Published in Neuron on January 01, 1993
The essential toxin: impact of zinc on human health. Int J Environ Res Public Health (2010) 2.09
Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production. Proc Natl Acad Sci U S A (1999) 1.96
Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes. Mol Brain (2010) 1.27
Zn2+ current is mediated by voltage-gated Ca2+ channels and enhanced by extracellular acidity in mouse cortical neurones. J Physiol (2000) 1.16
Vesicle-associated membrane protein-2 (synaptobrevin-2) forms a complex with synaptophysin. Biochem J (1995) 1.13
Zn2+ influx is critical for some forms of spreading depression in brain slices. J Neurosci (2008) 1.10
Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro. Exp Biol Med (Maywood) (2010) 1.10
Zn2+ currents are mediated by calcium-permeable AMPA/kainate channels in cultured murine hippocampal neurones. J Physiol (2002) 1.06
Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link? Pflugers Arch (2004) 1.05
Zinc porphyrins: potent inhibitors of hematopoieses in animal and human bone marrow. Proc Natl Acad Sci U S A (1997) 1.02
The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease. Front Aging Neurosci (2014) 0.98
Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc. J Biol Chem (2010) 0.96
Immersion autometallographic tracing of zinc ions in Alzheimer beta-amyloid plaques. Histochem Cell Biol (2005) 0.94
The role of zinc in Alzheimer's disease. Int J Alzheimers Dis (2010) 0.94
Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury. J Neurochem (2009) 0.93
Intracellular Zn2+ increases contribute to the progression of excitotoxic Ca2+ increases in apical dendrites of CA1 pyramidal neurons. Neuroscience (2008) 0.90
Brain-Delivery of Zinc-Ions as Potential Treatment for Neurological Diseases: Mini Review. Drug Deliv Lett (2011) 0.89
Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients. J Neurosci Methods (2011) 0.88
Zinc accumulation after target loss: an early event in retrograde degeneration of thalamic neurons. Eur J Neurosci (2005) 0.87
The molecular mechanisms of zinc neurotoxicity and the pathogenesis of vascular type senile dementia. Int J Mol Sci (2013) 0.85
Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences. PLoS One (2011) 0.84
Pyruvate blocks zinc-induced neurotoxicity in immortalized hypothalamic neurons. Cell Mol Neurobiol (2002) 0.84
Tissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4. J Neurosci (2010) 0.82
Mechanisms of rapid reactive oxygen species generation in response to cytosolic Ca2+ or Zn2+ loads in cortical neurons. PLoS One (2013) 0.79
Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria. J Neurosci (2017) 0.78
The interactive roles of zinc and calcium in mitochondrial dysfunction and neurodegeneration. J Neurochem (2013) 0.78
Contribution of calcium-conducting channels to the transport of zinc ions. Pflugers Arch (2013) 0.78
Reduced extracellular zinc levels facilitate glutamate-mediated oligodendrocyte death after trauma. J Neurosci Res (2013) 0.77
Amyloid-modifying therapies for Alzheimer's disease: therapeutic progress and its implications. Age (Dordr) (2010) 0.77
Zinc-permeable ion channels: effects on intracellular zinc dynamics and potential physiological/pathophysiological significance. Curr Med Chem (2015) 0.76
Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem (1999) 4.64
Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med (1999) 4.44
Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods (1987) 3.47
Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci (1988) 3.13
Ionic dependence of glutamate neurotoxicity. J Neurosci (1987) 3.01
The role of zinc in selective neuronal death after transient global cerebral ischemia. Science (1996) 2.99
Glutamate neurotoxicity in cortical cell culture. J Neurosci (1987) 2.98
The changing landscape of ischaemic brain injury mechanisms. Nature (1999) 2.91
Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci (1997) 2.88
Mediation of neuronal apoptosis by enhancement of outward potassium current. Science (1997) 2.47
Zinc and brain injury. Annu Rev Neurosci (1998) 2.43
Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons. Science (1987) 2.38
Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci (2000) 2.34
Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci (1993) 2.23
Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J Neurosci (1995) 2.20
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J Neurosci (1988) 2.14
Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nat Med (1998) 2.06
Carboxyfullerenes as neuroprotective agents. Proc Natl Acad Sci U S A (1997) 2.05
Potentiated necrosis of cultured cortical neurons by neurotrophins. Science (1995) 1.97
Dextrorphan inhibits the release of excitatory amino acids during spinal cord ischemia. Ann Thorac Surg (1994) 1.95
Measurement of intracellular free zinc in living cortical neurons: routes of entry. J Neurosci (1997) 1.95
Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci Lett (1985) 1.83
Brain tissue responses to ischemia. J Clin Invest (2000) 1.77
Differences in vulnerability to permanent focal cerebral ischemia among 3 common mouse strains. Stroke (2000) 1.77
Chlordiazepoxide selectively augments GABA action in spinal cord cell cultures. Nature (1977) 1.75
Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab (1996) 1.71
Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase. J Neurosci (1988) 1.71
GABA conductance of chick spinal cord and dorsal root ganglion neurons in cell culture. J Neurophysiol (1981) 1.69
Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons. J Neurosci (1990) 1.64
Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J Neurosci (2000) 1.59
Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons. Neurobiol Dis (1996) 1.57
An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid (2000) 1.56
Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin. J Neurosci (2000) 1.55
Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation. Neuroreport (1991) 1.55
Profound systemic hypothermia inhibits the release of neurotransmitter amino acids in spinal cord ischemia. J Thorac Cardiovasc Surg (1995) 1.55
Cyclosporine induces neuronal apoptosis and selective oligodendrocyte death in cortical cultures. Ann Neurol (1996) 1.51
Reducing calcium overload in the ischemic brain. N Engl J Med (1999) 1.50
Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis. J Neurosci (2000) 1.48
Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J Neurosci (1993) 1.44
Ischemic tolerance in murine cortical cell culture: critical role for NMDA receptors. J Neurosci (1999) 1.44
Ions, cell volume, and apoptosis. Proc Natl Acad Sci U S A (2000) 1.40
Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator. Science (1999) 1.37
Ion homeostasis and apoptosis. Curr Opin Cell Biol (2001) 1.33
A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils. Nat Struct Biol (2000) 1.31
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity. Science (1986) 1.31
A 2600-locus chromosome bin map of wheat homoeologous group 2 reveals interstitial gene-rich islands and colinearity with rice. Genetics (2004) 1.29
Expression of the barley dehydrin multigene family and the development of freezing tolerance. Mol Gen Genet (2000) 1.29
Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death. Neurobiol Dis (1998) 1.28
Staurosporine-induced neuronal apoptosis. Exp Neurol (1995) 1.28
Construction and evaluation of cDNA libraries for large-scale expressed sequence tag sequencing in wheat (Triticum aestivum L.). Genetics (2004) 1.23
Zinc toxicity on cultured cortical neurons: involvement of N-methyl-D-aspartate receptors. Neuroscience (1994) 1.22
Protection by pyruvate against transient forebrain ischemia in rats. J Neurosci (2001) 1.21
The first human case of Clinostomum complanatum (Trematoda: Clinostomidae) infection in Korea. Korean J Parasitol (1995) 1.21
Neuronal apoptosis after CNS injury: the roles of glutamate and calcium. J Neurotrauma (2000) 1.21
Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death. J Biol Chem (1998) 1.19
Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro. Neuroscience (1995) 1.18
Glial glycogen stores affect neuronal survival during glucose deprivation in vitro. J Cereb Blood Flow Metab (1993) 1.18
Zinc as a paracrine effector in pancreatic islet cell death. Diabetes (2000) 1.17
N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia? Ann Neurol (1989) 1.17
Non-NMDA receptor-mediated neurotoxicity in cortical culture. J Neurosci (1990) 1.17
Zn2+ current is mediated by voltage-gated Ca2+ channels and enhanced by extracellular acidity in mouse cortical neurones. J Physiol (2000) 1.16
Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: its role in zinc-induced neuronal death. J Neurochem (1999) 1.15
Selective vulnerability of the brain: new insights into the pathophysiology of stroke. Ann Intern Med (1989) 1.14
Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS. Neuron (1994) 1.12
Zinc translocation accelerates infarction after mild transient focal ischemia. Neuroscience (2002) 1.12
Chlordiazepoxide selectively potentiates GABA conductance of spinal cord and sensory neurons in cell culture. J Neurophysiol (1981) 1.12
Histochemically reactive zinc in plaques of the Swedish mutant beta-amyloid precursor protein transgenic mice. J Neurosci (1999) 1.12
Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Res (1990) 1.11
The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity. Science (1990) 1.11
A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C. Neurobiol Dis (2000) 1.10
Neurotoxicity of beta-N-methylamino-L-alanine (BMAA) and beta-N-oxalylamino-L-alanine (BOAA) on cultured cortical neurons. Brain Res (1989) 1.10
A chromosome bin map of 2148 expressed sequence tag loci of wheat homoeologous group 7. Genetics (2004) 1.10
Event-based biosurveillance of respiratory disease in Mexico, 2007-2009: connection to the 2009 influenza A(H1N1) pandemic? Euro Surveill (2010) 1.10
Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2001) 1.10
Medial medullary infarction with restricted sensory symptom. Eur Neurol (1998) 1.07
Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures. Eur J Neurosci (1999) 1.07
L-type Ca(2+) channel-mediated Zn(2+) toxicity and modulation by ZnT-1 in PC12 cells. Brain Res (2000) 1.06
NMDA receptor-mediated K+ efflux and neuronal apoptosis. Science (1999) 1.06
Role of the outward delayed rectifier K+ current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons. J Neurochem (1999) 1.06
The effect of NMDA, AMPA/kainate, and calcium channel antagonists on traumatic cortical neuronal injury in culture. Brain Res (1994) 1.06
Anthrax inhalation and lethal human infection. Lancet (2002) 1.06
In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease. Biochem J (2001) 1.06
Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals. Neuroscience (1999) 1.05
Secondary activation of a cation conductance is responsible for NMDA toxicity in acutely isolated hippocampal neurons. J Neurosci (1997) 1.05
N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture. J Pharmacol Exp Ther (1987) 1.05
21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures. Neuron (1990) 1.05
Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity. J Neurosci Res (1999) 1.04
Measurement of intracellular free zinc concentrations accompanying zinc-induced neuronal death. J Neurosci (1999) 1.04
Na(+)-Ca2+ exchange currents in cortical neurons: concomitant forward and reverse operation and effect of glutamate. Eur J Neurosci (1997) 1.03
Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity. Proc Natl Acad Sci U S A (2001) 1.03
Slowly triggered excitotoxicity occurs by necrosis in cortical cultures. Neuroscience (1997) 1.02