Published in Lancet on April 22, 1978
Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res (1999) 5.35
National Institute of Mental Health longitudinal study of chronic schizophrenia. Prognosis and predictors of outcome. Arch Gen Psychiatry (1991) 3.53
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc Natl Acad Sci U S A (1997) 3.00
Cognitive effects of corticosteroids. Am J Psychiatry (1990) 2.85
The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry. J Biol Chem (1996) 2.27
Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics. Neuropsychopharmacology (1997) 2.20
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc Natl Acad Sci U S A (1997) 2.03
Apolipoprotein E epsilon 4 and clinical phenotype in schizophrenia. Lancet (1997) 2.02
Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. Science (1997) 2.01
Clonidine blocks acute opiate-withdrawal symptoms. Lancet (1978) 1.97
Benzodiazepines in the treatment of schizophrenia: a review and reappraisal. Am J Psychiatry (1991) 1.94
Behaviour and emotional problems in toddlers with pervasive developmental disorders and developmental delay: associations with parental mental health and family functioning. J Intellect Disabil Res (2006) 1.94
Cognitive substrates of thought disorder, I: the semantic system. Am J Psychiatry (1998) 1.90
NMDA receptor function and human cognition: the effects of ketamine in healthy volunteers. Neuropsychopharmacology (1996) 1.88
Clozapine and risperidone in chronic schizophrenia: effects on symptoms, parkinsonian side effects, and neuroendocrine response. Am J Psychiatry (1999) 1.79
Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery. Am J Psychiatry (1993) 1.78
The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia. Br J Psychiatry (1993) 1.75
Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers. Am J Psychiatry (1997) 1.64
Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia. Am J Psychiatry (1999) 1.63
Quantification of amphetamine-induced changes in [11C]raclopride binding with continuous infusion. J Cereb Blood Flow Metab (1997) 1.55
Alprazolam augmentation of the antipsychotic effects of fluphenazine in schizophrenic patients. Preliminary results. Arch Gen Psychiatry (1988) 1.53
Is the mechanism of prefrontal hypofunction in depression the same as in schizophrenia? Regional cerebral blood flow during cognitive activation. Br J Psychiatry (1993) 1.47
Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease. Pathophysiologic and diagnostic implications. N Engl J Med (1986) 1.45
A quantitative analysis of smooth pursuit eye tracking in monozygotic twins discordant for schizophrenia. Arch Gen Psychiatry (1997) 1.41
Intracellular localization of phospholipase D1 in mammalian cells. Mol Biol Cell (2001) 1.41
Susceptibility to a parkinsonian toxin varies during primate development. Exp Neurol (2012) 1.41
Fetal neural graft survival. Lancet (1990) 1.40
Suicidal behavior in chronic schizophrenic patients: a follow-up study. Can J Psychiatry (1986) 1.39
Spontaneous blink rates correlate with dopamine levels in the caudate nucleus of MPTP-treated monkeys. Exp Neurol (1999) 1.38
Tobacco and cancer: the first clinical report, 1761. N Engl J Med (1970) 1.38
Neuropsychiatric assessment of a spinal cord injury patient with sudden recovery. Arch Phys Med Rehabil (1988) 1.38
Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers. Biol Psychiatry (1998) 1.38
Effort and cognition in depression. Arch Gen Psychiatry (1982) 1.37
Prednisone effects on neurochemistry and behavior. Preliminary findings. Arch Gen Psychiatry (1990) 1.35
Neuropsychiatric effects of anabolic steroids in male normal volunteers. JAMA (1993) 1.34
Current concepts. II. New evidence for a locus coeruleus-norepinephrine connection with anxiety. Life Sci (1979) 1.34
Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. Life Sci (1983) 1.32
Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6. Gene Ther (2009) 1.31
Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson's disease and memory. J Neurosci (2000) 1.30
Microbial infection and the septic response in critical surgical illness. Sepsis, not infection, determines outcome. Arch Surg (1990) 1.27
Global gene and cell replacement strategies via stem cells. Gene Ther (2002) 1.24
5-Azacytidine-treated human mesenchymal stem/progenitor cells derived from umbilical cord, cord blood and bone marrow do not generate cardiomyocytes in vitro at high frequencies. Vox Sang (2008) 1.23
Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques. Ann Neurol (1997) 1.23
High plasma norepinephrine levels in patients with major affective disorder. Am J Psychiatry (1982) 1.21
Clonidine and naltrexone. A safe, effective, and rapid treatment of abrupt withdrawal from methadone therapy. Arch Gen Psychiatry (1982) 1.20
Trichomonad invasion of the mucous layer requires adhesins, mucinases, and motility. Sex Transm Infect (1999) 1.18
Dopamine D2 receptor density and personal detachment in healthy subjects. Am J Psychiatry (1998) 1.16
In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Ther (1998) 1.16
Noradrenergic agonists and antagonists: effects on conditioned fear as measured by the potentiated startle paradigm. Psychopharmacology (Berl) (1979) 1.16
The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia. Neuropsychopharmacology (2000) 1.14
Effects of the acute administration of caffeine in patients with schizophrenia. Biol Psychiatry (1990) 1.13
No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. JAMA (1994) 1.12
Morbidity and mortality of reconstructive surgery of noninfected false aneurysms detected long after aortic prosthetic reconstruction. Arch Surg (1998) 1.11
Multiple mechanisms of withdrawal from opioid drugs. Annu Rev Neurosci (1984) 1.10
Norepinephrine and its metabolites in cerebrospinal fluid, plasma, and urine. Relationship to hypothalamic-pituitary-adrenal axis function in depression. Arch Gen Psychiatry (1988) 1.08
Inflammatory responses and their impact on beta-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus. Gene Ther (1999) 1.07
Clozapine blunts N-methyl-D-aspartate antagonist-induced psychosis: a study with ketamine. Biol Psychiatry (1997) 1.07
Somatic symptoms in primary affective disorder. Presence and relationship to the classification of depression. Arch Gen Psychiatry (1985) 1.07
Longitudinal measurement of plasma homovanillic acid levels in schizophrenic patients. Correlation with psychosis and response to neuroleptic treatment. Arch Gen Psychiatry (1986) 1.06
Early parental loss and development of adult psychopathology. Arch Gen Psychiatry (1988) 1.06
Disturbed very long chain (C24-C26) fatty acid pattern in fibroblasts of patients with Zellweger's syndrome. J Inherit Metab Dis (1985) 1.06
Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine. Lancet (1986) 1.06
Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment. Neuroscience (2000) 1.05
Mechanism of peripheral noradrenergic stimulation by clozapine. Neuropsychopharmacology (1999) 1.04
Apolipoprotein E epsilon 4 and fatal cerebral amyloid angiopathy associated with dementia pugilistica. Ann Neurol (1995) 1.03
Carbon dioxide sensitivity in panic anxiety. Ventilatory and anxiogenic response to carbon dioxide in healthy subjects and patients with panic anxiety before and after alprazolam treatment. Arch Gen Psychiatry (1986) 1.02
D1 and D2 dopamine receptors independently regulate spontaneous blink rate in the vervet monkey. J Pharmacol Exp Ther (1991) 1.02
Clonidine in opiate withdrawal. Lancet (1978) 1.01
AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL. Gene Ther (2005) 1.01
A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics. Mol Psychiatry (1998) 1.00
Behavioral effects of stimulation of the nucleus locus coeruleus in the stump-tailed monkey Macaca arctoides. Brain Res (1976) 1.00
Quantitative analysis of polyols in human plasma and cerebrospinal fluid. J Chromatogr (1989) 1.00
Controllable and uncontrollable stress in humans: alterations in mood and neuroendocrine and psychophysiological function. Am J Psychiatry (1987) 1.00
Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal. Psychopharmacology (Berl) (1988) 1.00
The clinical use of clonidine in abrupt withdrawal from methadone. Effects on blood pressure and specific signs and symptoms. Arch Gen Psychiatry (1981) 1.00
Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approach. Synapse (1998) 0.99
Diagnosis and therapy of aortic prosthetic fistulas: trends over a 30-year experience. Br J Surg (1996) 0.99
Papio cynocephalus endogenous retrovirus among old world monkeys: evidence for coevolution and ancient cross-species transmissions. J Virol (2000) 0.99
Effects of acute metabolic stress on striatal dopamine release in healthy volunteers. Neuropsychopharmacology (2000) 0.99
A new algorithm for treating schizophrenia. Psychopharmacol Bull (1998) 0.99
Neuroendocrine and behavioral effects of high-dose anabolic steroid administration in male normal volunteers. Psychoneuroendocrinology (2003) 0.98
Cerebrospinal fluid and behavioral changes after methyltestosterone administration: preliminary findings. Arch Gen Psychiatry (2001) 0.98
Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys. Eur J Pharmacol (1991) 0.97
Biocompatibility of PEG-based hydrogels in primate brain. Cell Transplant (2008) 0.97
Identification of Porphyromonas levii isolated from clinical cases of bovine interdigital necrobacillosis by 16S rRNA sequencing. Vet Ther (2009) 0.97
The use of high-dose human menopausal gonadotropin in an in vitro fertilization program. Fertil Steril (1983) 0.97
Reduced CSF concentrations of homovanillic acid and homovanillic acid to 5-hydroxyindoleacetic acid ratios in depressed patients: relationship to suicidal behavior and dexamethasone nonsuppression. Am J Psychiatry (1986) 0.97
Haematological profiles in pure bred cattle naturally infected with Theileria annulata in Saudi Arabia. Vet Parasitol (2002) 0.96
Surgical stress in humans is accompanied by an increase in plasma beta-endorphin immunoreactivity. Life Sci (1981) 0.96
Blastomycosis. An important medical problem in the Central United States. JAMA (1966) 0.95
Noradrenergic hyperactivity in opiate withdrawal supported by clonidine reversal of opiate withdrawal. Am J Psychiatry (1979) 0.95
Symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates: biochemical changes in striatal regions. Neuroscience (1989) 0.95
Severe long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the vervet monkey (Cercopithecus aethiops sabaeus). Neuroscience (1997) 0.95
Dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sci (1987) 0.95
Neuroleptic-induced decrease in plasma homovanillic acid and antipsychotic activity in schizophrenic patients. Science (1984) 0.95
Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system. Proc Natl Acad Sci U S A (1996) 0.95
Genetic differences between human immunodeficiency virus type 1 subpopulations in faeces and serum. J Gen Virol (1998) 0.94
The initiation of de novo methylation of foreign DNA integrated into a mammalian genome is not exclusively targeted by nucleotide sequence. J Virol (1995) 0.94
Physiological effects of high dose naloxone administration to normal adults. Life Sci (1982) 0.93
Tyramine infusions and selective monoamine oxidase inhibitor treatment. I. Changes in pressor sensitivity. Psychopharmacology (Berl) (1981) 0.93