Published in Clin Pharmacol Ther on March 01, 1980
Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol (2004) 3.23
Pharmacokinetics of brotizolam in healthy subjects following intravenous and oral administration. Br J Clin Pharmacol (1983) 1.78
Benzodiazepines: a summary of pharmacokinetic properties. Br J Clin Pharmacol (1981) 1.59
Influence of sex and oral contraceptive steroids on paracetamol metabolism. Br J Clin Pharmacol (1983) 1.50
The effects of age and smoking on the plasma protein binding of lignocaine and diazepam. Br J Clin Pharmacol (1985) 1.16
Protein binding predictions in infants. AAPS PharmSci (2002) 1.11
Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther (1993) 1.10
Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity. Br J Clin Pharmacol (1983) 1.05
Clobazam kinetics in the elderly. Br J Clin Pharmacol (1981) 1.04
Alterations in prednisolone disposition as a result of time of administration, gender and dose. Br J Clin Pharmacol (1984) 1.01
Effect of age and liver cirrhosis on the pharmacokinetics of nitrazepam. Br J Clin Pharmacol (1983) 0.98
Influence of sex, menstrual cycle and oral contraception on the disposition of nitrazepam. Br J Clin Pharmacol (1982) 0.93
The effect of intravenous cimetidine on the absorption of orally administered diazepam and lorazepam. Br J Clin Pharmacol (1982) 0.93
Prediction of drug concentrations in human skim milk from plasma protein binding and acid-base characteristics. Br J Clin Pharmacol (1988) 0.92
Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations. Br J Clin Pharmacol (1985) 0.87
Verapamil disposition--effects of sulphinpyrazone and cimetidine. Br J Clin Pharmacol (1985) 0.86
Diazepam tolerance: effect of age, regular sedation, and alcohol. Br Med J (Clin Res Ed) (1984) 0.86
Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration. Br J Clin Pharmacol (1981) 0.85
Single dose pharmacokinetics and pharmacodynamics of oral loprazolam in the elderly. Br J Clin Pharmacol (1985) 0.85
The pharmacokinetics of doxazosin in elderly normotensives. Br J Clin Pharmacol (1986) 0.84
Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM. Eur J Clin Pharmacol (2007) 0.83
Diazepam/beta-adrenoceptor antagonist interactions. Br J Clin Pharmacol (1984) 0.82
Pharmacokinetics of brotizolam in the elderly. Br J Clin Pharmacol (1983) 0.82
Valproic acid and diazepam interaction in vivo. Br J Clin Pharmacol (1982) 0.81
Diazepam kinetics in patients with renal insufficiency or hyperthyroidism. Br J Clin Pharmacol (1981) 0.81
Risk factors for excessive benzodiazepine use in a working age population: a nationwide 5-year survey in Norway. Scand J Prim Health Care (2015) 0.81
Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl) (2007) 0.79
Comparative study on the efficacy of and the tolerance to the triazolodiazepines, triazolam and brotizolam. Br J Clin Pharmacol (1983) 0.79
Drugs in the elderly. Bull N Y Acad Med (1980) 0.78
Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy. Br J Clin Pharmacol (1981) 0.78
The use of benzodiazepines in clinical practice. Br J Clin Pharmacol (1981) 0.78
Sex-dependent modulation of treatment response. Dialogues Clin Neurosci (2004) 0.77
Effects of seven-day diazepam administration on resting-state functional connectivity in healthy volunteers: a randomized, double-blind study. Psychopharmacology (Berl) (2014) 0.76
Relationship between sedation and pupillary function: comparison of diazepam and diphenhydramine. Br J Clin Pharmacol (2006) 0.76
Pharmacodynamics in the elderly. J R Soc Med (1994) 0.75
Single dose pharmacokinetics and pharmacodynamics of oral oxazepam in very elderly institutionalised subjects. Br J Clin Pharmacol (1991) 0.75
Benzodiazepines in clinical medicine: discussion. Br J Clin Pharmacol (1981) 0.75
A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther (1981) 69.83
Drug therapy. Clinical Pharmacokinetics (first of two parts). N Engl J Med (1975) 7.60
Clinical pharmacokinetics (second of two parts). N Engl J Med (1975) 3.17
Use of benzodiazepines in anxiety disorders. N Engl J Med (1993) 3.12
Drug therapy: drug disposition in old age. N Engl J Med (1982) 3.04
Effects of the antifungal agents on oxidative drug metabolism: clinical relevance. Clin Pharmacokinet (2000) 2.94
Midazolam: pharmacology and uses. Anesthesiology (1985) 2.89
Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J Clin Invest (1993) 2.89
Sensitivity to triazolam in the elderly. N Engl J Med (1991) 2.73
Vancomycin therapy in patients with impaired renal function: a nomogram for dosage. Ann Intern Med (1981) 2.68
Single-dose kinetics of intravenous vancomycin. J Clin Pharmacol (1980) 2.48
Intramuscular injection of drugs. N Engl J Med (1976) 2.20
Impairment of antipyrine clearance in humans by propranolol. Circulation (1978) 2.18
Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology (1984) 2.14
Toxicity of high-dose flurazepam in the elderly. Clin Pharmacol Ther (1977) 2.05
Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation (1996) 2.05
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants. Drug Metab Dispos (2000) 1.87
Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo. J Clin Psychopharmacol (1996) 1.86
Reduced benzodiazepine sensitivity in panic disorder. Arch Gen Psychiatry (1990) 1.84
Automated gas chromatography for studies of midazolam pharmacokinetics. Anesthesiology (1981) 1.78
Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program. Br J Clin Pharmacol (1978) 1.65
Clinical pharmacokinetics of quinidine. Clin Pharmacokinet (1980) 1.59
Benzodiazepines: a summary of pharmacokinetic properties. Br J Clin Pharmacol (1981) 1.59
Drug interactions with newer antidepressants: role of human cytochromes P450. J Clin Psychiatry (1998) 1.56
Adverse reactions to spironolactone. A report from the Boston Collaborative Drug Surveillance Program. JAMA (1973) 1.54
Adverse reactions to beta-adrenergic receptor blocking drugs: a report from the Boston collaborative drug surveillance program. Drugs (1974) 1.54
Dependence, tolerance, and addiction to benzodiazepines: clinical and pharmacokinetic considerations. Drug Metab Rev (1978) 1.54
Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther (2001) 1.52
Differential actions of chlordiazepoxide and oxazepam on hostility. Arch Gen Psychiatry (1968) 1.50
Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram. Drug Metab Dispos (2001) 1.47
Oxazepam kinetics: effects of age and sex. J Pharmacol Exp Ther (1980) 1.47
The use of autologous pericardium for ventricular aneurysm closure. Ann Thorac Surg (1988) 1.44
Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: kinetic-dynamic studies. Clin Pharmacol Ther (1994) 1.44
Clinical toxicity of furosemide in hospitalized patients. A report from the Boston Collaborative Drug Surveillance Program. Am Heart J (1977) 1.43
Reduction in lidocaine clearance during continuous infusion and by coadministration of propranolol. N Engl J Med (1980) 1.42
A retrospective study of children's perceptions of participation as clinical research subjects in a minimal risk study. J Dev Behav Pediatr (2001) 1.42
Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol (1997) 1.42
Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences. J Pharmacol Exp Ther (2000) 1.41
Possible interaction between fluoxetine and pimozide causing sinus bradycardia. Can J Psychiatry (1993) 1.41
Analysis of lorazepam and its glucuronide metabolite by electron-capture gas--liquid chromatography. Use in pharmacokinetic studies of lorazepam. J Chromatogr (1978) 1.41
Imipramine and buspirone in treatment of patients with generalized anxiety disorder who are discontinuing long-term benzodiazepine therapy. Am J Psychiatry (2000) 1.40
As originally published in 1988: The use of autologous pericardium for ventricular aneurysm closure. Updated in 1996. Ann Thorac Surg (1996) 1.40
Drug transporters in psychopharmacology--are they important? J Clin Psychopharmacol (2000) 1.40
Short-term morbidity and mortality of implantation of automatic implantable cardioverter-defibrillator. J Thorac Cardiovasc Surg (1990) 1.40
In vitro quantitation of benzodiazepine lipophilicity: relation to in vivo distribution. Br J Anaesth (1983) 1.39
Drug therapy. Current status of benzodiazepines. N Engl J Med (1983) 1.39
MAOIs and hypertension. J Clin Psychopharmacol (1992) 1.39
Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents. J Clin Pharmacol (1996) 1.39
Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans. J Pharm Sci (1979) 1.37
Pharmacokinetics, central nervous system uptake, and lipid solubility of propranolol, acebutolol, and sotalol. Cardiology (1984) 1.37
Effect of midazolam infusion and flumazenil administration on epinephrine arrhythmogenicity in dogs anesthetized with halothane. Anesthesiology (1993) 1.37
Long-term therapeutic use of benzodiazepines. I. Effects of abrupt discontinuation. Arch Gen Psychiatry (1990) 1.35
Lorazepam kinetics in the elderly. Clin Pharmacol Ther (1979) 1.35
Pharmacokinetic and clinical implications of quinidine protein binding. J Pharm Sci (1979) 1.34
Absorption and disposition of chlordiazepoxide in young and elderly male volunteers. J Clin Pharmacol (1978) 1.33
Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole. Clin Pharmacol Ther (1999) 1.32
Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes. Proc Natl Acad Sci U S A (1999) 1.31
Clinical pharmacokinetics of oxazepam and lorazepam. Clin Pharmacokinet (1981) 1.31
Kinetics of intravenous and intramuscular morphine. Clin Pharmacol Ther (1978) 1.29
Clinical implications of benzodiazepine pharmacokinetics. Am J Psychiatry (1977) 1.29
Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs. Clin Pharmacol Ther (1981) 1.29