Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.
|
Curr Biol
|
1994
|
1.80
|
2
|
Ubiquitin deposits in anterior horn cells in motor neurone disease.
|
Neurosci Lett
|
1988
|
1.77
|
3
|
Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity.
|
Brain
|
1991
|
1.74
|
4
|
A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength.
|
Pharm Res
|
1990
|
1.64
|
5
|
Brain diseases. Ubiquitous variations in nerves.
|
Nature
|
1989
|
1.53
|
6
|
Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation.
|
J Cell Sci
|
1996
|
1.49
|
7
|
Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470.
|
Cancer Res
|
2001
|
1.38
|
8
|
In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta.
|
J Neurochem
|
1996
|
1.31
|
9
|
Interactions of valproic acid with phenytoin.
|
Neurology
|
1980
|
1.24
|
10
|
3'-Azido-2',3'-dideoxyuridine (AzddU): comparative pharmacokinetics with 3'-azido-3'-deoxythymidine (AZT) in monkeys.
|
AIDS Res Hum Retroviruses
|
1990
|
1.24
|
11
|
Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease.
|
Mol Ther
|
2007
|
1.22
|
12
|
Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease.
|
J Neurochem
|
1993
|
1.18
|
13
|
Distribution of small magnetic particles in brain tumor-bearing rats.
|
J Neurooncol
|
1999
|
1.08
|
14
|
Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer.
|
J Clin Oncol
|
1996
|
1.07
|
15
|
Sites of phosphorylation in tau and factors affecting their regulation.
|
Biochem Soc Symp
|
2001
|
1.06
|
16
|
Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors.
|
J Biol Chem
|
1996
|
1.01
|
17
|
Activation of the AT(2) receptor of angiotensin II induces neurite outgrowth and cell migration in microexplant cultures of the cerebellum.
|
J Biol Chem
|
1999
|
0.97
|
18
|
Optimized formulation of magnetic chitosan microspheres containing the anticancer agent, oxantrazole.
|
Pharm Res
|
1992
|
0.95
|
19
|
Tau isoform expression and phosphorylation state during differentiation of cultured neuronal cells.
|
FEBS Lett
|
1995
|
0.94
|
20
|
Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated.
|
Biochem J
|
1991
|
0.94
|
21
|
Enhanced brain tumor selectivity of cationic magnetic polysaccharide microspheres.
|
J Drug Target
|
1998
|
0.94
|
22
|
The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures.
|
Biochem J
|
1995
|
0.93
|
23
|
Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz.
|
J Clin Invest
|
1996
|
0.92
|
24
|
In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-bearing rats.
|
Cancer Chemother Pharmacol
|
1996
|
0.91
|
25
|
Pharmacokinetics of 2',3'-dideoxyinosine in monkeys.
|
Antimicrob Agents Chemother
|
1991
|
0.91
|
26
|
High-performance liquid chromatographic determination of the calcium channel blocker nimodipine in monkey plasma.
|
J Chromatogr
|
1992
|
0.90
|
27
|
Truncated forms of the androgen receptor are associated with polyglutamine expansion in X-linked spinal and bulbar muscular atrophy.
|
Hum Mol Genet
|
1998
|
0.88
|
28
|
Pharmacokinetic evaluation of drug interactions with zidovudine. I: Probenecid and zidovudine in monkeys.
|
J Pharm Sci
|
1991
|
0.88
|
29
|
Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine.
|
J Med Chem
|
1990
|
0.88
|
30
|
Comparative pharmacokinetics and interspecies scaling of 3'-azido-3'-deoxythymidine (AZT) in several mammalian species.
|
J Pharmacobiodyn
|
1990
|
0.88
|
31
|
Modulation of angiogenesis by human glioma xenograft models that differentially express vascular endothelial growth factor.
|
Clin Exp Metastasis
|
1998
|
0.87
|
32
|
A.S. Lübbe et al., Preclinical experiences with magnetic drug targeting: tolerance and efficacy. Cancer Res., 56: 4694-4701, 1996; and Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors. Cancer Res., 56: 4686-4693, 1996.
|
Cancer Res
|
1997
|
0.86
|
33
|
Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470.
|
Cancer Res
|
1996
|
0.86
|
34
|
Determination of antisense phosphorothioate oligonucleotides and catabolites in biological fluids and tissue extracts using anion-exchange high-performance liquid chromatography and capillary gel electrophoresis.
|
J Chromatogr B Biomed Sci Appl
|
1997
|
0.86
|
35
|
Phase I trial of multiple cycles of high-dose carboplatin, paclitaxel, and topotecan with peripheral-blood stem-cell support as front-line therapy.
|
J Clin Oncol
|
2001
|
0.86
|
36
|
Effect of parameter variability on physiologically-based pharmacokinetic model predicted drug concentrations.
|
J Pharm Sci
|
1995
|
0.85
|
37
|
A subpopulation of trypanosome microtubules recognized by a monoclonal antibody to tubulin.
|
EMBO J
|
1983
|
0.85
|
38
|
Application of microdialysis to characterize drug disposition in tumors.
|
Adv Drug Deliv Rev
|
2000
|
0.84
|
39
|
NCOMP--a windows-based computer program for noncompartmental analysis of pharmacokinetic data.
|
J Pharm Sci
|
1996
|
0.84
|
40
|
Effect of increased glycogen synthase kinase-3 activity upon the maturation of the amyloid precursor protein in transfected cells.
|
Neuroreport
|
1997
|
0.84
|
41
|
Effect of dosing vehicles on the pharmacokinetics of orally administered carbon tetrachloride in rats.
|
Toxicol Appl Pharmacol
|
1990
|
0.84
|
42
|
Comparative pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU) in mice.
|
Drug Metab Dispos
|
1990
|
0.83
|
43
|
Homologies between paraflagellar rod proteins from trypanosomes and euglenoids revealed by a monoclonal antibody.
|
Eur J Cell Biol
|
1985
|
0.83
|
44
|
Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies.
|
Clin Cancer Res
|
2000
|
0.83
|
45
|
Physiological pharmacokinetic modeling of inhaled trichloroethylene in rats.
|
Toxicol Appl Pharmacol
|
1991
|
0.83
|
46
|
Pharmacokinetic evaluation of drug interactions with anti-human immunotrophic virus (HIV) Drugs. III. 2',3'-Dideoxycytidine (ddC) and zidovudine in monkeys.
|
Pharm Res
|
1992
|
0.83
|
47
|
Stimulation of MAP kinase by v-raf transformation of fibroblasts fails to induce hyperphosphorylation of transfected tau.
|
FEBS Lett
|
1995
|
0.83
|
48
|
Adenoviral modification of mouse brain derived endothelial cells, bEnd3, to induce apoptosis by vascular endothelial growth factor.
|
Oncogene
|
2006
|
0.82
|
49
|
Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model.
|
Cancer Chemother Pharmacol
|
2001
|
0.82
|
50
|
Enhanced brain delivery of an anti-HIV nucleoside 2'-F-ara-ddI by xanthine oxidase mediated biotransformation.
|
J Med Chem
|
1994
|
0.81
|
51
|
Evaluation of carboplatin pharmacokinetics in the absence and presence of paclitaxel.
|
Clin Cancer Res
|
1996
|
0.81
|
52
|
Ibuprofen kinetics in plasma and synovial fluid of arthritic patients.
|
J Clin Pharmacol
|
1986
|
0.80
|
53
|
Androgen-induced up-regulation of tubulin isoforms in neuroblastoma cells.
|
J Neurochem
|
2001
|
0.80
|
54
|
Proacrosin as a marker of meiotic and post-meiotic germ cell differentiation: quantitative assessment of human spermatogenesis with a monoclonal antibody.
|
J Reprod Fertil
|
1994
|
0.79
|
55
|
Characterization of presystemic elimination of trichloroethylene and its nonlinear kinetics in rats.
|
Toxicol Appl Pharmacol
|
1996
|
0.79
|
56
|
Androgen-controlled specific gene expression in neuroblastoma cells.
|
J Neurol Sci
|
1995
|
0.79
|
57
|
Targeting anticancer drugs to the brain. I: Enhanced brain delivery of oxantrazole following administration in magnetic cationic microspheres.
|
J Drug Target
|
1993
|
0.79
|
58
|
Human acrosome biogenesis: immunodetection of proacrosin in primary spermatocytes and of its partitioning pattern during meiosis.
|
Development
|
1991
|
0.79
|
59
|
Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate.
|
J Med Chem
|
1997
|
0.78
|
60
|
Zalcitabine. Clinical pharmacokinetics and efficacy.
|
Clin Pharmacokinet
|
1995
|
0.78
|
61
|
Identification of novel in vitro PKA phosphorylation sites on the low and middle molecular mass neurofilament subunits by mass spectrometry.
|
Biochemistry
|
1998
|
0.78
|
62
|
Immunochemical characterization of a human sperm fibrous sheath protein, its developmental expression pattern, and morphogenetic relationships with actin.
|
J Histochem Cytochem
|
1997
|
0.78
|
63
|
Incorporation of NF-L into keratin filaments in transfected epithelial cells.
|
Neuroreport
|
1997
|
0.77
|
64
|
Mutually exclusive expression of beta(III)-tubulin and vimentin in adrenal cortex carcinoma SW13 cells.
|
FEBS Lett
|
2000
|
0.77
|
65
|
Pharmacokinetic evaluation of drug interactions with anti-human immunodeficiency virus drugs. V. Effect of soluble CD4 on 2',3'-dideoxycytidine kinetics in monkeys.
|
Drug Metab Dispos
|
1992
|
0.77
|
66
|
Pharmacokinetics of the chemopreventive agent oltipraz and of its metabolite M3 in human subjects after a single oral dose.
|
Clin Cancer Res
|
2000
|
0.77
|
67
|
Synthesis, characterization, and in vitro stability of chitosan-methotrexate conjugates.
|
Pharm Res
|
1990
|
0.77
|
68
|
Use of a physiologically based model to predict systemic uptake and respiratory elimination of perchloroethylene.
|
Toxicol Appl Pharmacol
|
1994
|
0.77
|
69
|
Unexplained in-vitro fertilization failure: implication of acrosomes with a small reacting region, as revealed by a monoclonal antibody.
|
Hum Reprod
|
1992
|
0.76
|
70
|
Phase I trial of the thymidylate synthase inhibitor AG331 as a 5-day continuous infusion.
|
Clin Cancer Res
|
1996
|
0.76
|
71
|
Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells.
|
Neurobiol Aging
|
1995
|
0.76
|
72
|
Aggregation of neurofilaments in NF-L transfected neuronal cells: regeneration of the filamentous network by a protein kinase C inhibitor.
|
J Neurochem
|
1996
|
0.76
|
73
|
Tissue distribution of methotrexate following administration as a solution and as a magnetic microsphere conjugate in rats bearing brain tumors.
|
J Neurooncol
|
1995
|
0.76
|
74
|
Cytoplasmic events in human meiotic arrest as revealed by immunolabelling of spermatocyte proacrosin.
|
Differentiation
|
1992
|
0.76
|
75
|
The ins and outs of antiviral drug transport in the brain.
|
J Neurovirol
|
1997
|
0.75
|
76
|
Preparation and in vitro evaluation of magnetic microsphere-methotrexate conjugate drug delivery systems.
|
Bioconjug Chem
|
1995
|
0.75
|
77
|
Pharmacokinetics of the anticancer agent 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine in rats.
|
Cancer Chemother Pharmacol
|
1994
|
0.75
|
78
|
Ubiquitin, PGP 9.5 and dense body formation in trimethyltin intoxication: differential neuronal responses to chemically induced cell damage.
|
Neuropathol Appl Neurobiol
|
1992
|
0.75
|
79
|
Effect of phenytoin on protein binding of valproic acid.
|
Can J Neurol Sci
|
1979
|
0.75
|
80
|
High-performance liquid chromatographic analysis of the anticancer drug oxantrazole in rat whole blood and tissues.
|
J Chromatogr
|
1992
|
0.75
|
81
|
Comparison of cortical bone and serum concentrations of clindamycin achievable by direct local infusion and intravenous administration.
|
J Orthop Res
|
1991
|
0.75
|
82
|
Delivery of cytotoxic drugs from carrier cells to tumour cells by apoptosis.
|
Apoptosis
|
1998
|
0.75
|
83
|
Use of capillary electrophoresis methods to characterize the pharmacokinetics of antisense drugs.
|
Electrophoresis
|
1998
|
0.75
|
84
|
Pharmacokinetics of anti-HIV nucleosides in microswine.
|
J Pharm Pharmacol
|
1991
|
0.75
|
85
|
Immunochemical and immunocytochemical studies of the crustacean vitellogenesis-inhibiting hormone (VIH).
|
Gen Comp Endocrinol
|
1987
|
0.75
|
86
|
Pharmacokinetics and tissue distribution of a DNA-methyltransferase antisense (MT-AS) oligonucleotide and its catabolites in tumor-bearing nude mice.
|
J Pharmacol Exp Ther
|
1997
|
0.75
|
87
|
High-performance liquid chromatographic method for the determination of AG-331, a novel anti-cancer agent, in human serum and urine using solid-phase extraction and photodiode-array detection.
|
J Chromatogr B Biomed Appl
|
1995
|
0.75
|
88
|
The uptake and elimination of 1,1,1-trichloroethane during and following inhalation exposures in rats.
|
Toxicol Appl Pharmacol
|
1989
|
0.75
|
89
|
Effect of dietary fat content on the bioavailability of a sustained release quinidine gluconate tablet.
|
Biopharm Drug Dispos
|
1990
|
0.75
|
90
|
Differential distribution of tubulin epitopes in human spermatozoa.
|
Eur J Cell Biol
|
1986
|
0.75
|
91
|
Changes in inert gas rebreathing parameters after ozone exposure in dogs.
|
Am Rev Respir Dis
|
1983
|
0.75
|
92
|
Rapid and simultaneous determination of zidovudine and its glucuronide metabolite in plasma and urine. Application to the pharmacokinetic interaction of zidovudine and probenecid in the monkey.
|
J Pharm Biomed Anal
|
1991
|
0.75
|