Structural integrity of hepatocyte tight junctions.

A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J Cell Biol (1986) 5.75

Breaking through the tight junction barrier. J Cell Biol (1993) 3.01

Zonulae occludentes in junctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterization. J Cell Biol (1984) 2.35

Analysis of Borrelia burgdorferi membrane architecture by freeze-fracture electron microscopy. J Bacteriol (1994) 1.61

The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection. J Virol (2009) 1.36

Alteration of tight junctional permeability in the rat parotid gland after isoproterenol stimulation. J Cell Biol (1984) 1.26

Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome. Gastroenterology (2008) 1.23

Cholangiocyte endothelin 1 and transforming growth factor beta1 production in rat experimental hepatopulmonary syndrome. Gastroenterology (2005) 1.05

Hepatic immunohistochemical localization of the tight junction protein ZO-1 in rat models of cholestasis. Am J Pathol (1989) 0.81

Ca2+ depletion-induced disconnection of tight junctions in isolated rat brain microvessels. Acta Neuropathol (1985) 0.81

Interplay among cellular polarization, lipoprotein metabolism and hepatitis C virus entry. World J Gastroenterol (2011) 0.78

The missing pieces of the HCV entry puzzle. Future Virol (2015) 0.76

Mechanical characteristics of the pulmonary artery in beagle dogs with hepatopulmonary syndrome and portopulmonary hypertension. Biomed Rep (2015) 0.75

Junctional complexes in various epithelia. J Cell Biol (1963) 31.83

A fine structural analysis of intercellular junctions in the mouse liver. J Cell Biol (1970) 7.95

Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia. J Cell Biol (1973) 5.45

Route of passive ion permeation in epithelia. Nat New Biol (1972) 4.78

Further observations on the fine structure of freeze-cleaved tight junctions. J Cell Sci (1973) 4.66

Hemoglobin absorption by the cells of the proximal convoluted tubule in mouse kidney. J Biophys Biochem Cytol (1960) 4.44

Morphological factors influencing transepithelial permeability: a model for the resistance of the zonula occludens. J Membr Biol (1978) 3.02

Electrophysiology of proximal and distal tubules in the autoperfused dog kidney. Am J Physiol (1971) 2.62

Structure of tight junctions in epithelia with different permeability. Proc Natl Acad Sci U S A (1975) 2.27

Lack of correlation between tight junction morphology and permeability properties in developing choroid plexus. Nature (1976) 2.01

Evidence for the lipidic nature of tight junction strands. Nature (1982) 1.96

The structure of the zonula occludens. A single fibril model based on freeze-fracture. J Cell Biol (1974) 1.87

Plastic deformation during freeze-cleavage: a review. J Microsc (1977) 1.67

Functional significance of the variations in the geometrical organization of tight junction networks. J Cell Biol (1976) 1.58

Occluding junctions in a cultured transporting epithelium: structural and functional heterogeneity. J Membr Biol (1980) 1.49

Fracture faces of osmotically disrupted zonulae occludentes. J Cell Biol (1974) 1.34

A freeze-etch study of the tight junctions of the rat kidney tubules. Lab Invest (1974) 1.31

Tight junctions in the choroid plexus epithelium. A freeze-fracture study including complementary replicas. J Cell Biol (1979) 1.26

Morphological alterations and functional changes of interhepatocellular junctions induced by bile duct ligation. Cell Tissue Res (1977) 1.21

Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability. Proc Natl Acad Sci U S A (1980) 1.13

Development of intercellular junctions in the pulmonary epithelium of the foetal lamb. J Cell Sci (1978) 1.07

Rotary replication for freeze-etching. J Cell Biol (1977) 1.01

Morphologic changes of the junctional complex of the hepatocytes in rat liver after bile duct ligation. Br J Exp Pathol (1978) 0.98

Double replica technique applied to choroid plexus from early foetal sheep: completeness and complexity of tight junctions. J Neurocytol (1979) 0.91

Exocrine pancreas under experimental conditions. IV. Alterations of intercellular junctions between acinar cells following pancreatic duct ligation. Cell Tissue Res (1978) 0.87

Reformation of gap and tight junctions in regenerating liver after cholestasis. Cell Tissue Res (1979) 0.85

RAT BILIARY TREE DURING SHORT PERIODS OF OBSTRUCTION OF COMMON DUCT. Am J Physiol (1963) 0.84

Structural heterogeneity of hepatocyte "tight" junctions: a quantitative analysis. Hepatology (1981) 0.81

Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest (1999) 4.11

Radiologic, endoscopic, and surgical gastrostomy: an institutional evaluation and meta-analysis of the literature. Radiology (1995) 4.02

Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. Aliment Pharmacol Ther (2014) 2.88

The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci U S A (1998) 2.79

Molecular pathogenesis of cholestasis. N Engl J Med (1998) 2.68

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver. J Cell Biol (1984) 2.47

Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A (2002) 2.37

Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor. Br J Pharmacol (1996) 2.12

ADH action: evidence for a membrane shuttle mechanism. Ann N Y Acad Sci (1981) 2.03

Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop. Am J Physiol (1999) 2.01

Comparative biochemistry of non-muscle actins. J Biol Chem (1977) 1.92

Outpatient liver biopsy: how safe is it? Ann Intern Med (1993) 1.90

Laparoscopic injuries to the bile duct. A cause for concern. Ann Surg (1992) 1.89

Effect of osmotic gradients on intercellular junctions of the toad bladder. Am J Physiol (1973) 1.89

Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. Biochem J (1988) 1.88

The structure of the zonula occludens. A single fibril model based on freeze-fracture. J Cell Biol (1974) 1.87

Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem (2000) 1.85

P2-purinergic receptors: subtype-associated signaling responses and structure. Annu Rev Pharmacol Toxicol (1995) 1.84

Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. J Med Chem (1993) 1.84

The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology (1997) 1.83

Value of three-dimensional US for optimizing guidance for ablating focal liver tumors. J Vasc Interv Radiol (2001) 1.77

Isolated rat hepatocyte couplets: a primary secretory unit for electrophysiologic studies of bile secretory function. Proc Natl Acad Sci U S A (1984) 1.77

Expression of a cloned P2Y purinergic receptor that couples to phospholipase C. Mol Pharmacol (1994) 1.76

Peliosis hepatis associated with androgenic-anabolic steroid therapy. A severe form of hepatic injury. Ann Intern Med (1974) 1.75

Regulation of aquaporin-2 trafficking by vasopressin in the renal collecting duct. Roles of ryanodine-sensitive Ca2+ stores and calmodulin. J Biol Chem (2000) 1.75

Laparoscopic repair/peritoneal toilet of perforated duodenal ulcer. Surg Endosc (1990) 1.75

Agonist action of adenosine triphosphates at the human P2Y1 receptor. Mol Pharmacol (1998) 1.74

Mechanisms and regulation of bile secretion. Hepatology (1991) 1.74

The prognostic importance of clinical and histologic features in asymptomatic and symptomatic primary biliary cirrhosis. N Engl J Med (1983) 1.67

Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors. J Med Chem (1998) 1.61

Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem (1998) 1.61

Localization and regulation of the rat renal Na(+)-K(+)-2Cl- cotransporter, BSC-1. Am J Physiol (1996) 1.60

Hepatic injury from chronic hypervitaminosis a resulting in portal hypertension and ascites. N Engl J Med (1974) 1.58

Exercise therapy in hypertensive men. JAMA (1970) 1.58

Laser and laparoscopic cholecystectomy. A hazardous union? Arch Surg (1991) 1.57

Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc Natl Acad Sci U S A (1998) 1.56

Cytochemical localization of Na+, K+-ATPase in the rat hepatocyte. J Clin Invest (1978) 1.54

Regulation of collecting duct water permeability independent of cAMP-mediated AVP response. Am J Physiol (1991) 1.52

Idiopathic portal hypertension. Comparison with the portal hypertension of cirrhosis and extrahepatic portal vein obstruction. Ann Intern Med (1967) 1.51

Effect of UDCA on intracellular and biliary pH in isolated rat hepatocyte couplets and perfused livers. Am J Physiol (1991) 1.51

Pattern of necrosis in acute viral hepatitis. Prognostic value of bridging (subacute hepatic necrosis). N Engl J Med (1970) 1.50

Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3. J Physiol (2001) 1.47

Improved survival with primary sclerosing cholangitis. A review of clinicopathologic features and comparison of symptomatic and asymptomatic patients. Gastroenterology (1987) 1.45

Canalicular bile formation in the isolated perfused rat liver. Am J Physiol (1971) 1.43

Isolated rat hepatocyte couplets in short-term culture: structural characteristics and plasma membrane reorganization. Hepatology (1987) 1.35

Fracture faces of osmotically disrupted zonulae occludentes. J Cell Biol (1974) 1.34

Factors influencing survival after resection for periampullary neoplasms. Am J Surg (2000) 1.34

Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking. J Med Chem (2001) 1.32

Ultrastructural changes in livers of two patients with hypervitaminosis A. Am J Pathol (1974) 1.29

Cellular mechanisms of bile formation. Gastroenterology (1982) 1.28

Comparison of vitamin D and 25-hydroxy-vitamin-D in the therapy of primary biliary cirrhosis. Lancet (1976) 1.27

Vasopressin: induced structural change in toad bladder luminal membrane. Science (1975) 1.27

The clinical importance of a protein-bound fraction of serum bilirubin in patients with hyperbilirubinemia. N Engl J Med (1983) 1.26

Regulation of the abundance of renal sodium transporters and channels by vasopressin. Exp Neurol (2001) 1.26

Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate. Proc Natl Acad Sci U S A (2001) 1.26

Canalicular bile flow and bile secretory pressure. Evidence for a non-bile salt dependent fraction in the isolated perfused rat liver. Gastroenterology (1970) 1.26

The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies. J Exp Zool A Comp Exp Biol (2006) 1.25

Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. J Med Chem (1999) 1.25

Structural and functional study of the rat distal nephron: effects of potassium adaptation and depletion. Kidney Int (1981) 1.25

Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology (2001) 1.24

Toad urinary bladder epithelial cells in culture: maintenance of epithelial structure, sodium transport, and response to hormones. Proc Natl Acad Sci U S A (1979) 1.23

PROMIS computerised adaptive tests are dynamic instruments to measure health-related quality of life in patients with cirrhosis. Aliment Pharmacol Ther (2011) 1.22

A comparison of maximal oxygen uptake by treadmill and step-test procedures. J Appl Physiol (1966) 1.22

Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier. J Biol Chem (1984) 1.22

Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology (1996) 1.21

Relationship of aggregated intramembranous particles to water permeability in vasopressin-treated toad urinary bladder. J Clin Invest (1977) 1.21

Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest (1998) 1.21

Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles. J Clin Invest (1983) 1.19

Localization of ROMK channels in the rat kidney. J Am Soc Nephrol (1997) 1.19

Characterization of cytosolic Ca2+ signaling in rat bile duct epithelia. Am J Physiol (1996) 1.18

Ultrastructure of the human erythrocyte cytoskeleton and its attachment to the membrane. Cell Motil Cytoskeleton (1991) 1.18

Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry. J Clin Invest (1989) 1.18

Renal aquaporins. Kidney Int (1996) 1.17

Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein. J Biol Chem (1991) 1.17

Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology (2001) 1.16

Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J Cell Sci (1998) 1.16

New concepts of mechanisms of hepatocyte bile formation. Physiol Rev (1980) 1.16

Chronic hepatitis--a perspective on classification and determinants of prognosis. Gastroenterology (1976) 1.16

Intracellular pH regulation in isolated rat bile duct epithelial cells. J Clin Invest (1991) 1.15

A conformational mechanism for formation of a dead-end complex by the sarcoplasmic reticulum ATPase with thapsigargin. J Biol Chem (1992) 1.15

Integrins regulate the linkage between upstream and downstream events in G protein-coupled receptor signaling to mitogen-activated protein kinase. J Biol Chem (2000) 1.14

UT-A3: localization and characterization of an additional urea transporter isoform in the IMCD. Am J Physiol Renal Physiol (2001) 1.14

Isolation of small polarized bile duct units. Proc Natl Acad Sci U S A (1995) 1.14

Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells. J Clin Invest (1993) 1.13

Swelling-activated anion conductance in skate hepatocytes: regulation by cell Cl- and ATP. Am J Physiol (1996) 1.13

Phalloidin-induced cholestasis: a microfilament-mediated change in junctional complex permeability. Proc Natl Acad Sci U S A (1980) 1.13

Immunolocalization of the secretory isoform of Na-K-Cl cotransporter in rat renal intercalated cells. J Am Soc Nephrol (1996) 1.13

Cardiovascular changes with age and exercise. A 28-year longitudinal study. Scand J Med Sci Sports (1995) 1.13

Na-H exchange regulates intracellular pH in isolated rat hepatocyte couplets. Am J Physiol (1987) 1.12

Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. J Med Chem (2001) 1.12

Ultrastructure and immunocytochemistry of the isolated human erythrocyte membrane skeleton. Cell Motil Cytoskeleton (1993) 1.11

Nonalcoholic liver disease. Overlooked causes of liver injury in patients with heavy alcohol consumption. Am J Med (1979) 1.10

Regulation of potassium channel Kir 1.1 (ROMK) abundance in the thick ascending limb of Henle's loop. J Am Soc Nephrol (2001) 1.10

Properties of (Na+ plus K+)-activated ATPase in rat liver plasma membranes enriched with bile canaliculi. Biochim Biophys Acta (1975) 1.10

Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology (2000) 1.10

Promoting comparative molecular studies in environmental health research: an overview of the comparative toxicogenomics database (CTD). Pharmacogenomics J (2004) 1.10

Functional expression of a cDNA encoding a human ecto-ATPase. Br J Pharmacol (1999) 1.09

Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C. Br J Pharmacol (1997) 1.08

Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y(1) receptor antagonists. J Med Chem (2000) 1.08