The treatment of soft-tissue sarcomas of the extremities: prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy.

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Published in Ann Surg on September 01, 1982

Authors

S A Rosenberg, J Tepper, E Glatstein, J Costa, A Baker, M Brennan, E V DeMoss, C Seipp, W F Sindelar, P Sugarbaker, R Wesley

Associated clinical trials:

Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas (SA02) | NCT00881595

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Lymphokine-activated killer cell phenomenon. II. Precursor phenotype is serologically distinct from peripheral T lymphocytes, memory cytotoxic thymus-derived lymphocytes, and natural killer cells. J Exp Med (1983) 2.67

Grieving abortion loss. AWHONN Lifelines (2002) 2.66

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Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes. J Exp Med (1995) 2.54

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