Published in J Clin Invest on December 01, 1994
Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. Proc Natl Acad Sci U S A (2008) 3.12
Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax (2005) 2.22
Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ (2002) 2.14
Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clin Exp Allergy (2009) 1.87
Association of rhinovirus infections with asthma. Clin Microbiol Rev (1999) 1.70
The role of allergy in severe asthma. Clin Exp Allergy (2012) 1.54
A defective type 1 response to rhinovirus in atopic asthma. Thorax (2002) 1.48
Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J Clin Invest (1997) 1.48
Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation. Am J Respir Crit Care Med (2011) 1.48
Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma. Ann Allergy Asthma Immunol (2003) 1.40
Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16. J Allergy Clin Immunol (2009) 1.28
Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. J Clin Invest (1996) 1.27
An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: a pilot study. Respir Res (2006) 1.22
Mechanisms of virus induced exacerbations of asthma. Thorax (1997) 1.12
Rhinovirus replication in human macrophages induces NF-kappaB-dependent tumor necrosis factor alpha production. J Virol (2006) 1.11
Human rhinovirus type 16: mutant V1210A requires capsid-binding drug for assembly of pentamers to form virions during morphogenesis. J Virol (2003) 1.07
Airway inflammation and illness severity in response to experimental rhinovirus infection in asthma. Chest (2014) 1.00
Bugs and asthma: a different disease? Proc Am Thorac Soc (2009) 0.99
Rhinoviruses, allergic inflammation, and asthma. Immunol Rev (2011) 0.99
Expression of intercellular adhesion molecule-1 (ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection? Clin Exp Immunol (2000) 0.98
In vitro cytotoxicity of Manville Code 100 glass fibers: effect of fiber length on human alveolar macrophages. Part Fibre Toxicol (2006) 0.97
Rhinovirus-Induced Exacerbations of Asthma and COPD. Scientifica (Cairo) (2013) 0.97
FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment. PLoS One (2012) 0.95
Role of infection in the development and exacerbation of asthma. Expert Rev Respir Med (2010) 0.95
Asthma exacerbations. 2: aetiology. Thorax (2006) 0.94
Virus/allergen interactions in asthma. Curr Allergy Asthma Rep (2013) 0.93
Similarities and discrepancies between exacerbations of asthma and chronic obstructive pulmonary disease. Thorax (1998) 0.92
Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells. J Biol Chem (2008) 0.92
Virus/allergen interactions and exacerbations of asthma. Immunol Allergy Clin North Am (2010) 0.91
Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M₂ muscarinic receptor dysfunction. Br J Pharmacol (2011) 0.85
Effect of gender, age, and severity of asthma attack on patterns of emergency department visits due to asthma by month and day of the week. Eur J Epidemiol (2005) 0.84
Viral respiratory infection and the link to asthma. Pediatr Infect Dis J (2008) 0.84
Rhinovirus-induced VP1-specific Antibodies are Group-specific and Associated With Severity of Respiratory Symptoms. EBioMedicine (2014) 0.82
Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol (2014) 0.78
Effects of montelukast on patients with asthma after experimental inoculation with human rhinovirus 16. Ann Allergy Asthma Immunol (2011) 0.78
Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in basophils of atopic asthmatics. Clin Exp Allergy (2014) 0.78
Mast Cells in Lung Homeostasis: Beyond Type I Hypersensitivity. Curr Respir Med Rev (2014) 0.75
Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans. J Immunol (2016) 0.75
Role of viral infections in exacerbations of asthma. Allergy must also be a factor. BMJ (1995) 0.75
Virus-induced asthma attack: The importance of allergic inflammation in response to viral antigen in an animal model of asthma. PLoS One (2017) 0.75
Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol (1975) 10.52
Eosinophilic inflammation in asthma. N Engl J Med (1990) 8.05
Respiratory viruses and exacerbations of asthma in adults. BMJ (1993) 6.37
Viruses as precipitants of asthmatic attacks in children. JAMA (1974) 3.30
Respiratory syncytial virus infection in adults: clinical, virologic, and serial pulmonary function studies. Ann Intern Med (1978) 2.25
Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions. J Clin Invest (1989) 1.97
Activation of basophil and mast cell histamine release by eosinophil granule major basic protein. J Exp Med (1983) 1.69
Enhanced superoxide production by alveolar macrophages and air-space cells, airway inflammation, and alveolar macrophage density changes after segmental antigen bronchoprovocation in allergic subjects. Am Rev Respir Dis (1992) 1.57
Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma. Am Rev Respir Dis (1988) 1.52
Kinins are generated during experimental rhinovirus colds. J Infect Dis (1988) 1.44
Enhanced ELISA: how to measure less than 10 picograms of a specific protein (immunoglobulin) in less than 8 hours. FASEB J (1988) 1.41
Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes. Am Rev Respir Dis (1991) 1.38
A model for obtaining predictable natural transmission of rhinoviruses in human volunteers. J Infect Dis (1984) 1.22
Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators. Am Rev Respir Dis (1991) 1.17
Respiratory virus infection of monolayer cultures of human nasal epithelial cells. Am Rev Respir Dis (1990) 1.12
Rat histamine N-methyltransferase. Quantification, tissue distribution, purification, and immunologic properties. J Biol Chem (1983) 1.08
Experimental rhinovirus 16 infection potentiates histamine release after antigen bronchoprovocation in allergic subjects. Am Rev Respir Dis (1991) 1.08
IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction. Am Rev Respir Dis (1993) 1.08
Hemopoietins for eosinophils. Glycoprotein hormones that regulate the development of inflammation in eosinophilia-associated disease. Hematol Oncol Clin North Am (1989) 1.08
Noncytotoxic activation of neutrophils by eosinophil granule major basic protein. Effect on superoxide anion generation and lysosomal enzyme release. J Immunol (1990) 1.02
Bronchial reactivity. Adv Intern Med (1983) 0.92
New therapeutic approaches in asthma. J Allergy Clin Immunol (1986) 0.89
Peripheral blood mononuclear cell interleukin-2 and interferon-gamma production, cytotoxicity, and antigen-stimulated blastogenesis during experimental rhinovirus infection. J Infect Dis (1990) 0.89
Enhanced reactive oxygen species metabolism of airspace cells and airway inflammation follow antigen challenge in human asthma. J Allergy Clin Immunol (1990) 0.84
The effects of eosinophil-granule major basic protein on lung-macrophage superoxide anion generation. J Allergy Clin Immunol (1992) 0.83
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy (2008) 12.35
Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med (2000) 5.82
Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res (2001) 4.87
Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med (1999) 4.75
Ragweed immunotherapy in adult asthma. N Engl J Med (1996) 4.69
Endometriosis. N Engl J Med (1993) 4.38
Isolation and partial characterization of the multiple forms of deoxyribonucleic acid-dependent ribonucleic acid polymerase in the mouse myeloma, MOPC 315. J Biol Chem (1974) 3.84
Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria. Eur J Clin Invest (2007) 3.58
Two types of human mast cells that have distinct neutral protease compositions. Proc Natl Acad Sci U S A (1986) 3.34
Viruses as precipitants of asthmatic attacks in children. JAMA (1974) 3.30
A new perspective on concepts of asthma severity and control. Eur Respir J (2008) 3.16
Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction. N Engl J Med (1998) 3.05
Efficacy and safety of inhaled corticosteroids. New developments. Am J Respir Crit Care Med (1998) 2.96
Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol (1991) 2.88
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. N Engl J Med (1987) 2.59
Fluticasone propionate/salmeterol combination provides more effective asthma control than low-dose inhaled corticosteroid plus montelukast. J Allergy Clin Immunol (2000) 2.51
Tryptase from human pulmonary mast cells. Purification and characterization. J Biol Chem (1981) 2.37
Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection. Am J Respir Crit Care Med (2000) 2.29
Rhinovirus and influenza type A infections as precipitants of asthma. Am Rev Respir Dis (1976) 2.20
Increased matrix metalloproteinase-9 in the airway after allergen challenge. Am J Respir Crit Care Med (2000) 2.18
Cloning and characterization of complementary DNA for human tryptase. J Clin Invest (1989) 2.12
A collaborative report: rhinoviruses--extension of the numbering system from 89 to 100. Virology (1987) 2.10
Greater frequency of viral respiratory infections in asthmatic children as compared with their nonasthmatic siblings. J Pediatr (1974) 2.09
Immunologic release of beta-hexosaminidase and beta-glucuronidase from purified rat serosal mast cells. J Immunol (1979) 2.01
Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells. J Immunol (1987) 2.00
Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions. J Clin Invest (1989) 1.97
Persistent wheezing in very young children is associated with lower respiratory inflammation. Am J Respir Crit Care Med (2001) 1.94
Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor. J Clin Invest (1997) 1.89
Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer. J Biol Chem (1986) 1.79
Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. J Histochem Cytochem (1989) 1.79
Primary ovarian pregnancy successfully treated with methotrexate. Am J Obstet Gynecol (1992) 1.76
Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells. J Immunol (1981) 1.76
Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy (1997) 1.76
Rapid detection and identification of respiratory viruses by direct immunofluorescence. Appl Microbiol (1970) 1.73
A novel heparin-dependent processing pathway for human tryptase. Autocatalysis followed by activation with dipeptidyl peptidase I. J Clin Invest (1996) 1.73
Detection of rhinovirus RNA in lower airway cells during experimentally induced infection. Am J Respir Crit Care Med (1997) 1.72
Structure and function of the chemical mediators of mast cells. Prog Allergy (1984) 1.71
The mesenteric circulation. Anatomy and physiology. Surg Clin North Am (1997) 1.71
Association of rhinovirus infections with asthma. Clin Microbiol Rev (1999) 1.70
Increased serum baseline tryptase levels and extensive skin involvement are predictors for the severity of mast cell activation episodes in children with mastocytosis. Allergy (2012) 1.66
Transmission of experimental rhinovirus colds in volunteer married couples. J Infect Dis (1976) 1.66
Comparison of airway and blood eosinophil function after in vivo antigen challenge. J Immunol (1992) 1.63
Cost-effectiveness of asthma control: an economic appraisal of the GOAL study. Allergy (2006) 1.62
Grass pollen immunotherapy inhibits seasonal increases in basophils and eosinophils in the nasal epithelium. Clin Exp Allergy (2001) 1.61
Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J Allergy Clin Immunol (1991) 1.60
Failure of inactivated influenza vaccine to protect an aged population. JAMA (1969) 1.56
Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase I from the mouse myeloma, MOPC 315. J Biol Chem (1974) 1.56
Evolution of dry powder inhaler design, formulation, and performance. Respir Med (2002) 1.55
Experimental rhinovirus 16 infection. Effects on cell differentials and soluble markers in sputum in asthmatic subjects. Am J Respir Crit Care Med (1997) 1.55
Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma. Am Rev Respir Dis (1988) 1.52
Effect of long-term salmeterol therapy compared with as-needed albuterol use on airway hyperresponsiveness. Chest (1999) 1.51
Is unrecognized anaphylaxis a cause of sudden unexpected death? Clin Exp Allergy (1995) 1.49
Aerosol transmission of rhinovirus colds. J Infect Dis (1987) 1.45
Prolonged Salmonella contamination of a recreational lake by runoff waters. Appl Microbiol (1971) 1.44
Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase. J Immunol (1983) 1.44
Experimental infections of chimpanzees with human rhinovirus types 14 and 43. Proc Soc Exp Biol Med (1968) 1.43
Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation. J Clin Invest (1989) 1.42
Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis. J Immunol (1997) 1.41
Rhinovirus enters but does not replicate inside monocytes and airway macrophages. J Immunol (1996) 1.37
Evaluation of human peripheral blood leukocytes for mast cell tryptase. J Immunol (1987) 1.37
Cloning and characterization of a second complementary DNA for human tryptase. J Clin Invest (1990) 1.36
Vancomycin and the red-man syndrome: pharmacodynamics of histamine release. J Infect Dis (1988) 1.35
Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function. J Immunol (1987) 1.34
Purification and subunit structure of deoxyribonucleic acid-dependent ribonucleic acid polymerase II from the mouse plasmacytoma, MOPC 315. J Biol Chem (1975) 1.33
Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma. Ann Allergy Asthma Immunol (1998) 1.33
The correlation between asthma control and health status: the GOAL study. Eur Respir J (2006) 1.33
Bronchodilation with a potent and selective leukotriene D4 (LTD4) receptor antagonist (MK-571) in patients with asthma. Am Rev Respir Dis (1992) 1.33
Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics. Am J Respir Crit Care Med (2000) 1.32
Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol (2001) 1.32
Peanut oil is not allergenic to peanut-sensitive individuals. J Allergy Clin Immunol (1981) 1.32
Virus-induced airway hyperresponsiveness and asthma. Am J Respir Crit Care Med (1998) 1.30
Development of human mast cells from umbilical cord blood cells by recombinant human and murine c-kit ligand. Proc Natl Acad Sci U S A (1993) 1.30
Synergistic effect in viral-bacterial infection: combined infection of the murine respiratory tract with Sendai virus and Pasteurella pneumotropica. Infect Immun (1973) 1.29
Monoclonal antibodies against human mast cell tryptase demonstrate shared antigenic sites on subunits of tryptase and selective localization of the enzyme to mast cells. J Immunol (1985) 1.29
Use of an anti-IgE humanized monoclonal antibody in ragweed-induced allergic rhinitis. J Allergy Clin Immunol (1997) 1.29
Histamine and tryptase levels in patients with acute allergic reactions: An emergency department-based study. J Allergy Clin Immunol (2000) 1.29
The fibrinogenolytic activity of purified tryptase from human lung mast cells. J Immunol (1985) 1.28
Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells. Blood (1992) 1.28
Histamine inhibition of neutrophil lysosomal enzyme release: an H2 histamine receptor response. Science (1976) 1.27
In vivo and in vitro studies on the use of the guinea pig as a model for virus-provoked airway hyperreactivity. Am Rev Respir Dis (1985) 1.27
Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J Exp Med (1996) 1.27
Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma. Am J Respir Crit Care Med (1999) 1.25
Development and implementation of guidelines in allergic rhinitis – an ARIA-GA2LEN paper. Allergy (2010) 1.24
NIH conference. Asthma. Ann Intern Med (1994) 1.22
A model for obtaining predictable natural transmission of rhinoviruses in human volunteers. J Infect Dis (1984) 1.22
Stability of asthma control with regular treatment: an analysis of the Gaining Optimal Asthma controL (GOAL) study. Allergy (2008) 1.20
Cleavage of type I procollagen by human mast cell chymase initiates collagen fibril formation and generates a unique carboxyl-terminal propeptide. J Biol Chem (1997) 1.20
Cell association of complexes of chymase, heparin proteoglycan, and protein after degranulation by rat mast cells. J Immunol (1981) 1.19
Markers of mast cell degranulation. Methods (1997) 1.19
Regulation of human mast cell tryptase. Effects of enzyme concentration, ionic strength and the structure and negative charge density of polysaccharides. Biochem J (1987) 1.19
Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell. J Immunol (1990) 1.19
Response to corticosteroids in the hypereosinophilic syndrome. Association with increased serum IgE levels. Arch Intern Med (1978) 1.18
IgE-regulated loss, not IgE-regulated synthesis, controls expression of FcepsilonRI in human basophils. J Leukoc Biol (2001) 1.18
Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo. Am J Respir Crit Care Med (1995) 1.17
Distinct molecular structures of nuclear class I, II, and III DNA-dependent RNA polymerases. Proc Natl Acad Sci U S A (1975) 1.17