Published in Eur J Biochem on June 01, 1980
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A (1982) 8.71
Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest (1991) 1.18
Prelysosomal and lysosomal connections between autophagy and endocytosis. Biochem J (1992) 1.16
Preparation of isolated rat liver cells. Methods Cell Biol (1976) 17.96
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A (1982) 8.71
Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. Exp Cell Res (1973) 4.32
Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin. Eur J Biochem (1979) 3.66
Inhibitors of lysosomal function. Methods Enzymol (1983) 3.17
Ammonia inhibition of protein degradation in isolated rat hepatocytes. Quantitative ultrastructural alterations in the lysosomal system. Exp Cell Res (1976) 3.10
Prelysosomal convergence of autophagic and endocytic pathways. Biochem Biophys Res Commun (1988) 2.95
Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes. J Cell Biol (1990) 2.84
Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes. J Biol Chem (1998) 2.44
Preparation of rat liver cells. I. Effect of Ca 2+ on enzymatic dispersion of isolated, perfused liver. Exp Cell Res (1972) 2.37
Purification and characterization of autophagosomes from rat hepatocytes. Biochem J (1998) 2.20
Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway. Exp Cell Res (1986) 2.10
Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions. Exp Cell Res (1995) 2.03
Protein degradation in isolated rat hepatocytes is inhibited by ammonia. Biochem Biophys Res Commun (1975) 2.00
Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis (1993) 1.80
Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes. Exp Cell Res (1981) 1.78
Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes. Biochim Biophys Acta (1980) 1.68
Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine. Exp Cell Res (1982) 1.63
Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy. Eur J Cell Biol (2000) 1.62
Preparation of rat liver cells. II. Effects of ions and chelators on tissue dispersion. Exp Cell Res (1973) 1.62
Effects of lysosomotropic monoamines, diamines, amino alcohols, and other amino compounds on protein degradation and protein synthesis in isolated rat hepatocytes. Mol Pharmacol (1980) 1.56
Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes. J Cell Biol (1984) 1.50
Mass isolation and culture of rat kupffer cells. J Exp Med (1975) 1.47
Dependence of hepatocytic autophagy on intracellularly sequestered calcium. J Biol Chem (1993) 1.46
From bad to worse: evaluation by Journal Impact. Trends Biochem Sci (1989) 1.45
Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes. Biochem J (1978) 1.45
Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J Biol Chem (1998) 1.42
Hepatocyte suspensions and cultures as tools in experimental carcinogenesis. J Toxicol Environ Health (1979) 1.41
Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes. Biochim Biophys Acta (1980) 1.40
Inhibition of hepatocytic protein degradation by methylaminopurines and inhibitors of protein synthesis. Biochim Biophys Acta (1981) 1.40
Proteases and proteolysis in the lysosome. Experientia (1992) 1.38
The use of Metrizamide as a gradient medium for isopycnic separation of rat liver cells. FEBS Lett (1974) 1.37
Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine. J Cell Biol (1991) 1.36
Autophagic sequestration of [14C]sucrose, introduced into rat hepatocytes by reversible electro-permeabilization. Exp Cell Res (1982) 1.35
Amino acid control of protein synthesis and degradation in isolated rat hepatocytes. Ann N Y Acad Sci (1980) 1.31
Citation frequency and journal impact: valid indicators of scientific quality? J Intern Med (1991) 1.26
Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy. Biochim Biophys Acta (2001) 1.24
Energy dependence of different steps in the autophagic-lysosomal pathway. J Biol Chem (1989) 1.22
Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity. Biochem J (1992) 1.21
Use of [3H]raffinose as a specific probe of autophagic sequestration. Exp Cell Res (1986) 1.21
Prelysosomal and lysosomal connections between autophagy and endocytosis. Biochem J (1992) 1.16
Inhibitors and pathways of hepatocytic protein degradation. Acta Biol Med Ger (1981) 1.14
Binucleation and polyploidization patterns in developmental and regenerative rat liver growth. Cell Prolif (1993) 1.14
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. J Neurosci (1998) 1.13
Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats. Exp Cell Res (1985) 1.12
Protein-catabolic stage of isolated rat hepatocytes. Biochim Biophys Acta (1977) 1.09
Evidence for acidity of prelysosomal autophagic/endocytic vacuoles (amphisomes). Biochem J (1993) 1.09
Valine uptake and incorporation into protein in isolated rat hepatocytes. Nature of the precursor pool for protein synthesis. Eur J Biochem (1978) 1.07
Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis. Carcinogenesis (1984) 1.06
Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid. Exp Cell Res (1995) 1.05
Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors. Eur J Biochem (1993) 1.04
Autophagic-lysosomal and mitochondrial sequestration of [14C]sucrose. Density gradient distribution of sequestered radioactivity. Eur J Biochem (1985) 1.03
Effects of insulin and anchorage on hepatocytic protein metabolism and amino acid transport. J Cell Sci (1981) 1.02
Role of microtubuli in the lysosomal degradation of endogenous and exogenous protein in isolated rat hepatocytes. Hoppe Seylers Z Physiol Chem (1981) 1.02
Separation of lysosomes and autophagosomes by means of glycyl-phenylalanine-naphthylamide, a lysosome-disrupting cathepsin-C substrate. Eur J Biochem (1994) 1.02
Induction of tryptophan oxygenase in primary rat liver cell suspensions by glucocorticoid hormone. Exp Cell Res (1972) 1.02
Protein synthesis and protein degradation through the cell cycle of human NHIK 3025 cells in vitro. Exp Cell Res (1979) 1.01
Energy dependence of autophagic protein degradation in isolated rat hepatocytes. Eur J Biochem (1987) 1.01
Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes. Biochem J (1985) 1.01
Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy. Exp Cell Res (1985) 0.99
Changes in ploidy distributions in human liver carcinogenesis. J Natl Cancer Inst (1988) 0.98
Increase in cis-dichlorodiammineplatinum (II) cytotoxicity upon reversible electropermeabilization of the plasma membrane in cultured human NHIK 3025 cells. Eur J Cancer Clin Oncol (1986) 0.98
Structural and physical changes in lysosomes from isolated rat hepatocytes treated with methylamine. Biochim Biophys Acta (1983) 0.97
Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes. Biochem Soc Symp (1989) 0.97
Role of cAMP in the regulation of hepatocytic autophagy. Eur J Biochem (1996) 0.96
Tryptophan oxygenase activation and ascorbate oxidation in whole homogenates from rat liver. Biochim Biophys Acta (1969) 0.96
Incorporation of radioactive amino acids into protein in isolated rat hepatocytes. Biochim Biophys Acta (1976) 0.94
Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine. Biochem J (1990) 0.94
Cellular and lysosomal uptake of methylamine in isolated rat hepatocytes. Biochem J (1983) 0.94
Vanadate inhibits protein degradation in isolated rat hepatocytes. J Biol Chem (1981) 0.91
The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas. Carcinogenesis (1988) 0.91
Inhibitor of protein degradation formed during incubation of isolated rat hepatocytes in a cell culture medium. Its identification as ammonia. Exp Cell Res (1977) 0.91
Ammonia inhibits protein secretion in isolated rat hepatocytes. Biochim Biophys Acta (1977) 0.90
Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes. Eur J Cell Biol (1997) 0.90
Inhibition of hepatocytic autophagy by adenosine, adenosine analogs and AMP. Biol Chem (1998) 0.90
Adsorption, simple binding and complex binding of rat hepatocytes to various in vitro substrata. Exp Cell Res (1980) 0.89
Effects of aminooxyacetate, alanine and other amino acids on protein synthesis in isolated rat hepatocytes. Biochim Biophys Acta (1978) 0.89
Use of electrical methods in the study of hepatocytic autophagy. Biomed Biochim Acta (1986) 0.89
Inhibition of autophagy and multiple steps in asialoglycoprotein endocytosis by inhibitors of tyrosine protein kinases (tyrphostins). J Biol Chem (1995) 0.89
Autophagosome-associated variant isoforms of cytosolic enzymes. Biochem J (2000) 0.88
Autophagic sequestration of [14C]sucrose introduced into isolated rat hepatocytes by electrical and non-electrical methods. Exp Cell Res (1985) 0.88
Amino acid control of protein degradation in normal and leukemic human lymphocytes. Exp Cell Res (1984) 0.88
Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells. Toxicon (2001) 0.88
Trapping of electro-injected [14C]sucrose by hepatocyte mitochondria: a mechanism for cellular autofiltration? Biochem Biophys Res Commun (1984) 0.88
The effect of perfusate pH on respiration and glycolysis in the isolated rat liver perfused with an erythrocyte- and protein-free medium. Biochim Biophys Acta (1972) 0.87
Radiolabelled sugars as probes of hepatocytic autophagy. Biomed Biochim Acta (1986) 0.87
Protein metabolism and survival of rat hepatocytes in early culture. Exp Cell Res (1980) 0.87
6-substituted purines: a novel class of inhibitors of endogenous protein degradation in isolated rat hepatocytes. Arch Biochem Biophys (1982) 0.86
A simple perfusion technique applied to glucocorticoid regulation of tryptophan oxygenase turnover and bile production in the isolated rat liver. Hoppe Seylers Z Physiol Chem (1969) 0.86
The role of protein accumulation in the cell cycle control of human NHIK 3025 cells. J Cell Physiol (1981) 0.86
Ploidy-dependent growth and binucleation in cultured rat hepatocytes. Exp Cell Res (1994) 0.85
Inhibition of cell spreading by lysosomotropic amines. FEBS Lett (1979) 0.85