Published in Infect Immun on April 01, 1995
Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev (1998) 6.28
Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol (2010) 5.59
A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J Clin Invest (1996) 2.94
Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infect Immun (2004) 2.74
Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis. Infect Immun (1998) 2.71
Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis. Infect Immun (1998) 2.27
Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun (2005) 1.77
Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'-phosphatase activities. Cell Microbiol (2009) 1.66
Porphyromonas gingivalis as a potential community activist for disease. J Dent Res (2012) 1.61
Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics? Microbes Infect (2009) 1.61
Escherichia coli msbB gene as a virulence factor and a therapeutic target. Infect Immun (1999) 1.59
Structural characterization of the lipid A component of Helicobacter pylori rough- and smooth-form lipopolysaccharides. J Bacteriol (1997) 1.49
Breaking bad: manipulation of the host response by Porphyromonas gingivalis. Eur J Immunol (2014) 1.47
Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4. Infect Immun (2002) 1.46
The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway. J Bacteriol (2006) 1.43
The oral microbial consortium's interaction with the periodontal innate defense system. DNA Cell Biol (2009) 1.41
Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells. Infect Immun (2003) 1.34
Polymicrobial synergy and dysbiosis in inflammatory disease. Trends Mol Med (2014) 1.27
Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activation. Infect Immun (2002) 1.18
Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes. Infect Immun (1998) 1.17
Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis. Periodontol 2000 (2010) 1.17
Porphyromonas gingivalis lipopolysaccharide is poorly recognized by molecular components of innate host defense in a mouse model of early inflammation. Infect Immun (1995) 1.16
Unique structural modifications are present in the lipopolysaccharide from colistin-resistant strains of Acinetobacter baumannii. Antimicrob Agents Chemother (2013) 1.14
A novel class of lipoprotein lipase-sensitive molecules mediates Toll-like receptor 2 activation by Porphyromonas gingivalis. Infect Immun (2013) 1.12
Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14. Infect Immun (1996) 1.12
Effects of Porphyromonas gingivalis and Escherichia coli lipopolysaccharides on mononuclear phagocytes. Infect Immun (1997) 1.08
Fimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells. Infect Immun (2002) 1.08
Strain-dependent activation of monocytes and inflammatory macrophages by lipopolysaccharide of Porphyromonas gingivalis. Infect Immun (1998) 1.03
Nucleotide sequence of the Porphyromonas gingivalis W83 recA homolog and construction of a recA-deficient mutant. Infect Immun (1997) 1.01
The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses. Microb Pathog (2009) 0.99
Porphyromonas gingivalis lipids inhibit osteoblastic differentiation and function. Infect Immun (2010) 0.97
Constitutive mutations of the Salmonella enterica serovar Typhimurium transcriptional virulence regulator phoP. Infect Immun (2000) 0.96
Acyl chain specificity of the acyltransferases LpxA and LpxD and substrate availability contribute to lipid A fatty acid heterogeneity in Porphyromonas gingivalis. J Bacteriol (2008) 0.95
The K1 serotype capsular polysaccharide of Porphyromonas gingivalis elicits chemokine production from murine macrophages that facilitates cell migration. Infect Immun (2006) 0.95
Helicobacter pylori lipopolysaccharide can activate 70Z/3 cells via CD14. Infect Immun (1997) 0.94
Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide. PLoS One (2013) 0.93
Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis. J Biol Chem (2012) 0.92
Effect of temperature on growth, hemagglutination, and protease activity of Porphyromonas gingivalis. Infect Immun (1999) 0.91
Lipopolysaccharide modification in Gram-negative bacteria during chronic infection. FEMS Microbiol Rev (2016) 0.88
Porphyromonas gingivalis strain-dependent activation of human endothelial cells. Infect Immun (2004) 0.88
Identification of CD14 residues involved in specific lipopolysaccharide recognition. Infect Immun (1997) 0.88
P. gingivalis and E. coli lipopolysaccharides exhibit different systemic but similar local induction of inflammatory markers. J Periodontol (2008) 0.85
Serum antibodies to Porphyromonas gingivalis block the prostaglandin E2 response to lipopolysaccharide by mononuclear cells. Infect Immun (1997) 0.84
Different effects of Porphyromonas gingivalis lipopolysaccharide and TLR2 agonist Pam3CSK4 on the adhesion molecules expression in endothelial cells. Odontology (2013) 0.82
Structural modifications of Helicobacter pylori lipopolysaccharide: an idea for how to live in peace. World J Gastroenterol (2014) 0.81
Effects of oral commensal and pathogenic bacteria on human dendritic cells. Oral Microbiol Immunol (2009) 0.80
Cryptococcal glucuronoxylomannan inhibits adhesion of neutrophils to stimulated endothelium in vitro by affecting both neutrophils and endothelial cells. Infect Immun (2002) 0.80
Gingipains of Porphyromonas gingivalis modulate leukocyte adhesion molecule expression induced in human endothelial cells by ligation of CD99. Infect Immun (2006) 0.80
Soluble endothelial selectin in acute lung injury complicated by severe pneumonia. Int J Med Sci (2011) 0.79
Major neutrophil functions subverted by Porphyromonas gingivalis. J Oral Microbiol (2016) 0.79
Modulation of host defense peptide-mediated human mast cell activation by LPS. Innate Immun (2015) 0.78
Porphyromonas gingivalis activates NFκB and MAPK pathways in human oral epithelial cells. BMC Immunol (2017) 0.75
Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell (1994) 27.85
Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science (1989) 10.70
Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci U S A (1987) 10.43
Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains. J Bacteriol (1983) 8.19
Interleukin-1 and interleukin-1 antagonism. Blood (1991) 7.67
The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol (1992) 4.76
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci U S A (1993) 4.35
Soluble CD14 participates in the response of cells to lipopolysaccharide. J Exp Med (1992) 4.02
Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J Exp Med (1994) 3.61
Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis. Science (1988) 3.59
Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest (1976) 3.21
Bacterial entry into eukaryotic cells. Cell (1991) 3.09
Pathogenicity of Helicobacter pylori: a perspective. Infect Immun (1993) 3.08
The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res (1991) 2.95
IL-1 induction-capacity of defined lipopolysaccharide partial structures. J Immunol (1989) 2.41
Brief report: recurrent severe infections caused by a novel leukocyte adhesion deficiency. N Engl J Med (1992) 2.12
A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis. Infect Immun (1991) 2.07
Deacylated lipopolysaccharide inhibits neutrophil adherence to endothelium induced by lipopolysaccharide in vitro. J Exp Med (1987) 2.01
Low biological activity of Helicobacter pylori lipopolysaccharide. Infect Immun (1992) 1.71
Chemical structure of lipid A from Porphyromonas (Bacteroides) gingivalis lipopolysaccharide. FEBS Lett (1993) 1.61
Composition and structure of lipopolysaccharides from Pseudomonas aeruginosa. Rev Infect Dis (1984) 1.48
Antigens of Actinobacillus actinomycetemcomitans recognized by patients with juvenile periodontitis and periodontally normal subjects. Infect Immun (1991) 1.41
Changes in the gastric mucosa following eradication of Helicobacter pylori. Mod Pathol (1993) 1.41
Localized expression of mRNA for phagocyte-specific chemotactic cytokines in human periodontal infections. Infect Immun (1994) 1.39
Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman reaction revisited. J Clin Invest (1992) 1.37
Endothelial cell leukocyte adhesion molecule-1 (ELAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression in gingival tissue during health and experimentally-induced gingivitis. J Periodontal Res (1992) 1.31
Immunobiological properties of chemically defined lipid A from lipopolysaccharide of Porphyromonas (Bacteroides) gingivalis. Eur J Biochem (1994) 1.16
Chemical, immunobiological and antigenic characterizations of lipopolysaccharides from Bacteroides gingivalis strains. J Gen Microbiol (1990) 1.15
A critical role for monocytes and CD14 in endotoxin-induced endothelial cell activation. J Exp Med (1993) 1.12
Lipid A in Helicobacter pylori. Infect Immun (1992) 1.10
Expression of the endothelial leukocyte adhesion molecule-1 (ELAM-1) on endothelial cells in experimental gingivitis in humans. J Periodontol (1993) 1.01
Human endothelial cell adhesiveness for neutrophils, induced by Escherichia coli lipopolysaccharide in vitro, is inhibited by Bacteroides fragilis lipopolysaccharide. J Immunol (1989) 1.00
Chemokines: combinatorial mediators of inflammation? Curr Biol (1993) 0.89
Interaction between Pseudomonas aeruginosa and host defenses in cystic fibrosis. Semin Respir Infect (1991) 0.85
Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc Natl Acad Sci U S A (1987) 12.15
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med (1991) 8.78
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature (1996) 6.61
Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ. Science (1997) 4.81
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci U S A (1992) 4.77
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med (1997) 3.89
Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Science (1990) 3.74
Immune regulation by CD40 and its ligand GP39. Annu Rev Immunol (1996) 3.56
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med (1997) 3.31
Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science (1993) 3.30
Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest (1976) 3.21
The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J (1991) 3.20
A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J Clin Invest (1996) 2.94
gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J Exp Med (1994) 2.87
Changes in cellular enzyme levels and extracellular release of lysosomal acid hydrolases in macrophages exposed to group A streptococcal cell wall substance. J Exp Med (1974) 2.72
In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J Exp Med (1993) 2.72
Accumulation of cholesterol with age in human Bruch's membrane. Invest Ophthalmol Vis Sci (2001) 2.54
The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J Immunol (1993) 2.53
Detection of Aspergillus fumigatus by polymerase chain reaction. J Clin Microbiol (1993) 2.51
Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J Exp Med (1992) 2.42
Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. J Exp Med (1996) 2.39
CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci U S A (1996) 2.38
CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor. J Cell Biol (1995) 2.38
Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J Exp Med (1994) 2.37
Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes. J Immunol (1992) 2.36
The wound healing process: an overview of the cellular and molecular mechanisms. J Int Med Res (2009) 2.34
The microbial challenge in periodontitis. Periodontol 2000 (1997) 2.27
The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells. Cell (1991) 2.24
Expression of functional CD40 by vascular endothelial cells. J Exp Med (1995) 2.16
Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J Exp Med (1992) 2.11
The host response to the microbial challenge in periodontitis: assembling the players. Periodontol 2000 (1997) 2.10
Rapidly progressive periodontitis. A distinct clinical condition. Dent Health (London) (1984) 2.08
CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency. Proc Natl Acad Sci U S A (1994) 1.94
CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation. Immunol Today (1992) 1.93
Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome. Blood (1998) 1.89
Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience. Clin Endocrinol (Oxf) (1999) 1.85
Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J Immunol (1995) 1.84
A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK. J Biol Chem (1994) 1.83
Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes. Proc Natl Acad Sci U S A (1991) 1.81
Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Eur J Immunol (1995) 1.78
Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J Cell Biol (1993) 1.77
Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype. Blood (1997) 1.77
Self-reported measures for surveillance of periodontitis. J Dent Res (2013) 1.69
Expression cloning of an adenylate cyclase-coupled calcitonin receptor. Science (1991) 1.67
Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood (1993) 1.67
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation (1996) 1.63
Pathogenesis of the chronic inflammatory lesion induced by group A streptococcal cell walls. Lab Invest (1974) 1.60
Participation of mononuclear phagocytes in chronic inflammatory diseases. J Reticuloendothel Soc (1974) 1.59
One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract (2011) 1.59
5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]-[1, 4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide (VPA-985): an orally active arginine vasopressin antagonist with selectivity for V2 receptors. J Med Chem (1998) 1.55
Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins. Cancer Res (1995) 1.48
Rapidly progressive periodontitis. A distinct clinical condition. J Periodontol (1983) 1.47
Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells. J Exp Med (1995) 1.47
Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons. J Cell Biol (1995) 1.43
Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease. J Clin Invest (1994) 1.41
Antigens of Actinobacillus actinomycetemcomitans recognized by patients with juvenile periodontitis and periodontally normal subjects. Infect Immun (1991) 1.41
Diminished expression of CD40 ligand by activated neonatal T cells. J Clin Invest (1995) 1.39
Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7. J Immunol (1994) 1.39
Measurement of interleukin-1 alpha and -1 beta in gingival crevicular fluid: implications for the pathogenesis of periodontal disease. J Periodontal Res (1990) 1.39
The microbiota of young children from tooth and tongue samples. J Dent Res (2002) 1.38
Histopathologic features of the initial and early stages of experimental gingivitis in man. J Periodontal Res (1975) 1.37
Defective neutrophil chemotaxis in juvenile periodontitis. Infect Immun (1977) 1.36
T-cell activation molecule 4-1BB binds to extracellular matrix proteins. Proc Natl Acad Sci U S A (1992) 1.36
E-selectin is present in proliferating endothelial cells in human hemangiomas. Am J Pathol (1996) 1.35
An essential role for gp39, the ligand for CD40, in thymic selection. J Exp Med (1995) 1.35
B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells. J Exp Med (1993) 1.35
Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver. Proc Natl Acad Sci U S A (1997) 1.35
Serum immunoglobulin G antibody to Porphyromonas gingivalis in rapidly progressive periodontitis: titer, avidity, and subclass distribution. Infect Immun (1992) 1.34
GMP-140 (P-selectin/CD62) binds to chronically stimulated but not resting CD4+ T lymphocytes and regulates their production of proinflammatory cytokines. Eur J Immunol (1992) 1.33
Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells. J Biol Chem (1995) 1.33
The immunodominant outer membrane antigen of Actinobacillus actinomycetemcomitans is located in the serotype-specific high-molecular-mass carbohydrate moiety of lipopolysaccharide. Infect Immun (1991) 1.33
Stabilization and transport of severely ill infants. Pediatr Clin North Am (1973) 1.33
Interleukin-6 signal transducer gp130 mediates oncostatin M signaling. J Biol Chem (1992) 1.31
Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. J Cell Biol (1996) 1.31
Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates. Infect Immun (1994) 1.30
Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction. J Biol Chem (1998) 1.28
Fibroblast heterogeneity and prostaglandin regulation of subpopulations. Proc Natl Acad Sci U S A (1977) 1.27
The macrophage as a secretory cell. Int Rev Cytol (1978) 1.27
Binding, internalization, and intracellular localization of interleukin-1 beta in human diploid fibroblasts. J Biol Chem (1988) 1.27
Effects of dental plaque on the production and release of lysosomal hydrolases by macrophages in culture. Arch Oral Biol (1973) 1.27
Association of low birth weight with beta cell function in the adult first degree relatives of non-insulin dependent diabetic subjects. BMJ (1993) 1.27
Diphenylhydantoin (dilantin) gingival hyperplasia: drug-induced abnormality of connective tissue. Proc Natl Acad Sci U S A (1976) 1.25
CD44 binds to the Shigella IpaB protein and participates in bacterial invasion of epithelial cells. Cell Microbiol (2000) 1.24
In the absence of a CD40 signal, B cells are tolerogenic. Immunity (1995) 1.23
CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling. J Immunol (1992) 1.22
Peptides related to the carboxyl terminus of human platelet factor IV with antibacterial activity. J Clin Invest (1992) 1.22
Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding. Eur J Immunol (1997) 1.22
Adherence of Candida albicans to immobilized extracellular matrix proteins is mediated by calcium-dependent surface glycoproteins. Microb Pathog (1993) 1.21
Biochemical characterization of collagens synthesized by fibroblasts derived from normal and diseased human gingiva. J Biol Chem (1976) 1.20
Cloning and expression of the tumor-associated antigen L6. Proc Natl Acad Sci U S A (1992) 1.18
Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway. Eur J Immunol (1998) 1.18
Molecular cloning, genomic organization and cell-binding characteristics of mouse Spalpha. Immunology (2000) 1.17
Enzyme production and secretion by lymphokine-activated macrophages. J Reticuloendothel Soc (1977) 1.17
Beta-lactam antibiotics potentiate magainin 2 antimicrobial activity in vitro and in vivo. Antimicrob Agents Chemother (1991) 1.15
A validation of a scoring system to evaluate the condition of transported very-low-birthweight neonates. Am J Perinatol (1988) 1.15
Molecular diseases of connective and vascular tissues. II. Amine oxidase inhibition by the lathyrogen, beta-aminopropionitrile. Biochemistry (1967) 1.15