Mutagenesis of codon 248 of the human p53 tumor suppressor gene by N-ethyl-N-nitrosourea.

PubWeight™: 0.83‹?›

🔗 View Article (PMID 7905619)

Published in Oncogene on January 01, 1994

Authors

S P Hussain1, F Aguilar, P Cerutti

Author Affiliations

1: Department of Carcinogenesis, Swiss Institute for Experimental Cancer Research, Epalinges, Lausanne.

Articles by these authors

Making and reading microarrays. Nat Genet (1999) 2.81

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B. Chem Biol (1995) 2.05

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A (1993) 1.95

Geographic variation of p53 mutational profile in nonmalignant human liver. Science (1994) 1.51

Esophageal motility disorders in Mexican patients with Duchenne's muscular dystrophy. Acta Gastroenterol Latinoam (1997) 1.39

The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress. Biochemistry (1991) 1.32

Rapid detection of influenza virus H1 by the polymerase chain reaction. Biochem Biophys Res Commun (1990) 1.26

High glucose induces antioxidant enzymes in human endothelial cells in culture. Evidence linking hyperglycemia and oxidative stress. Diabetes (1996) 1.23

Spontaneous reactions of aflatoxin B1 modified deoxyribonucleic acid in vitro. Biochemistry (1980) 1.23

Immortalization of normal human bronchial epithelial cells by human papillomaviruses 16 or 18. Cancer Res (1991) 1.20

Selective reduction of yeast transfer ribonucleic acid with sodium borohydride. J Mol Biol (1967) 1.19

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines. Carcinogenesis (1997) 1.15

Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts. Proc Natl Acad Sci U S A (1984) 1.13

Glutathione peroxidase compensates for the hypersensitivity of Cu,Zn-superoxide dismutase overproducers to oxidant stress. J Biol Chem (1994) 1.08

Active oxygen induced DNA strand breakage and poly ADP-ribosylation in promotable and non-promotable JB6 mouse epidermal cells. Carcinogenesis (1988) 1.07

A genotypic mutation system measuring mutations in restriction recognition sequences. Nucleic Acids Res (1991) 1.03

Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Oncogene (1994) 1.03

Apyrimidinic sites in gamma-irradiated DNA. FEBS Lett (1975) 1.02

Poly(ADP-ribosylation) of histones in intact human keratinocytes. Biochemistry (1989) 1.02

Structure of the photohydration products of cytidine and uridine. Proc Natl Acad Sci U S A (1968) 1.01

Laurdan properties in glycosphingolipid-phospholipid mixtures: a comparative fluorescence and calorimetric study. Biochim Biophys Acta (1997) 1.00

Interaction of partially reduced polyuridylic acid with polyadenylic acid. Biochem Biophys Res Commun (1966) 1.00

Genotypic mutation analysis by RFLP/PCR. Mutat Res (1993) 0.99

Transfection with human copper-zinc superoxide dismutase induces bidirectional alterations in other antioxidant enzymes, proteins, growth factor response, and paraquat resistance. Free Radic Biol Med (1995) 0.98

Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity. Eur J Biochem (1989) 0.98

Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis. Hum Immunol (2002) 0.97

Detection and determination of 5,6-dihydrouridine and 4-thiouridine in transfer ribonucleic acid from different sources. J Mol Biol (1968) 0.95

Primary structure of spinach-chloroplast thioredoxin f. Protein sequencing and analysis of complete cDNA clones for spinach-chloroplast thioredoxin f. Eur J Biochem (1989) 0.94

Continuous production of Rous sarcoma virus free of transformation defective virus in clones of established RSV-transformed quail cells. Virology (1981) 0.93

[New approach in the surgical treatment of the urogenital sinus]. Cir Pediatr (2000) 0.92

Suppression of tumor promoter phorbolmyristate acetate-induced chromosome breakage by antioxidants and inhibitors of arachidonic acid metabolism. Mutat Res (1983) 0.91

Clastogenic activity from Bloom syndrome fibroblast cultures. Proc Natl Acad Sci U S A (1981) 0.91

Tumor promoter phorbol-12-myristate-13-acetate induces poly(ADP)-ribosylation in fibroblasts. EMBO J (1985) 0.91

Genetic modulation of the cellular antioxidant defense capacity. Environ Health Perspect (1990) 0.91

Formation and excision of covalent deoxyribonucleic acid adducts of benzo[a]pyrene 4,5-epoxide and benzo[a]pyrenediol epoxide I in human lung cells A549. Biochemistry (1980) 0.91

Complement component C7 deficiency in a Spanish family. Clin Exp Immunol (2003) 0.90

Photoreduction of uridine and reduction of dihydrouridine with sodium borohydride. J Am Chem Soc (1968) 0.89

Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene. Cancer Res (1994) 0.89

UVB-induced DNA breaks interfere with transcriptional induction of c-fos. Mol Cell Biol (1993) 0.88

Screening for TP53 mutations in osteosarcomas using constant denaturant gel electrophoresis (CDGE). Hum Mutat (1993) 0.88

Template activity of uridylic acid-dihydrouridylic acid copolymers. Proc Natl Acad Sci U S A (1966) 0.88

Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants. Cancer Res (1989) 0.87

ADP-ribosylation of ADPR-transferase and topoisomerase I in intact mouse epidermal cells JB6. Biochemistry (1989) 0.87

Excisability and persistence of benzo(a)pyrene DNA adducts in epithelioid human lung cells. Nature (1978) 0.87

Oxidants stress induces the proto-oncogenes, C-fos and C-myc in mouse epidermal cells. Bull Cancer (1990) 0.87

The induction of ornithine decarboxylase by phorbol 12-myristate 13-acetate or by serum is inhibited by antioxidants. Carcinogenesis (1983) 0.86

N-Acetoxy-acetylaminofluorene reacts preferentially with a control region of intracellular SV40 chromosome. Nature (1981) 0.86

Tumor promoter phorbol-12-myristate-13-acetate induces poly ADP-ribosylation in human monocytes. Biochem Biophys Res Commun (1985) 0.86

Distribution and function of cytoskeletal proteins in lung cells with particular reference to 'contractile interstitial cells'. Methods Achiev Exp Pathol (1979) 0.85

Molecular mechanisms involved in T cell activation. I. Evidence for independent signal-transducing pathways in lymphokine production vs proliferation in cloned cytotoxic T lymphocytes. J Immunol (1987) 0.85

[Ethmoidal metastasis of renal adenocarcinoma]. Acta Otorrinolaringol Esp (2000) 0.84

Reflex excitability of facial motoneurons at onset of muscle reinnervation after facial nerve palsy. Muscle Nerve (1999) 0.84

Lack of association of MICA transmembrane region polymorphism and Behçet's disease in Spain. Tissue Antigens (1999) 0.84

Oxidants induce phosphorylation of ribosomal protein S6. J Biol Chem (1988) 0.83

Association of NRAMP1 promoter gene polymorphism with the susceptibility and radiological severity of rheumatoid arthritis. Tissue Antigens (2002) 0.83

FcgammaRIIA, FcgammaRIIIA and FcgammaRIIIB polymorphisms in Spanish patients with systemic lupus erythematosus. Eur J Immunogenet (2002) 0.83

Clastogenic action of tumor promoter phorbol-12-myristate-13 acetate in mixed human leukocyte cultures. Carcinogenesis (1983) 0.82

Determination of inflammatory markers in allergic reactions to drugs. Allergy Proc (1995) 0.82

Fat embolism syndrome. Orthop Rev (1993) 0.82

Poly ADP-ribosylation of histones in tumor promoter phorbol-12-myristate-13-acetate treated mouse embryo fibroblasts C3H10T1/2. Biochem Biophys Res Commun (1985) 0.82

Identification of hydrogen peroxide as the relevant messenger in the activation pathway of transcription factor NF-kappaB. Adv Exp Med Biol (1996) 0.82

Evidence for membrane-mediated chromosomal damage by aflatoxin B1 in human lymphocytes. Carcinogenesis (1984) 0.82

SLC11A1 promoter gene polymorphisms and fibrosis progression in chronic hepatitis C. Gut (2004) 0.82

In vitro reaction of radioactive 7beta, 8alpha, --dihydroxy--9alpha, 10alpha-epoxy--7,8,9,10--tetrahydrobenzo (A) pyrene and 7beta,8alpha--dihydroxy--9beta, 10beta--epoxy--7,8,9,10--tetrahydrobenzo (A) pyrene with DNA. Biochem Biophys Res Commun (1977) 0.81

A mammalian mutation system avoiding phenotypic selection: the RFLP/PCR approach. Prog Clin Biol Res (1990) 0.81

Selective photoreduction of nucleotides and nucleic acids. II. Mechanism of the two-step reduction of thymidine. J Am Chem Soc (1966) 0.81

Hydrogen peroxide insult in cultured mammalian cells: relationships between DNA single-strand breakage, poly(ADP-ribose) metabolism and cell killing. Biochim Biophys Acta (1989) 0.81

Quantitative determination of gamma-globulin in the human sera by column chromatography. Anal Biochem (1968) 0.81

Effect of polyunsaturated fatty acid deficiency on dipole relaxation in the membrane interface of rat liver microsomes. Biochim Biophys Acta (1997) 0.81

Effects of genitofemoral nerve transection on copulatory behavior and fertility in male rats. Physiol Behav (2001) 0.81

Cu2+ ions interact with cell membranes. J Inorg Biochem (1998) 0.80

Photoreductions and photocyclizations of tryptophan. J Am Chem Soc (1966) 0.80

Gene expression rather than the initiation of DNA replication is the principal target of lethal u.v.-induced damage in a regulatory region of SV40 DNA. Carcinogenesis (1987) 0.80

Phorbol ester-induced formation of clastogenic factor from human monocytes. Carcinogenesis (1987) 0.79

Effects of metabolite VIII of bromexine (Na 872) on type II epithelium of the lung: an experimental and morphological study with reference to surfactant secretion. Respiration (1979) 0.79

Two distinguishable fluorescent modes of 1-anilino-8-naphthalenesulfonate bound to human albumin. J Fluoresc (1996) 0.78

DNA binding of aflatoxin B1 by co-oxygenation in mouse embryo fibroblasts C3H/10T1/2. Biochem Biophys Res Commun (1983) 0.78

Quantitative determination of gamma-globulin in human sera by column chromatography. Anal Biochem (1968) 0.78

The organochlorine pesticide heptachlor disrupts the structure of model and cell membranes. Biochim Biophys Acta (1997) 0.78

Cytidine photohydration in R17 RNA. J Mol Biol (1972) 0.78

Mutation frequencies at codon 248 of the p53 tumour suppressor gene are not increased in colon cancer cell lines with the RER+ phenotype. Nucleic Acids Res (1997) 0.77

Antioxidant enzymes in xeroderma pigmentosum fibroblasts. Cancer Res (1988) 0.77

The anticancer drug adriamycin interacts with the human erythrocyte membrane. Z Naturforsch C (1999) 0.77

Enhanced formation of benzo(a)pyrene:DNA adducts in monocytes of patients with a presumed predisposition to lung cancer. Cancer Res (1985) 0.77

Interaction of 2,4-dichlorophenoxyacetic acid (2,4-D) with cell and model membranes. Biochim Biophys Acta (1996) 0.77

Reproducibility of ambulatory blood pressure monitoring in children. J Hypertens Suppl (1993) 0.77

The effect of the selective reduction of yeast transfer ribonucleic acid with sodium borohydride on the acceptance of valine and serine. Biochem Biophys Res Commun (1968) 0.77

An immunohistochemical study of the gut neuroendocrine system in juvenile pejerrey Odontesthes bonariensis (Valenciennes). J Fish Biol (2011) 0.77

Ultraviolet B light-induced mutagenesis of p53 hotspot codons 248 and 249 in human skin fibroblasts. Mol Carcinog (1994) 0.77

Diagnosis of reversible versus irreversible cerebral ischemia by the intravenous administration of naloxone. Stroke (1986) 0.76

In vitro transformation of human skin epithelial cells: Role of RAS oncogene in malignant progression. Toxicol In Vitro (1990) 0.76

Interaction of the anticancer drug tamoxifen with the human erythrocyte membrane and molecular models. Z Naturforsch C (1998) 0.76

Effect of exercise supplementation during adenosine infusion on hyperemic blood flow and flow reserve. Am Heart J (1994) 0.76

Role of tryptase, eosinophil cationic protein and histamine in immediate allergic reactions to drugs. Int Arch Allergy Immunol (1995) 0.76

[Contribution to studies of seizures in Rett's syndrome. Analysis of critical forms of four cases]. Rev Neurol (1996) 0.75

The defence against free radicals protects endothelial cells from hyperglycaemia-induced plasminogen activator inhibitor 1 over-production. Blood Coagul Fibrinolysis (1995) 0.75

Repair of DNA damage induced by ionizing radiation and benzo[a]pyrene in mammalian cells. J Toxicol Environ Health (1977) 0.75

Non-histone chromosomal protein acceptors for poly(ADP)-ribose in phorbol-12-myristate-13-acetate treated mouse embryo fibroblasts (C3H10T1/2). Carcinogenesis (1985) 0.75