. Can J Biochem (1980) 0.79
Increased calcium uptake by muscle mitochondria of cold-acclimated rats. Am J Physiol (1978) 0.79
Growth of interscapular brown adipose tissue in cold-acclimated hypophysectomized rats maintained on thyroxine and corticosterone. Can J Biochem (1982) 0.78
beta-Adrenergic stimulated lipolysis in pony adipocytes is exclusively via a beta2-subtype and is not affected by lactation. Comp Biochem Physiol A Mol Integr Physiol (2003) 0.78
Specific decrease of mitochondrial thermogenic capacity in brown adipose tissue of obese SHR/N-cp rats. Am J Physiol (1993) 0.78
Phosphatidic acid synthesis in the heart. 1. Effect of age and species difference in the mitochondrial and microsomal synthesis. Can J Biochem (1977) 0.78
Treatment with CL 316,243, a beta 3-adrenoceptor agonist, reduces serum leptin in rats with diet- or aging-associated obesity, but not in Zucker rats with genetic (fa/fa) obesity. Int J Obes Relat Metab Disord (1998) 0.78
Alteration in skeletal muscle mitochondria of cold-acclimated rats: association with enhanced metabolic response to noradrenaline. J Bioenerg Biomembr (1977) 0.78
Metabolism of individual fatty acids in heart muscle. Recent Adv Stud Cardiac Struct Metab (1978) 0.78
Inhibition by oxytetracycline of the development of the enhanced response to noradrenaline in cold-acclimated rats: a new approach to the study of nonshivering thermogenesis. Can J Physiol Pharmacol (1971) 0.77
Control of norepinephrine turnover in brown adipose tissue of Syrian hamsters. Am J Physiol (1988) 0.77
Is acute morphine hyperthermia of unrestrained rats due to selective activation of brown adipose tissue thermogenesis? J Pharmacol Exp Ther (1984) 0.77
Defective regulation of thyroxine 5'-deiodinase in brown adipose tissue of ob/ob mice. Am J Physiol (1990) 0.77
Adrenalectomy prevents obesity in glutamate-treated mice. Am J Physiol (1989) 0.77
Effects of ethanol consumption on brown adipose tissue thermogenic capacity in mice. Physiol Behav (1996) 0.76
Enhanced acute response to corticosterone in genetically obese (ob/ob) mice. Am J Physiol (1989) 0.76
Recovery of function in sympathetic nerves of interscapular brown adipose tissue of rats treated with 6-hydroxydopamine. Can J Physiol Pharmacol (1984) 0.76
Changes in brown adipose tissue composition during fasting and refeeding of diet-induced obese mice. Am J Physiol (1994) 0.76
Interscapular location of brown adipose tissue: role in noradrenaline-induced calorigenesis in cold-acclimated rats. Can J Physiol Pharmacol (1974) 0.76
Increased brown adipose tissue thermogenesis in obese (ob/ob) mice fed a palatable diet. Am J Physiol (1986) 0.76
Adrenergic effects on thyroxine 5'-deiodinase in brown adipose tissue of lean and ob/ob mice. Am J Physiol (1990) 0.76
Effects of cold acclimation and fasting on thyroxine 5'-deiodinase in brown adipose tissue of ob/ob mice. Proc Soc Exp Biol Med (1992) 0.76
ATPase-inhibitor proteins of brown-adipose-tissue mitochondria from warm- and cold-acclimated rats. Biochem J (1992) 0.75