Published in Diabetes on February 01, 1993
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Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A (1994) 1.83
Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol (1993) 1.56
Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. J Clin Invest (1997) 1.43
Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy. Proc Natl Acad Sci U S A (1998) 1.36
Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock. Br J Pharmacol (1995) 1.16
Vascular hypertrophy in experimental diabetes. Role of advanced glycation end products. J Clin Invest (1997) 1.12
Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. J Exp Med (1995) 1.11
Diabetes-induced activation of system y+ and nitric oxide synthase in human endothelial cells: association with membrane hyperpolarization. J Physiol (1995) 1.01
Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents. J Clin Invest (1995) 1.00
Glycation, oxidation, and lipoxidation in the development of the complications of diabetes: a carbonyl stress hypothesis. Diabetes Rev (Alex) (1) 0.95
Increased nitric oxide synthase activity despite lack of response to endothelium-dependent vasodilators in postischemic acute renal failure in rats. J Clin Invest (1995) 0.95
Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice. Invest Ophthalmol Vis Sci (2002) 0.95
Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response. J Clin Invest (1994) 0.91
Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells. Am J Physiol Cell Physiol (2001) 0.89
Beneficial effects of aminoguanidine on skin flap survival in diabetic rats. Exp Diabetes Res (2012) 0.84
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Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats. Br J Pharmacol (2006) 0.82
Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Med Gas Res (2012) 0.82
Role of nitric oxide in the pathogenesis of diabetic nephropathy in streptozotocin-induced diabetic rats. Korean J Intern Med (1999) 0.81
Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice. World J Gastroenterol (2009) 0.80
Aminoguanidine prevents age-related aortic stiffening in Fisher 344 rats: aortic impedance analysis. Br J Pharmacol (2003) 0.80
The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy. Diabetologia (2014) 0.80
Implications of treatment that target protective mechanisms against diabetic nephropathy. Semin Nephrol (2012) 0.79
Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives. Tetrahedron Lett (2015) 0.79
Prevention of arterial stiffening by pyridoxamine in diabetes is associated with inhibition of the pathogenic glycation on aortic collagen. Br J Pharmacol (2009) 0.79
Protective effect of aminoguanidine against nephrotoxicity induced by amikacin in rats. Urol Res (2004) 0.78
Regenerative therapies for diabetic microangiopathy. Exp Diabetes Res (2012) 0.78
Aminoguanidine prevents impaired healing and deficient angiogenesis in diabetic rats. Inflammation (1999) 0.77
Experimental nonenzymatic glycosylation of vitreous collagens occurs by two pathways. Trans Am Ophthalmol Soc (1996) 0.76
NADPH diaphorase activity in the rat retina during the early stages of experimental diabetes. Graefes Arch Clin Exp Ophthalmol (2003) 0.76
Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers. Bioorg Med Chem Lett (2015) 0.75
Nitric Oxide and Lutein: Function, Performance, and Protection of Neural Tissue. Foods (2015) 0.75
The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise. J Exerc Nutrition Biochem (2017) 0.75
Jakyakgamcho-tang and Its Major Component, Paeonia Lactiflora, Exhibit Potent Anti-glycation Properties. J Exerc Nutrition Biochem (2017) 0.75
Pectin lyase-modified red ginseng extract exhibits potent anti-glycation effects in vitro and in vivo. J Exerc Nutrition Biochem (2017) 0.75
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Identifying and defining the dimensions of community capacity to provide a basis for measurement. Health Educ Behav (1998) 5.44
A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature (1997) 4.27
Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci U S A (1993) 3.93
A fluorometric assay for the measurement of nitrite in biological samples. Anal Biochem (1993) 3.92
An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes. Proc Natl Acad Sci U S A (1989) 3.65
CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity (2000) 3.28
Increased visceral fat and decreased energy expenditure during the menopausal transition. Int J Obes (Lond) (2008) 3.18
Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol (1993) 3.00
Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature (1987) 2.98
Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes (1992) 2.92
Campylobacter hyointestinalis (new species) isolated from swine with lesions of proliferative ileitis. Am J Vet Res (1983) 2.85
Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ Res (1999) 2.79
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Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene (2006) 2.74
Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. J Immunol (1993) 2.73
A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science (1999) 2.68
Hyperglycemic pseudohypoxia and diabetic complications. Diabetes (1993) 2.62
Reliability and validity of DSM-IV axis V. Am J Psychiatry (2000) 2.59
Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol (2003) 2.57
Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol (1996) 2.55
Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria. Science (1983) 2.53
Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. Int J Obes Relat Metab Disord (2004) 2.40
Direct detection of nucleic acid hybridization on the surface of a charge coupled device. Nucleic Acids Res (1994) 2.38
Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science (1997) 2.31
A metabolite-regulated potassium channel in rat pancreatic B cells. Proc Natl Acad Sci U S A (1986) 2.27
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem (1994) 2.13
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Weight and recumbent length from 1 to 12 mo of age: reference data for 1-mo increments. Am J Clin Nutr (1989) 2.10
Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci U S A (1993) 2.06
An inventory of heavy metals inputs to agricultural soils in England and Wales. Sci Total Environ (2003) 2.04
Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM. Diabetes (1992) 2.04
Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes. Cell (2000) 1.96
Atriopeptins as cardiac hormones. Hypertension (1985) 1.91
Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Cancer Res (2000) 1.91
Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. J Biol Chem (1998) 1.85
Purification and sequence analysis of bioactive atrial peptides (atriopeptins). Science (1984) 1.85
Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. J Clin Invest (1992) 1.82
Cloning, expression, and chaperone-like activity of human alphaA-crystallin. J Biol Chem (1996) 1.82
Head circumference reference data: birth to 18 years. Pediatrics (1987) 1.75
Preliminary characterization of calcium binding in islet-cell plasma membranes. Diabetologia (1980) 1.75
Abolition of in vivo platelet thrombus formation in primates with monoclonal antibodies to the platelet GPIIb/IIIa receptor. Correlation with bleeding time, platelet aggregation, and blockade of GPIIb/IIIa receptors. Circulation (1989) 1.74
TNF-alpha causes reversible in vivo systemic vascular barrier dysfunction via NO-dependent and -independent mechanisms. Am J Physiol (1997) 1.73
Recent advances in brain injury research: a new human head model development and validation. Stapp Car Crash J (2001) 1.73
Sarcopenic obesity: A Critical appraisal of the current evidence. Clin Nutr (2012) 1.73
A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology (1998) 1.73
Reciprocal changes in serum concentrations of 3,3',5-triiodothyronine (T3) in systemic illnesses. J Clin Endocrinol Metab (1975) 1.72
Randomized clinical trial of short-term outcomes following purse-string versus conventional closure of ileostomy wounds. Br J Surg (2010) 1.71
Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages. Proc Natl Acad Sci U S A (1987) 1.70
Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets. J Biol Chem (1986) 1.70
The shear mode of multilayer graphene. Nat Mater (2012) 1.64
Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocrinol Metab (2004) 1.63
Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J Clin Invest (1994) 1.63
Duplication of the 15q11-13 region in a patient with autism, epilepsy and ataxia. Dev Med Child Neurol (1994) 1.63
Dependence of Ethanolic Fermentation, Cytoplasmic pH Regulation, and Viability on the Activity of Alcohol Dehydrogenase in Hypoxic Maize Root Tips. Plant Physiol (1989) 1.63
Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes. Eur J Clin Invest (2002) 1.61
Reliability and validity of a macronutrient self-selection paradigm and a food preference questionnaire. Physiol Behav (1998) 1.60
Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion. J Biol Chem (1991) 1.59
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J Clin Invest (1994) 1.59
Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol Motil (2009) 1.58
Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. J Neurosci (1997) 1.57
Association of amyloidosis with erythema nodosum leprosum reactions and recurrent neutrophil leucocytosis in leprosy. Lancet (1975) 1.56
Increased collagen cross-linkages in experimental diabetes: reversal by beta-aminopropionitrile and D-penicillamine. Diabetes (1980) 1.56
Characterization of the cytoprotective action of peroxynitrite decomposition catalysts. J Biol Chem (1998) 1.55
Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur J Pharmacol (1995) 1.55
Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. Invest Ophthalmol Vis Sci (1994) 1.53
Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema. Eur J Pharmacol (1996) 1.52
Effects of sulfonamides on a metabolite-regulated ATPi-sensitive K+ channel in rat pancreatic B-cells. Am J Physiol (1989) 1.51
Randomized clinical trial of ropivacaine wound infusion following laparoscopic colorectal surgery. Tech Coloproctol (2012) 1.50
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Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proc Natl Acad Sci U S A (2001) 1.49
Ventricular atriopeptin. Unmasking of messenger RNA and peptide synthesis by hypertrophy or dexamethasone. Hypertension (1987) 1.49
Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia (2007) 1.49
A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans. Methods Enzymol (1983) 1.48
Infections complicating pulsed carbon dioxide laser resurfacing for photoaged facial skin. Dermatol Surg (1997) 1.48
Comparison of regional fat distribution and health risk factors in middle-aged white and African American women: The Healthy Transitions Study. Obes Res (2001) 1.48
IL-1 produced and released endogenously within human islets inhibits beta cell function. J Clin Invest (1998) 1.46
In vivo measurement of tissue metabolism in tendons of the rotator cuff: implications for surgical management. J Bone Joint Surg Br (2007) 1.46
Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110. J Biol Chem (1993) 1.45
Peroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathology. Proc Natl Acad Sci U S A (1998) 1.45
The effect of hip resurfacing on oxygen concentration in the femoral head. J Bone Joint Surg Br (2005) 1.45