Published in Xenobiotica on December 01, 1982
Detection and quantitation of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung by liquid chromatography-electrospray ionization-tandem mass spectrometry. Chem Res Toxicol (2007) 1.58
Molecular mechanisms of DNA damage initiated by alpha, beta-unsaturated carbonyl compounds as criteria for genotoxicity and mutagenicity. Environ Health Perspect (1990) 0.77
Mode of action and the assessment of chemical hazards in the presence of limited data: use of structure-activity relationships (SAR) under TSCA, Section 5. Environ Health Perspect (1990) 0.76
Biomonitoring studies and susceptibility markers for acrolein congeners and allylic and benzyl compounds. Environ Health Perspect (1993) 0.75
Renal cell cancer correlated with occupational exposure to trichloroethene. J Cancer Res Clin Oncol (1998) 2.96
Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation. Biochem Pharmacol (1975) 1.41
Reactions of trichloroethylene epoxide in aqueous systems. Biochem Pharmacol (1979) 1.41
Metabolism of trichloroethylene in man. III. Interaction of trichloroethylene and ethanol. Arch Toxicol (1975) 1.20
Albumin adducts, hemoglobin adducts and urinary metabolites in workers exposed to 4,4'-methylenediphenyl diisocyanate. Carcinogenesis (1995) 1.18
Estimation of exposure of man to substances reacting covalently with macromolecules. Arch Toxicol (1987) 1.14
Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene. Chem Biol Interact (1986) 1.14
Novel metabolites of trichloroethylene through dechlorination reactions in rats, mice and humans. Biochem Pharmacol (1984) 1.12
Carcinogenicity study of trichloroethylene by longterm inhalation in three animal species. Arch Toxicol (1980) 1.08
Metabolism of trichloroethylene in man. II. Pharmacokinetics of metabolites. Arch Toxicol (1974) 1.03
Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation. Arch Toxicol (1996) 1.02
Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma. J Cancer Res Clin Oncol (1995) 1.02
Carcinogenicity of trichloroethylene: fact or artifact? Arch Toxicol (1977) 1.00
Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation. Biochem Pharmacol (1975) 0.99
Chemical reactivity, biotransformation, and toxicity of polychlorinated aliphatic compounds. CRC Crit Rev Toxicol (1976) 0.95
Metabolism of trichloroethene--in vivo and in vitro evidence for activation by glutathione conjugation. Chem Biol Interact (1990) 0.95
Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: implications for the risk of trichloroethene exposure. Environ Health Perspect (1993) 0.92
Detection of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal after gavage of trans-4-hydroxy-2-nonenal or induction of lipid peroxidation with carbon tetrachloride in F344 rats. Chem Biol Interact (2001) 0.90
Crotonaldehyde is mutagenic in Salmonella typhimurium TA100. Environ Mol Mutagen (1989) 0.90
Characterization of an in vitro micronucleus assay with Syrian hamster embryo fibroblasts. Mutat Res (1988) 0.89
Mutagenicity of methylvinyl ketone in Salmonella typhimurium TA100--indication for epoxidation as an activation mechanism. Mutat Res (1989) 0.89
Breast reconstruction by the free lower transverse rectus abdominis musculocutaneous flap. Br J Plast Surg (1988) 0.88
Isocyanate-specific hemoglobin adduct in rats exposed to 4, 4'-methylenediphenyl diisocyanate. Chem Res Toxicol (2000) 0.88
Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation. Drug Metab Dispos (1988) 0.88
Trichloroethylene exposure and trichloroethylene metabolites in urine and blood. Arch Toxikol (1972) 0.88
Metabolism of tetrachloroethene in rats: identification of N epsilon-(dichloroacetyl)-L-lysine and N epsilon-(trichloroacetyl)-L-lysine as protein adducts. Chem Res Toxicol (1995) 0.87
Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity. J Biochem Toxicol (1986) 0.86
Development of a (32)P-postlabeling method for the detection of 1,N(2)-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal in vivo. Chem Res Toxicol (2000) 0.86
Biomonitoring of workers exposed to 4,4'-methylenedianiline or 4,4'-methylenediphenyl diisocyanate. Carcinogenesis (1995) 0.86
Mutagenicity of amino acid and glutathione S-conjugates in the Ames test. Mutat Res (1988) 0.86
Genotoxicity and mutagenicity of the alpha, beta-unsaturated carbonyl compound crotonaldehyde (butenal) on a plasmid shuttle vector. Mutat Res (1998) 0.85
The saphenous neurovascular free flap. Plast Reconstr Surg (1981) 0.85
[Irreversible lesions of the trigeminal nerve caused by chlorinated acetylenes in two patients]. Dtsch Z Nervenheilkd (1970) 0.85
Heterocyclic aromatic amine-DNA-adducts in bacteria and mammalian cells detected by 32P-postlabeling analysis. Carcinogenesis (1987) 0.85
Metabolism of trichloroethylene in man. I. The significance of trichloroethanol in long-term exposure conditions. Arch Toxikol (1972) 0.85
Crotonaldehyde is mutagenic in a modified Salmonella typhimurium mutagenicity testing system. Mutat Res (1981) 0.85
Mutagenic potential of allyl and allylic compounds. Structure-activity relationship as determined by alkylating and direct in vitro mutagenic properties. Biochem Pharmacol (1980) 0.84
Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate beta-lyase. Chem Res Toxicol (1992) 0.84
Mutagenicity and genotoxicity of ethylvinyl ketone in bacterial tests. J Appl Toxicol (1990) 0.83
Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats. Biochem Pharmacol (1986) 0.83
Correlation of alkylating and mutagenic activities of allyl and allylic compounds: standard alkylation test vs. kinetic investigation. Chem Biol Interact (1982) 0.83
[Treatment of poisoning by binding of poisons in the gastrointestinal tract: charcoal of "universal antidote"?]. Dtsch Med Wochenschr (1966) 0.83
Development of a 32P-postlabelling method for the detection of 1,N2-propanodeoxyguanosine adducts of crotonaldehyde in vivo. Arch Toxicol (2000) 0.83
Allylic compounds bind directly to DNA: investigation of the binding mechanisms in vitro. Chem Biol Interact (1987) 0.83
Detection of 1,N(2)-propanodeoxyguanosine adducts in DNA of Fischer 344 rats by an adapted (32)P-post-labeling technique after per os application of crotonaldehyde. Carcinogenesis (2000) 0.83
[Effect of low chlorine and bromine concentrations on man]. Int Arch Arbeitsmed (1967) 0.82
Assessment of unscheduled DNA synthesis in a cultured line of renal epithelial cells exposed to cysteine S-conjugates of haloalkenes and haloalkanes. Mutat Res (1989) 0.82
The role of biotransformation in the genotoxicity of allylic compounds. Arch Toxicol (1987) 0.82
Carcinogenicity study of trichloroethylene, with and without epoxide stabilizers, in mice. J Cancer Res Clin Oncol (1984) 0.82
Mutagenicity of hexachloro-1,3-butadiene and its S-conjugates in the Ames test--role of activation by the mercapturic acid pathway in its nephrocarcinogenicity. Carcinogenesis (1988) 0.82
Metabolism of the nephrotoxin dichloroacetylene by glutathione conjugation. Chem Res Toxicol (1991) 0.82
Cancer risk assessment for crotonaldehyde and 2-hexenal: an approach. IARC Sci Publ (1999) 0.81
Photolysis of arylazides and generation of highly electrophilic DNA-binding and mutagenic intermediates. Carcinogenesis (1989) 0.81
Synthesis and genotoxicity of acetoxyoxirane, the epoxide of vinyl acetate. J Biochem Toxicol (1986) 0.81
A new pathway of acrolein metabolism in rats. Arch Toxicol (1983) 0.81
[On the mechanism of methanol poisoning. The toxic agent and influence of acid-base balance]. Arch Toxikol (1969) 0.80
Detection of acrolein congener-DNA adducts isolated from cellular systems. Arch Toxicol Suppl (1989) 0.80
Hemoglobin adducts and urine metabolites of 4,4'-methylenedianiline after 4,4'-methylenediphenyl diisocyanate exposure of rats. Chem Biol Interact (1995) 0.80
Thioacylating agents as ultimate intermediates in the beta-lyase catalysed metabolism of S-(pentachloro-butadienyl)-L-cysteine. Chem Biol Interact (1988) 0.80
Occupational exposure to perchloroethylene. Cancer Causes Control (1996) 0.80
Toxicological problems relating to changes in the environment. Angew Chem Int Ed Engl (1973) 0.80
Unaltered brain levels of 1,N2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal in Alzheimer's disease. Neurosci Lett (2002) 0.80
Enzymatic conjugation of hexachloro-1,3-butadiene with glutathione. Formation of 1-(glutathion-S-yl)-1,2,3,4,4-pentachlorobuta-1,3-diene and 1,4-bis(glutathion-S-yl)-1,2,3,4-tetrachlorobuta-1,3-diene. Drug Metab Dispos (1989) 0.80
Mutagenicity of chloro-olefins in the Salmonella/mammalian microsome test. I. Allyl chloride mutagenicity re-examined. Mutat Res (1985) 0.80
[On the problem of cancerogenic effect of inhaled nitrogen oxides]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol (1966) 0.80
Metabolism of hexachloro-1,3-butadiene in mice: in vivo and in vitro evidence for activation by glutathione conjugation. Xenobiotica (1988) 0.80
Malignancies in patients treated with high doses of radium-224. Radiat Res (1999) 0.79
Absorption, elimination and metabolism of trichloroethylene: a quantitative comparison between rats and mice. Xenobiotica (1986) 0.79
Exposure to toluenediamines from polyurethane-covered breast implants. Toxicol Lett (1995) 0.79
Mutagenic activity in rat urine after feeding with the azo dye tartrazine. Arch Toxicol (1985) 0.79
Metabolism and mutagenicity of halogenated olefins--a comparison of structure and activity. Environ Health Perspect (1977) 0.79
Induction of morphological transformation and unscheduled DNA synthesis in Syrian hamster embryo fibroblasts by hexachlorobutadiene and its putative metabolite pentachlorobutenoic acid. Cancer Lett (1984) 0.79
SOS-dependent mutagenic activity of 5-azacytidine in salmonella. Mutat Res (1986) 0.79
Genotoxicity of 1,3-dichloro-2-propanol in the SOS chromotest and in the Ames test. Elucidation of the genotoxic mechanism. Chem Biol Interact (1991) 0.79
A "chemical" concept for the therapy of glyoxylate-induced oxalurias (1). Life Sci (1992) 0.79
[Toxicity of chlorine and bromine in single and repeated inhalation]. Int Arch Arbeitsmed (1967) 0.78
Bacterial cysteine conjugate beta-lyase and the metabolism of cysteine S-conjugates: structural requirements for the cleavage of S-conjugates and the formation of reactive intermediates. Chem Biol Interact (1988) 0.78
Mutagenicity of tetrachloroethene in the Ames test--metabolic activation by conjugation with glutathione. J Biochem Toxicol (1989) 0.78
Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates. Biochem Pharmacol (1987) 0.78
Induction of unscheduled DNA synthesis in HeLa cells by allylic compounds. Cancer Lett (1983) 0.78
A mechanism of haloalkene-induced renal carcinogenesis. Environ Health Perspect (1990) 0.78
Genotoxic and cell-transforming properties of (trans,trans)-muconaldehyde. Mutat Res (1991) 0.78