Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E epsilon 4 allele.

PubWeight™: 1.03‹?› | Rank: Top 15%

🔗 View Article (PMID 7986172)

Published in Arch Neurol on December 01, 1994

Authors

T Reed1, D Carmelli, G E Swan, J C Breitner, K A Welsh, G P Jarvik, S Deeb, J Auwerx

Author Affiliations

1: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis.

Articles citing this

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A (1998) 1.90

Neuropsychological and neuroimaging changes in preclinical Alzheimer's disease. J Int Neuropsychol Soc (2006) 1.90

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am J Pathol (2000) 1.25

Specific regional transcription of apolipoprotein E in human brain neurons. Am J Pathol (1999) 1.24

Genetics and visual attention: selective deficits in healthy adult carriers of the epsilon 4 allele of the apolipoprotein E gene. Proc Natl Acad Sci U S A (2000) 1.22

Epidemiology of the dementias: recent developments and new approaches. J Neurol Neurosurg Psychiatry (1996) 1.12

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord. Am J Pathol (2000) 1.11

Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype. Curr Alzheimer Res (2014) 1.07

The apolipoprotein E gene, attention, and brain function. Neuropsychology (2002) 1.05

Normal genetic variation, cognition, and aging. Behav Cogn Neurosci Rev (2003) 1.04

Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism. J Neurol Neurosurg Psychiatry (1998) 0.98

Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study. Clin Neuropsychol (2008) 0.97

Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia. Am J Geriatr Psychiatry (2003) 0.95

Apolipoprotein E and cholesterol in aging and disease in the brain. Future Lipidol (2008) 0.94

Reduced physiological complexity in robust elderly adults with the APOE epsilon4 allele. PLoS One (2009) 0.87

Lifelong vitamin E intake retards age-associated decline of spatial learning ability in apoE-deficient mice. Age (Dordr) (2005) 0.81

Gene by neuroticism interaction and cognitive function among older adults. Int J Geriatr Psychiatry (2012) 0.79

Sex Differences in Presynaptic Density and Neurogenesis in Middle-Aged ApoE4 and ApoE Knockout Mice. J Neurodegener Dis (2013) 0.78

Cognitive deficits and disruption of neurogenesis in a mouse model of apolipoprotein E4 domain interaction. J Biol Chem (2013) 0.78

Articles by these authors

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet (1998) 8.02

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell (2000) 6.48

Genetic influence on smoking--a study of male twins. N Engl J Med (1992) 4.93

The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem (1997) 4.55

Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation (1998) 4.39

Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry (2000) 4.23

Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet (1991) 4.19

PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J (1996) 4.11

Genetic linkage between hereditary hemochromatosis and HLA. Am J Hum Genet (1979) 3.96

Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias. Neurology (2000) 3.61

Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet (1996) 3.58

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res (1996) 3.36

Research ethics. Research practice and participant preferences: the growing gulf. Science (2011) 3.27

Numerical studies on two-loci selection models with general viabilities. Theor Popul Biol (1975) 3.20

Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med (1998) 3.13

Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc Natl Acad Sci U S A (1998) 2.93

The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes. Am J Hum Genet (1988) 2.85

The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta (1996) 2.83

Transient increase in obese gene expression after food intake or insulin administration. Nature (1995) 2.79

Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study. Int J Geriatr Psychiatry (2001) 2.63

Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet (1993) 2.57

Predictors of brain morphology for the men of the NHLBI twin study. Stroke (1999) 2.41

Thiazolidinediones: an update. Lancet (2000) 2.25

Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study. Arch Neurol (2001) 2.22

Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies. J Exp Med (2001) 2.21

Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. J Biol Chem (1997) 2.18

Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet (1999) 2.12

Utah pedigree studies: design and preliminary data for premature male CHD deaths. Prog Clin Biol Res (1979) 2.11

Activation of PPARdelta alters lipid metabolism in db/db mice. FEBS Lett (2000) 2.10

Association of midlife blood pressure to late-life cognitive decline and brain morphology. Neurology (1998) 2.09

Characteristics of nonresponders in a community survey of the elderly. J Am Geriatr Soc (1994) 2.05

Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol Cell Biol (1999) 2.05

APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease. Nat Genet (1998) 2.05

Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology (1994) 2.04

A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell (2001) 2.02

Alzheimer's disease in the NAS-NRC Registry of aging twin veterans, IV. Performance characteristics of a two-stage telephone screening procedure for Alzheimer's dementia. Psychol Med (1995) 2.01

Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke (1998) 1.99

Prevalence of depression and its treatment in an elderly population: the Cache County study. Arch Gen Psychiatry (2000) 1.97

Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes (1997) 1.92

Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm. J Biol Chem (1996) 1.88

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. J Clin Invest (1995) 1.88

Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. Am J Hum Genet (2001) 1.85

Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J Biol Chem (1997) 1.84

Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr Opin Lipidol (1997) 1.82

Reliability of the family history method in genetic studies of Alzheimer's disease and related dementias. Am J Psychiatry (1986) 1.80

Midlife cardiovascular risk factors and brain morphology in identical older male twins. Neurology (1999) 1.79

Obesity and 33-year follow-up for coronary heart disease and cancer mortality. Epidemiology (1997) 1.75

An evidence-based proposal for the classification of neuropsychiatric disturbance in Alzheimer's disease. Int J Geriatr Psychiatry (2001) 1.75

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J Clin Invest (1995) 1.74

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. Proc Natl Acad Sci U S A (2001) 1.74

Performance on the digit symbol substitution test and 5-year mortality in the Western Collaborative Group Study. Am J Epidemiol (1995) 1.71

Inflammatory alterations in mesenteric adipose tissue in Crohn's disease. Gastroenterology (1999) 1.68

Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25. Am J Hum Genet (1997) 1.68

p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively. J Biol Chem (1999) 1.66

Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem (1995) 1.66

Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs. Neurobiol Aging (1996) 1.65

Genetic association studies: genes in search of diseases. Neurology (2001) 1.65

Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes (1998) 1.63

Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis. J Mol Endocrinol (2001) 1.63

Hereditary influences on cognitive functioning in older men. A study of 4000 twin pairs. Arch Neurol (1993) 1.62

MR imaging of adventitial vasa vasorum in carotid atherosclerosis. Magn Reson Med (2008) 1.57

Heritability of hippocampal size in elderly twin men: equivalent influence from genes and environment. Hippocampus (2001) 1.55

Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem (1995) 1.54

Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell lines. Biochemistry (1988) 1.52

Transcriptional control of adipogenesis. Curr Opin Cell Biol (1998) 1.52

Intelligence and education as predictors of cognitive state in late life: a 50-year follow-up. Neurology (1995) 1.50

Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition. Neurology (1997) 1.47

Enhanced cognitive performance with estrogen use in nondemented community-dwelling older women. J Am Geriatr Soc (1999) 1.47

Cell-to-cell interaction in the immune response. VII. Requirement for differentiation of thymus-derived cells. J Exp Med (1971) 1.46

Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics (2001) 1.46

Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. J Biol Chem (1994) 1.45

Recent advances in the genetics of Alzheimer's disease and vascular dementia with an emphasis on gene-environment interactions. J Am Geriatr Soc (1996) 1.44

Heavy consumption of cigarettes, alcohol and coffee in male twins. J Stud Alcohol (1997) 1.44

Dementia diagnoses from clinical and neuropsychological data compared: the Cache County study. Neurology (2000) 1.44

Genetic and behavioral influences on body fat distribution. Int J Obes (1990) 1.43

Smoking, Alzheimer's disease, and confounding with genes. Lancet (1995) 1.43

A major insertion accounts for a significant proportion of mutations underlying human lipoprotein lipase deficiency. Proc Natl Acad Sci U S A (1989) 1.41

Genetic regulation of regional microstructure of the corpus callosum in late life. Neuroreport (2001) 1.41

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility. Oncogene (2010) 1.41

Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques. J Clin Invest (1992) 1.40

Structured exploratory data analysis (SEDA) for determining mode of inheritance of quantitative traits. I. Simulation studies on the effect of background distributions. Am J Hum Genet (1981) 1.40

Treatment and control of sheep scab (Psoroptes ovis) with ivermectin under field conditions in South Africa. Vet Rec (1992) 1.39

A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. Biol Psychiatry (1997) 1.39

Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. Mol Endocrinol (2000) 1.38

PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter. FEBS Lett (1998) 1.38

The pleiotropic functions of peroxisome proliferator-activated receptor gamma. J Mol Med (Berl) (2001) 1.36

Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport. J Biol Chem (1997) 1.36

Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells. J Endocrinol (1999) 1.35

Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines. J Biol Chem (2001) 1.34

Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study. Neurology (2000) 1.33

A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries. J Clin Invest (1990) 1.32