Published in Neuroscience on June 01, 1995
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol (1997) 3.37
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J Clin Invest (2001) 2.15
Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain. J Virol (2004) 2.12
Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases. Proc Natl Acad Sci U S A (2000) 2.05
Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene. Proc Natl Acad Sci U S A (1996) 1.72
An immune response after intraocular administration of an adenoviral vector containing a beta galactosidase reporter gene slows retinal degeneration in the rd mouse. Br J Ophthalmol (2001) 1.42
Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system. J Virol (2003) 1.41
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. Mol Ther (2007) 1.36
The influence of innate and pre-existing immunity on adenovirus therapy. J Cell Biochem (2009) 1.25
Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defective adenoviruses. J Virol (1997) 1.23
Gene transfer into rat brain using adenoviral vectors. Curr Protoc Neurosci (2010) 1.05
Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types. J Virol (2002) 1.02
Gene delivery to the spinal cord: comparison between lentiviral, adenoviral, and retroviral vector delivery systems. J Neurosci Res (2006) 1.02
Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells. Neuron Glia Biol (2006) 1.00
Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor. Behav Brain Res (2012) 0.98
Group D adenoviruses infect primary central nervous system cells more efficiently than those from group C. J Virol (1999) 0.95
Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 108 international units, but not lower doses, of adenoviral vectors into the brain. J Virol (2006) 0.92
In vivo electroporation mediated gene delivery to the beating heart. PLoS One (2010) 0.90
Gene therapy in clinical medicine. Postgrad Med J (2004) 0.89
Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors. Viral Immunol (2006) 0.88
Recent advances in the pharmacology of neurological gene therapy. Curr Opin Pharmacol (2004) 0.86
Viral vectors for in vivo gene transfer in Parkinson's disease: properties and clinical grade production. Exp Neurol (2007) 0.86
A replication-incompetent adenovirus vector with the preterminal protein gene deleted efficiently transduces mouse ears. J Virol (1999) 0.85
Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells. Mol Ther (2012) 0.84
Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells). Cell Biol Toxicol (2009) 0.84
Comparison of non-viral methods to genetically modify and enrich populations of primary human corneal endothelial cells. Mol Vis (2009) 0.83
Modulation of hydrogen peroxide induced injury to corneal endothelium by virus mediated catalase gene transfer. Br J Ophthalmol (2002) 0.82
Adenovirus expression of IL-1 and NF-kappaB inhibitors does not inhibit acute adenoviral-induced brain inflammation, but delays immune system-mediated elimination of transgene expression. Mol Ther (2003) 0.81
The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier. J Drug Deliv (2011) 0.79
Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders. Int Rev Neurobiol (2003) 0.79
Identification and visualization of CD8+ T cell mediated IFN-γ signaling in target cells during an antiviral immune response in the brain. PLoS One (2011) 0.76
Hybrid lentivirus-phiC31-int-NLS vector allows site-specific recombination in murine and human cells but induces DNA damage. PLoS One (2014) 0.76
In vivo transgene expression from an adenoviral vector is altered following a 6-OHDA lesion of the dopamine system. Brain Res Mol Brain Res (2005) 0.76
DNA as therapeutics; an update. Indian J Pharm Sci (2009) 0.75
The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors. Adv Pharmacol (2016) 0.75
Oral acyclovir in acute herpes zoster. Br Med J (Clin Res Ed) (1986) 2.39
Derivation of mouse intestinal crypts from single progenitor cells. Nature (1985) 2.31
Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrob Agents Chemother (1995) 2.16
Toxic megacolon: the knee-elbow position relieves bowel distension. Gut (1993) 1.93
A large outbreak of Q fever in the West Midlands: windborne spread into a metropolitan area? Commun Dis Public Health (1998) 1.92
Lack of effect of acyclovir on postherpetic neuralgia. BMJ (1989) 1.88
Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism. Nature (1977) 1.71
Phase specific analysis of herpes zoster associated pain data: a new statistical approach. Stat Med (2001) 1.60
Sociodemographic characteristics associated with medical appointment adherence among HIV-seropositive patients seeking treatment in a county outpatient facility. Prev Med (2001) 1.48
The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology (2000) 1.43
Ciprofloxacin and Salmonella carriage. J Hosp Infect (1992) 1.39
Consensus statement on diagnosis, investigation, treatment and prevention of acute bacterial meningitis in immunocompetent adults. British Infection Society Working Party. J Infect (1999) 1.27
Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function. Endocrinology (1998) 1.24
Ribozyme-mediated trans-splicing of a trinucleotide repeat. Nat Genet (1998) 1.16
Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology (2007) 1.14
Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene. Gene Ther (2000) 1.14
Delayed primary repair of intrathoracic esophageal perforation: is it safe? J Thorac Cardiovasc Surg (1996) 1.14
Immune responses to adenoviral vectors during gene transfer in the brain. Hum Gene Ther (1997) 1.13
Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination. J Neurosci (1996) 1.12
Role of T cells in inflammation caused by adenovirus vectors in the brain. Gene Ther (1996) 1.11
Immune responses to adenovirus vectors in the nervous system. Trends Neurosci (1996) 1.10
Cannabinoids in humans. II. The influence of three methods of hydrolysis on the concentration of THC and two metabolites in urine. J Anal Toxicol (1995) 1.09
The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodents. Neuroscience (1986) 1.08
Over-the-counter antibiotics. J Antimicrob Chemother (1999) 1.07
Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency. Nature (1982) 1.07
Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology (2008) 1.05
Restoration of a normal reproductive lifespan after grafting of cryopreserved mouse ovaries. Hum Reprod (2000) 1.05
Squamous cell carcinoma arising in a tall cell papillary carcinoma of the thyroid. J Clin Pathol (2005) 1.03
Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea. Gene Ther (1997) 1.02
Role of the fetal pituitary in cryptorchidism induced by exogenous maternal oestrogen during pregnancy in mice. J Reprod Fertil (1988) 1.02
Time-resolved circular dichroism studies of protein folding intermediates of cytochrome c. Biochemistry (1998) 1.00
Staphylococcus lugdunensis vertebral osteomyelitis. Clin Microbiol Infect (2003) 1.00
Age-related uterine and ovarian hypertrophy in FSH receptor knockout and FSHbeta subunit knockout mice. Reproduction (2003) 0.99
Postnatal ovarian follicle development in hypogonadal (hpg) and normal mice and associated changes in the hypothalamic-pituitary ovarian axis. J Reprod Fertil (1986) 0.98
Effects of electric current on bone in vivo. Nature (1969) 0.98
Increasing local levels of IGF-I mRNA expression using adenoviral vectors does not alter oligodendrocyte remyelination in the CNS of aged rats. Mol Cell Neurosci (2002) 0.98
A model for long-term transgene expression in spinal cord regeneration studies. Gene Ther (1999) 0.97
The immune response to intracerebral neural grafts. Trends Neurosci (1991) 0.97
Cytokines and peripheral tolerance to alloantigen. Immunol Rev (1993) 0.97
Genital ulcers associated with acute Epstein-Barr virus infection. Sex Transm Infect (1998) 0.94
Conformational dimorphism and transmembrane orientation of prion protein residues 110-136 in bicelles. Biochemistry (2001) 0.94
Determinants of distribution and prevalence of avian malaria in blue tit populations across Europe: separating host and parasite effects. J Evol Biol (2011) 0.94
Oral cefuroxime axetil: clinical pharmacology and comparative dose studies in urinary tract infection. J Antimicrob Chemother (1985) 0.94
Ciprofloxacin for soft tissue infections. J Antimicrob Chemother (1986) 0.93
Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology (1998) 0.92
Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors. Gene Ther (1994) 0.92
Innervation of the lungs of the toad (Bufo marinus). I. Physiology and pharmacology. Comp Biochem Physiol (1967) 0.92
Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse. J Mol Endocrinol (2009) 0.92
Mouse mutants as models in endocrine research. Q J Exp Physiol (1984) 0.92
More macrolides. BMJ (1991) 0.90
Detection of neuronal tissue from brain grafts with anti-Thy-1.1 antibody. Nature (1983) 0.90
Sentinel lymph node biopsy after previous axillary surgery: A review. Eur J Surg Oncol (2011) 0.89
The effects of daily administration of single and multiple injections of gonadotropin-releasing hormone on pituitary and gonadal function in the hypogonadal (hpg) mouse. Endocrinology (1983) 0.89
The clinical pharmacokinetics of famciclovir. Clin Pharmacokinet (1996) 0.89
Follicular development in cryopreserved marmoset ovarian tissue after transplantation. Hum Reprod (1995) 0.88
Incidence of chromosome anomalies in first-cleavage mouse embryos obtained from frozen-thawed oocytes fertilized in vitro. Gamete Res (1987) 0.87
Determinants of optimal mastectomy skin flap thickness. Br J Surg (2014) 0.87
Implantation of normal fetal preoptic area into hypogonadal mutant mice: temporal relationships of the growth of gonadotropin-releasing hormone neurons and the development of the pituitary/testicular axis. Neuroscience (1985) 0.86
Variation in the immune response to adenoviral vectors in the brain: influence of mouse strain, environmental conditions and priming. Gene Ther (1999) 0.86
Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts. Science (1984) 0.86
Normal fertilization and development of frozen-thawed mouse oocytes: protective action of certain macromolecules. Biol Reprod (1993) 0.86
Effect of cryoprotectants on the survival of follicles in frozen mouse ovaries. J Reprod Fertil (1997) 0.86
Preservation of mouse embryos by two-step freezing. Cryobiology (1980) 0.86
Effect of LH injections on testicular steroidogenesis, cholesterol side-chain cleavage P450 mRNA content and Leydig cell morphology in hypogonadal mice. J Endocrinol (1990) 0.86
The effect of site of transplantation and histocompatibility differences on the survival of neural tissue transplanted to the CNS of defined inbred rat strains. Prog Brain Res (1990) 0.86
Effects of FSH on Leydig cell morphology and function in the hypogonadal mouse. J Endocrinol (1992) 0.85
A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain. Neuroscience (1998) 0.85
Innervation of the lungs of the sleepy lizard (Trachysaurus rugosus). II. Physiology and pharmacology. Comp Biochem Physiol (1967) 0.85
Differentiation of adult-type Leydig cells occurs in gonadotrophin-deficient mice. Reprod Biol Endocrinol (2003) 0.85
Cytogenetical analysis and developmental potential of vitrified mouse oocytes. Biol Reprod (1995) 0.85
Extra-ovarian production of mature viable mouse oocytes from frozen primary follicles. J Reprod Fertil (1990) 0.85
Preoptic area brain grafts in hypogonadal (hpg) female mice abolish effects of congenital hypothalamic gonadotropin-releasing hormone (GnRH) deficiency. Endocrinology (1984) 0.84
Comparison of urinary excretion of tobramycin and gentamicin in adults. J Infect Dis (1976) 0.84
Activity of minocycline and tetracycline against respiratory pathogens related to blood levels. J Antimicrob Chemother (1975) 0.84
The management of travellers' diarrhoea. J Antimicrob Chemother (1993) 0.84
Specific patterns of defective HSV-1 gene transfer in the adult central nervous system: implications for gene targeting. Exp Neurol (1994) 0.84
The clinical presentation and diagnosis of invasive fungal infections. J Antimicrob Chemother (1991) 0.84
Gonadal steroids influence neurophysin II distribution in the forebrain of normal and mutant mice. Neuroscience (1988) 0.83
Angioarchitecture of the CNS, pituitary gland, and intracerebral grafts revealed with peroxidase cytochemistry. J Comp Neurol (1987) 0.83
Leucocyte recruitment and inflammation in the CNS. Trends Neurosci (1992) 0.82
Bone mineral density of the total body and forearm in premenopausal black and white women. Bone (1995) 0.82
Genome cryopreservation: a valuable contribution to mammalian genetic research. Genet Res (1991) 0.82
Treatment of typhoid in pregnancy. Lancet (1995) 0.82
Humoral immune responses to adenovirus vectors in the brain. J Neuroimmunol (2000) 0.81
Mechanisms and clinical significance of resistance to new beta-lactam antibiotics. Br J Hosp Med (1990) 0.81
Prolactin measurements in normal and hypogonadal (hpg) mice: developmental and experimental studies. Endocrinology (1983) 0.81
Desmoglein II-derived glycopeptides in human epidermis. J Invest Dermatol (1989) 0.81
Cryopreservation of immature mouse oocytes. Hum Reprod (1994) 0.81
Pubertal development and testicular function in the male growth hormone-deficient rat. J Endocrinol (1990) 0.81
Contributions of donor and host blood vessels in CNS allografts. Exp Neurol (1996) 0.81
Habituation and motion sickness. J Clin Pharmacol (1994) 0.81
Effects of short-term injection of gonadotrophins on ovarian follicle development in hypogonadal (hpg) mice. J Reprod Fertil (1988) 0.81