Metabolic products and myocardial ischemia.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 1903670)

Published in Am J Pathol on February 01, 1981

Authors

J R Neely, D Feuvray

Articles citing this

Neuronal calcium homeostasis and dysregulation. Antioxid Redox Signal (2010) 1.19

Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle. Implications for ischemia and reperfusion injury. J Clin Invest (1989) 1.18

Direct activation of Ca2+ channels by palmitoyl carnitine, a putative endogenous ligand. Br J Pharmacol (1987) 1.09

Interaction of palmitoyl carnitine with calcium antagonists in myocytes. Br J Pharmacol (1989) 0.95

Modification of the transient outward current of rat atrial myocytes by metabolic inhibition and oxidant stress. J Physiol (1993) 0.91

The effect of respiratory chain impairment of beta-oxidation in rat heart mitochondria. Biochem J (1996) 0.87

Pyrophosphate metabolism in the perfused heart and isolated heart mitochondria and its role in regulation of mitochondrial function by calcium. Biochem J (1993) 0.86

Ketone bodies disturb fatty acid handling in isolated cardiomyocytes derived from control and diabetic rats. Biochem J (2003) 0.85

Na+/H+ exchange and its inhibition in cardiac ischemia and reperfusion. Basic Res Cardiol (1994) 0.84

Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. PLoS One (2013) 0.84

Lipid peroxidation and scavenger mechanism in experimentally induced heart infarcts. Basic Res Cardiol (1986) 0.82

Ultrastructural modifications in the mitochondria of hypoxia-adapted Drosophila melanogaster. PLoS One (2012) 0.77

Proceedings of the British Pharmacological Society. 10th-18th September 1986. Abstracts. Br J Pharmacol (1986) 0.75

Interactions of palmitoyl carnitine with the endothelium in rat aorta. Br J Pharmacol (1990) 0.75

Na+/H+ exchange inhibitors reverse lactate-induced depression in postischaemic ventricular recovery. Br J Pharmacol (1993) 0.75

Morphological changes in endocardium subjected to global ischaemia. Basic Res Cardiol (1987) 0.75

Intracellular sodium in the ischemic and reperfused heart and its role in injury. MAGMA (2000) 0.75

Articles cited by this

Coenzyme A and carnitine distribution in normal and ischemic hearts. J Biol Chem (1978) 2.03

The oxygen paradox and the calcium paradox: two facets of the same problem? J Mol Cell Cardiol (1978) 1.95

Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog. Am J Pathol (1978) 1.84

Early phase of myocardial ischemic injury and infarction. Am J Cardiol (1969) 1.70

Effects of ischemia on function and metabolism of the isolated working rat heart. Am J Physiol (1973) 1.60

Functional compartmentation of ATP and creatine phosphate in heart muscle. J Mol Cell Cardiol (1970) 1.57

Control of fatty acid metabolism in ischemic and hypoxic hearts. J Biol Chem (1978) 1.45

Effects of acidosis and ischemia on contractility and intracellular pH of rat heart. Circ Res (1977) 1.44

Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium. J Clin Invest (1978) 1.34

Effect of coronary blood flow on glycolytic flux and intracellular pH in isolated rat hearts. Circ Res (1975) 1.31

Ultrastructural, functional, and biochemical criteria for estimation of reversibility of ischemic injury: a study on the effects of global ischemia on the isolated dog heart. J Mol Cell Cardiol (1979) 1.31

Myocardial ATP synthesis and mechanical function following oxygen deficiency. Am J Physiol (1978) 1.29

Comparison of the effects of anoxia and whole heart ischemia on carbohydrate utilization in isolated working rat hearts. Circ Res (1973) 1.26

Lysosomal alterations in ischemic myocardium: result or cause of myocellular damage? J Mol Cell Cardiol (1978) 1.22

Effect of pressure development on membrane transport of glucose in isolated rat heart. Am J Physiol (1967) 1.20

Effects of substrates on tissue metabolic changes in the isolated rat heart during underperfusion and on release of lactate dehydrogenase and arrhythmias during reperfusion. Circ Res (1978) 1.16

Potential arrhythmogenic electrophysiological derangements in canine Purkinje fibers induced by lysophosphoglycerides. Circ Res (1979) 1.02

Inhibition of fatty acid oxidation and in normal and hypoxic perfused rat hearts by 2-tetradecylglycidic acid. J Mol Cell Cardiol (1979) 1.01

Mitochondrial oxidative phosphorylation in myocardial anoxia: effects of albumin. J Mol Cell Cardiol (1976) 0.99

Mitochondrial oxidative phosphorylation in low-flow hypoxia: role of free fatty acids. J Mol Cell Cardiol (1978) 0.92

Ultrastructural alterations during ischemia and reperfusion in human hearts during cardiac surgery. J Mol Cell Cardiol (1977) 0.92

Palmitylcarnitine inhibition of the calcium pump in cardiac sarcoplasmic reticulum: a possible role in myocardial ischemia. Life Sci (1978) 0.89

Analysis of control of glycolysis in ischemic hearts having heterogeneous zones of anoxia. J Mol Cell Cardiol (1978) 0.89

Role of carnitine in fatty acid metabolism of normal and ischemic myocardium. Am Heart J (1979) 0.87

Effects of anoxia and severe ischemia on the turnover of myocardial proteins. Acta Med Scand Suppl (1976) 0.86

Control of glyceraldehyde-3-phosphate dehydrogenase in cardiac muscle. J Mol Cell Cardiol (1979) 0.82

Ischaemia-induced damage in the working rat heart preparation: the effect of perfusate substrate composition upon subendocardial ultrastructure of the ischaemic left ventricular wall. J Mol Cell Cardiol (1977) 0.80

Changes in glycolysis and in high-energy phosphates during myocardial ischemia with intermittent coronary perfusion. Cardiology (1971) 0.80

Ultrastructural alterations in the mitochondrial membranes of ischemic myocardium as revealed by freeze-fracture technique. J Mol Cell Cardiol (1978) 0.79

Hydrolysis of myocardial lipids during acidosis and ischemia. Recent Adv Stud Cardiac Struct Metab (1973) 0.79

Articles by these authors

Effect of pressure development on oxygen consumption by isolated rat heart. Am J Physiol (1967) 4.61

The effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart. Biochem J (1972) 2.36

Coenzyme A and carnitine distribution in normal and ischemic hearts. J Biol Chem (1978) 2.03

Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts. Circ Res (1984) 1.99

Myocardial utilization of carbohydrate and lipids. Prog Cardiovasc Dis (1973) 1.99

Control of maximum rates of glycolysis in rat cardiac muscle. Circ Res (1979) 1.81

Changes in intracellular sodium and pH during ischaemia-reperfusion are attenuated by trimetazidine. Comparison between low- and zero-flow ischaemia. Cardiovasc Res (2000) 1.60

Coenzyme A metabolism. Am J Physiol (1985) 1.60

Effects of ischemia on function and metabolism of the isolated working rat heart. Am J Physiol (1973) 1.60

Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange. Circ Res (1989) 1.57

Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine. Circ Res (1978) 1.52

Factors affecting glucose transport in heart muscle and erythrocytes. Fed Proc (1966) 1.48

Control of fatty acid metabolism in ischemic and hypoxic hearts. J Biol Chem (1978) 1.45

Effects of ventricular pressure development and palmitate on glucose transport. Am J Physiol (1969) 1.43

Regulation of fatty acid utilization in isolated perfused rat hearts. J Biol Chem (1973) 1.32

Effect of coronary blood flow on glycolytic flux and intracellular pH in isolated rat hearts. Circ Res (1975) 1.31

Techniques for perfusing isolated rat hearts. Methods Enzymol (1975) 1.27

Comparison of the effects of anoxia and whole heart ischemia on carbohydrate utilization in isolated working rat hearts. Circ Res (1973) 1.26

Mechanisms of glycolytic inhibition in ischemic rat hearts. Circ Res (1975) 1.24

Effect of pressure development on membrane transport of glucose in isolated rat heart. Am J Physiol (1967) 1.20

Calcium and potassium currents in ventricular myocytes isolated from diabetic rats. J Physiol (1993) 1.13

Rate-limiting step and control of coenzyme A synthesis in cardiac muscle. J Biol Chem (1982) 1.10

Altered Ca2+ handling in ventricular myocytes isolated from diabetic rats. Am J Physiol (1996) 1.08

Effects of ischemia and reperfusion on pyruvate dehydrogenase activity in isolated rat hearts. J Mol Cell Cardiol (1983) 1.08

Mechanism of pyruvate dehydrogenase activation by increased cardiac work. J Mol Cell Cardiol (1983) 1.07

Regulation of glycogenolysis in hearts: effects of pressure development, glucose, and FFA. Am J Physiol (1970) 1.02

Regulation of long chain fatty acid activation in heart muscle. J Biol Chem (1975) 1.02

Effects of trimetazidine on pHi regulation in the rat isolated ventricular myocyte. Br J Pharmacol (1996) 0.99

Fatty acid oxidation by isolated perfused working hearts of aged rats. Am J Physiol (1977) 0.98

Fatty acid metabolism in hearts containing elevated levels of CoA. Am J Physiol (1986) 0.94

Factors affecting the release of lactate dehydrogenase from isolated rat heart after calcium and magnesium free perfusions. Cardiovasc Res (1973) 0.93

Na+ accumulation increases Ca2+ overload and impairs function in anoxic rat heart. J Mol Cell Cardiol (1990) 0.92

Decreased myocardial function and myosin ATPase in hearts from diabetic rats. Am J Physiol (1983) 0.91

Effects of ischemia on rat myocardial function and metabolism in diabetes. Circ Res (1979) 0.91

Hearts from diabetic rats are more resistant to in vitro ischemia: possible role of altered Ca2+ metabolism. Circ Res (1988) 0.90

An experimental model for studying myocardial ischemia. Correlation of hemodynamic performance and metabolism in the working swine heart. J Thorac Cardiovasc Surg (1975) 0.89

Intracellular sodium increase and susceptibility to ischaemia in hearts from type 2 diabetic db/db mice. Diabetologia (2006) 0.89

Decrease in sodium-calcium exchange and calcium currents in diabetic rat ventricular myocytes. Acta Physiol Scand (1999) 0.89

Control of energy metabolism of heart muscle. Annu Rev Physiol (1981) 0.88

Electron microscopic observations and acid phosphatase activity in the ischemic rat heart. J Mol Cell Cardiol (1977) 0.88

Diltiazem protects the isolated rabbit heart from the mechanical and ultrastructural damage produced by transient hypoxia, low-flow ischemia and exposure to Ca++-free medium. J Pharmacol Exp Ther (1983) 0.87

Effect of short dimethylsulfoxide perfusions on ultrastructure of the isolated rat heart. J Mol Cell Cardiol (1973) 0.87

Inhibition of carnitine palmitoyl-CoA transferase activity and fatty acid oxidation by lactate and oxfenicine in cardiac muscle. J Mol Cell Cardiol (1985) 0.87

Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the Goto-Kakizaki rat model of type 2 diabetes: critical role of Akt. Diabetologia (2007) 0.87

Utilization of leucine by working rat heart. Am J Physiol (1980) 0.86

HCO3(-)-dependent alkalinizing transporter in adult rat ventricular myocytes: characterization and modulation. Am J Physiol (1997) 0.86

Slowly inactivating component of sodium current in ventricular myocytes is decreased by diabetes and partially inhibited by known Na(+)-H(+)Exchange blockers. J Mol Cell Cardiol (2000) 0.86

Structural, functional, and metabolic correlates in ischemic hearts: effects of substrates. Am J Physiol (1981) 0.86

Cardiac function and myosin ATPase in diabetic rats treated with insulin, T3, and T4. Am J Physiol (1983) 0.85

Regulation of fatty acid utilization in heart. Role of the carnitine-acetyl-CoA transferase and carnitine-acetyl carnitine translocase system. J Mol Cell Cardiol (1982) 0.85

Intracellular pH and role of Na+/H+ exchange during ischaemia and reperfusion of normal and diabetic rat hearts. Cardiovasc Res (1990) 0.85

Effects of diabetes and fasting on pantothenic acid metabolism in rats. Am J Physiol (1981) 0.84

Protection of the ischemic myocardium. Ultrastructural, enzymatic, and functional assessment of the efficacy of various cardioplegic infusates. J Thorac Cardiovasc Surg (1978) 0.84

The St. Thomas' hospital cardioplegic solution: a characterization in two species. Scand J Thorac Cardiovasc Surg Suppl (1981) 0.84

Effects of mechanical activity and hormones on myocardial glucose and fatty acid utilization. Circ Res (1976) 0.84

Pantothenate kinase and control of CoA synthesis in heart. Am J Physiol (1984) 0.84

Electrophysiological analysis of the sensitivity to calcium in ventricular muscle from alloxan diabetic rats. Basic Res Cardiol (1987) 0.83

Mechanisms of reduced reperfusion injury by low Ca2+ and/or high K+. Am J Physiol (1990) 0.83

The properties and regulation of pantothenate kinase from rat heart. J Biol Chem (1985) 0.83

Mitochondrial synthesis of coenzyme A is on the external surface. J Mol Cell Cardiol (1987) 0.83

Modulation by pH0 and intracellular Ca2+ of Na(+)-H+ exchange in diabetic rat isolated ventricular myocytes. Circ Res (1997) 0.83

A transport system for coenzyme A in isolated rat heart mitochondria. J Biol Chem (1987) 0.83

Control of glyceraldehyde-3-phosphate dehydrogenase in cardiac muscle. J Mol Cell Cardiol (1979) 0.82

Factors determining the utilization of glucose in isolated rat hearts. Basic Res Cardiol (1984) 0.82

Morphometric observations on the effects of ischemia in the isolated perfused rat heart. J Mol Cell Cardiol (1979) 0.82

Rate-limiting steps of carbohydrate and fatty acid metabolism in ischemic hearts. Acta Med Scand Suppl (1976) 0.82

A biochemical and ultrastructural study of the species variation in myocardial cell damage. J Mol Cell Cardiol (1976) 0.81

Coenzyme A metabolism in pantothenic acid-deficient rats. J Nutr (1982) 0.81

Acetylcholine-induced release of lactate dehydrogenase from isolated perfused rat heart. J Mol Cell Cardiol (1972) 0.81

Inhibition of post-ischemic ventricular recovery by low concentrations of prostacyclin in isolated working rat hearts: dependency on concentration, ischemia duration, calcium and relationship to myocardial energy metabolism. J Mol Cell Cardiol (1989) 0.81

An improved method for isolation of mitochondria in high yields from normal, ischemic, and autolyzed rat hearts. Anal Biochem (1982) 0.81

Intracellular pH regulation in papillary muscle cells from streptozotocin diabetic rats: an ion-sensitive microelectrode study. Pflugers Arch (1988) 0.81

Mechanisms of intracellular pH regulation during postischemic reperfusion of diabetic rat hearts. Diabetes (1995) 0.80

Metabolism of pantothenic acid in hearts of diabetic rats. J Mol Cell Cardiol (1989) 0.80

Effects of increased cardiac work on pyruvate dehydrogenase activity in hearts from diabetic animals. J Mol Cell Cardiol (1983) 0.80

Ischaemia-induced damage in the working rat heart preparation: the effect of perfusate substrate composition upon subendocardial ultrastructure of the ischaemic left ventricular wall. J Mol Cell Cardiol (1977) 0.80

Characterization of carnitine transport in isolated perfused adult rat hearts. Am J Physiol (1982) 0.80

Regulation of coenzyme A synthesis in heart muscle: effects of diabetes and fasting. Am J Physiol (1981) 0.80

Regulation of pantothenate kinase from various tissues of the rat. FEBS Lett (1985) 0.80

Effects of excess glucose and insulin on glycolytic metabolism during experimental myocardial ischemia. Am J Cardiol (1976) 0.79

Sodium dependence of carnitine transport in isolated perfused adult rat hearts. Am J Physiol (1983) 0.79

Chronic infarction decreases maximum cardiac work and sensitivity of heart to extracellular calcium. Am J Physiol (1985) 0.79

The mechanism of myocardial protection from ischemic arrest by intracoronary tetrodotoxin administration. J Thorac Cardiovasc Surg (1975) 0.79

Effects of treatment with pyruvate and tromethamine in experimental myocardial ischemia. Circ Res (1976) 0.79

Lacticodehydrogenase release from perfused rat heart under the effect of abnormal media. Arch Int Physiol Biochim (1969) 0.79

Integration of lipid utilization with Krebs cycle activity in muscle. Fed Proc (1977) 0.78

Intermittent perfusion of ischemic myocardium. Possible mechanisms of protective effects on mechanical function in isolated rat heart. Circulation (1990) 0.78

Energy metabolism during reperfusion following ischemia. J Physiol (Paris) (1980) 0.78

Recovery of ventricular function in reperfused ischemic rat hearts exposed to fatty acids. Am J Physiol (1985) 0.78

Relationship between coronary flow and adenosine triphosphate production from glycolysis and oxidative metabolism. Recent Adv Stud Cardiac Struct Metab (1975) 0.78

Skinned cardiac fibres of diabetic rats: contractile activation and effects of 2,3-butanedione monoxime (BDM) and caffeine. Cardiovasc Res (1993) 0.78

A mechanism for reduced myocardial carnitine levels in diabetic animals. Am J Physiol (1982) 0.78

Protection of ischemic myocardium from metabolic products. Acta Med Scand Suppl (1981) 0.77

Coenzyme A degradation in the heart: effects of diabetes and insulin. J Mol Cell Cardiol (1987) 0.77

Control of myocardial levels of CoA and carnitine. J Mol Cell Cardiol (1982) 0.77

Insulin therapy for depressed myocardial contractility after prolonged ischemia. Am J Cardiol (1978) 0.77

Effect of dimethylsulfoxide on isolated rat heart and lacticodehydrogenase release. Eur J Pharmacol (1971) 0.77

Ultrastructural modifications induced by reoxygenation in the anoxic isolated rat heart perfused without exogenous substrate. J Mol Cell Cardiol (1975) 0.77

Metabolic responses to varying restrictions of coronary blood flow in swine. Am J Physiol (1975) 0.77