Published in J Med Chem on September 01, 1982
Physiological and x-ray studies of potential antisickling agents. Proc Natl Acad Sci U S A (1983) 0.95
Phytomedicines and nutraceuticals: alternative therapeutics for sickle cell anemia. ScientificWorldJournal (2013) 0.80
Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration. Nutr Metab (Lond) (2016) 0.75
CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem (2001) 3.28
Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation. J Histochem Cytochem (1989) 3.26
Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease? J Cell Commun Signal (2009) 2.00
Hydrophobicity: is LogP(o/w) more than the sum of its parts? Eur J Med Chem (2000) 1.68
Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis. Curr Opin Rheumatol (2001) 1.55
The enigma of the liganded hemoglobin end state: a novel quaternary structure of human carbonmonoxy hemoglobin. Biochemistry (2005) 1.54
Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1. J Invest Dermatol (2001) 1.51
Is the Armadale epidemic over? Air pollution and mortality from lung cancer and other diseases, 1961-82. Br J Ind Med (1985) 1.49
Twinning in human populations and in cattle exposed to air pollution from incinerators. Br J Ind Med (1988) 1.46
Two simple methods for quantifying low-affinity dye-substrate binding. J Histochem Cytochem (1989) 1.45
Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Arthritis Rheum (2002) 1.40
Assessment of the anti-inflammatory effect of intra-articular steroids by means of external temperature measurements. Ann Rheum Dis (1970) 1.39
HINT: a new method of empirical hydrophobic field calculation for CoMFA. J Comput Aided Mol Des (1991) 1.37
Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. Exp Cell Res (2000) 1.30
The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts. Mol Pathol (2001) 1.24
Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis. Arthritis Rheum (1999) 1.15
Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis. Eur Respir J (2009) 1.08
Cerebrovascular disease in Scotland during 1959 to 1983: its geographical distribution and associations. Community Med (1989) 1.07
Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction analysis of novel hemoglobin oxygen effectors. J Med Chem (1991) 1.06
Applications of extraction mapping in environmental epidemiology. Stat Med (1993) 1.06
High mortality from coronary heart disease in south-west Scottish communities during three quinquennia. Public Health (1986) 1.01
X-ray structure of Escherichia coli pyridoxine 5'-phosphate oxidase complexed with FMN at 1.8 A resolution. Structure (2000) 1.00
Swainsonine affects the processing of glycoproteins in vivo. FEBS Lett (1983) 1.00
Vanillin, a potential agent for the treatment of sickle cell anemia. Blood (1991) 0.99
Endothelin-1 regulation of intercellular adhesion molecule-1 expression in normal and sclerodermal fibroblasts. J Cardiovasc Pharmacol (1998) 0.97
Circulating levels of active transforming growth factor beta1 are reduced in diffuse cutaneous systemic sclerosis and correlate inversely with the modified Rodnan skin score. Rheumatology (Oxford) (2005) 0.97
Physiological and x-ray studies of potential antisickling agents. Proc Natl Acad Sci U S A (1983) 0.95
Scleroderma fibroblasts promote migration of mononuclear leucocytes across endothelial cell monolayers. Clin Exp Immunol (1998) 0.95
The X-ray structure determination of bovine carbonmonoxy hemoglobin at 2.1 A resoultion and its relationship to the quaternary structures of other hemoglobin crystal froms. Protein Sci (2001) 0.95
High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector. Protein Sci (2001) 0.93
Fagaronine, a new tumor inhibitor isolated from Fagara zanthoxyloides Lam. (Rutaceae). J Pharm Sci (1972) 0.93
Structure of human erythrocyte catalase. Acta Crystallogr D Biol Crystallogr (2000) 0.92
Effects of long-term therapy with naltrexone on body weight in obesity. Clin Pharmacol Ther (1985) 0.92
Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis. Arthritis Rheum (1997) 0.92
Toxicity from ragwort and fat cow syndrome, or from industrial chemicals: the value of epidemiological analysis for interpreting clinico-pathological findings. Sci Total Environ (1991) 0.90
Computational methodology for estimating changes in free energies of biomolecular association upon mutation. The importance of bound water in dimer-tetramer assembly for beta 37 mutant hemoglobins. Biochemistry (2000) 0.89
Respiratory cancer and air pollution from iron foundries in a Scottish town: an epidemiological and environmental study. Br J Ind Med (1987) 0.89
Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents. J Med Chem (1991) 0.89
Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturation. Am J Physiol (1993) 0.87
Screening practices for gestational diabetes mellitus in UK obstetric units. Diabet Med (1999) 0.87
Bisaldehyde allosteric effectors as molecular ratchets and probes. Biochemistry (1995) 0.87
Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine. Rheumatology (Oxford) (2006) 0.86
Rattling the plate--reasons and rationales for early weaning. Health Educ Res (2001) 0.86
Limb joint surface areas and their ratios in Malagasy lemurs and other mammals. Am J Phys Anthropol (1995) 0.86
Expression and function of heterotypic adhesion molecules during differentiation of human skeletal muscle in culture. Am J Pathol (1992) 0.86
Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia. Blood (2001) 0.86
Design, synthesis, and testing of antisickling agents. 2. Proline derivatives designed for the donor site. J Med Chem (1983) 0.85
Very empirical treatment of solvation and entropy: a force field derived from log Po/w. J Comput Aided Mol Des (2001) 0.85
Oral itraconazole therapy for mycotic keratitis. Mycoses (1988) 0.85
Increased angiogenic response but deficient arteriolization and abnormal microvessel ultrastructure in critical leg ischaemia. Br J Surg (2006) 0.85
Evaluating docked complexes with the HINT exponential function and empirical atomic hydrophobicities. J Comput Aided Mol Des (1994) 0.85
A review of aging of dental components and a retrospective radiographic study of aging of the dental pulp and dentin in normal teeth. Quintessence Int (1991) 0.84
Long-term central cholinergic hypofunction induced in mice by ethylcholine aziridinium ion (AF64A) in vivo. J Pharmacol Exp Ther (1982) 0.84
Endothelins: effect on matrix biosynthesis and proliferation in normal and scleroderma fibroblasts. J Cardiovasc Pharmacol (1998) 0.84
Comparison of crystal and solution hemoglobin binding of selected antigelling agents and allosteric modifiers. Biochemistry (1990) 0.84
Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice. J Virol (1995) 0.83
X-ray diffraction study of the binding of the antisickling agent 12C79 to human hemoglobin. Proc Natl Acad Sci U S A (1991) 0.83
Low-affinity hemoglobin increases tissue PO2 and decreases arteriolar diameter and flow in the rat cremaster muscle. Microvasc Res (1996) 0.83
Design, synthesis, and testing of potential antisickling agents. 5. Disubstituted benzoic acids designed for the donor site and proline salicylates designed for the acceptor site. J Med Chem (1984) 0.83
KEY, LOCK, and LOCKSMITH: complementary hydropathic map predictions of drug structure from a known receptor-receptor structure from known drugs. J Mol Graph (1992) 0.82
Management of degenerative disc disease above an L5-S1 segment requiring arthrodesis. Spine (Phila Pa 1976) (1999) 0.82
Different patterns of endothelial cell activation in renal and pulmonary vascular disease in scleroderma. QJM (1998) 0.82
Oral ketoconazole in Keratomycosis. Indian J Ophthalmol (1989) 0.82
Deposition and distribution of carcass fat for steers differing in frame size and muscle thickness. J Anim Sci (1991) 0.81
Modulating the oxygen affinity of human fetal haemoglobin with synthetic allosteric modulators. Br J Haematol (1998) 0.80
Development of a quantitative quality grading system for mature cow carcasses. J Anim Sci (1992) 0.80
Design, synthesis, and testing of potential antisickling agents. 4. Structure-activity relationships of benzyloxy and phenoxy acids. J Med Chem (1984) 0.80
QSAR: hydropathic analysis of inhibitors of the p53-mdm2 interaction. Proteins (2001) 0.80
Evaluation of the side arm of (naphthylvinyl)pyridinium inhibitors of choline acetyltransferase. J Med Chem (1988) 0.80
Serological assessment of type I collagen burden in scleroderma spectrum disorders: a systematic review. Clin Exp Rheumatol (2004) 0.79
Reactions of sulfenes with ketene acetals and ketene animals. J Org Chem (1967) 0.79
RSR-13, an allosteric effector of hemoglobin, increases systemic and iliac vascular resistance in rats. Am J Physiol (1996) 0.79
Endothelin receptor selectivity: evidence from in vitro and pre-clinical models of scleroderma. Eur J Clin Invest (2009) 0.79
Filamentous proteins in Alzheimer's disease: new insights through molecular biology. Psychiatr Dev (1988) 0.79
Itraconazole therapy for fungal keratitis. Indian J Ophthalmol (1987) 0.79
A phase I study of RSR13, a radiation-enhancing hemoglobin modifier: tolerance of repeated intravenous doses and correlation of pharmacokinetics with pharmacodynamics. Int J Radiat Oncol Biol Phys (2001) 0.79
An evaluation of current and alternative systems for quality grading carcasses of mature slaughter cows. J Anim Sci (1998) 0.78
HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism. Genes Funct (1997) 0.78
Using live estimates and ultrasound measurements to predict beef carcass cutability. J Anim Sci (2000) 0.78
Structure of tetragonal crystals of human erythrocyte catalase. Acta Crystallogr D Biol Crystallogr (2001) 0.78
Nitric oxide synthase expression and activity in the tight-skin mouse model of fibrosis. Rheumatology (Oxford) (2008) 0.78
The epidemic of respiratory cancer in the town of Armadale: the use of long-term epidemiological surveillance to test a causal hypothesis. Public Health (1988) 0.78
Assessment of uterine arterial notching as a screening test for adverse pregnancy outcome. Am J Obstet Gynecol (1998) 0.78
Effect of distamycin on chlorambucil-induced mutagenesis in pZ189: evidence of a role for minor groove alkylation at adenine N-3. Mutagenesis (1994) 0.78
A reference map of human lung MRC-5 fibroblast proteins using immobilized pH gradient-isoelectric focusing-based two-dimensional electrophoresis. Proteomics (2001) 0.77
Influence of diet on growth rate and carcass composition of steers differing in frame size and muscle thickness. J Anim Sci (1988) 0.77
Biological and phytochemical evaluation of plants. IX. Antitumor activity of Maytenus senegalensis (Celastraceae) and a preliminary phytochemical investigation. Lloydia (1971) 0.77
Influence of gender, breed and age on maturity characteristics of sheep. J Anim Sci (1989) 0.77
Chimeric beta-EF3-alpha hemoglobin (Psi): energetics of subunit interaction and ligand binding. Biochemistry (1998) 0.77
Design, synthesis, and testing of potential antisickling agents. 3. Ethacrynic acid. J Med Chem (1984) 0.77
Structure elucidation of maytenonic acid, a new triterpene from Maytenus senegalensis (celastraceae). J Pharm Sci (1971) 0.77
HINT predictive analysis of binding between retinol binding protein and hydrophobic ligands. Bioorg Med Chem Lett (2000) 0.76
Influence of age and testosterone levels on masculine development in rams. J Anim Sci (1989) 0.76
Studies on Nigerian plants. 3. Biological and phytochemical screening of Lophira lanceolata, and the isolation of benzamide. Planta Med (1967) 0.76
Design, synthesis, and testing of potential antisickling agents. 9. Cyclic tetrapeptide homologs as mimics of the mutation site of hemoglobin S. Int J Pept Protein Res (1987) 0.76