Published in Eur J Clin Pharmacol on August 01, 1980
Lack of effect of ranitidine on warfarin action. Br J Clin Pharmacol (1981) 1.45
Cimetidine increases steady state plasma levels of propranolol. Br J Clin Pharmacol (1981) 1.16
Factors affecting the response to inhibition of drug metabolism by cimetidine--dose response and sensitivity of elderly and induced subjects. Br J Clin Pharmacol (1984) 1.08
The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function. Br J Clin Pharmacol (1982) 1.04
Cimetidine does not alter morphine disposition in man. Br J Clin Pharmacol (1982) 0.94
Ranitidine and cimetidine; drug interactions with single dose and steady-state nifedipine administration. Br J Clin Pharmacol (1987) 0.93
Antipyrine clearance and metabolite formation in patients with alcoholic cirrhosis. Br J Clin Pharmacol (1984) 0.93
Omeprazole: effects on oxidative drug metabolism. Br J Clin Pharmacol (1984) 0.92
Clinical risk factors for prolonged PT/PTT in abdominal sepsis patients treated with moxalactam or tobramycin plus clindamycin. Ann Surg (1985) 0.89
The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man. Br J Clin Pharmacol (1986) 0.78
Comparative effects of famotidine and cimetidine on 7-ethoxycoumarin O-deethylase activity in human livers. Br J Clin Pharmacol (1986) 0.78
A comparison of the influence of famotidine and cimetidine on phenytoin elimination and hepatic blood flow. Br J Clin Pharmacol (1989) 0.75
Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects. Br J Clin Pharmacol (1989) 0.75
H2 receptor antagonists: cimetidine and ranitidine. Br Med J (Clin Res Ed) (1983) 0.75
The influence of cimetidine on the pharmacokinetics of 5-fluorouracil. Br J Clin Pharmacol (1984) 0.75
An open, controlled, crossover study on the effects of cimetidine on the steady-state pharmacokinetics of trovafloxacin. Eur J Clin Microbiol Infect Dis (1998) 0.75
Cimetidine inhibits microsomal drug metabolism in the rat. Eur J Pharmacol (1979) 1.85
Cardiac arrest after interscalene brachial plexus block with ropivacaine and lidocaine. Acta Anaesthesiol Scand (2003) 1.83
Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. Pharmacol Rev (1982) 1.70
Oral, transdermal and vaginal combined contraceptives induce an increase in markers of chronic inflammation and impair insulin sensitivity in young healthy normal-weight women: a randomized study. Hum Reprod (2012) 1.52
Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions. Clin Pharmacol Ther (1997) 1.46
The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat. Biochem Pharmacol (1980) 1.45
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am J Hum Genet (1995) 1.33
Human placenta: a human organ for developmental toxicology research and biomonitoring. Placenta (2005) 1.32
Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population. FEBS Lett (1999) 1.23
Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse. Biochem Pharmacol (1988) 1.20
Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoreceptors. J Auton Pharmacol (1986) 1.19
Interindividual variability of coumarin 7-hydroxylation in healthy volunteers. Pharmacogenetics (1992) 1.18
Alpha-1 adrenoceptor-mediated positive inotropic effect and inositol trisphosphate increase in mammalian heart. J Pharmacol Exp Ther (1988) 1.12
Comparison of activities of drug-metabolizing enzymes in human fetal and adult livers. Clin Pharmacol Ther (1973) 1.10
Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes. Biochem Pharmacol (1993) 1.08
Expression of CYP2A genes in human liver and extrahepatic tissues. Biochem Pharmacol (1999) 1.04
Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism. FEBS Lett (1999) 1.04
Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity. Crit Rev Toxicol (1998) 1.04
Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver. Biochem Pharmacol (1994) 1.03
Interstitial lung disease induced by exogenous agents: factors governing susceptibility. Eur Respir J Suppl (2001) 1.02
Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review. Gene (1995) 1.01
Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons. Br J Clin Pharmacol (1985) 1.01
Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells. Carcinogenesis (1997) 1.01
Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Biochem Pharmacol (1996) 1.00
Cocaine N-demethylation and the metabolism-related hepatotoxicity can be prevented by cytochrome P450 3A inhibitors. Eur J Pharmacol (1994) 0.99
Efeect of temperature on hospital admissions for myocardial infarction in a subarctic area. Br Med J (1970) 0.98
Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. Br J Clin Pharmacol (1995) 0.98
The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue. Breast Cancer Res Treat (2001) 0.97
The effects of cigarette smoke on the metabolism of [3H]benzo(a)pyrene by rat lung microsomes. Cancer Res (1977) 0.97
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. Chem Res Toxicol (1995) 0.97
The expression and environmental regulation of P450 enzymes in human placenta. Crit Rev Toxicol (1994) 0.96
CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes. Drug Metab Dispos (2001) 0.96
Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase. FEBS Lett (1998) 0.95
A study on the mutagenic activity of styrene and styrene oxide. Scand J Work Environ Health (1976) 0.95
Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. Am J Respir Cell Mol Biol (2000) 0.95
Effect of maternal cigarette smoking on 3,4-benzpyrene and N-methylaniline metabolism in human fetal liver and placenta. Toxicol Appl Pharmacol (1972) 0.95
The effect of cigarette smoking on 7-ethoxyresorufin O-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. Br J Clin Pharmacol (1986) 0.93
Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. Biochem Pharmacol (1996) 0.93
Hepatic drug-oxidizing enzyme systems and urinary D-glucaric acid excretion in patients with congestive heart failure. Br J Clin Pharmacol (1975) 0.92
In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene. Drug Metab Dispos (2001) 0.92
Atrial natriuretic peptide (ANP) in rat gastrointestinal tract. FEBS Lett (1988) 0.92
Polymorphisms of CYP2A6 and its practical consequences. Br J Clin Pharmacol (2001) 0.92
Cytochrome P450 3A expression in the human fetal liver: evidence that CYP3A5 is expressed in only a limited number of fetal livers. Biol Neonate (2001) 0.92
Effect of prostaglandin E2, cimetidine, and atropine on ethanol-induced gastric mucosal damage in the rat. Scand J Gastroenterol (1980) 0.92
Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma. Hepatology (1998) 0.91
Transfer of clonidine and dexmedetomidine across the isolated perfused human placenta. Acta Anaesthesiol Scand (1997) 0.90
Ovarian toxicity of cigarette smoke exposure during pregnancy in mice. Toxicol Lett (1985) 0.90
CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients. Br J Clin Pharmacol (1995) 0.90
Metabolism and covalent binding of [3H]benzo(a)pyrene by isolated perfused lungs and short-term tracheal organ culture of cigarette smoke-exposed rats. Cancer Res (1977) 0.90
Expression and localization of CYP3A4 and CYP3A5 in human lung. Am J Respir Cell Mol Biol (1997) 0.90
Retrovirus-mediated stable expression of human CYP2A6 in mammalian cells. Eur J Pharmacol (1993) 0.90
Expression of xenobiotic-metabolizing CYPs in human pulmonary tissue. Exp Toxicol Pathol (1999) 0.89
Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: a comparative study in vitro. Xenobiotica (2007) 0.89
Cytochrome P450 isoforms in human fetal tissues related to phenobarbital-inducible forms in the mouse. Biochem Pharmacol (1993) 0.89
Hepatitis A impairs the function of human hepatic CYP2A6 in vivo. Toxicology (1997) 0.88
Correlations between cytochrome P-450 and oxidative metabolism of benzo[a]pyrene and 7-ethoxycoumarin in human liver in vitro and antipyrine elimination in vivo. Drug Metab Dispos (1980) 0.88
Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression. Biochem J (1992) 0.87
Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors. Xenobiotica (1990) 0.87
New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. Br J Pharmacol (2007) 0.87
Properties of benzpyrene hydroxylase from human liver and comparison with the rat, rabbit and guinea-pig enzymes. Xenobiotica (1975) 0.86
Cytochrome P4502A5 expression and inducibility by phenobarbital is modulated by cAMP in mouse primary hepatocytes. Biochem Biophys Res Commun (1994) 0.86
Interindividual variability of coumarin 7-hydroxylation in a Turkish population. Eur J Clin Pharmacol (1994) 0.86
Is ethanol-induced damage of the gastric mucosa a hyperosmotic effect? Comparative studies on the effects of ethanol, some other hyperosmotic solutions and acetylsalicylic acid on rat gastric mucosa. Acta Pharmacol Toxicol (Copenh) (1980) 0.85
Cytochrome P-450-linked monooxygenase system and drug-induced spectral interactions in human liver microsomes. Chem Biol Interact (1974) 0.85
Aryl hydrocarbon hydroxylase activity in cultured lymphocytes of psoriatic patients. Arch Dermatol Res (1982) 0.85
Pyrazole is different from acetone and ethanol as an inducer of the polysubstrate monooxygenase system in mice: evidence that pyrazole-inducible P450Coh is distinct from acetone-inducible P450ac. Arch Biochem Biophys (1988) 0.84
Differential inhibition of aryl hydrocarbon hydroxylase in human foetal liver, adrenal gland and placenta*. Acta Pharmacol Toxicol (Copenh) (1977) 0.84
Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail. Xenobiotica (2010) 0.84
Serum zinc and serum copper and indices of drug metabolism in alcoholics. Eur J Clin Pharmacol (1977) 0.84
Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica (1997) 0.84
Toluene metabolism by cDNA-expressed human hepatic cytochrome P450. Biochem Pharmacol (1997) 0.84
Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes. Mol Carcinog (1997) 0.84
CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers. Drug Metab Dispos (2000) 0.84
Increased clearance of ethanol from the blood of asthmatic patients. Ann Allergy (1972) 0.84
Developmental expression of cytochrome P450 enzymes in human liver. Pharmacol Toxicol (1998) 0.84
Serum sex hormone levels after replacing carbamazepine with oxcarbazepine. Eur J Clin Pharmacol (1995) 0.83
Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach. Pharmacogenomics J (2007) 0.83
Central nervous system effects of arachidonic acid, PGE2, PGF2 alpha, PGD2 and PGI2 on gastric secretion in the rat. Br J Pharmacol (1983) 0.82
Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital. Biochem Pharmacol (1988) 0.82
Effect of five structurally diverse H2-receptor antagonists on drug metabolism. Biochem Pharmacol (1986) 0.82
Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases. Naunyn Schmiedebergs Arch Pharmacol (1993) 0.82
Pertussis toxin does not inhibit the alpha 1-adrenoceptor-mediated effect on inositol phosphate production in the heart. Eur J Pharmacol (1987) 0.82
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls. Int J Cancer (1987) 0.82
Mutagenicity studies of different polycyclic aromatic hydrocarbons: the significance of enzymatic factors and molecular structure. Carcinogenesis (1987) 0.82
Polymorphism of debrisoquine hydroxylation among Finns and Lapps. Br J Clin Pharmacol (1988) 0.82
Biotransformation of xenobiotics in the fetus. Pharmacol Ther (1980) 0.82
Effect of estrogen on the serum cholesterol and triglyceride levels of prostatic cancer patients. J Urol (1971) 0.82
Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium. Pharmacol Toxicol (1998) 0.82
Effect of the phosphodiesterase inhibitor 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711) on gastric secretion and gastric mucosal cyclic AMP. Naunyn Schmiedebergs Arch Pharmacol (1978) 0.82
Immunochemical and molecular biological studies on human placental cigarette smoke-inducible cytochrome P-450-dependent monooxygenase activities. Toxicology (1990) 0.81
Studies on the mechanism of the inhibitory effect of ethanol on the gastric acid output in the rat. Naunyn Schmiedebergs Arch Pharmacol (1978) 0.81
Expression of xenobiotic-metabolizing enzymes in human pulmonary tissue: possible role in susceptibility for ILD. Eur Respir J Suppl (2001) 0.81
Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices. Drug Metab Dispos (2000) 0.81
Human placental xenobiotic and steroid biotransformations catalyzed by cytochrome P450, epoxide hydrolase, and glutathione S-transferase activities and their relationships to maternal cigarette smoking. Drug Metab Rev (1990) 0.81