Published in Am J Hum Genet on November 01, 1994
A perspective on epistasis: limits of models displaying no main effect. Am J Hum Genet (2002) 5.63
Multilocus linkage tests based on affected relative pairs. Am J Hum Genet (2000) 3.57
Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. Am J Hum Genet (1995) 3.02
Genetic analysis of type 1 diabetes using whole genome approaches. Proc Natl Acad Sci U S A (1995) 1.66
Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes. Diabetologia (2008) 1.61
Reproductive failure and the major histocompatibility complex. Am J Hum Genet (1995) 0.90
The genetics of complex ophthalmic disorders. Br J Ophthalmol (1996) 0.81
Optimal strategies for mapping complex diseases in the presence of multiple loci. Am J Hum Genet (1997) 0.79
From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era. Rev Diabet Stud (2012) 0.75
Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet (1993) 51.42
Polymorphic DNA region adjacent to the 5' end of the human insulin gene. Proc Natl Acad Sci U S A (1981) 12.86
A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes (1984) 10.09
Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature (1991) 6.17
The insulin gene and susceptibility to IDDM. Genet Epidemiol (1989) 5.24
Genetic analysis of IDDM: summary of GAW5 IDDM results. Genet Epidemiol (1989) 5.06
Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet (1993) 3.76
Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11. Diabetologia (1985) 3.65
Bias of the estimated recombination fraction and lod score due to an association between a disease gene and a marker gene. Ann Hum Genet (1982) 3.12
Segregation analysis incorporating linkage markers. I. Single-locus models with an application to type I diabetes. Am J Hum Genet (1984) 2.74
Genetic analysis of IDDM: the GAW5 multiplex family dataset. Genet Epidemiol (1989) 2.73
Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals. Nat Genet (1992) 2.63
A new method to test genetic models in HLA associated diseases: the MASC method. Ann Hum Genet (1988) 2.03
Restriction fragment length polymorphism of the insulin gene in diabetes mellitus. Diabetes (1982) 1.75
Two-disease locus model: sib pair method using information on both HLA and Gm. Genet Epidemiol (1986) 1.49
Complementation and maternal effect in insulin-dependent diabetes. Am J Hum Genet (1991) 1.12
HLA and insulin-dependent diabetes: an overview. Genet Epidemiol (1989) 1.08
Discrimination between genetic models for insulin dependent diabetes mellitus. Genet Epidemiol Suppl (1986) 1.04
Two-disease-locus model: segregation analysis using information on two markers in nuclear families. Application to IDDM. Tissue Antigens (1990) 0.81
Effects of misspecifying genetic parameters in lod score analysis. Biometrics (1986) 6.36
Genetic analysis of IDDM: summary of GAW5 IDDM results. Genet Epidemiol (1989) 5.06
Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet (1999) 3.14
Bias of the estimated recombination fraction and lod score due to an association between a disease gene and a marker gene. Ann Hum Genet (1982) 3.12
Linkage detection by the Affected-Pedigree-Member method: what is really tested? Genet Epidemiol (1993) 2.88
A second locus for Marfan syndrome maps to chromosome 3p24.2-p25. Nat Genet (1994) 2.71
A new method to test genetic models in HLA associated diseases: the MASC method. Ann Hum Genet (1988) 2.03
Statistical properties of the allelic and genotypic transmission/disequilibrium test for multiallelic markers. Genet Epidemiol (1995) 1.92
Autosomal dominant Marfan-like connective-tissue disorder with aortic dilation and skeletal anomalies not linked to the fibrillin genes. Am J Hum Genet (1993) 1.74
Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease. Am J Hum Genet (1992) 1.71
Conclusions of segregation analysis for family data generated under two-locus models. Am J Hum Genet (1993) 1.67
Search for multifactorial disease susceptibility genes in founder populations. Ann Hum Genet (2000) 1.66
Posterior probability of linkage and maximal lod score. Ann Hum Genet (1995) 1.58
HLA-DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease. Tissue Antigens (2004) 1.56
HLA-DR53 molecules are associated with susceptibility to celiac disease and selectively bind gliadin-derived peptides. Immunogenetics (1999) 1.49
Two-disease locus model: sib pair method using information on both HLA and Gm. Genet Epidemiol (1986) 1.49
On the use of chi 2 tests for nested categorized data. Ann Hum Genet (1990) 1.44
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. Genes Immun (2008) 1.43
A gene for Meckel syndrome maps to chromosome 11q13. Am J Hum Genet (1998) 1.42
Application of the lod score method to detection of linkage between HLA and juvenile insulin-dependent diabetes. Clin Genet (1980) 1.41
Strategy for detecting susceptibility genes with weak or no marginal effect. Hum Hered (2007) 1.41
Manic depressive illness is linked to factor IX in a French pedigree. Ann Genet (1992) 1.40
Assessing the effect of multiple linkage tests in complex diseases. Genet Epidemiol (1990) 1.33
Optimization of genome search strategies for homozygosity mapping: influence of marker spacing on power and threshold criteria for identification of candidate regions. Ann Hum Genet (1998) 1.29
Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. Am J Hum Genet (1997) 1.27
Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum Mol Genet (1996) 1.26
Linkage analysis in spinal muscular atrophy, by six closely flanking markers on chromosome 5. Am J Hum Genet (1991) 1.26
Use of closely related affected individuals for the genetic study of complex diseases in founder populations. Am J Hum Genet (2000) 1.23
Improved use of SNP information to detect the role of genes. Genet Epidemiol (2003) 1.20
Juvenile insulin-dependent diabetes: a possible susceptibility gene in interaction with HLA. Ann Hum Genet (1981) 1.15
Genome search in celiac disease. Am J Hum Genet (1998) 1.14
Complementation and maternal effect in insulin-dependent diabetes. Am J Hum Genet (1991) 1.12
Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1. Genet Epidemiol (2001) 1.09
Apolipoprotein E epsilon4 allele and familial aggregation of Alzheimer disease. Arch Neurol (1998) 1.09
The triangle test statistic (TTS): a test of genetic homogeneity using departure from the triangle constraints in IBD distribution among affected sib-pairs. Ann Hum Genet (2000) 1.08
Investigation of the HLA component involved in rheumatoid arthritis (RA) by using the marker association-segregation chi-square (MASC) method: rejection of the unifying-shared-epitope hypothesis. Am J Hum Genet (1993) 1.07
Discrimination between genetic models for insulin dependent diabetes mellitus. Genet Epidemiol Suppl (1986) 1.04
Genetic study of transthyretin amyloid neuropathies: carrier risks among French and Portuguese families. J Med Genet (2003) 1.03
Segregation analysis of the Jacobsen data. Genet Epidemiol Suppl (1986) 1.01
Excess of maternal HLA-DR3 antigens in HLA DR3,4 positive type 1 (insulin-dependent) diabetic patients. Diabetologia (1990) 1.00
Conclusion of LOD-score analysis for family data generated under two-locus models. Am J Hum Genet (1996) 0.99
Existence of a genetic risk factor on chromosome 5q in Italian coeliac disease families. Ann Hum Genet (2001) 0.99
Interactive effect of HLA and Gm tested in a study of 135 juvenile insulin-dependent diabetic families. Tissue Antigens (1986) 0.96
Thrombosis in systemic lupus erythematosus: a French collaborative study. Arch Dis Child (1991) 0.95
Consanguinity and the sib-pair method: an approach using identity by descent between and within individuals. Am J Hum Genet (1996) 0.94
An extension of the admixture test for the study of genetic heterogeneity in hereditary multiple exostoses. Hum Genet (1997) 0.94
Power and robustness of the linkage homogeneity test in genetic analysis of common disorders. J Psychiatr Res (1987) 0.94
Performance of linkage analysis under misclassification error when the genetic model is unknown. Genet Epidemiol (1989) 0.93
Testing genetic models for IDDM by the MASC method. Genet Epidemiol (1989) 0.93
Candidate gene region 2q33 in European families with coeliac disease. Tissue Antigens (2004) 0.92
Testing parental imprinting in insulin-dependent diabetes mellitus by the marker-association-segregation-chi 2 method. Am J Hum Genet (1995) 0.91
Proximal spinal muscular atrophy (SMA) types II and III in the same sibship are not caused by different alleles at the SMA locus on 5q. Am J Hum Genet (1992) 0.91
Pleiotropic syndrome of dehydrated hereditary stomatocytosis, pseudohyperkalemia, and perinatal edema maps to 16q23-q24. Blood (2000) 0.90
A novel presenilin 1 mutation resulting in familial Alzheimer's disease with an onset age of 29 years. Neuroreport (1996) 0.90
Maximum identity length contrast: a powerful method for susceptibility gene detection in isolated populations. Genet Epidemiol (2001) 0.89
Indication of linkage and genetic heterogeneity of asthma according to age at onset on chromosome 7q in 107 French EGEA families. Eur J Hum Genet (2001) 0.89
High risk genotypes for celiac disease. C R Acad Sci III (1994) 0.89
Missing data in haplotype analysis: a study on the MILC method. Ann Hum Genet (2002) 0.89
Synergistic effect of two HLA heterodimers in the susceptibility to celiac disease in Tunisia. Genet Epidemiol (1997) 0.88
Association in multifactorial traits: how to deal with rare observations? Hum Hered (2004) 0.88
De novo presenilin 1 mutations are rare in clinically sporadic, early onset Alzheimer's disease cases. French Alzheimer's Disease Study Group. J Med Genet (1998) 0.88
HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis. Genes Immun (2008) 0.86
Modelling the major histocompatibility complex susceptibility to RA using the MASC method. Genet Epidemiol (1998) 0.86
Season of birth and not vitamin D receptor promoter polymorphisms is a risk factor for multiple sclerosis. Mult Scler (2009) 0.85
Modeling the HLA component in rheumatoid arthritis: sensitivity to DRB1 allele frequencies. Genet Epidemiol (2000) 0.84
No founder effect in three novel Alzheimer's disease families with APP 717 Val-->Ile mutation. Clerget-darpoux. French Alzheimer's Disease Study Group. J Med Genet (1996) 0.84
Caution in the interpretation of MLS. Genet Epidemiol (1997) 0.84
Linkage study of a large family with autosomal dominant polycystic kidney disease with reduced expression. Absence of linkage to the PKD 1 locus. Hum Genet (1990) 0.83
APOE promoter polymorphisms do not confer independent risk for Alzheimer's disease in a French population. Eur J Hum Genet (2000) 0.83
Becker's model and prenatal diagnosis in proximal spinal muscular atrophy (SMA): a note of caution. Am J Hum Genet (1991) 0.83
More missense in amyloid gene. Nat Genet (1992) 0.83
Cytokines in genetic susceptibility to multiple sclerosis: a candidate gene approach. French Multiple Sclerosis Genetics Group. J Neuroimmunol (2000) 0.82
Childhood-onset systemic lupus erythematosus: antiphospholipid antibodies in 37 patients and their first-degree relatives. Pediatrics (1993) 0.82
Comparing the power of linkage detection by the transmission disequilibrium test and the identity-by-descent test. Genet Epidemiol (1995) 0.82
Characteristics of familial aggregation in early-onset Alzheimer's disease: evidence of subgroups. Am J Med Genet (1995) 0.82
Evidence for apolipoprotein E epsilon 4 association in early-onset Alzheimer's patients with late-onset relatives. Am J Med Genet (1995) 0.82
Two-disease-locus model: segregation analysis using information on two markers in nuclear families. Application to IDDM. Tissue Antigens (1990) 0.81
POINTER correctly estimates the transmission probabilities under the general transmission model in the case of incomplete selection. Am J Hum Genet (1992) 0.81
A test based on the exact probability distribution of the chi 2 statistic--incorporation into the MASC method. Ann Hum Genet (1991) 0.81
Lack of correlation between genotype and phenotype in celiac disease. J Pediatr Gastroenterol Nutr (1998) 0.80
Genetic susceptibility to leprosy on a Caribbean Island: linkage analysis with five markers. Int J Lepr Other Mycobact Dis (1989) 0.80
Alpha2-macroglobulin gene and Alzheimer's disease: confirmation of association by haplotypes analyses. Ann Neurol (2000) 0.80
On the probability of identity states in permutable populations: reply to Cannings. Am J Hum Genet (1998) 0.79
Segregation analysis of Alzheimer pedigrees: rare Mendelian dominant mutation(s) explain a minority of early-onset cases. French Alzheimer Collaborative Group. Am J Med Genet (1996) 0.79
Evidence for linkage disequilibrium between HLA-DRB1 gene and multiple sclerosis. The French Research Group on Genetic Susceptibility to MS. Science (1997) 0.79