Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.

PubWeight™: 1.37‹?› | Rank: Top 10%

🔗 View Article (PMC 294644)

Published in J Clin Invest on November 01, 1994

Authors

J J Goronzy1, P Bartz-Bazzanella, W Hu, M C Jendro, D R Walser-Kuntz, C M Weyand

Author Affiliations

1: Division of Rheumatology, Mayo Clinic, Rochester, Minnesota 55905.

Articles citing this

CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest (1996) 2.95

Perturbation of the T cell repertoire in rheumatoid arthritis. Proc Natl Acad Sci U S A (1998) 2.33

Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthritis Res Ther (2003) 1.61

CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis. J Exp Med (2002) 1.38

Giant cell vasculitis is a T cell-dependent disease. Mol Med (1997) 1.23

Telomeres and immunological diseases of aging. Gerontology (2009) 1.22

The repertoire of CD4+ CD28- T cells in rheumatoid arthritis. Mol Med (1996) 1.16

Diagnostic role of tests for T cell receptor (TCR) genes. J Clin Pathol (2003) 1.14

Clonal expansion is a characteristic feature of the B-cell repetoire of patients with rheumatoid arthritis. Arthritis Res (2000) 1.03

Epstein-Barr virus and rheumatoid arthritis: is there a link? Arthritis Res Ther (2006) 1.01

Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies. Nat Methods (2016) 1.00

Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay. J Clin Invest (1996) 0.90

The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target. Clin Dev Immunol (2012) 0.89

Long-term persistent accumulation of CD8+ T cells in synovial fluid of rheumatoid arthritis. Ann Rheum Dis (1997) 0.86

Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins. J Clin Invest (1996) 0.84

The contact-mediated response of peripheral-blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis. Arthritis Res Ther (2005) 0.84

Immunosenescence and rheumatoid arthritis: does telomere shortening predict impending disease? Autoimmun Rev (2011) 0.83

T cell receptor VB repertoire diversity in patients with immune thrombocytopenia following splenectomy. Clin Exp Immunol (2003) 0.81

Multiple mechanisms support oligoclonal T cell expansion in rheumatoid synovitis. Mol Med (1997) 0.81

Characterisation of T cell clonotypes that accumulated in multiple joints of patients with rheumatoid arthritis. Ann Rheum Dis (1999) 0.79

Quantitative and qualitative characterization of expanded CD4+ T cell clones in rheumatoid arthritis patients. Sci Rep (2015) 0.79

Association of MHC and rheumatoid arthritis. Why is rheumatoid arthritis associated with the MHC genetic region? An introduction. Arthritis Res (2000) 0.78

Prevalence of an ulcerative colitis-associated CD8+ T cell receptor beta-chain CDR3-region motif and its association with disease activity. J Clin Immunol (2001) 0.77

Immune system derived from homeostatic proliferation generates normal CD8 T-cell memory but altered repertoires and diminished heterologous immune responses. Blood (2008) 0.75

The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape. J Immunol Res (2016) 0.75

Simultaneous analysis of T cell clonality and cytokine production in rheumatoid arthritis using three-colour flow cytometry. Clin Exp Immunol (2002) 0.75

Increased activation-induced cell death in peripheral lymphocytes of rheumatoid arthritis patients: the mechanism of action. Immunology (2004) 0.75

Articles cited by this

The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum (1988) 111.05

The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum (1987) 14.21

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature (1993) 8.75

Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med (1978) 7.97

Genomic amplification with transcript sequencing. Science (1988) 7.52

Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med (1990) 7.49

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells. Proc Natl Acad Sci U S A (1989) 7.48

Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell (1990) 6.33

Programmed cell death and extrathymic reduction of Vbeta8+ CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature (1991) 5.56

Cellular events in the lymph node and lung of mice with influenza. Consequences of depleting CD4+ T cells. J Immunol (1990) 4.83

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J Exp Med (1994) 4.41

Evidence for the effects of a superantigen in rheumatoid arthritis. Science (1991) 3.71

The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med (1992) 3.36

Predominantly T-cell infiltrate in rheumatoid synovial membranes. N Engl J Med (1975) 3.35

The preferential accumulation of helper-inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion. Eur J Immunol (1988) 3.05

Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects. J Immunol (1993) 2.73

Selective expansion of T cells expressing V beta 2 in toxic shock syndrome. J Exp Med (1990) 2.71

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B. J Exp Med (1990) 2.69

Residues of the variable region of the T-cell-receptor beta-chain that interact with S. aureus toxin superantigens. Nature (1990) 2.60

Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a. Cell (1990) 2.42

Clonal dominance among T-lymphocyte infiltrates in arthritis. Proc Natl Acad Sci U S A (1988) 2.36

Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci U S A (1991) 2.29

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis. J Clin Invest (1992) 2.09

T cell receptor gene diversity and selection. Annu Rev Biochem (1990) 1.69

The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal. Proc Natl Acad Sci U S A (1991) 1.67

Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium. J Exp Med (1983) 1.57

Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients. J Exp Med (1993) 1.47

Identification of HLA-Dw14 genes in DR4+ rheumatoid arthritis. Lancet (1986) 1.45

Phenotypic analysis of the inflammatory exudate in murine lymphocytic choriomeningitis. J Exp Med (1987) 1.29

Strong primary selection for the Dw4 subtype of DR4 accounts for the HLA-DQw7 association with Felty's syndrome. Hum Immunol (1991) 1.27

Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis. Proc Natl Acad Sci U S A (1989) 1.25

Structure of T cell antigen receptor beta chain in synovial fluid cells from patients with rheumatoid arthritis. Arthritis Rheum (1988) 1.15

Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium. J Clin Invest (1992) 1.15

Interplay of T lymphocytes and HLA-DR molecules in rheumatoid arthritis. Curr Opin Rheumatol (1993) 1.05

Rheumatoid arthritis associated with expanded populations of granular lymphocytes. Ann Intern Med (1986) 1.03

Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis. Proc Natl Acad Sci U S A (1993) 1.01

Clonal proliferation of large granular lymphocytes in rheumatoid arthritis. Arthritis Rheum (1988) 0.98

Clonal heterogeneity of superantigen reactivity in human V beta 6+ T cell clones. Limited contributions of V beta sequence polymorphisms. J Immunol (1992) 0.98

Disease-associated human histocompatibility leukocyte antigen determinants in patients with seropositive rheumatoid arthritis. Functional role in antigen-specific and allogeneic T cell recognition. J Clin Invest (1990) 0.97

Nonrandom selection of T cell specificities in anti-HLA-DR responses. Sequence motifs of the responder HLA-DR allele influence T cell recruitment. J Immunol (1991) 0.95

Lymphocyte subsets associated with T cell receptor beta-chain gene rearrangement in patients with rheumatoid arthritis and neutropenia. Arthritis Rheum (1992) 0.87

Immunosuppression by anti-CD4 treatment in vivo. Persistence of secondary antiviral immune responses. Transplantation (1989) 0.83

Selection of T cell receptor V beta elements by HLA-DR determinants predisposing to rheumatoid arthritis. Arthritis Rheum (1992) 0.79

Articles by these authors

(truncated to the top 100)

High-resolution conformation of gramicidin A in a lipid bilayer by solid-state NMR. Science (1993) 5.33

The P53 pathway: what questions remain to be explored? Cell Death Differ (2006) 4.91

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. J Clin Oncol (1997) 4.51

Lymphoid neogenesis in rheumatoid synovitis. J Immunol (2001) 3.63

Perturbation of the T-cell repertoire in patients with unstable angina. Circulation (1999) 3.20

T cell homeostasis in patients with rheumatoid arthritis. Proc Natl Acad Sci U S A (2000) 3.06

CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest (1996) 2.95

Disease pattern in cranial and large-vessel giant cell arteritis. Arthritis Rheum (1999) 2.90

Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol (2001) 2.78

T cell activation in rheumatoid synovium is B cell dependent. J Immunol (2001) 2.73

Systemic anticancer therapy in gynecological cancer patients with renal dysfunction. Int J Gynecol Cancer (2007) 2.71

Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia (2002) 2.68

Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation (2000) 2.56

Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments. J Biol Chem (2000) 2.54

Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. J Exp Med (2001) 2.41

Perturbation of the T cell repertoire in rheumatoid arthritis. Proc Natl Acad Sci U S A (1998) 2.33

Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells. J Virol (1989) 2.28

Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging (2001) 2.20

Chlamydia and Borrelia DNA in synovial fluid of patients with early undifferentiated oligoarthritis: results of a prospective study. Arthritis Rheum (2001) 2.20

Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis. Arthritis Rheum (1993) 2.11

Expansion of unusual CD4+ T cells in severe rheumatoid arthritis. Arthritis Rheum (1997) 2.11

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils. J Cell Biol (1995) 2.11

How aggressive should initial therapy for rheumatoid arthritis be? Factors associated with response to 'non-aggressive' DMARD treatment and perspective from a 2-yr open label trial. Rheumatology (Oxford) (2004) 2.06

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices. J Cell Biol (1994) 2.03

Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. Proc Natl Acad Sci U S A (1986) 1.85

Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc Natl Acad Sci U S A (2001) 1.84

Intracranial hemorrhage after stenting and angioplasty of extracranial carotid stenosis. AJNR Am J Neuroradiol (2001) 1.78

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes. Nature (1986) 1.78

Detection and enumeration of circulating tumour cells in colorectal cancer. Br J Surg (1993) 1.77

Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis. J Immunol (2000) 1.73

Serum glucose level and diabetes predict tissue plasminogen activator-related intracerebral hemorrhage in acute ischemic stroke. Stroke (1999) 1.71

Brain tissue sodium is a ticking clock telling time after arterial occlusion in rat focal cerebral ischemia. Stroke (2000) 1.68

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4. J Biol Chem (2000) 1.67

Role of the carboxy-terminal portion of the HIV-1 transmembrane protein in viral transmission and cytopathogenicity. AIDS Res Hum Retroviruses (1989) 1.67

High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70. J Mol Biol (1999) 1.66

Down-regulation of CD28 expression by TNF-alpha. J Immunol (2001) 1.65

Modulation of CD4 by antigenic activation. J Immunol (1987) 1.63

IkappaB is a substrate for a selective pathway of lysosomal proteolysis. Mol Biol Cell (1998) 1.63

Functional subsets of CD4 T cells in rheumatoid synovitis. Arthritis Rheum (1998) 1.56

CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. Arthritis Rheum (2001) 1.55

T cell receptor peptide vaccination in rheumatoid arthritis: a placebo-controlled trial using a combination of Vbeta3, Vbeta14, and Vbeta17 peptides. Arthritis Rheum (1998) 1.55

Orientational constraints as three-dimensional structural constraints from chemical shift anisotropy: the polypeptide backbone of gramicidin A in a lipid bilayer. Protein Sci (1993) 1.53

Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity. J Biol Chem (1998) 1.52

The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis. J Immunol (1998) 1.50

Detection of free malignant cells in the peritoneal cavity before and after resection of colorectal cancer. Dis Colon Rectum (1994) 1.49

Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27. J Biol Chem (1997) 1.47

Persistent suppression of virus-specific cytotoxic T cell responses after transient depletion of CD4+ T cells in vivo. J Immunol (1989) 1.47

The inflammatory infiltrate in giant cell arteritis selects against B lymphocytes. J Rheumatol (1996) 1.45

Solution structure of P22 transcriptional antitermination N peptide-boxB RNA complex. Nat Struct Biol (1998) 1.45

Heart rhythm disorders and pacemakers: Pulmonary vein isolation combined with substrate modification for persistent atrial fibrillation treatment in patients with valvular heart diseases. Heart (2009) 1.44

Spontaneous deletions and duplications of sequences in the genome of cowpox virus. Proc Natl Acad Sci U S A (1984) 1.44

Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4. J Exp Med (1986) 1.43

Randomized, double-blind, placebo-controlled trial of oral enalapril in patients with neurally mediated syncope. Am Heart J (1998) 1.43

Interferon-gamma-producing T cells in giant cell vasculitis represent a minority of tissue-infiltrating cells and are located distant from the site of pathology. Am J Pathol (1996) 1.43

NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry (1998) 1.41

Formation of new vasa vasorum in vasculitis. Production of angiogenic cytokines by multinucleated giant cells. Am J Pathol (1999) 1.41

Resistance to apoptosis and elevated expression of Bcl-2 in clonally expanded CD4+CD28- T cells from rheumatoid arthritis patients. J Immunol (1998) 1.40

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis. Trends Immunol (2001) 1.39

Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia. Leukemia (2003) 1.39

Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells. J Immunol (2000) 1.38

Tissue cytokine patterns distinguish variants of rheumatoid synovitis. Am J Pathol (1997) 1.38

A new non-syndromic type of familial carcinomas? J Eur Acad Dermatol Venereol (2008) 1.38

Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. J Immunol (1999) 1.32

Conformational trapping in a membrane environment: a regulatory mechanism for protein activity? Proc Natl Acad Sci U S A (1996) 1.30

Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. J Clin Invest (1999) 1.30

Saccharide-RNA recognition in a complex formed between neomycin B and an RNA aptamer. Structure (1999) 1.29

Triggering of T-lymphocytes via either T3-Ti or T11 surface structures opens a voltage-insensitive plasma membrane calcium-permeable channel: requirement for interleukin-2 gene function. J Biol Chem (1989) 1.28

Functional profile of tissue-infiltrating and circulating CD68+ cells in giant cell arteritis. Evidence for two components of the disease. J Clin Invest (1994) 1.26

Characterization of adult human marrow hematopoietic progenitors highly enriched by two-color cell sorting with My10 and major histocompatibility class II monoclonal antibodies. J Immunol (1987) 1.26

The spectrum of dilated cardiomyopathy. The Johns Hopkins experience with 1,278 patients. Medicine (Baltimore) (1999) 1.25

Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways. J Immunol (2000) 1.25

Glucocorticoid-mediated repression of cytokine gene transcription in human arteritis-SCID chimeras. J Clin Invest (1997) 1.24

Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. J Biol Chem (1999) 1.24

Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia (2004) 1.24

Tissue-destructive macrophages in giant cell arteritis. Circ Res (1999) 1.23

Giant cell vasculitis is a T cell-dependent disease. Mol Med (1997) 1.23

Monovalent cation transport: lack of structural deformation upon cation binding. Biochemistry (1996) 1.22

Production of cytokines and metalloproteinases in rheumatoid synovitis is T cell dependent. Clin Immunol (1999) 1.21

Platelet-derived growth factor, intimal hyperplasia, and ischemic complications in giant cell arteritis. Arthritis Rheum (1998) 1.19

Genome-wide association study validation identifies novel loci for atherosclerotic cardiovascular disease. J Thromb Haemost (2012) 1.17

The repertoire of CD4+ CD28- T cells in rheumatoid arthritis. Mol Med (1996) 1.16

Modulation of helper T cell function by prostaglandins. Arthritis Rheum (1994) 1.16

p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback. Syst Biol (Stevenage) (2005) 1.15

Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis. Arthritis Rheum (1995) 1.15

Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis. J Clin Invest (1986) 1.14

Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings. Arthritis Rheum (1996) 1.13

IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation. Cell Death Differ (2008) 1.12

2H NMR determination of the global correlation time of the gramicidin channel in a lipid bilayer. Biophys J (1993) 1.12

Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells. Cell Growth Differ (1998) 1.12

Climate variation and incidence of Ross river virus in Cairns, Australia: a time-series analysis. Environ Health Perspect (2001) 1.12

Co-stimulatory pathways controlling activation and peripheral tolerance of human CD4+CD28- T cells. Eur J Immunol (1997) 1.12

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors. Proc Natl Acad Sci U S A (1999) 1.11

Peptide-triggered conformational switch in HIV-1 RRE RNA complexes. Nat Struct Biol (2001) 1.11

Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis. Immunity (1995) 1.10

Epoxides and aziridines from diazoacetates via ylide intermediates. Org Lett (2001) 1.10

IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis. J Immunol (1999) 1.10

Determination of the peptide torsion angle phi by 15N chemical shift and 13Calpha-1Halpha dipolar tensor correlation in solid-state MAS NMR. J Magn Reson (1998) 1.07

Visualization of secreted Hrp and Avr proteins along the Hrp pilus during type III secretion in Erwinia amylovora and Pseudomonas syringae. Mol Microbiol (2001) 1.07

Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1. J Biol Chem (1997) 1.06

Interplay of T lymphocytes and HLA-DR molecules in rheumatoid arthritis. Curr Opin Rheumatol (1993) 1.05