Heymann nephritis induced by kidney brush border glycoproteins.

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Published in Lab Invest on December 01, 1980

Authors

A Miettinen, T Törnroth, I Tikkanen, I Virtanen, E Linder

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Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med (1983) 4.89

The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci U S A (1982) 4.65

Antibodies to basement membrane heparan sulfate proteoglycans bind to the laminae rarae of the glomerular basement membrane (GBM) and induce subepithelial GBM thickening. J Exp Med (1986) 1.22

Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis. J Clin Invest (1997) 1.10

Identification of a 400-kd protein in the brush borders of human kidney tubules that is similar to gp330, the nephritogenic antigen of rat Heymann nephritis. Am J Pathol (1987) 1.00

Lymph node cells from rats with Heymann's nephritis produce in vitro autoantibodies directed against purified renal tubular antigen. Immunology (1984) 0.99

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Decrease of glomerular disialogangliosides in puromycin nephrosis of the rat. Am J Pathol (1996) 0.92

Mapping rat megalin: the second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis. Proc Natl Acad Sci U S A (1996) 0.85

Isolation and characterization of rat nephritogenic and non nephritogenic brush border antigens. Clin Exp Immunol (1986) 0.84

Lipoproteins accumulate in immune deposits and are modified by lipid peroxidation in passive Heymann nephritis. Am J Pathol (1996) 0.82

Interstitial mononuclear cell infiltration in Heymann nephritis. Clin Exp Immunol (1987) 0.81

A simple technique for detecting the antigen of Heymann nephritis in glomeruli by immunofluorescence. Clin Exp Immunol (1986) 0.78

Molecular analysis of the pathological autoimmune antigens of Heymann nephritis. Am J Pathol (1996) 0.77

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