Published in Ann R Coll Surg Engl on September 01, 1995
The dedicated emergency surgeon: towards consultant-based acute surgical admissions. Ann R Coll Surg Engl (2008) 1.55
Accident and emergency 24 hour senior cover--a necessity or a luxury? J Accid Emerg Med (1998) 1.30
Emergency admission of patients to general surgical beds: attitudes of general practitioners, surgical trainees, and consultants in Liverpool, UK. J Epidemiol Community Health (1997) 0.76
A report on an acute, in-hours, outpatient review clinic with ultrasonography facilities for the early evaluation of general surgical patients. Ann R Coll Surg Engl (2016) 0.75
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (1999) 36.25
Functional discovery via a compendium of expression profiles. Cell (2000) 31.39
EXPERIMENTAL EPIDEMIC POLIOMYELITIS IN MONKEYS. J Exp Med (1910) 15.24
Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat Med (1998) 9.72
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev (1997) 8.35
Widespread aneuploidy revealed by DNA microarray expression profiling. Nat Genet (2000) 7.26
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J (1998) 5.25
Methods for studying the yeast vacuole. Methods Enzymol (1991) 4.55
Availability of cadaveric kidneys for transplantation. Br Med J (1971) 4.41
Integrating genetic approaches into the discovery of anticancer drugs. Science (1997) 3.99
Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction. Mol Cell Biol (1999) 3.90
Cystic fibrosis in the United Kingdom, 1968-1988: incidence, population and survival. Paediatr Perinat Epidemiol (1993) 3.37
Early smoking initiation and nicotine dependence in a cohort of young adults. Drug Alcohol Depend (1993) 3.01
Routine preoperative chest radiography in non-cardiopulmonary surgery. Br Med J (1976) 2.85
Raynaud's phenomenon as side effect of beta-blockers in hypertension. Br Med J (1976) 2.79
THE PHYSIOLOGY OF THE IMMEDIATE REACTION OF ANAPHYLAXIS IN THE GUINEA-PIG. J Exp Med (1910) 2.78
Implementation of guidelines for the use of skull radiographs in patients with head injuries. Lancet (1984) 2.60
Cystic fibrosis mortality and survival in the UK: 1947-2003. Eur Respir J (2006) 2.54
How much can the NHS afford to spend to save a life or avoid a severe disability? Lancet (1985) 2.39
Relation between birth weight at term and systolic blood pressure in adolescence. BMJ (1994) 2.37
Fatal outcome from administration of a salt emetic. Postgrad Med J (1974) 2.36
Biogenesis of the vacuole in Saccharomyces cerevisiae. Int Rev Cytol (1992) 2.31
A pilot evaluation of radiography of the acute abdomen. Clin Radiol (1984) 2.28
Association between mortality from ischaemic heart-disease and rainfall in South Wales and in the county boroughs of England and Wales. Lancet (1972) 2.26
Multicentre trial of four strategies to reduce use of a radiological test. Lancet (1986) 2.26
Can health visitors prevent fractures in elderly people? BMJ (1992) 2.25
Hospital admission and the start of benzodiazepine use. BMJ (1992) 2.20
Hyponatraemia: adverse effect of diuretic treatment. Br Med J (1977) 2.16
Membrane protein retention in the yeast Golgi apparatus: dipeptidyl aminopeptidase A is retained by a cytoplasmic signal containing aromatic residues. J Cell Biol (1993) 2.15
Transformation of C3H 10T1/2 cells by low doses of ionising radiation: a collaborative study by six European laboratories strongly supporting a linear dose-response relationship. J Radiol Prot (1998) 2.14
Incidence, population, and survival of cystic fibrosis in the UK, 1968-95. UK Cystic Fibrosis Survey Management Committee. Arch Dis Child (1997) 2.12
Detection of antigen-antibody binding events with the atomic force microscope. Biochemistry (1997) 2.05
The Saccharomyces cerevisiae SPT8 gene encodes a very acidic protein that is functionally related to SPT3 and TATA-binding protein. Genetics (1994) 2.04
Surgical wards and progressive patient care: new challenges. Br J Hosp Med (1991) 2.03
Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition. Xenobiotica (2006) 1.96
Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation. Science (1993) 1.92
Malformations of central nervous system and softness of local water supplies. Br Med J (1971) 1.92
Cost of saving a life by cervical screening. Lancet (1985) 1.92
Integrated regional haemodialysis and renal transplantation centre. Br Med J (1970) 1.89
The relationship between liver volume, antipyrine clearance and indocyanine green clearance before and after phenobarbitone administration in man. Br J Clin Pharmacol (1976) 1.88
Comparison of azathioprine, cyclophosphamide, and gold in treatment of rheumatoid arthritis. Br Med J (1974) 1.87
Choosing who shall not be treated in the NHS. Soc Sci Med (1989) 1.87
Pharmacokinetics of ketoconazole in normal subjects. J Antimicrob Chemother (1981) 1.84
Clinical guidelines, medical litigation, and the current medical defence system. Lancet (1987) 1.83
Prospective comparison of double-contrast barium meal examination and fibreoptic endoscopy in acute upper gastrointestinal haemorrhage. Br Med J (1976) 1.82
Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins. Curr Biol (2001) 1.82
Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects. Br J Clin Pharmacol (1978) 1.82
Relationship between time-integrated C-reactive protein levels and radiologic progression in patients with rheumatoid arthritis. Arthritis Rheum (2000) 1.81
Physiological and pharmacological variability in estimated hepatic blood flow in man. Br J Clin Pharmacol (1981) 1.81
Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae. Cancer Res (2000) 1.72
Inguinal hernia and a single strenuous event. Ann R Coll Surg Engl (1996) 1.68
Compliance with standardised assessment scales for elderly people among consultant geriatricians in Wessex. BMJ (1993) 1.63
The "at risk" infant. Lancet (1967) 1.62
Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis. Gut (1982) 1.59
Post operative care: the role of the high dependency unit. Ann R Coll Surg Engl (1983) 1.57
Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase. Br J Pharmacol (1995) 1.57
Determinants of response to frusemide in normal subjects. Br J Clin Pharmacol (1977) 1.54
Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell (1996) 1.53
A PARALYTIC DISEASE OF GUINEA PIGS DUE TO THE TUBERCLE BACILLUS. J Exp Med (1929) 1.52
Genetic selection of peptide inhibitors of biological pathways. Science (1999) 1.51
Area differences in prevalence of neural tube malformations in South Wales. A study of possible demographic determinants. Br J Prev Soc Med (1972) 1.50
People's knowledge of health and disease. J Public Health Med (1990) 1.50
The Royal College of Radiologists Multicentre Guideline Study: implications for clinical practice. Clin Radiol (1992) 1.50
The efficacy of a serum screening service for neural-tube defects: the South Wales experience. Lancet (1983) 1.49
The short term effects of propranolol, atenolol and labetalol on antipyrine kinetics in normal subjects. Br J Clin Pharmacol (1982) 1.49
Hemorrhagic Hepatitis in Antitoxin Horses. J Med Res (1906) 1.47
Peritoneal drainage following cholecystectomy: a controlled trial. Ann R Coll Surg Engl (1983) 1.42
A mathematical model of an integrated haemodialysis and renal transplantation programme. Br J Prev Soc Med (1974) 1.41
Cell-free assays for gamma-secretase activity. FASEB J (2000) 1.41
In-situ atomic force microscopy study of beta-amyloid fibrillization. J Mol Biol (2000) 1.40
Survey of attitudes of hospital staff to cadaveric kidney transplantation. Br Med J (1972) 1.36
Possible impact of audit on chest X-ray requests from surgical wards. Lancet (1983) 1.35
Multiple dose pharmacokinetics of ketoconazole and their effects on antipyrine kinetics in man. J Antimicrob Chemother (1983) 1.34
Can we afford screening for neural tube defects? The South Wales experience. Br Med J (Clin Res Ed) (1985) 1.34
Area differences in spontaneous abortion rates in South Wales and their relation to neural tube defect incidence. Br Med J (1973) 1.33
Surface plasmon resonance analysis of dynamic biological interactions with biomaterials. Biomaterials (2000) 1.33
Comparative morphology of the tapetum lucidum (among selected species). Vet Ophthalmol (2004) 1.32
Prognostic factors and survival of horses with ocular/adnexal squamous cell carcinoma: 147 cases (1978-1988). J Am Vet Med Assoc (1991) 1.32
The cost of saving a life through cervical cytology screening: implications for health policy. Health Policy (1987) 1.31
Policy for controlling pain after surgery: effect of sequential changes in management. BMJ (1992) 1.31
Epidemiologic study of ocular/adnexal squamous cell carcinoma in horses. J Am Vet Med Assoc (1991) 1.29
Variation in repeat rates between 18 radiology departments. Br J Radiol (1987) 1.28
Compliance with the Royal College of Radiologists' guidelines on the use of pre-operative chest radiographs. Clin Radiol (1987) 1.28
A male sterilization clinic. Br Med J (1970) 1.27
Birth weight at term and lung function in adolescence: no evidence for a programmed effect. Arch Dis Child (1995) 1.25
A test for space clustering and its application to congenital limb defects in Cardiff. Br J Prev Soc Med (1973) 1.25
Precision in estimating gestational age and its influence on sensitivity of alphafetoprotein screening. Br Med J (1979) 1.24
Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage. J Biol Chem (2000) 1.22
Inequalities in access to knee joint replacements for people in need. Ann Rheum Dis (2004) 1.22
Severe occlusive carotid artery disease: hemodynamic assessment by MR perfusion imaging in symptomatic patients. AJNR Am J Neuroradiol (1999) 1.21
Decreased first-pass metabolism of labetalol in chronic liver disease. Br Med J (1978) 1.21
Medical care as a risk-avoidance procedure: underwriting the cost of care in the UK. Br Med J (Clin Res Ed) (1982) 1.20
Ion effects on the lac repressor--operator equilibrium. Biochemistry (1981) 1.20
Some observations on the management of appendicitis in Wales. Int J Epidemiol (1974) 1.19
Diagnostic effectiveness of ultrasound in detection of neural tube defect. The South Wales experience of 2509 scans (1977-1982) in high-risk mothers. Lancet (1983) 1.19
Supporting elderly dependent people at home. BMJ (1992) 1.15
Characterization of the surfaces generated by liposome binding to the modified dextran matrix of a surface plasmon resonance sensor chip. Anal Biochem (2000) 1.15
Compliance with guidelines for choice of radiographic projections: a multicentre study. Clin Radiol (1994) 1.15
An evaluation of developmental examination as a method of detecting neurological, visual, and auditory handicaps in infancy. Br J Prev Soc Med (1972) 1.14